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Protein

Neuropeptide Y receptor type 4

Gene

Npy4r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY.

GO - Molecular functioni

  • pancreatic polypeptide receptor activity Source: RGD
  • peptide binding Source: RGD
  • peptide YY receptor activity Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 4
Short name:
NPY4-R
Alternative name(s):
Pancreatic polypeptide receptor 1
Short name:
PP1
Gene namesi
Name:Npy4r
Synonyms:Ppyr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi61864. Npy4r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence analysisAdd
BLAST
Transmembranei40 – 6021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini61 – 7818CytoplasmicSequence analysisAdd
BLAST
Transmembranei79 – 9921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini100 – 11617ExtracellularSequence analysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 15518CytoplasmicSequence analysisAdd
BLAST
Transmembranei156 – 17621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini177 – 21135ExtracellularSequence analysisAdd
BLAST
Transmembranei212 – 23221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini233 – 26230CytoplasmicSequence analysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini284 – 30118ExtracellularSequence analysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini323 – 37553CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4827.
GuidetoPHARMACOLOGYi307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Neuropeptide Y receptor type 4PRO_0000069937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi114 ↔ 201PROSITE-ProRule annotation
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence analysis
Lipidationi340 – 3401S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ63447.
PRIDEiQ63447.

PTM databases

PhosphoSiteiQ63447.

Expressioni

Gene expression databases

GenevisibleiQ63447. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027469.

Chemistry

BindingDBiQ63447.

Structurei

3D structure databases

ProteinModelPortaliQ63447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiQ63447.
KOiK04206.
OMAiTAVYTIM.
OrthoDBiEOG773XGC.
PhylomeDBiQ63447.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001933. NPY4_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01015. NRPEPTIDEY4R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSHLMASL SPAFLQGKNG TNPLDSLYNL SDGCQDSADL LAFIITTYSV
60 70 80 90 100
ETVLGVLGNL CLIFVTTRQK EKSNVTNLLI ANLAFSDFLM CLICQPLTVT
110 120 130 140 150
YTIMDYWIFG EVLCKMLTFI QCMSVTVSIL SLVLVALERH QLIINPTGWK
160 170 180 190 200
PSISQAYLGI VVIWFISCFL SLPFLANSIL NDLFHYNHSK VVEFLEDKVV
210 220 230 240 250
CFVSWSSDHH RLIYTTFLLL FQYCVPLAFI LVCYMRIYQR LQRQRRAFHT
260 270 280 290 300
HTCSSRVGQM KRINGMLMAM VTAFAVLWLP LHVFNTLEDW YQEAIPACHG
310 320 330 340 350
NLIFLMCHLF AMASTCVNPF IYGFLNINFK KDIKALVLTC RCRPPQGEPE
360 370
PLPLSTVHTD LSKGSMRMGS KSNVM
Length:375
Mass (Da):42,568
Last modified:November 1, 1997 - v1
Checksum:iF8535C8C3EAD4FB9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231P → S in AAB07761 (PubMed:8643460).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68180 Genomic DNA. Translation: CAA92322.1.
U42388 mRNA. Translation: AAB07761.1.
U84245 Genomic DNA. Translation: AAB87736.1.
RefSeqiNP_113769.1. NM_031581.2.
UniGeneiRn.10574.

Genome annotation databases

EnsembliENSRNOT00000083105; ENSRNOP00000069607; ENSRNOG00000061026.
GeneIDi29471.
KEGGirno:29471.
UCSCiRGD:61864. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68180 Genomic DNA. Translation: CAA92322.1.
U42388 mRNA. Translation: AAB07761.1.
U84245 Genomic DNA. Translation: AAB87736.1.
RefSeqiNP_113769.1. NM_031581.2.
UniGeneiRn.10574.

3D structure databases

ProteinModelPortaliQ63447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027469.

Chemistry

BindingDBiQ63447.
ChEMBLiCHEMBL4827.
GuidetoPHARMACOLOGYi307.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ63447.

Proteomic databases

PaxDbiQ63447.
PRIDEiQ63447.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000083105; ENSRNOP00000069607; ENSRNOG00000061026.
GeneIDi29471.
KEGGirno:29471.
UCSCiRGD:61864. rat.

Organism-specific databases

CTDi5540.
RGDi61864. Npy4r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiQ63447.
KOiK04206.
OMAiTAVYTIM.
OrthoDBiEOG773XGC.
PhylomeDBiQ63447.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ63447.

Gene expression databases

GenevisibleiQ63447. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001933. NPY4_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01015. NRPEPTIDEY4R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor."
    Lundell I., Statnick M.A., Johnson D., Schober D.A., Starback P., Gehlert D.R., Larhammar D.
    Proc. Natl. Acad. Sci. U.S.A. 93:5111-5115(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
  2. "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors."
    Yan H., Yang J., Marasco J., Yamaguchi K., Brenner S., Collins F., Karbon W.
    Proc. Natl. Acad. Sci. U.S.A. 93:4661-4665(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide."
    Walker M.W., Smith K.E., Bard J., Vaysse P.J.-J., Gerald C., Daouti S., Weinshank R.L., Branchek T.A.
    Peptides 18:609-612(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.

Entry informationi

Entry nameiNPY4R_RAT
AccessioniPrimary (citable) accession number: Q63447
Secondary accession number(s): Q62892
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.