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Protein

Solute carrier family 15 member 2

Gene

Slc15a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:8639691). Transports the dipeptide-like aminopeptidase inhibitor bestatin (PubMed:8639691). Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity).By similarity1 Publication

GO - Molecular functioni

  • antibiotic transmembrane transporter activity Source: RGD
  • dipeptide transporter activity Source: RGD
  • high-affinity oligopeptide transmembrane transporter activity Source: RGD
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

  • antibiotic transport Source: RGD
  • dipeptide transport Source: RGD
  • oligopeptide transport Source: RGD
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processPeptide transport, Protein transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 2
Alternative name(s):
Kidney H(+)/peptide cotransporter
Oligopeptide transporter, kidney isoform
Peptide transporter 2
Gene namesi
Name:Slc15a2
Synonyms:Pept2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61972 Slc15a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57CytoplasmicCuratedAdd BLAST57
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 87ExtracellularCurated9
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 113CytoplasmicCurated5
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 139ExtracellularCurated5
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 183CytoplasmicCuratedAdd BLAST23
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 217ExtracellularCuratedAdd BLAST13
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 295CytoplasmicCuratedAdd BLAST57
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 343ExtracellularCuratedAdd BLAST27
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 380CytoplasmicCuratedAdd BLAST16
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 611ExtracellularCuratedAdd BLAST210
Transmembranei612 – 632HelicalSequence analysisAdd BLAST21
Topological domaini633 – 643CytoplasmicCuratedAdd BLAST11
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Topological domaini665 – 674ExtracellularCurated10
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Topological domaini696 – 729CytoplasmicCuratedAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3325

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643111 – 729Solute carrier family 15 member 2Add BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei12PhosphothreonineBy similarity1
Modified residuei28PhosphoserineCombined sources1
Glycosylationi435N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi448N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi528N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi587N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63424
PRIDEiQ63424

PTM databases

iPTMnetiQ63424
PhosphoSitePlusiQ63424

Expressioni

Tissue specificityi

Strongly expressed in kidney cortex and medulla. Also detected in brain, lung and spleen.1 Publication

Gene expression databases

GenevisibleiQ63424 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003189

Chemistry databases

BindingDBiQ63424

Structurei

Secondary structure

1729
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi413 – 420Combined sources8
Beta strandi422 – 424Combined sources3
Beta strandi426 – 431Combined sources6
Beta strandi437 – 443Combined sources7
Beta strandi453 – 456Combined sources4
Beta strandi458 – 470Combined sources13
Beta strandi473 – 484Combined sources12
Beta strandi486 – 494Combined sources9
Beta strandi497 – 504Combined sources8
Beta strandi514 – 521Combined sources8
Beta strandi523 – 525Combined sources3
Beta strandi527 – 532Combined sources6
Beta strandi537 – 539Combined sources3
Turni541 – 543Combined sources3
Beta strandi549 – 555Combined sources7
Beta strandi557 – 565Combined sources9
Beta strandi567 – 570Combined sources4
Beta strandi573 – 575Combined sources3
Beta strandi580 – 585Combined sources6
Beta strandi595 – 599Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A9HX-ray2.06A410-601[»]
5A9IX-ray2.84A/B/C410-601[»]
ProteinModelPortaliQ63424
SMRiQ63424
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237 Eukaryota
COG3104 LUCA
HOGENOMiHOG000285186
HOVERGENiHBG052962
InParanoidiQ63424
OrthoDBiEOG091G0M1S
PhylomeDBiQ63424

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004768 Oligopep_transport
IPR000109 POT_fam
IPR018456 PTR2_symporter_CS
PANTHERiPTHR11654 PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854 PTR2, 2 hits
SUPFAMiSSF103473 SSF103473, 2 hits
SSF75217 SSF75217, 1 hit
TIGRFAMsiTIGR00926 2A1704, 1 hit
PROSITEiView protein in PROSITE
PS01022 PTR2_1, 1 hit
PS01023 PTR2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q63424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPFQKNESK ETLFSPVSTE EMLPRPPSPP KKSPPKIFGS SYPVSIAFIV
60 70 80 90 100
VNEFCERFSY YGMKAVLTLY FLYFLHWNED TSTSVYHAFS SLCYFTPILG
110 120 130 140 150
AAIADSWLGK FKTIIYLSLV YVLGHVFKSL GAIPILGGKM LHTILSLVGL
160 170 180 190 200
SLIALGTGGI KPCVAAFGGD QFEEEHAEAR TRYFSVFYLA INAGSLISTF
210 220 230 240 250
ITPMLRGDVK CFGQDCYALA FGVPGLLMVL ALVVFAMGSK MYRKPPPEGN
260 270 280 290 300
IVAQVIKCIW FALCNRFRNR SGDLPKRQHW LDWAAEKYPK HLIADVKALT
310 320 330 340 350
RVLFLYIPLP MFWALLDQQG SRWTLQANKM NGDLGFFVLQ PDQMQVLNPF
360 370 380 390 400
LVLIFIPLFD LVIYRLISKC RINFSSLRKM AVGMILACLA FAVAALVETK
410 420 430 440 450
INGMIHPQPA SQEIFLQVLN LADGDVKVTV LGSRNNSLLV ESVSSFQNTT
460 470 480 490 500
HYSKLHLEAK SQDLHFHLKY NSLSVHNDHS VEEKNCYQLL IHQDGESISS
510 520 530 540 550
MLVKDTGIKP ANGMAAIRFI NTLHKDLNIS LDTDAPLSVG KDYGVSAYRT
560 570 580 590 600
VLRGKYPAVH CETEDKVFSL DLGQLDFGTT YLFVITNITS QGLQAWKAED
610 620 630 640 650
IPVNKLSIAW QLPQYVLVTA AEVMFSVTGL EFSYSQAPSS MKSVLQAAWL
660 670 680 690 700
LTVAVGNIIV LVVAQFSGLA QWAEFVLFSC LLLVVCLIFS VMAYYYVPLK
710 720
SEDTREATDK QIPAVQGNMI NLETKNTRL
Length:729
Mass (Da):81,320
Last modified:November 1, 1996 - v1
Checksum:i66F5E88B9DF83DAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63149 mRNA Translation: BAA09631.1
UniGeneiRn.89268

Genome annotation databases

UCSCiRGD:61972 rat

Similar proteinsi

Entry informationi

Entry nameiS15A2_RAT
AccessioniPrimary (citable) accession number: Q63424
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health