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Protein

Solute carrier family 15 member 2

Gene

Slc15a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

GO - Molecular functioni

  • antibiotic transporter activity Source: RGD
  • dipeptide transporter activity Source: RGD
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

  • antibiotic transport Source: RGD
  • dipeptide transport Source: RGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 2
Alternative name(s):
Kidney H(+)/peptide cotransporter
Oligopeptide transporter, kidney isoform
Peptide transporter 2
Gene namesi
Name:Slc15a2
Synonyms:Pept2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61972. Slc15a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei568 – 588HelicalSequence analysisAdd BLAST21
Transmembranei612 – 632HelicalSequence analysisAdd BLAST21
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643111 – 729Solute carrier family 15 member 2Add BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Modified residuei9PhosphoserineBy similarity1
Modified residuei12PhosphothreonineBy similarity1
Modified residuei28PhosphoserineCombined sources1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Glycosylationi373N-linked (GlcNAc...)Sequence analysis1
Glycosylationi435N-linked (GlcNAc...)Sequence analysis1
Glycosylationi448N-linked (GlcNAc...)Sequence analysis1
Glycosylationi528N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63424.
PRIDEiQ63424.

PTM databases

iPTMnetiQ63424.
PhosphoSitePlusiQ63424.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002305.
GenevisibleiQ63424. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003189.

Chemistry databases

BindingDBiQ63424.

Structurei

Secondary structure

1729
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi413 – 420Combined sources8
Beta strandi422 – 424Combined sources3
Beta strandi426 – 431Combined sources6
Beta strandi437 – 443Combined sources7
Beta strandi453 – 456Combined sources4
Beta strandi458 – 470Combined sources13
Beta strandi473 – 484Combined sources12
Beta strandi486 – 494Combined sources9
Beta strandi497 – 504Combined sources8
Beta strandi514 – 521Combined sources8
Beta strandi523 – 525Combined sources3
Beta strandi527 – 532Combined sources6
Beta strandi537 – 539Combined sources3
Turni541 – 543Combined sources3
Beta strandi549 – 555Combined sources7
Beta strandi557 – 565Combined sources9
Beta strandi567 – 570Combined sources4
Beta strandi573 – 575Combined sources3
Beta strandi580 – 585Combined sources6
Beta strandi595 – 599Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A9HX-ray2.06A410-601[»]
5A9IX-ray2.84A/B/C410-601[»]
ProteinModelPortaliQ63424.
SMRiQ63424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiQ63424.
OrthoDBiEOG091G0M1S.
PhylomeDBiQ63424.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPFQKNESK ETLFSPVSTE EMLPRPPSPP KKSPPKIFGS SYPVSIAFIV
60 70 80 90 100
VNEFCERFSY YGMKAVLTLY FLYFLHWNED TSTSVYHAFS SLCYFTPILG
110 120 130 140 150
AAIADSWLGK FKTIIYLSLV YVLGHVFKSL GAIPILGGKM LHTILSLVGL
160 170 180 190 200
SLIALGTGGI KPCVAAFGGD QFEEEHAEAR TRYFSVFYLA INAGSLISTF
210 220 230 240 250
ITPMLRGDVK CFGQDCYALA FGVPGLLMVL ALVVFAMGSK MYRKPPPEGN
260 270 280 290 300
IVAQVIKCIW FALCNRFRNR SGDLPKRQHW LDWAAEKYPK HLIADVKALT
310 320 330 340 350
RVLFLYIPLP MFWALLDQQG SRWTLQANKM NGDLGFFVLQ PDQMQVLNPF
360 370 380 390 400
LVLIFIPLFD LVIYRLISKC RINFSSLRKM AVGMILACLA FAVAALVETK
410 420 430 440 450
INGMIHPQPA SQEIFLQVLN LADGDVKVTV LGSRNNSLLV ESVSSFQNTT
460 470 480 490 500
HYSKLHLEAK SQDLHFHLKY NSLSVHNDHS VEEKNCYQLL IHQDGESISS
510 520 530 540 550
MLVKDTGIKP ANGMAAIRFI NTLHKDLNIS LDTDAPLSVG KDYGVSAYRT
560 570 580 590 600
VLRGKYPAVH CETEDKVFSL DLGQLDFGTT YLFVITNITS QGLQAWKAED
610 620 630 640 650
IPVNKLSIAW QLPQYVLVTA AEVMFSVTGL EFSYSQAPSS MKSVLQAAWL
660 670 680 690 700
LTVAVGNIIV LVVAQFSGLA QWAEFVLFSC LLLVVCLIFS VMAYYYVPLK
710 720
SEDTREATDK QIPAVQGNMI NLETKNTRL
Length:729
Mass (Da):81,320
Last modified:November 1, 1996 - v1
Checksum:i66F5E88B9DF83DAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63149 mRNA. Translation: BAA09631.1.
UniGeneiRn.89268.

Genome annotation databases

UCSCiRGD:61972. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63149 mRNA. Translation: BAA09631.1.
UniGeneiRn.89268.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A9HX-ray2.06A410-601[»]
5A9IX-ray2.84A/B/C410-601[»]
ProteinModelPortaliQ63424.
SMRiQ63424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003189.

Chemistry databases

BindingDBiQ63424.
ChEMBLiCHEMBL3325.

PTM databases

iPTMnetiQ63424.
PhosphoSitePlusiQ63424.

Proteomic databases

PaxDbiQ63424.
PRIDEiQ63424.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:61972. rat.

Organism-specific databases

RGDi61972. Slc15a2.

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiQ63424.
OrthoDBiEOG091G0M1S.
PhylomeDBiQ63424.

Miscellaneous databases

PROiQ63424.

Gene expression databases

BgeeiENSRNOG00000002305.
GenevisibleiQ63424. RN.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS15A2_RAT
AccessioniPrimary (citable) accession number: Q63424
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.