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Protein

Peroxisomal acyl-coenzyme A oxidase 3

Gene

Acox3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Oxidizes the CoA-esters of 2-methyl-branched fatty acids.1 Publication

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

Pathwayi: peroxisomal fatty acid beta-oxidation

This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.

GO - Molecular functioni

  • acyl-CoA dehydrogenase activity Source: GO_Central
  • FAD binding Source: InterPro
  • fatty acid binding Source: RGD
  • flavin adenine dinucleotide binding Source: RGD
  • pristanoyl-CoA oxidase activity Source: RGD
  • receptor binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

SABIO-RKiQ63448.
UniPathwayiUPA00661.

Chemistry databases

SwissLipidsiSLP:000000545.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 3 (EC:1.3.3.6)
Alternative name(s):
Branched-chain acyl-CoA oxidase
Short name:
BRCACox
Pristanoyl-CoA oxidase
Gene namesi
Name:Acox3
Synonyms:Prcox
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69245. Acox3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002046871 – 700Peroxisomal acyl-coenzyme A oxidase 3Add BLAST700

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei281PhosphothreonineBy similarity1
Modified residuei505N6-succinyllysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63448.
PRIDEiQ63448.

PTM databases

iPTMnetiQ63448.
PhosphoSitePlusiQ63448.

Expressioni

Tissue specificityi

Most abundant in liver, kidney, lung, and testis. Present in all tissues tested.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ63448. 1 interactor.
STRINGi10116.ENSRNOP00000042002.

Structurei

3D structure databases

ProteinModelPortaliQ63448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi698 – 700Microbody targeting signal3

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0136. Eukaryota.
COG1960. LUCA.
HOGENOMiHOG000245077.
HOVERGENiHBG101107.
InParanoidiQ63448.
KOiK00232.
PhylomeDBiQ63448.

Family and domain databases

CDDicd01150. AXO. 1 hit.
Gene3Di1.10.540.10. 1 hit.
InterProiView protein in InterPro
IPR034171. ACO.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR036250. AcylCo_DH-like_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR037069. AcylCoA_DH/ox_N_sf.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
PfamiView protein in Pfam
PF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSSERRDS VLWSDIPKGP LSAYRARASF NSKELMLFWD GQDVLDFKKT
60 70 80 90 100
IFSTLENDPL FARPFGADLP LEKERELNFL RCKRVFEYGF FNAEDMLKNP
110 120 130 140 150
LKILVLMNCL GMYDWSLANK CVLHMLVFGS TIIGSGSEHH FKYLEKIYNL
160 170 180 190 200
EIFGCFALTE LSHGSNTKAM RTTAHYDPAT QEFILHSPDF EAAKFWVGNL
210 220 230 240 250
GKTATHAVVF AQLYTPDGQC RGLHSFLVQI RDPKTLLPMP GVMVGDMGKK
260 270 280 290 300
LGQNGLDNGF AMFHKVRIPR QNLLDRTGNV TSEGHYHTPF KDVRQRLGAS
310 320 330 340 350
LGSLSSGRIS IISISVVNLK LAVIIAIRFS ATRRQFGPTD KEEIPVLEYP
360 370 380 390 400
LQQWRLLPYL AAAYALDHFS KTIFLDLIEL QRAGKVGTTV TGRQSSGREI
410 420 430 440 450
HALASAGKPL ASWTAQRGIQ ECREVVGGHG YLAMNRFGEL RNDNDPNCTY
460 470 480 490 500
EGDNNVLLQQ TSNYLLSLLE HPLQDGAHFT SPLKTVNFLE AYPGILGQKF
510 520 530 540 550
MASSKADWLD SEAPLAAYRW LVCYLLRESH QRYCQEKKSR GSDFEARNNS
560 570 580 590 600
QVYGCRPLAL AFMELTVMQR FHEHTHSSSV PPSLRTVLGR LSMLYGLWCL
610 620 630 640 650
SQHTALLYRG GYISGEQTGK AMEDAILMLC VQLKDDAVAL VDAIAPSDFV
660 670 680 690 700
LGSPIGRADG ELYKNLWAAV LQQSGVLERA AWWPEFTANK SVANRLKSQL
Length:700
Mass (Da):78,446
Last modified:November 1, 1997 - v1
Checksum:iDE2327CEFA7423DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95188 mRNA. Translation: CAA64487.1.
RefSeqiNP_445791.1. NM_053339.1.
UniGeneiRn.10546.

Genome annotation databases

GeneIDi83522.
KEGGirno:83522.

Similar proteinsi

Entry informationi

Entry nameiACOX3_RAT
AccessioniPrimary (citable) accession number: Q63448
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 22, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families