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Protein

Proprotein convertase subtilisin/kexin type 6

Gene

Pcsk6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.

Cofactori

Ca2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei186Charge relay systemBy similarity1
Active sitei227Charge relay systemBy similarity1
Active sitei401Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
LigandCalcium

Enzyme and pathway databases

BRENDAi3.4.21.B25 5301

Protein family/group databases

MEROPSiS08.075

Names & Taxonomyi

Protein namesi
Recommended name:
Proprotein convertase subtilisin/kexin type 6 (EC:3.4.21.-)
Alternative name(s):
Paired basic amino acid cleaving enzyme 4
Subtilisin-like proprotein convertase 4
Short name:
SPC4
Subtilisin/kexin-like protease PACE4
Gene namesi
Name:Pcsk6
Synonyms:Pace4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3246 Pcsk6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5507

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 451 PublicationAdd BLAST45
PropeptideiPRO_000002711246 – 1321 PublicationAdd BLAST87
ChainiPRO_0000027113133 – 937Proprotein convertase subtilisin/kexin type 6Add BLAST805

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi882N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi900N-linked (GlcNAc...) asparagineSequence analysis1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei132 – 133Cleavage; by autolysis2

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ63415
PRIDEiQ63415

Expressioni

Tissue specificityi

High expression in the anterior pituitary and in several brain regions, the atrium, and the ventricle.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015845

Chemistry databases

BindingDBiQ63415

Structurei

3D structure databases

ProteinModelPortaliQ63415
SMRiQ63415
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 468Peptidase S8Add BLAST288
Domaini476 – 616P/Homo BPROSITE-ProRule annotationAdd BLAST141
Repeati660 – 707FU 1Add BLAST48
Repeati711 – 758FU 2Add BLAST48
Repeati762 – 806FU 3Add BLAST45
Repeati810 – 855FU 4Add BLAST46
Repeati863 – 911FU 5Add BLAST49
Domaini899 – 937PLACPROSITE-ProRule annotationAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni680 – 898CRM (Cys-rich motif)Add BLAST219

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi534 – 536Cell attachment siteSequence analysis3

Domaini

The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.

Sequence similaritiesi

Belongs to the peptidase S8 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3525 Eukaryota
COG1404 LUCA
COG4935 LUCA
HOGENOMiHOG000192536
HOVERGENiHBG008705
InParanoidiQ63415
KOiK08672
PhylomeDBiQ63415

Family and domain databases

CDDicd04059 Peptidases_S8_Protein_converta, 1 hit
Gene3Di2.60.120.2601 hit
3.30.70.8501 hit
3.40.50.2001 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR006212 Furin_repeat
IPR008979 Galactose-bd-like_sf
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR010909 PLAC
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
PfamiView protein in Pfam
PF14843 GF_recep_IV, 1 hit
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF08686 PLAC, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00261 FU, 5 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS50900 PLAC, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPRAPPAPG PRPPPRAAGR HGLSPLAPRP WRWLLLLALP AVCSALPPPR
60 70 80 90 100
PVYTNHWAVQ VLGGPGAADR VAAAHGYLNL GQIGNLDDYY HFYHSKTFKR
110 120 130 140 150
STLSSRGPHT FLRMDPQVKW LQQQEVKRRV KRQARSDSLY FNDPIWSNMW
160 170 180 190 200
YMHCADKNSR CRSEMNVQAA WKRGYTGKNV VVTILDDGIE RNHPDLAPNY
210 220 230 240 250
DSYASYDVNG NDYDPSPRYD ASNENKHGTR CAGEVAASAN NSYCIVGIAY
260 270 280 290 300
NAKIGGIRML DGDVTDVVEA KSLGIRPNYI DIYSASWGPD DDGKTVDGPG
310 320 330 340 350
RLAKQAFEYG IKKGRQGLGS IFVWASGNGG REGDHCSCDG YTNSIYTISV
360 370 380 390 400
SSTTENGHKP WYLEECASTL ATTYSSGAFY ERKIVTTDLR QRCTDGHTGT
410 420 430 440 450
SVSAPMVAGI IALALEANNQ LTWRDVQHLL VKTSRPAHLK ASDWKVNGAG
460 470 480 490 500
HKVSHLYGFG LVDAEALVLE ARKWTAVPSQ HMCVATADKR PRSIPVVQVL
510 520 530 540 550
RTTALTNACA DHSDQRVVYL EHVVVRISIS HPRRGDLQIH LISPSGTKSQ
560 570 580 590 600
LLAKRLLDFS NEGFTNWEFM TVHCWGEKAE GEWTLEVQDI PSQVRNPEKQ
610 620 630 640 650
GKLKEWSLIL YGTAEHPYRT FSSHQSRSRM LELSVPEQEP LKAEGPPPQA
660 670 680 690 700
ETPEEEEEYT GVCHPECGDK GCDGPSADQC LNCVHFSLGN SKTNRKCVSE
710 720 730 740 750
CPLGYFGDTA ARRCRRCHKG CETCTGRSPT QCLSCRRGFY HHQETNTCVT
760 770 780 790 800
LCPAGLYADE SQRLCLRCHP SCQKCVDEPE KSTVCKEGFS LARGSCIPDC
810 820 830 840 850
EPGTYFDSEL IRCGECHHTC RTCVGPSREE CIHCAKSFHF QDWKCVPACG
860 870 880 890 900
EGFYPEEMPG LPHKVCRRCD ENCLSCEGSS RNCSRCKAGF TQLGTSCITN
910 920 930
HTCSNADETF CEMVKSNRLC ERKLFIQFCC RTCLLAG
Length:937
Mass (Da):104,053
Last modified:November 1, 1996 - v1
Checksum:iF3865557C33705C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31894 mRNA Translation: AAA61987.1
PIRiI53282
RefSeqiNP_037131.1, NM_012999.1
UniGeneiRn.950

Genome annotation databases

GeneIDi25507
KEGGirno:25507
UCSCiRGD:3246 rat

Similar proteinsi

Entry informationi

Entry nameiPCSK6_RAT
AccessioniPrimary (citable) accession number: Q63415
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome