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Q63450

- KCC1A_RAT

UniProt

Q63450 - KCC1A_RAT

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Protein

Calcium/calmodulin-dependent protein kinase type 1

Gene

Camk1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca2+ elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-516', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation (By similarity). Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-275' and 'Ser-294'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K+ and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.By similarity8 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by Ca2+/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-177 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-177 results in several fold increase in total activity. Unlike CaMK4, is unable to exhibit autonomous activity after Ca2+/calmodulin activation.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATPPROSITE-ProRule annotation
Active sitei141 – 1411Proton acceptor

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calmodulin-dependent protein kinase activity Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. nucleocytoplasmic transport Source: Ensembl
  3. positive regulation of dendritic spine development Source: UniProtKB
  4. positive regulation of muscle cell differentiation Source: Ensembl
  5. positive regulation of neuron projection development Source: UniProtKB
  6. positive regulation of protein export from nucleus Source: Ensembl
  7. positive regulation of protein serine/threonine kinase activity Source: UniProtKB
  8. positive regulation of synapse structural plasticity Source: UniProtKB
  9. protein phosphorylation Source: UniProtKB
  10. regulation of muscle cell differentiation Source: UniProtKB
  11. regulation of protein binding Source: UniProtKB
  12. regulation of protein localization Source: UniProtKB
  13. signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Differentiation, Neurogenesis

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.17. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type 1 (EC:2.7.11.17)
Alternative name(s):
CaM kinase I
Short name:
CaM-KI
CaM kinase I alpha
Short name:
CaMKI-alpha
Gene namesi
Name:Camk1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi629473. Camk1.

Subcellular locationi

Cytoplasm. Nucleus
Note: Predominantly cytoplasmic.

GO - Cellular componenti

  1. calcium- and calmodulin-dependent protein kinase complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB-KW
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi177 – 1771T → A: Loss of activation by CaMKK1 and CaMKK2. 1 Publication
Mutagenesisi263 – 2642KR → AA: Partially excluded from the nucleus; when associated with 319-AQA-321. 1 Publication
Mutagenesisi319 – 3213LQL → AQA: Retention in the nucleus. Partially excluded from the nucleus; when associated with 263-AA-264. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Calcium/calmodulin-dependent protein kinase type 1PRO_0000086078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki59 – 59Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei177 – 1771Phosphothreonine; by CaMKK1 and CaMKK21 Publication

Post-translational modificationi

Phosphorylated by CaMKK1 and CaMKK2 on Thr-177.1 Publication
Polybiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL12), leading to proteasomal degradation.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ63450.

PTM databases

PhosphoSiteiQ63450.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

GenevestigatoriQ63450.

Interactioni

Subunit structurei

Monomer. Interacts with XPO1.2 Publications

Protein-protein interaction databases

BioGridi251279. 1 interaction.
IntActiQ63450. 5 interactions.
MINTiMINT-3375300.
STRINGi10116.ENSRNOP00000033456.

Structurei

Secondary structure

1
374
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 183Combined sources
Beta strandi20 – 289Combined sources
Helixi29 – 335Combined sources
Beta strandi34 – 396Combined sources
Turni40 – 423Combined sources
Beta strandi45 – 528Combined sources
Helixi65 – 717Combined sources
Beta strandi81 – 866Combined sources
Beta strandi88 – 958Combined sources
Helixi103 – 1086Combined sources
Helixi115 – 13420Combined sources
Helixi144 – 1463Combined sources
Beta strandi147 – 1537Combined sources
Beta strandi158 – 1603Combined sources
Helixi187 – 1904Combined sources
Helixi198 – 21316Combined sources
Helixi223 – 2319Combined sources
Turni239 – 2446Combined sources
Helixi247 – 25610Combined sources
Helixi261 – 2633Combined sources
Helixi267 – 2726Combined sources
Turni274 – 2763Combined sources
Beta strandi277 – 2793Combined sources
Helixi287 – 29711Combined sources
Helixi298 – 31720Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A06X-ray2.50A1-329[»]
1MXEX-ray1.70E/F294-318[»]
2L7LNMR-B299-320[»]
ProteinModelPortaliQ63450.
SMRiQ63450. Positions 10-316.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63450.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 276257Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni276 – 31641Autoinhibitory domainAdd
BLAST
Regioni296 – 31722Calmodulin-bindingAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi263 – 2642Involved in nuclear importCurated
Motifi315 – 3217Nuclear export signal

