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Q63421

- PDE1C_RAT

UniProt

Q63421 - PDE1C_RAT

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Protein
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Gene
Pde1c
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. May play an essential role in the rapid termination of the odorant-induced cAMP signal.

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Enzyme regulationi

Type I PDE are activated by the binding of calmodulin in the presence of Ca2+.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei288 – 2881Proton donor By similarity
Metal bindingi292 – 2921Divalent metal cation 1 By similarity
Metal bindingi328 – 3281Divalent metal cation 1 By similarity
Metal bindingi329 – 3291Divalent metal cation 1 By similarity
Metal bindingi329 – 3291Divalent metal cation 2 By similarity
Metal bindingi436 – 4361Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: RGD
  2. cAMP binding Source: RGD
  3. calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity Source: MGI
  4. calmodulin-dependent cyclic-nucleotide phosphodiesterase activity Source: MGI
  5. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cAMP catabolic process Source: RGD
  2. cGMP catabolic process Source: RGD
  3. negative regulation of insulin secretion Source: RGD
  4. response to calcium ion Source: MGI
  5. sensory perception of smell Source: RGD
  6. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Olfaction, Sensory transduction

Keywords - Ligandi

Calmodulin-binding, cAMP, cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC:3.1.4.17)
Short name:
Cam-PDE 1C
Gene namesi
Name:Pde1c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi68332. Pde1c.

Subcellular locationi

GO - Cellular componenti

  1. neuronal cell body Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 768768Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
PRO_0000198794Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ63421.
PRIDEiQ63421.

Expressioni

Tissue specificityi

Enriched in olfactory sensory neurons.

Gene expression databases

GenevestigatoriQ63421.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ63421.
SMRiQ63421. Positions 211-584.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni262 – 581320Catalytic By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG139098.
HOGENOMiHOG000231888.
HOVERGENiHBG056120.
InParanoidiQ63421.
KOiK13755.
PhylomeDBiQ63421.

Family and domain databases

Gene3Di1.10.1300.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63421-1 [UniParc]FASTAAdd to Basket

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MTDTSHKKEG FKKCRSATFS IDGYSFTIVA NEAGDKNARP LARFSRSKSQ    50
NCLWNSLIDG LTGNVKEKPR PTIVQDTRPP EEILADELPQ LDSPEALVKT 100
SFRLRSLVKQ LERGEASVVD LKKNLEYAAT VLESVYIDET RRLLDTEDEL 150
SDIQSDAVPS EVRDWLASTF TRQMGMMLRR SDEKPRFKSI VHAVQAGIFV 200
ERMYRRTSNM VGLSYPPAVI DALKDVDTWS FDVFSLNEAS GDHALKFIFY 250
ELLTRYDLIS RFKIPISALV SFVEALEVGY SKHKNPYHNL MHAADVTQTV 300
HYLLYKTGVA NWLTELEIFA IIFSAAIHDY EHTGTTNNFH IQTRSDPAIL 350
YNDRSVLENH HLSAAYRLLQ EDEEMNILVN LSKDDWREFR TLVIEMVMAT 400
DMSCHFQQIK AMKTALQQPE AIEKPKALSL MLHTADISHP AKAWDLHHRW 450
TMSLLEEFFR QGDREAELGL PFSPLCDRKS TMVAQSQVGF IDFIVEPTFT 500
VLTDMTEKIV SPLIDETSQT GGTGQRRSSL NSINSSDAKR SGVKSSGSEG 550
SAPINNSVIP VDYKSFKATW TEVVQINRER WRAKVPKEEK AKKEAEEKAR 600
LAAEEKQKEM EAKSQAEQGT TSKAEKKTSG ETKGQVNGTR TSKGDNPRGK 650
NSKGDKAGEK QQNGDLKDGK NKADKKDHSN TGNESKKADG TKKRSHGSPA 700
PSTSSTSRLT LPVIKPPLRH FKRPAYASSS YAPSVPKKTD DHPVRYKMLD 750
QRIKIKKIQN ISHHWNKK 768
Length:768
Mass (Da):86,671
Last modified:November 1, 1997 - v1
Checksum:i8816C208A30DD55E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41045 mRNA. Translation: AAB00868.1.
PIRiT10796.
RefSeqiNP_112340.1. NM_031078.2.
UniGeneiRn.10289.

Genome annotation databases

GeneIDi81742.
KEGGirno:81742.
UCSCiRGD:68332. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41045 mRNA. Translation: AAB00868.1 .
PIRi T10796.
RefSeqi NP_112340.1. NM_031078.2.
UniGenei Rn.10289.

3D structure databases

ProteinModelPortali Q63421.
SMRi Q63421. Positions 211-584.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q63421.
ChEMBLi CHEMBL2111322.

Proteomic databases

PaxDbi Q63421.
PRIDEi Q63421.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 81742.
KEGGi rno:81742.
UCSCi RGD:68332. rat.

Organism-specific databases

CTDi 5137.
RGDi 68332. Pde1c.

Phylogenomic databases

eggNOGi NOG139098.
HOGENOMi HOG000231888.
HOVERGENi HBG056120.
InParanoidi Q63421.
KOi K13755.
PhylomeDBi Q63421.

Miscellaneous databases

NextBioi 615460.
PROi Q63421.

Gene expression databases

Genevestigatori Q63421.

Family and domain databases

Gene3Di 1.10.1300.10. 2 hits.
InterProi IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view ]
Pfami PF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons."
    Yan C., Zhao A.Z., Bentley J.K., Loughney K., Ferguson K., Beavo J.A.
    Proc. Natl. Acad. Sci. U.S.A. 92:9677-9681(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiPDE1C_RAT
AccessioniPrimary (citable) accession number: Q63421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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