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Protein

Peroxisomal acyl-coenzyme A oxidase 3

Gene

Acox3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Oxidizes the CoA-esters of 2-methyl-branched fatty acids.1 Publication

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

Pathwayi: peroxisomal fatty acid beta-oxidation

This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.

GO - Molecular functioni

  • acyl-CoA dehydrogenase activity Source: GO_Central
  • FAD binding Source: InterPro
  • fatty acid binding Source: RGD
  • flavin adenine dinucleotide binding Source: RGD
  • pristanoyl-CoA oxidase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

SABIO-RKQ63448
UniPathwayiUPA00661

Chemistry databases

SwissLipidsiSLP:000000545

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 3 (EC:1.3.3.6)
Alternative name(s):
Branched-chain acyl-CoA oxidase
Short name:
BRCACox
Pristanoyl-CoA oxidase
Gene namesi
Name:Acox3
Synonyms:Prcox
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69245 Acox3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002046871 – 700Peroxisomal acyl-coenzyme A oxidase 3Add BLAST700

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei281PhosphothreonineBy similarity1
Modified residuei505N6-succinyllysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63448
PRIDEiQ63448

PTM databases

iPTMnetiQ63448
PhosphoSitePlusiQ63448

Expressioni

Tissue specificityi

Most abundant in liver, kidney, lung, and testis. Present in all tissues tested.

Interactioni

Protein-protein interaction databases

IntActiQ63448, 1 interactor
STRINGi10116.ENSRNOP00000042002

Structurei

3D structure databases

ProteinModelPortaliQ63448
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi698 – 700Microbody targeting signal3

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0136 Eukaryota
COG1960 LUCA
HOGENOMiHOG000245077
HOVERGENiHBG101107
InParanoidiQ63448
KOiK00232
PhylomeDBiQ63448

Family and domain databases

CDDicd01150 AXO, 1 hit
InterProiView protein in InterPro
IPR034171 ACO
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit

Sequencei

Sequence statusi: Complete.

Q63448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSSERRDS VLWSDIPKGP LSAYRARASF NSKELMLFWD GQDVLDFKKT
60 70 80 90 100
IFSTLENDPL FARPFGADLP LEKERELNFL RCKRVFEYGF FNAEDMLKNP
110 120 130 140 150
LKILVLMNCL GMYDWSLANK CVLHMLVFGS TIIGSGSEHH FKYLEKIYNL
160 170 180 190 200
EIFGCFALTE LSHGSNTKAM RTTAHYDPAT QEFILHSPDF EAAKFWVGNL
210 220 230 240 250
GKTATHAVVF AQLYTPDGQC RGLHSFLVQI RDPKTLLPMP GVMVGDMGKK
260 270 280 290 300
LGQNGLDNGF AMFHKVRIPR QNLLDRTGNV TSEGHYHTPF KDVRQRLGAS
310 320 330 340 350
LGSLSSGRIS IISISVVNLK LAVIIAIRFS ATRRQFGPTD KEEIPVLEYP
360 370 380 390 400
LQQWRLLPYL AAAYALDHFS KTIFLDLIEL QRAGKVGTTV TGRQSSGREI
410 420 430 440 450
HALASAGKPL ASWTAQRGIQ ECREVVGGHG YLAMNRFGEL RNDNDPNCTY
460 470 480 490 500
EGDNNVLLQQ TSNYLLSLLE HPLQDGAHFT SPLKTVNFLE AYPGILGQKF
510 520 530 540 550
MASSKADWLD SEAPLAAYRW LVCYLLRESH QRYCQEKKSR GSDFEARNNS
560 570 580 590 600
QVYGCRPLAL AFMELTVMQR FHEHTHSSSV PPSLRTVLGR LSMLYGLWCL
610 620 630 640 650
SQHTALLYRG GYISGEQTGK AMEDAILMLC VQLKDDAVAL VDAIAPSDFV
660 670 680 690 700
LGSPIGRADG ELYKNLWAAV LQQSGVLERA AWWPEFTANK SVANRLKSQL
Length:700
Mass (Da):78,446
Last modified:November 1, 1997 - v1
Checksum:iDE2327CEFA7423DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95188 mRNA Translation: CAA64487.1
RefSeqiNP_445791.1, NM_053339.1
UniGeneiRn.10546

Genome annotation databases

GeneIDi83522
KEGGirno:83522

Similar proteinsi

Entry informationi

Entry nameiACOX3_RAT
AccessioniPrimary (citable) accession number: Q63448
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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