Domaini

The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.1 Publication

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118944.
HOVERGENiHBG108055.
InParanoidiQ63450.
KOiK08794.
OMAiGKENNIE.
OrthoDBiEOG7WHH9K.
PhylomeDBiQ63450.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63450-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGAVEGPRW KQAEDIRDIY DFRDVLGTGA FSEVILAEDK RTQKLVAIKC
60 70 80 90 100
IAKKALEGKE GSMENEIAVL HKIKHPNIVA LDDIYESGGH LYLIMQLVSG
110 120 130 140 150
GELFDRIVEK GFYTERDASR LIFQVLDAVK YLHDLGIVHR DLKPENLLYY
160 170 180 190 200
SLDEDSKIMI SDFGLSKMED PGSVLSTACG TPGYVAPEVL AQKPYSKAVD
210 220 230 240 250
CWSIGVIAYI LLCGYPPFYD ENDAKLFEQI LKAEYEFDSP YWDDISDSAK
260 270 280 290 300
DFIRHLMEKD PEKRFTCEQA LQHPWIAGDT ALDKNIHQSV SEQIKKNFAK
310 320 330 340 350
SKWKQAFNAT AVVRHMRKLQ LGTSQEGQGQ TASHGELLTP TAGGPAAGCC
360 370
CRDCCVEPGS ELPPAPPPSS RAMD
Length:374
Mass (Da):41,638
Last modified:July 15, 1998 - v2
Checksum:i37889B3DEF033AB2
GO

Sequence cautioni

The sequence AAA19670.1 differs from that shown. Reason: Frameshift at positions 321 and 363. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371A → T AA sequence (PubMed:8386178)Curated
Sequence conflicti112 – 1121F → G in AAA19670. (PubMed:8253780)Curated
Sequence conflicti118 – 1181A → R in AAA19670. (PubMed:8253780)Curated
Sequence conflicti239 – 2391S → V AA sequence (PubMed:8386178)Curated
Sequence conflicti309 – 3091A → R in AAA19670. (PubMed:8253780)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24907 mRNA. Translation: AAA19670.1. Frameshift.
L26288 mRNA. Translation: AAA66944.1.
BC071177 mRNA. Translation: AAH71177.1.
PIRiS50193.
RefSeqiNP_604463.1. NM_134468.1.
XP_006237065.1. XM_006237003.2.
UniGeneiRn.11018.

Genome annotation databases

EnsembliENSRNOT00000029728; ENSRNOP00000033456; ENSRNOG00000021781.
GeneIDi171503.
KEGGirno:171503.
UCSCiRGD:629473. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24907 mRNA. Translation: AAA19670.1 . Frameshift.
L26288 mRNA. Translation: AAA66944.1 .
BC071177 mRNA. Translation: AAH71177.1 .
PIRi S50193.
RefSeqi NP_604463.1. NM_134468.1.
XP_006237065.1. XM_006237003.2.
UniGenei Rn.11018.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A06 X-ray 2.50 A 1-329 [» ]
1MXE X-ray 1.70 E/F 294-318 [» ]
2L7L NMR - B 299-320 [» ]
ProteinModelPortali Q63450.
SMRi Q63450. Positions 10-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 251279. 1 interaction.
IntActi Q63450. 5 interactions.
MINTi MINT-3375300.
STRINGi 10116.ENSRNOP00000033456.

PTM databases

PhosphoSitei Q63450.

Proteomic databases

PRIDEi Q63450.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000029728 ; ENSRNOP00000033456 ; ENSRNOG00000021781 .
GeneIDi 171503.
KEGGi rno:171503.
UCSCi RGD:629473. rat.

Organism-specific databases

CTDi 8536.
RGDi 629473. Camk1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118944.
HOVERGENi HBG108055.
InParanoidi Q63450.
KOi K08794.
OMAi GKENNIE.
OrthoDBi EOG7WHH9K.
PhylomeDBi Q63450.

Enzyme and pathway databases

BRENDAi 2.7.11.17. 5301.

Miscellaneous databases

EvolutionaryTracei Q63450.
NextBioi 622477.

Gene expression databases

Genevestigatori Q63450.

