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Q63421

- PDE1C_RAT

UniProt

Q63421 - PDE1C_RAT

Protein

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Gene

Pde1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. May play an essential role in the rapid termination of the odorant-induced cAMP signal.

    Catalytic activityi

    Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Enzyme regulationi

    Type I PDE are activated by the binding of calmodulin in the presence of Ca2+.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei288 – 2881Proton donorBy similarity
    Metal bindingi292 – 2921Divalent metal cation 1By similarity
    Metal bindingi328 – 3281Divalent metal cation 1By similarity
    Metal bindingi329 – 3291Divalent metal cation 1By similarity
    Metal bindingi329 – 3291Divalent metal cation 2By similarity
    Metal bindingi436 – 4361Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: RGD
    2. calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity Source: MGI
    3. calmodulin-dependent cyclic-nucleotide phosphodiesterase activity Source: MGI
    4. cAMP binding Source: RGD
    5. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cAMP catabolic process Source: RGD
    2. cGMP catabolic process Source: RGD
    3. negative regulation of insulin secretion Source: RGD
    4. response to calcium ion Source: MGI
    5. sensory perception of smell Source: RGD
    6. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Keywords - Ligandi

    Calmodulin-binding, cAMP, cGMP, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC:3.1.4.17)
    Short name:
    Cam-PDE 1C
    Gene namesi
    Name:Pde1c
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi68332. Pde1c.

    Subcellular locationi

    GO - Cellular componenti

    1. neuronal cell body Source: RGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 768768Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CPRO_0000198794Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ63421.
    PRIDEiQ63421.

    Expressioni

    Tissue specificityi

    Enriched in olfactory sensory neurons.

    Gene expression databases

    GenevestigatoriQ63421.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ63421.
    SMRiQ63421. Positions 211-584.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni262 – 581320CatalyticBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG139098.
    HOGENOMiHOG000231888.
    HOVERGENiHBG056120.
    InParanoidiQ63421.
    KOiK13755.
    PhylomeDBiQ63421.

    Family and domain databases

    Gene3Di1.10.1300.10. 2 hits.
    InterProiIPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    IPR013706. PDEase_N.
    [Graphical view]
    PfamiPF00233. PDEase_I. 1 hit.
    PF08499. PDEase_I_N. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63421-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDTSHKKEG FKKCRSATFS IDGYSFTIVA NEAGDKNARP LARFSRSKSQ    50
    NCLWNSLIDG LTGNVKEKPR PTIVQDTRPP EEILADELPQ LDSPEALVKT 100
    SFRLRSLVKQ LERGEASVVD LKKNLEYAAT VLESVYIDET RRLLDTEDEL 150
    SDIQSDAVPS EVRDWLASTF TRQMGMMLRR SDEKPRFKSI VHAVQAGIFV 200
    ERMYRRTSNM VGLSYPPAVI DALKDVDTWS FDVFSLNEAS GDHALKFIFY 250
    ELLTRYDLIS RFKIPISALV SFVEALEVGY SKHKNPYHNL MHAADVTQTV 300
    HYLLYKTGVA NWLTELEIFA IIFSAAIHDY EHTGTTNNFH IQTRSDPAIL 350
    YNDRSVLENH HLSAAYRLLQ EDEEMNILVN LSKDDWREFR TLVIEMVMAT 400
    DMSCHFQQIK AMKTALQQPE AIEKPKALSL MLHTADISHP AKAWDLHHRW 450
    TMSLLEEFFR QGDREAELGL PFSPLCDRKS TMVAQSQVGF IDFIVEPTFT 500
    VLTDMTEKIV SPLIDETSQT GGTGQRRSSL NSINSSDAKR SGVKSSGSEG 550
    SAPINNSVIP VDYKSFKATW TEVVQINRER WRAKVPKEEK AKKEAEEKAR 600
    LAAEEKQKEM EAKSQAEQGT TSKAEKKTSG ETKGQVNGTR TSKGDNPRGK 650
    NSKGDKAGEK QQNGDLKDGK NKADKKDHSN TGNESKKADG TKKRSHGSPA 700
    PSTSSTSRLT LPVIKPPLRH FKRPAYASSS YAPSVPKKTD DHPVRYKMLD 750
    QRIKIKKIQN ISHHWNKK 768
    Length:768
    Mass (Da):86,671
    Last modified:November 1, 1997 - v1
    Checksum:i8816C208A30DD55E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41045 mRNA. Translation: AAB00868.1.
    PIRiT10796.
    RefSeqiNP_112340.1. NM_031078.2.
    UniGeneiRn.10289.

    Genome annotation databases

    GeneIDi81742.
    KEGGirno:81742.
    UCSCiRGD:68332. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41045 mRNA. Translation: AAB00868.1 .
    PIRi T10796.
    RefSeqi NP_112340.1. NM_031078.2.
    UniGenei Rn.10289.

    3D structure databases

    ProteinModelPortali Q63421.
    SMRi Q63421. Positions 211-584.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q63421.
    ChEMBLi CHEMBL2111322.

    Proteomic databases

    PaxDbi Q63421.
    PRIDEi Q63421.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 81742.
    KEGGi rno:81742.
    UCSCi RGD:68332. rat.

    Organism-specific databases

    CTDi 5137.
    RGDi 68332. Pde1c.

    Phylogenomic databases

    eggNOGi NOG139098.
    HOGENOMi HOG000231888.
    HOVERGENi HBG056120.
    InParanoidi Q63421.
    KOi K13755.
    PhylomeDBi Q63421.

    Miscellaneous databases

    NextBioi 615460.
    PROi Q63421.

    Gene expression databases

    Genevestigatori Q63421.

    Family and domain databases

    Gene3Di 1.10.1300.10. 2 hits.
    InterProi IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    IPR013706. PDEase_N.
    [Graphical view ]
    Pfami PF00233. PDEase_I. 1 hit.
    PF08499. PDEase_I_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons."
      Yan C., Zhao A.Z., Bentley J.K., Loughney K., Ferguson K., Beavo J.A.
      Proc. Natl. Acad. Sci. U.S.A. 92:9677-9681(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiPDE1C_RAT
    AccessioniPrimary (citable) accession number: Q63421
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3