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Protein

Placenta growth factor

Gene

Pgf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth (By similarity).By similarity

GO - Molecular functioni

  • growth factor activity Source: UniProtKB
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • vascular endothelial growth factor receptor binding Source: RGD

GO - Biological processi

  • branching involved in ureteric bud morphogenesis Source: Ensembl
  • cell differentiation Source: UniProtKB-KW
  • cellular response to hormone stimulus Source: RGD
  • female pregnancy Source: RGD
  • organ regeneration Source: RGD
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of endothelial cell proliferation Source: RGD
  • regulation of morphogenesis of a branching structure Source: Ensembl
  • response to drug Source: RGD
  • response to hypoxia Source: RGD
  • sprouting angiogenesis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-RNO-194313. VEGF ligand-receptor interactions.
R-RNO-195399. VEGF binds to VEGFR leading to receptor dimerization.

Names & Taxonomyi

Protein namesi
Recommended name:
Placenta growth factor
Short name:
PlGF
Gene namesi
Name:Pgf
Synonyms:Plgf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi619850. Pgf.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Or 26Add
BLAST
Chaini24 – 158135Placenta growth factorPRO_0000023422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Glycosylationi30 – 301N-linked (GlcNAc...)
Disulfide bondi48 ↔ 90By similarity
Disulfide bondi73 – 73InterchainBy similarity
Disulfide bondi79 ↔ 125By similarity
Disulfide bondi82 – 82InterchainBy similarity
Disulfide bondi83 ↔ 127By similarity
Glycosylationi97 – 971N-linked (GlcNAc...)

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63434.

Expressioni

Gene expression databases

GenevisibleiQ63434. RN.

Interactioni

Subunit structurei

Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF.

GO - Molecular functioni

  • growth factor activity Source: UniProtKB
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • vascular endothelial growth factor receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007790.

Structurei

3D structure databases

ProteinModelPortaliQ63434.
SMRiQ63434. Positions 31-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY55. Eukaryota.
ENOG410YNR0. LUCA.
GeneTreeiENSGT00730000110791.
HOGENOMiHOG000230896.
HOVERGENiHBG000105.
InParanoidiQ63434.
KOiK16859.
OMAiRCECRPL.
OrthoDBiEOG74R1S0.
PhylomeDBiQ63434.
TreeFamiTF319554.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63434-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAMKLFTCF LQVLAGLAVH SQGALSAGNN STEMEVVPFN EVWGRSYCRP
60 70 80 90 100
MEKLVYIADE HPNEVSHIFS PSCVLLSRCS GCCGDEGLHC VALKTANITM
110 120 130 140 150
QILKIPPNRD PHSYVEMTFS QDVLCECRPI LETTKAERRK TKGKRKQSKT

PQTEEPHL
Length:158
Mass (Da):17,681
Last modified:November 1, 1996 - v1
Checksum:iB4771373A82E15B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40030 mRNA. Translation: AAA97426.1.
BC087006 mRNA. Translation: AAH87006.1.
PIRiA56125.
RefSeqiNP_446047.1. NM_053595.2.
UniGeneiRn.6960.

Genome annotation databases

EnsembliENSRNOT00000007790; ENSRNOP00000007790; ENSRNOG00000005650.
GeneIDi94203.
KEGGirno:94203.
UCSCiRGD:619850. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40030 mRNA. Translation: AAA97426.1.
BC087006 mRNA. Translation: AAH87006.1.
PIRiA56125.
RefSeqiNP_446047.1. NM_053595.2.
UniGeneiRn.6960.

3D structure databases

ProteinModelPortaliQ63434.
SMRiQ63434. Positions 31-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007790.

Proteomic databases

PaxDbiQ63434.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007790; ENSRNOP00000007790; ENSRNOG00000005650.
GeneIDi94203.
KEGGirno:94203.
UCSCiRGD:619850. rat.

Organism-specific databases

CTDi5228.
RGDi619850. Pgf.

Phylogenomic databases

eggNOGiENOG410IY55. Eukaryota.
ENOG410YNR0. LUCA.
GeneTreeiENSGT00730000110791.
HOGENOMiHOG000230896.
HOVERGENiHBG000105.
InParanoidiQ63434.
KOiK16859.
OMAiRCECRPL.
OrthoDBiEOG74R1S0.
PhylomeDBiQ63434.
TreeFamiTF319554.

Enzyme and pathway databases

ReactomeiR-RNO-194313. VEGF ligand-receptor interactions.
R-RNO-195399. VEGF binds to VEGFR leading to receptor dimerization.

Miscellaneous databases

PROiQ63434.

Gene expression databases

GenevisibleiQ63434. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Purification and characterization of a naturally occurring vascular endothelial growth factor.placenta growth factor heterodimer."
    DiSalvo J., Bayne M.L., Conn G., Kwok P.W., Trivedi P.G., Soderman D.D., Palisi T.M., Sullivan K.A., Thomas K.A.
    J. Biol. Chem. 270:7717-7723(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, HETERODIMERIZATION WITH VEGFA.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiPLGF_RAT
AccessioniPrimary (citable) accession number: Q63434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.