Family and domain databases

InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
PANTHERi PTHR24347. PTHR24347. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Calcium/calmodulin-dependent protein kinase I. cDNA cloning and identification of autophosphorylation site."
    Picciotto M.R., Czernik A.J., Nairn A.C.
    J. Biol. Chem. 268:26512-26521(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Erratum
    Picciotto M.R., Czernik A.J., Nairn A.C.
    J. Biol. Chem. 270:10358-10358(1995)
  3. "Characterization of a rat cDNA clone encoding calcium/calmodulin-dependent protein kinase I."
    Cho F.S., Phillips K.S., Bogucki B., Weaver T.E.
    Biochim. Biophys. Acta 1224:156-160(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Lung.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "Purification and characterization of Ca2+/calmodulin-dependent protein kinase V from rat cerebrum."
    Mochizuki H., Ito T., Hidaka H.
    J. Biol. Chem. 268:9143-9147(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 12-37; 158-167; 233-241 AND 285-295.
  6. "CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases."
    Sheng M., Thompson M.A., Greenberg M.E.
    Science 252:1427-1430(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF CREB1.
  7. "Similar substrate recognition motifs for mammalian AMP-activated protein kinase, higher plant HMG-CoA reductase kinase-A, yeast SNF1, and mammalian calmodulin-dependent protein kinase I."
    Dale S., Wilson W.A., Edelman A.M., Hardie D.G.
    FEBS Lett. 361:191-195(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBSTRATE RECOGNITION MOTIF.
  8. "Immunochemical localization of calcium/calmodulin-dependent protein kinase I."
    Picciotto M.R., Zoli M., Bertuzzi G., Nairn A.C.
    Synapse 20:75-84(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  9. "Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases type I, II, and IV."
    Sun P., Lou L., Maurer R.A.
    J. Biol. Chem. 271:3066-3073(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF ATF1 AND CREB1.
  10. "Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence."
    Edelman A.M., Mitchelhill K.I., Selbert M.A., Anderson K.A., Hook S.S., Stapleton D., Goldstein E.G., Means A.R., Kemp B.E.
    J. Biol. Chem. 271:10806-10810(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION, PHOSPHORYLATION AT THR-177 BY CAMKK1 AND CAMKK2, MUTAGENESIS OF THR-177.
  11. "Activation of a calcium-calmodulin-dependent protein kinase I cascade in PC12 cells."
    Aletta J.M., Selbert M.A., Nairn A.C., Edelman A.M.
    J. Biol. Chem. 271:20930-20934(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION.
  12. "Expression and subcellular localization of multifunctional calmodulin-dependent protein kinases-I, -II and -IV are altered in rat hippocampal CA1 neurons after induction of long-term potentiation."
    Ahmed B.Y., Yamaguchi F., Tsumura T., Gotoh T., Sugimoto K., Tai Y., Konishi R., Kobayashi R., Tokuda M.
    Neurosci. Lett. 290:149-153(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  13. "Characterization of Ca2+/calmodulin-dependent protein kinase I as a myosin II regulatory light chain kinase in vitro and in vivo."
    Suizu F., Fukuta Y., Ueda K., Iwasaki T., Tokumitsu H., Hosoya H.
    Biochem. J. 367:335-345(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION IN PHOSPHORYLATION OF MYL9.
  14. "Cytoplasmic localization of calcium/calmodulin-dependent protein kinase I-alpha depends on a nuclear export signal in its regulatory domain."
    Stedman D.R., Uboha N.V., Stedman T.T., Nairn A.C., Picciotto M.R.
    FEBS Lett. 566:275-280(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL, MUTAGENESIS OF 319-LEU--LEU-321 AND 263-LYS-ARG-264, INTERACTION WITH XPO1.
  15. "Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I."
    Wayman G.A., Kaech S., Grant W.F., Davare M., Impey S., Tokumitsu H., Nozaki N., Banker G., Soderling T.R.
    J. Neurosci. 24:3786-3794(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN AXONAL OUTGROWTH.
  16. "Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation."
    Schmitt J.M., Guire E.S., Saneyoshi T., Soderling T.R.
    J. Neurosci. 25:1281-1290(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN LONG-TERM POTENTIATION.
  17. "Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2."
    Tokumitsu H., Hatano N., Yokokura S., Sueyoshi Y., Nozaki N., Kobayashi R.
    FEBS Lett. 580:5797-5801(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF NUMB.
  18. "Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2."
    Wayman G.A., Impey S., Marks D., Saneyoshi T., Grant W.F., Derkach V., Soderling T.R.
    Neuron 50:897-909(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN DENDTRITIC GROWTH.
  19. "Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1."
    Davare M.A., Saneyoshi T., Soderling T.R.
    J. Neurooncol. 104:65-82(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MEDULLOBLASTOMA CELLS MIGRATION.
  20. "Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I."
    Goldberg J., Nairn A.C., Kuriyan J.
    Cell 84:875-887(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
    Tissue: Brain.
  21. "Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism."
    Clapperton J.A., Martin S.R., Smerdon S.J., Gamblin S.J., Bayley P.M.
    Biochemistry 41:14669-14679(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 294-318 IN COMPLEX WITH CALMODULIN, DOMAIN.

Entry informationi

Entry nameiKCC1A_RAT
AccessioniPrimary (citable) accession number: Q63450
Secondary accession number(s): Q63084
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 26, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Dendrite development is blocked in hippocampal neurons silencing CAKM1.

Keywords - Technical termi

3D-structure, Allosteric enzyme, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3