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Protein

Cold shock domain-containing protein C2

Gene

Csdc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain.1 Publication

GO - Molecular functioni

  • DNA binding Source: InterPro
  • RNA binding Source: RGD
  • transcription factor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cold shock domain-containing protein C2
Alternative name(s):
RNA-binding protein PIPPin
Gene namesi
Name:Csdc2
Synonyms:Pippin
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi628780. Csdc2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003531 – 154Cold shock domain-containing protein C2Add BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63430.

PTM databases

iPTMnetiQ63430.
PhosphoSitePlusiQ63430.

Expressioni

Tissue specificityi

Brain-specific. Expression restricted to the pyramidal neurons of the cerebral cortex and in the Purkinje cells of the cerebellum.1 Publication

Developmental stagei

At E18 dpc, expressed in the cerebellum.1 Publication

Gene expression databases

BgeeiENSRNOG00000005332.
GenevisibleiQ63430. RN.

Interactioni

GO - Molecular functioni

  • transcription factor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007091.

Structurei

3D structure databases

ProteinModelPortaliQ63430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 136CSDAdd BLAST68

Sequence similaritiesi

Contains 1 CSD (cold-shock) domain.Curated

Phylogenomic databases

eggNOGiKOG3070. Eukaryota.
COG1278. LUCA.
GeneTreeiENSGT00390000000022.
HOGENOMiHOG000059524.
HOVERGENiHBG050947.
InParanoidiQ63430.
OMAiTFPFQRE.
OrthoDBiEOG091G0TYX.
PhylomeDBiQ63430.
TreeFamiTF324381.

Family and domain databases

CDDicd04458. CSP_CDS. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSESTSPPV VPPLHSPKSP VWPTFPFHRE SSRIWERGGG VSPRDLPSPL
60 70 80 90 100
PTKRTRTYSA TARASAGPVF KGVCKQFSRS QGHGFITPEN GSEDIFVHVS
110 120 130 140 150
DIEGEYVPVE GDEVTYKMCP IPPKNQKFQA VEVVLTQLAP HTPHETWSGQ

VVGS
Length:154
Mass (Da):16,877
Last modified:June 16, 2003 - v3
Checksum:i5827AC90328BF613
GO

Sequence cautioni

The sequence CAA62001 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89962 mRNA. Translation: CAA62001.2. Different initiation.
PIRiJC4588.
RefSeqiNP_001164013.1. NM_001170542.1.
UniGeneiRn.1171.

Genome annotation databases

EnsembliENSRNOT00000007091; ENSRNOP00000007091; ENSRNOG00000005332.
GeneIDi266600.
KEGGirno:266600.
UCSCiRGD:628780. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89962 mRNA. Translation: CAA62001.2. Different initiation.
PIRiJC4588.
RefSeqiNP_001164013.1. NM_001170542.1.
UniGeneiRn.1171.

3D structure databases

ProteinModelPortaliQ63430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007091.

PTM databases

iPTMnetiQ63430.
PhosphoSitePlusiQ63430.

Proteomic databases

PaxDbiQ63430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007091; ENSRNOP00000007091; ENSRNOG00000005332.
GeneIDi266600.
KEGGirno:266600.
UCSCiRGD:628780. rat.

Organism-specific databases

CTDi27254.
RGDi628780. Csdc2.

Phylogenomic databases

eggNOGiKOG3070. Eukaryota.
COG1278. LUCA.
GeneTreeiENSGT00390000000022.
HOGENOMiHOG000059524.
HOVERGENiHBG050947.
InParanoidiQ63430.
OMAiTFPFQRE.
OrthoDBiEOG091G0TYX.
PhylomeDBiQ63430.
TreeFamiTF324381.

Miscellaneous databases

PROiQ63430.

Gene expression databases

BgeeiENSRNOG00000005332.
GenevisibleiQ63430. RN.

Family and domain databases

CDDicd04458. CSP_CDS. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSDC2_RAT
AccessioniPrimary (citable) accession number: Q63430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: November 2, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.