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Protein

Protocadherin-3

Gene

Pcdh3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-3
Gene namesi
Name:Pcdh3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi3266 Pcdh3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 691ExtracellularSequence analysisAdd BLAST661
Transmembranei692 – 712HelicalSequence analysisAdd BLAST21
Topological domaini713 – 797CytoplasmicSequence analysisAdd BLAST85

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000394731 – 797Protocadherin-3Add BLAST767

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi276N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi566N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ63418
PRIDEiQ63418

PTM databases

iPTMnetiQ63418
PhosphoSitePlusiQ63418
SwissPalmiQ63418

Expressioni

Tissue specificityi

Expressed in brain.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045459

Structurei

3D structure databases

ProteinModelPortaliQ63418
SMRiQ63418
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 346Cadherin 3PROSITE-ProRule annotationAdd BLAST100
Domaini351 – 450Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini455 – 560Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini567 – 670Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
HOVERGENiHBG054878
InParanoidiQ63418
KOiK16494
PhylomeDBiQ63418

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 4 hits
PS50268 CADHERIN_2, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63418-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METALAKIPQ QRQVFFLTIL SLLWKSSSEA IRYSMPEETE SGYMVANLAK
60 70 80 90 100
DLGIRVGELS SRGAQIHYKG NKELLQLDAE TGNLFLKEKL DRELLCGETE
110 120 130 140 150
PCVLNFQIIL ENPMQFFQTE LQLTDINDHS PEFPNKKMLL TIPESAHPGT
160 170 180 190 200
VFPLKAARDS DIGSNAVQNY TVNPNLHFHV VTHSRTDGRK YPELVLDRAL
210 220 230 240 250
DREEQPELTL ILTALDGGAP SRSGTTTVHI EVVDINDNSP QFVQSLYKVQ
260 270 280 290 300
VPENNPLNAF VVTVSATDLD AGVYGNVTYS LFQGYGVFQP FVIDEITGEI
310 320 330 340 350
HLSKELDFEE ISNHNIEIAA TDGGGLSGKC TVAVQVLDVN DNAPELTIRK
360 370 380 390 400
LTVLVPENSA ETVVAVFSVS DSDSGDNGRM VCSIPNNIPF LLKPTFENYY
410 420 430 440 450
TLVTEGPLDR ENRAEYNITI TVSDLGTPRL TTQHTITVQV SDINDNAPAF
460 470 480 490 500
TQTSYTMFVH ENNSPALHIG TISATDSDSG SNAHITYSLL PPDDPQLALD
510 520 530 540 550
SLISINVDNG QLFALRALDY EALQSFEFYV GATDGGSPAL SSQTLVRMVV
560 570 580 590 600
LDDNDNAPFV LYPLQNASAP CTELLPRAAE PGYLITKVVA VDRDSGQNAW
610 620 630 640 650
LSFQLLKATE PGLFSVWAHN GEVRTTRLLS ERDAQKHKLL LLVKDNGDPL
660 670 680 690 700
RSANVTLHVL VVDGFSQPYL PLAEVAQDSM QDNYDVLTLY LVIALASVSS
710 720 730 740 750
LFLLSVVLFV GVRLCRRARE ASLGDYSVPE GHFPSHLVDV SGAGTLSQSY
760 770 780 790
QYEVCLNGGT RTNEFNFLKP LFPILPTQAA AAEERENAVV HNSVGFY
Length:797
Mass (Da):87,474
Last modified:November 1, 1996 - v1
Checksum:i42E279E6C6117861
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43592 mRNA Translation: AAC42079.1
RefSeqiNP_775122.1, NM_173099.1
UniGeneiRn.10166

Genome annotation databases

GeneIDi25133
KEGGirno:25133
UCSCiRGD:3266 rat

Similar proteinsi

Entry informationi

Entry nameiPCDH3_RAT
AccessioniPrimary (citable) accession number: Q63418
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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