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Protein

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Gene

Pde1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. May play an essential role in the rapid termination of the odorant-induced cAMP signal.

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Enzyme regulationi

Type I PDE are activated by the binding of calmodulin in the presence of Ca2+.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei288 – 2881Proton donorBy similarity
Metal bindingi292 – 2921Divalent metal cation 1By similarity
Metal bindingi328 – 3281Divalent metal cation 1By similarity
Metal bindingi329 – 3291Divalent metal cation 1By similarity
Metal bindingi329 – 3291Divalent metal cation 2By similarity
Metal bindingi436 – 4361Divalent metal cation 1By similarity

GO - Molecular functioni

  • 3',5'-cyclic-AMP phosphodiesterase activity Source: RGD
  • calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity Source: RGD
  • calmodulin-dependent cyclic-nucleotide phosphodiesterase activity Source: MGI
  • cAMP binding Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cAMP catabolic process Source: RGD
  • cGMP catabolic process Source: RGD
  • negative regulation of insulin secretion Source: RGD
  • response to calcium ion Source: MGI
  • sensory perception of smell Source: RGD
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Olfaction, Sensory transduction

Keywords - Ligandi

Calmodulin-binding, cAMP, cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC:3.1.4.17)
Short name:
Cam-PDE 1C
Gene namesi
Name:Pde1c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68332. Pde1c.

Subcellular locationi

GO - Cellular componenti

  • neuronal cell body Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 768768Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CPRO_0000198794Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ63421.
PRIDEiQ63421.

Expressioni

Tissue specificityi

Enriched in olfactory sensory neurons.

Gene expression databases

GenevisibleiQ63421. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017531.

Structurei

3D structure databases

ProteinModelPortaliQ63421.
SMRiQ63421. Positions 211-584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni262 – 581320CatalyticBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG139098.
HOGENOMiHOG000231888.
HOVERGENiHBG056120.
InParanoidiQ63421.
KOiK13755.
PhylomeDBiQ63421.

Family and domain databases

Gene3Di1.10.1300.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTSHKKEG FKKCRSATFS IDGYSFTIVA NEAGDKNARP LARFSRSKSQ
60 70 80 90 100
NCLWNSLIDG LTGNVKEKPR PTIVQDTRPP EEILADELPQ LDSPEALVKT
110 120 130 140 150
SFRLRSLVKQ LERGEASVVD LKKNLEYAAT VLESVYIDET RRLLDTEDEL
160 170 180 190 200
SDIQSDAVPS EVRDWLASTF TRQMGMMLRR SDEKPRFKSI VHAVQAGIFV
210 220 230 240 250
ERMYRRTSNM VGLSYPPAVI DALKDVDTWS FDVFSLNEAS GDHALKFIFY
260 270 280 290 300
ELLTRYDLIS RFKIPISALV SFVEALEVGY SKHKNPYHNL MHAADVTQTV
310 320 330 340 350
HYLLYKTGVA NWLTELEIFA IIFSAAIHDY EHTGTTNNFH IQTRSDPAIL
360 370 380 390 400
YNDRSVLENH HLSAAYRLLQ EDEEMNILVN LSKDDWREFR TLVIEMVMAT
410 420 430 440 450
DMSCHFQQIK AMKTALQQPE AIEKPKALSL MLHTADISHP AKAWDLHHRW
460 470 480 490 500
TMSLLEEFFR QGDREAELGL PFSPLCDRKS TMVAQSQVGF IDFIVEPTFT
510 520 530 540 550
VLTDMTEKIV SPLIDETSQT GGTGQRRSSL NSINSSDAKR SGVKSSGSEG
560 570 580 590 600
SAPINNSVIP VDYKSFKATW TEVVQINRER WRAKVPKEEK AKKEAEEKAR
610 620 630 640 650
LAAEEKQKEM EAKSQAEQGT TSKAEKKTSG ETKGQVNGTR TSKGDNPRGK
660 670 680 690 700
NSKGDKAGEK QQNGDLKDGK NKADKKDHSN TGNESKKADG TKKRSHGSPA
710 720 730 740 750
PSTSSTSRLT LPVIKPPLRH FKRPAYASSS YAPSVPKKTD DHPVRYKMLD
760
QRIKIKKIQN ISHHWNKK
Length:768
Mass (Da):86,671
Last modified:November 1, 1997 - v1
Checksum:i8816C208A30DD55E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41045 mRNA. Translation: AAB00868.1.
PIRiT10796.
RefSeqiNP_112340.1. NM_031078.2.
UniGeneiRn.10289.

Genome annotation databases

GeneIDi81742.
KEGGirno:81742.
UCSCiRGD:68332. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41045 mRNA. Translation: AAB00868.1.
PIRiT10796.
RefSeqiNP_112340.1. NM_031078.2.
UniGeneiRn.10289.

3D structure databases

ProteinModelPortaliQ63421.
SMRiQ63421. Positions 211-584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017531.

Chemistry

ChEMBLiCHEMBL2111322.

Proteomic databases

PaxDbiQ63421.
PRIDEiQ63421.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81742.
KEGGirno:81742.
UCSCiRGD:68332. rat.

Organism-specific databases

CTDi5137.
RGDi68332. Pde1c.

Phylogenomic databases

eggNOGiNOG139098.
HOGENOMiHOG000231888.
HOVERGENiHBG056120.
InParanoidiQ63421.
KOiK13755.
PhylomeDBiQ63421.

Miscellaneous databases

NextBioi615460.
PROiQ63421.

Gene expression databases

GenevisibleiQ63421. RN.

Family and domain databases

Gene3Di1.10.1300.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons."
    Yan C., Zhao A.Z., Bentley J.K., Loughney K., Ferguson K., Beavo J.A.
    Proc. Natl. Acad. Sci. U.S.A. 92:9677-9681(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiPDE1C_RAT
AccessioniPrimary (citable) accession number: Q63421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.