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Protein

Inter-alpha-trypsin inhibitor heavy chain H3

Gene

Itih3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H3
Short name:
ITI heavy chain H3
Short name:
ITI-HC3
Short name:
Inter-alpha-inhibitor heavy chain 3
Gene namesi
Name:Itih3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi620633. Itih3.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 3312By similarityPRO_0000016538Add
BLAST
Chaini34 – 647614Inter-alpha-trypsin inhibitor heavy chain H3PRO_0000016539Add
BLAST
Propeptidei648 – 887240By similarityPRO_0000016540Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence analysis
Glycosylationi580 – 5801N-linked (GlcNAc...)Sequence analysis
Modified residuei647 – 6471Aspartate 1-(chondroitin 4-sulfate)-esterBy similarity

Post-translational modificationi

Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiQ63416.
PRIDEiQ63416.

Expressioni

Gene expression databases

ExpressionAtlasiQ63416. baseline and differential.
GenevisibleiQ63416. RN.

Interactioni

Subunit structurei

I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023984.

Structurei

3D structure databases

ProteinModelPortaliQ63416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 158130VITPROSITE-ProRule annotationAdd
BLAST
Domaini282 – 442161VWFAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ITIH family.Curated
Contains 1 VIT domain.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
GeneTreeiENSGT00550000074468.
HOGENOMiHOG000000680.
HOVERGENiHBG057734.
InParanoidiQ63416.
OMAiFVVVLHQ.
OrthoDBiEOG7CRTP5.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTLWWPCLV LALLSGLETS GFPRSPLRLL GKRSLPEGVV DGIEIYSTKI
60 70 80 90 100
SCKVTSRFAH NVVTTRAVNR ADKAKEVSFD VELPKTAFIT NFTLTIDGVT
110 120 130 140 150
YPGSVKEKEV AQKQYEKAVS QGKTAGLVKA SGRKLEKFTV SVNVAAGSKV
160 170 180 190 200
IFELTYEELL KRNKGKYEMY LKVQPKQLVR HFEIDAHIFE PQGISMLDAD
210 220 230 240 250
ASFITNDLLG SALTKSFSGK KGHVSFKPSL DQQRSCPTCT DSLLNGDFTI
260 270 280 290 300
VYDVNRESPG NVQIVNGYFV HFFAPQGLPV VPKNIAFVID VSGSMSGRKI
310 320 330 340 350
QQTREALLKI LDDMKEEDYL NFILFSTGVT TWKDHLVKAT PANLEEARAF
360 370 380 390 400
VKNIRDRSMT NINDGLLRGI EMLNKAREDH LVPERSTSIL VMLTDGDANT
410 420 430 440 450
GESRPEKIQE NVRNAIRGKF PLYNLGFGNN LNYNFLESLA LENHGFARRI
460 470 480 490 500
YEDSDASLQL QGFYEEVANP LLTNVELEYP ENAILDLTRN SYPHFYDGSE
510 520 530 540 550
IVVAGRLVDR NVDNFKADVK GHGALNDLTF TEEVDMKEMD AALKEQGYIF
560 570 580 590 600
GDYIERLWAY LTIEQLLEKR KNARGDEKEN ITAEALELSL KYHFVTPLTS
610 620 630 640 650
MVVTKPEDNE DQTAIADKPG EEAISASTAY LTSQQSSHSP YYYVDGDPHF
660 670 680 690 700
IIQVPGKNDT ICFNIDEKPG TVLSLIQDPV TGIAVTGQII GEKGNNASSR
710 720 730 740 750
TGKTYFGKLG IANAWMDFRI EVTTEKIILG NGDALSTFSW LDTVTVTQTG
760 770 780 790 800
LSVTINRKKN MVVSFEDGIS FVIVLHQVWK KHPVHQDFLG FYVVDSHRMS
810 820 830 840 850
AQTHGLLGQF FQPFDFKVFD VRPGSDPMKP DATMVVKSHR LTVTRGSQKD
860 870 880
YRKDASVGTK VVCWFVHNNG EGFIDGVHTD YIVPSLF
Length:887
Mass (Da):99,098
Last modified:November 1, 1996 - v1
Checksum:i3B9F0FF96D514096
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83231 mRNA. Translation: CAA58233.1.
RefSeqiNP_059047.1. NM_017351.1.
UniGeneiRn.89576.

Genome annotation databases

EnsembliENSRNOT00000023984; ENSRNOP00000023984; ENSRNOG00000017689.
GeneIDi50693.
KEGGirno:50693.
UCSCiRGD:620633. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83231 mRNA. Translation: CAA58233.1.
RefSeqiNP_059047.1. NM_017351.1.
UniGeneiRn.89576.

3D structure databases

ProteinModelPortaliQ63416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023984.

Proteomic databases

PaxDbiQ63416.
PRIDEiQ63416.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023984; ENSRNOP00000023984; ENSRNOG00000017689.
GeneIDi50693.
KEGGirno:50693.
UCSCiRGD:620633. rat.

Organism-specific databases

CTDi3699.
RGDi620633. Itih3.

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
GeneTreeiENSGT00550000074468.
HOGENOMiHOG000000680.
HOVERGENiHBG057734.
InParanoidiQ63416.
OMAiFVVVLHQ.
OrthoDBiEOG7CRTP5.

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Miscellaneous databases

PROiQ63416.

Gene expression databases

ExpressionAtlasiQ63416. baseline and differential.
GenevisibleiQ63416. RN.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Blom A., Fries E.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiITIH3_RAT
AccessioniPrimary (citable) accession number: Q63416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.