Q63448 (ACOX3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxisomal acyl-coenzyme A oxidase 3
EC=1.3.3.6

Alternative name(s):
Branched-chain acyl-CoA oxidase
Short name=BRCACox
Pristanoyl-CoA oxidase

Gene names

Name:	Acox3
Synonyms:	Prcox

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	700 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Oxidizes the CoA-esters of 2-methyl-branched fatty acids. Ref.1
Catalytic activity	Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.
Cofactor	FAD.
Pathway	Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Subcellular location	Peroxisome.
Tissue specificity	Most abundant in liver, kidney, lung, and testis. Present in all tissues tested.
Sequence similarities	Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	fatty acid beta-oxidation using acyl-CoA oxidase Inferred from direct assay. Source: RGD
Cellular component	peroxisome Inferred from direct assay. Source: HGNC
Molecular function	acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro fatty acid binding Inferred from direct assay. Source: RGD flavin adenine dinucleotide binding Inferred from direct assay. Source: RGD pristanoyl-CoA oxidase activity Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 700	700	Peroxisomal acyl-coenzyme A oxidase 3		PRO_0000204687
Regions
	Motif	698 – 700	3	Microbody targeting signal
Amino acid modifications
	Modified residue	281	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q63448 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: DE2327CEFA7423DF	FASTA	700	78,446
	10 20 30 40 50 60 MGSSSERRDS VLWSDIPKGP LSAYRARASF NSKELMLFWD GQDVLDFKKT IFSTLENDPL 70 80 90 100 110 120 FARPFGADLP LEKERELNFL RCKRVFEYGF FNAEDMLKNP LKILVLMNCL GMYDWSLANK 130 140 150 160 170 180 CVLHMLVFGS TIIGSGSEHH FKYLEKIYNL EIFGCFALTE LSHGSNTKAM RTTAHYDPAT 190 200 210 220 230 240 QEFILHSPDF EAAKFWVGNL GKTATHAVVF AQLYTPDGQC RGLHSFLVQI RDPKTLLPMP 250 260 270 280 290 300 GVMVGDMGKK LGQNGLDNGF AMFHKVRIPR QNLLDRTGNV TSEGHYHTPF KDVRQRLGAS 310 320 330 340 350 360 LGSLSSGRIS IISISVVNLK LAVIIAIRFS ATRRQFGPTD KEEIPVLEYP LQQWRLLPYL 370 380 390 400 410 420 AAAYALDHFS KTIFLDLIEL QRAGKVGTTV TGRQSSGREI HALASAGKPL ASWTAQRGIQ 430 440 450 460 470 480 ECREVVGGHG YLAMNRFGEL RNDNDPNCTY EGDNNVLLQQ TSNYLLSLLE HPLQDGAHFT 490 500 510 520 530 540 SPLKTVNFLE AYPGILGQKF MASSKADWLD SEAPLAAYRW LVCYLLRESH QRYCQEKKSR 550 560 570 580 590 600 GSDFEARNNS QVYGCRPLAL AFMELTVMQR FHEHTHSSSV PPSLRTVLGR LSMLYGLWCL 610 620 630 640 650 660 SQHTALLYRG GYISGEQTGK AMEDAILMLC VQLKDDAVAL VDAIAPSDFV LGSPIGRADG 670 680 690 700 ELYKNLWAAV LQQSGVLERA AWWPEFTANK SVANRLKSQL

References

[1]

"Rat pristanoyl-CoA oxidase. cDNA cloning and recognition of its C-terminal (SQL) by the peroxisomal-targeting signal 1 receptor." Vanhooren J.C.T., Fransen M., de Bethune B., Baumgart E., Baes M., Torrekens S., van Leuven F., Mannaerts G.P., van Veldhoven P.P. Eur. J. Biochem. 239:302-309(1996) [PubMed: 8706733] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, FUNCTION. Tissue: Liver.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X95188 mRNA. Translation: CAA64487.1.
IPI	IPI00339123.
RefSeq	NP_445791.1. NM_053339.1.
UniGene	Rn.10546.
3D structure databases
ProteinModelPortal	Q63448.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q63448. 1 interaction.
STRING	Q63448.
Proteomic databases
PRIDE	Q63448.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	83522.
KEGG	rno:83522.
UCSC	NM_053339. rat.
Organism-specific databases
CTD	8310.
RGD	69245. Acox3.
Phylogenomic databases
eggNOG	roNOG10439.
GeneTree	ENSGT00530000062919.
HOVERGEN	HBG101107.
InParanoid	Q63448.
PhylomeDB	Q63448.
Gene expression databases
ArrayExpress	Q63448.
Genevestigator	Q63448.
GermOnline	ENSRNOG00000008474. Rattus norvegicus.
Family and domain databases
InterPro	IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_cen-dom. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR023570. Acyl-CoA_oxidase_perosiome. IPR009075. AcylCo_DH/oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR009100. AcylCoA_DH/oxidase. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
KO	K00232.
PANTHER	PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAM	SSF56645. AcylCoA_dehyd_NM. 1 hit. SSF47203. AcylCoADH_C_like. 2 hits.
ProtoNet	Search...
Other
NextBio	615999.

Entry information

Entry name

ACOX3_RAT

Accession

Primary (citable) accession number: Q63448

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 16, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program