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Protein

Solute carrier family 15 member 2

Gene

Slc15a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

GO - Molecular functioni

  • antibiotic transporter activity Source: RGD
  • dipeptide transporter activity Source: RGD
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

  • antibiotic transport Source: RGD
  • dipeptide transport Source: RGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-427975. Proton/oligopeptide cotransporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 2
Alternative name(s):
Kidney H(+)/peptide cotransporter
Oligopeptide transporter, kidney isoform
Peptide transporter 2
Gene namesi
Name:Slc15a2
Synonyms:Pept2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61972. Slc15a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei58 – 7821HelicalSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence analysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence analysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence analysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence analysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence analysisAdd
BLAST
Transmembranei568 – 58821HelicalSequence analysisAdd
BLAST
Transmembranei612 – 63221HelicalSequence analysisAdd
BLAST
Transmembranei644 – 66421HelicalSequence analysisAdd
BLAST
Transmembranei675 – 69521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Solute carrier family 15 member 2PRO_0000064311Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei12 – 121PhosphothreonineBy similarity
Modified residuei28 – 281PhosphoserineCombined sources
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence analysis
Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence analysis
Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence analysis
Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63424.
PRIDEiQ63424.

PTM databases

iPTMnetiQ63424.
PhosphoSiteiQ63424.

Expressioni

Gene expression databases

GenevisibleiQ63424. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003189.

Chemistry

BindingDBiQ63424.

Structurei

Secondary structure

1
729
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi413 – 4208Combined sources
Beta strandi422 – 4243Combined sources
Beta strandi426 – 4316Combined sources
Beta strandi437 – 4437Combined sources
Beta strandi453 – 4564Combined sources
Beta strandi458 – 47013Combined sources
Beta strandi473 – 48412Combined sources
Beta strandi486 – 4949Combined sources
Beta strandi497 – 5048Combined sources
Beta strandi514 – 5218Combined sources
Beta strandi523 – 5253Combined sources
Beta strandi527 – 5326Combined sources
Beta strandi537 – 5393Combined sources
Turni541 – 5433Combined sources
Beta strandi549 – 5557Combined sources
Beta strandi557 – 5659Combined sources
Beta strandi567 – 5704Combined sources
Beta strandi573 – 5753Combined sources
Beta strandi580 – 5856Combined sources
Beta strandi595 – 5995Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5A9HX-ray2.06A410-601[»]
5A9IX-ray2.84A/B/C410-601[»]
ProteinModelPortaliQ63424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiQ63424.
OMAiHIVAEPA.
OrthoDBiEOG7M3J0R.
PhylomeDBiQ63424.

Family and domain databases

InterProiIPR029028. Alpha/beta_knot_MTases.
IPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPFQKNESK ETLFSPVSTE EMLPRPPSPP KKSPPKIFGS SYPVSIAFIV
60 70 80 90 100
VNEFCERFSY YGMKAVLTLY FLYFLHWNED TSTSVYHAFS SLCYFTPILG
110 120 130 140 150
AAIADSWLGK FKTIIYLSLV YVLGHVFKSL GAIPILGGKM LHTILSLVGL
160 170 180 190 200
SLIALGTGGI KPCVAAFGGD QFEEEHAEAR TRYFSVFYLA INAGSLISTF
210 220 230 240 250
ITPMLRGDVK CFGQDCYALA FGVPGLLMVL ALVVFAMGSK MYRKPPPEGN
260 270 280 290 300
IVAQVIKCIW FALCNRFRNR SGDLPKRQHW LDWAAEKYPK HLIADVKALT
310 320 330 340 350
RVLFLYIPLP MFWALLDQQG SRWTLQANKM NGDLGFFVLQ PDQMQVLNPF
360 370 380 390 400
LVLIFIPLFD LVIYRLISKC RINFSSLRKM AVGMILACLA FAVAALVETK
410 420 430 440 450
INGMIHPQPA SQEIFLQVLN LADGDVKVTV LGSRNNSLLV ESVSSFQNTT
460 470 480 490 500
HYSKLHLEAK SQDLHFHLKY NSLSVHNDHS VEEKNCYQLL IHQDGESISS
510 520 530 540 550
MLVKDTGIKP ANGMAAIRFI NTLHKDLNIS LDTDAPLSVG KDYGVSAYRT
560 570 580 590 600
VLRGKYPAVH CETEDKVFSL DLGQLDFGTT YLFVITNITS QGLQAWKAED
610 620 630 640 650
IPVNKLSIAW QLPQYVLVTA AEVMFSVTGL EFSYSQAPSS MKSVLQAAWL
660 670 680 690 700
LTVAVGNIIV LVVAQFSGLA QWAEFVLFSC LLLVVCLIFS VMAYYYVPLK
710 720
SEDTREATDK QIPAVQGNMI NLETKNTRL
Length:729
Mass (Da):81,320
Last modified:November 1, 1996 - v1
Checksum:i66F5E88B9DF83DAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63149 mRNA. Translation: BAA09631.1.
UniGeneiRn.89268.

Genome annotation databases

UCSCiRGD:61972. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63149 mRNA. Translation: BAA09631.1.
UniGeneiRn.89268.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5A9HX-ray2.06A410-601[»]
5A9IX-ray2.84A/B/C410-601[»]
ProteinModelPortaliQ63424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003189.

Chemistry

BindingDBiQ63424.
ChEMBLiCHEMBL3325.

PTM databases

iPTMnetiQ63424.
PhosphoSiteiQ63424.

Proteomic databases

PaxDbiQ63424.
PRIDEiQ63424.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:61972. rat.

Organism-specific databases

RGDi61972. Slc15a2.

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiQ63424.
OMAiHIVAEPA.
OrthoDBiEOG7M3J0R.
PhylomeDBiQ63424.

Enzyme and pathway databases

ReactomeiR-RNO-427975. Proton/oligopeptide cotransporters.

Miscellaneous databases

NextBioi612288.
PROiQ63424.

Gene expression databases

GenevisibleiQ63424. RN.

Family and domain databases

InterProiIPR029028. Alpha/beta_knot_MTases.
IPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and tissue distribution of rat peptide transporter PEPT2."
    Saito H., Terada T., Okuda M., Sasaki S., Inui K.
    Biochim. Biophys. Acta 1280:173-177(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Kidney.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS15A2_RAT
AccessioniPrimary (citable) accession number: Q63424
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 17, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.