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Q63421 (PDE1C_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Short name=Cam-PDE 1C
EC=3.1.4.17
Gene names
Name:Pde1c
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length768 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. May play an essential role in the rapid termination of the odorant-induced cAMP signal.

Catalytic activity

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Enzyme regulation

Type I PDE are activated by the binding of calmodulin in the presence of Ca2+.

Subunit structure

Homodimer By similarity.

Tissue specificity

Enriched in olfactory sensory neurons.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 768768Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
PRO_0000198794

Regions

Region262 – 581320Catalytic By similarity

Sites

Active site2881Proton donor By similarity
Metal binding2921Divalent metal cation 1 By similarity
Metal binding3281Divalent metal cation 1 By similarity
Metal binding3291Divalent metal cation 1 By similarity
Metal binding3291Divalent metal cation 2 By similarity
Metal binding4361Divalent metal cation 1 By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63421 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 8816C208A30DD55E

FASTA76886,671
        10         20         30         40         50         60 
MTDTSHKKEG FKKCRSATFS IDGYSFTIVA NEAGDKNARP LARFSRSKSQ NCLWNSLIDG 

        70         80         90        100        110        120 
LTGNVKEKPR PTIVQDTRPP EEILADELPQ LDSPEALVKT SFRLRSLVKQ LERGEASVVD 

       130        140        150        160        170        180 
LKKNLEYAAT VLESVYIDET RRLLDTEDEL SDIQSDAVPS EVRDWLASTF TRQMGMMLRR 

       190        200        210        220        230        240 
SDEKPRFKSI VHAVQAGIFV ERMYRRTSNM VGLSYPPAVI DALKDVDTWS FDVFSLNEAS 

       250        260        270        280        290        300 
GDHALKFIFY ELLTRYDLIS RFKIPISALV SFVEALEVGY SKHKNPYHNL MHAADVTQTV 

       310        320        330        340        350        360 
HYLLYKTGVA NWLTELEIFA IIFSAAIHDY EHTGTTNNFH IQTRSDPAIL YNDRSVLENH 

       370        380        390        400        410        420 
HLSAAYRLLQ EDEEMNILVN LSKDDWREFR TLVIEMVMAT DMSCHFQQIK AMKTALQQPE 

       430        440        450        460        470        480 
AIEKPKALSL MLHTADISHP AKAWDLHHRW TMSLLEEFFR QGDREAELGL PFSPLCDRKS 

       490        500        510        520        530        540 
TMVAQSQVGF IDFIVEPTFT VLTDMTEKIV SPLIDETSQT GGTGQRRSSL NSINSSDAKR 

       550        560        570        580        590        600 
SGVKSSGSEG SAPINNSVIP VDYKSFKATW TEVVQINRER WRAKVPKEEK AKKEAEEKAR 

       610        620        630        640        650        660 
LAAEEKQKEM EAKSQAEQGT TSKAEKKTSG ETKGQVNGTR TSKGDNPRGK NSKGDKAGEK 

       670        680        690        700        710        720 
QQNGDLKDGK NKADKKDHSN TGNESKKADG TKKRSHGSPA PSTSSTSRLT LPVIKPPLRH 

       730        740        750        760 
FKRPAYASSS YAPSVPKKTD DHPVRYKMLD QRIKIKKIQN ISHHWNKK 

« Hide

References

[1]"Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons."
Yan C., Zhao A.Z., Bentley J.K., Loughney K., Ferguson K., Beavo J.A.
Proc. Natl. Acad. Sci. U.S.A. 92:9677-9681(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L41045 mRNA. Translation: AAB00868.1.
PIRT10796.
RefSeqNP_112340.1. NM_031078.2.
UniGeneRn.10289.

3D structure databases

ProteinModelPortalQ63421.
SMRQ63421. Positions 211-584.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ63421.
ChEMBLCHEMBL2111322.

Proteomic databases

PaxDbQ63421.
PRIDEQ63421.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID81742.
KEGGrno:81742.
UCSCRGD:68332. rat.

Organism-specific databases

CTD5137.
RGD68332. Pde1c.

Phylogenomic databases

eggNOGNOG139098.
HOGENOMHOG000231888.
HOVERGENHBG056120.
InParanoidQ63421.
KOK13755.
PhylomeDBQ63421.

Gene expression databases

GenevestigatorQ63421.

Family and domain databases

Gene3D1.10.1300.10. 2 hits.
InterProIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view]
PfamPF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00471. HDc. 1 hit.
[Graphical view]
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615460.
PROQ63421.

Entry information

Entry namePDE1C_RAT
AccessionPrimary (citable) accession number: Q63421
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families