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Protein

Placenta growth factor

Gene

Pgf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth (By similarity).By similarity

GO - Molecular functioni

  • growth factor activity Source: UniProtKB
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • vascular endothelial growth factor receptor binding Source: RGD

GO - Biological processi

  • animal organ regeneration Source: RGD
  • branching involved in ureteric bud morphogenesis Source: Ensembl
  • cell differentiation Source: UniProtKB-KW
  • cellular response to hormone stimulus Source: RGD
  • female pregnancy Source: RGD
  • induction of positive chemotaxis Source: GO_Central
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of endothelial cell proliferation Source: RGD
  • positive regulation of mast cell chemotaxis Source: GO_Central
  • regulation of morphogenesis of a branching structure Source: Ensembl
  • response to drug Source: RGD
  • response to hypoxia Source: RGD
  • sprouting angiogenesis Source: RGD
  • vascular endothelial growth factor receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-RNO-194313 VEGF ligand-receptor interactions
R-RNO-195399 VEGF binds to VEGFR leading to receptor dimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Placenta growth factor
Short name:
PlGF
Gene namesi
Name:Pgf
Synonyms:Plgf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi619850 Pgf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Or 26Add BLAST23
ChainiPRO_000002342224 – 158Placenta growth factorAdd BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi30N-linked (GlcNAc...) asparagine1
Disulfide bondi48 ↔ 90By similarity
Disulfide bondi73InterchainBy similarity
Disulfide bondi79 ↔ 125By similarity
Disulfide bondi82InterchainBy similarity
Disulfide bondi83 ↔ 127By similarity
Glycosylationi97N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63434

Expressioni

Gene expression databases

BgeeiENSRNOG00000005650
GenevisibleiQ63434 RN

Interactioni

Subunit structurei

Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF.

GO - Molecular functioni

  • growth factor activity Source: UniProtKB
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • vascular endothelial growth factor receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007790

Structurei

3D structure databases

ProteinModelPortaliQ63434
SMRiQ63434
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY55 Eukaryota
ENOG410YNR0 LUCA
GeneTreeiENSGT00730000110791
HOGENOMiHOG000230896
HOVERGENiHBG000105
InParanoidiQ63434
KOiK16859
OMAiRCECRPL
OrthoDBiEOG091G0G6M
PhylomeDBiQ63434
TreeFamiTF319554

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63434-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAMKLFTCF LQVLAGLAVH SQGALSAGNN STEMEVVPFN EVWGRSYCRP
60 70 80 90 100
MEKLVYIADE HPNEVSHIFS PSCVLLSRCS GCCGDEGLHC VALKTANITM
110 120 130 140 150
QILKIPPNRD PHSYVEMTFS QDVLCECRPI LETTKAERRK TKGKRKQSKT

PQTEEPHL
Length:158
Mass (Da):17,681
Last modified:November 1, 1996 - v1
Checksum:iB4771373A82E15B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40030 mRNA Translation: AAA97426.1
BC087006 mRNA Translation: AAH87006.1
PIRiA56125
RefSeqiNP_446047.1, NM_053595.2
UniGeneiRn.6960

Genome annotation databases

EnsembliENSRNOT00000007790; ENSRNOP00000007790; ENSRNOG00000005650
GeneIDi94203
KEGGirno:94203
UCSCiRGD:619850 rat

Similar proteinsi

Entry informationi

Entry nameiPLGF_RAT
AccessioniPrimary (citable) accession number: Q63434
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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