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Protein

Protocadherin-3

Gene

Pcdh3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-3
Gene namesi
Name:Pcdh3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3266. Pcdh3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 691661ExtracellularSequence analysisAdd
BLAST
Transmembranei692 – 71221HelicalSequence analysisAdd
BLAST
Topological domaini713 – 79785CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 797767Protocadherin-3PRO_0000003947Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence analysis
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence analysis
Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ63418.
PRIDEiQ63418.

PTM databases

PhosphoSiteiQ63418.

Expressioni

Tissue specificityi

Expressed in brain.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045459.

Structurei

3D structure databases

ProteinModelPortaliQ63418.
SMRiQ63418. Positions 31-133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 13399Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 242105Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini247 – 346100Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini351 – 450100Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini455 – 560106Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini567 – 670104Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOVERGENiHBG054878.
InParanoidiQ63418.
KOiK16494.
PhylomeDBiQ63418.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 4 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63418-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METALAKIPQ QRQVFFLTIL SLLWKSSSEA IRYSMPEETE SGYMVANLAK
60 70 80 90 100
DLGIRVGELS SRGAQIHYKG NKELLQLDAE TGNLFLKEKL DRELLCGETE
110 120 130 140 150
PCVLNFQIIL ENPMQFFQTE LQLTDINDHS PEFPNKKMLL TIPESAHPGT
160 170 180 190 200
VFPLKAARDS DIGSNAVQNY TVNPNLHFHV VTHSRTDGRK YPELVLDRAL
210 220 230 240 250
DREEQPELTL ILTALDGGAP SRSGTTTVHI EVVDINDNSP QFVQSLYKVQ
260 270 280 290 300
VPENNPLNAF VVTVSATDLD AGVYGNVTYS LFQGYGVFQP FVIDEITGEI
310 320 330 340 350
HLSKELDFEE ISNHNIEIAA TDGGGLSGKC TVAVQVLDVN DNAPELTIRK
360 370 380 390 400
LTVLVPENSA ETVVAVFSVS DSDSGDNGRM VCSIPNNIPF LLKPTFENYY
410 420 430 440 450
TLVTEGPLDR ENRAEYNITI TVSDLGTPRL TTQHTITVQV SDINDNAPAF
460 470 480 490 500
TQTSYTMFVH ENNSPALHIG TISATDSDSG SNAHITYSLL PPDDPQLALD
510 520 530 540 550
SLISINVDNG QLFALRALDY EALQSFEFYV GATDGGSPAL SSQTLVRMVV
560 570 580 590 600
LDDNDNAPFV LYPLQNASAP CTELLPRAAE PGYLITKVVA VDRDSGQNAW
610 620 630 640 650
LSFQLLKATE PGLFSVWAHN GEVRTTRLLS ERDAQKHKLL LLVKDNGDPL
660 670 680 690 700
RSANVTLHVL VVDGFSQPYL PLAEVAQDSM QDNYDVLTLY LVIALASVSS
710 720 730 740 750
LFLLSVVLFV GVRLCRRARE ASLGDYSVPE GHFPSHLVDV SGAGTLSQSY
760 770 780 790
QYEVCLNGGT RTNEFNFLKP LFPILPTQAA AAEERENAVV HNSVGFY
Length:797
Mass (Da):87,474
Last modified:November 1, 1996 - v1
Checksum:i42E279E6C6117861
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43592 mRNA. Translation: AAC42079.1.
RefSeqiNP_775122.1. NM_173099.1.
UniGeneiRn.10166.

Genome annotation databases

GeneIDi25133.
KEGGirno:25133.
UCSCiRGD:3266. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43592 mRNA. Translation: AAC42079.1.
RefSeqiNP_775122.1. NM_173099.1.
UniGeneiRn.10166.

3D structure databases

ProteinModelPortaliQ63418.
SMRiQ63418. Positions 31-133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045459.

PTM databases

PhosphoSiteiQ63418.

Proteomic databases

PaxDbiQ63418.
PRIDEiQ63418.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25133.
KEGGirno:25133.
UCSCiRGD:3266. rat.

Organism-specific databases

CTDi56124.
RGDi3266. Pcdh3.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOVERGENiHBG054878.
InParanoidiQ63418.
KOiK16494.
PhylomeDBiQ63418.

Miscellaneous databases

NextBioi605545.
PROiQ63418.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 4 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, expression, and chromosomal localization of a novel cadherin-related protein, protocadherin-3."
    Sago H., Kitagawa M., Obata S., Mori N., Taketani S., Rochelle J.M., Seldin M.F., Davidson M.K., John T., Suzuki S.T.
    Genomics 29:631-640(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiPCDH3_RAT
AccessioniPrimary (citable) accession number: Q63418
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.