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Protein

Homeobox protein OTX1

Gene

Otx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3' (By similarity). May play a role in the specification or differentiation of neurons in the deep layers of the cerebral cortex, and also in cerebellar regionalization during early development.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi38 – 9760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein OTX1
Alternative name(s):
Orthodenticle homolog 1
Gene namesi
Name:Otx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3237. Otx1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Homeobox protein OTX1PRO_0000049209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki345 – 345Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ63410.

Expressioni

Tissue specificityi

Brain: restricted regions of the developing rostral brain including the presumptive cerebral cortex and olfactory bulbs; expressed in the developing olfactory, auricolar and ocular systems, including the covering of the optic nerve.

Developmental stagei

Expressed throughout the forebrain and midbrain during development, and in addition is also seen in discrete spatial and temporal domains in the developing cerebral cortex and cerebellum. Confined to a subpopulation of neurons in layers 5 and 6 within the adult cerebral cortex and during development expression is high in the progenitors of these deep-layer cells. Expressed in the developing cerebellum in spatially restricted regions of the external granular layer.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011668.

Structurei

3D structure databases

ProteinModelPortaliQ63410.
SMRiQ63410. Positions 39-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi275 – 30228His-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2251. Eukaryota.
ENOG4111XIJ. LUCA.
HOVERGENiHBG004028.
InParanoidiQ63410.
KOiK09326.
PhylomeDBiQ63410.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003026. Otx1_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01256. OTX1HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL
60 70 80 90 100
DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG
110 120 130 140 150
NGTKSRPVKK KSSPVRESSG SESSGQFTPP AVSSSASSSS SASSASANPA
160 170 180 190 200
AAAAAGLGGN PVAAASSLST PTASSIWSPA SISPGSAPAS VSVPEPLGAP
210 220 230 240 250
SNASCMQRSV AAGAATAATS YPMSYGQGRS YGQGYPAPSS SYFGGVDCSS
260 270 280 290 300
YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH
310 320 330 340 350
HHQGYGGSGL AFNSADCLDY KEPAAAAASS AWKLNFNSPD CLDYKDQASW

RFQVL
Length:355
Mass (Da):37,603
Last modified:November 1, 1996 - v1
Checksum:iC875871723D0B876
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2191T → A in S81924 (PubMed:8613727).Curated
Sequence conflicti229 – 2291R → G in S81924 (PubMed:8613727).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32602 mRNA. Translation: AAA53557.1.
S81924 mRNA. No translation available.
PIRiI56547.
RefSeqiNP_037241.1. NM_013109.2.
UniGeneiRn.33443.

Genome annotation databases

GeneIDi25646.
KEGGirno:25646.
UCSCiRGD:3237. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32602 mRNA. Translation: AAA53557.1.
S81924 mRNA. No translation available.
PIRiI56547.
RefSeqiNP_037241.1. NM_013109.2.
UniGeneiRn.33443.

3D structure databases

ProteinModelPortaliQ63410.
SMRiQ63410. Positions 39-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011668.

Proteomic databases

PaxDbiQ63410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25646.
KEGGirno:25646.
UCSCiRGD:3237. rat.

Organism-specific databases

CTDi5013.
RGDi3237. Otx1.

Phylogenomic databases

eggNOGiKOG2251. Eukaryota.
ENOG4111XIJ. LUCA.
HOVERGENiHBG004028.
InParanoidiQ63410.
KOiK09326.
PhylomeDBiQ63410.

Miscellaneous databases

PROiQ63410.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003026. Otx1_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01256. OTX1HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum."
    Frantz G.D., Weimann J.M., Levin M.E., McConnell S.K.
    J. Neurosci. 14:5725-5740(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Fibroblast growth factor 2 increases Otx2 expression in precursor cells from mammalian telencephalon."
    Robel L., Ding M., James A.J., Lin X., Simeone A., Leckman J.F., Vaccarino F.M.
    J. Neurosci. 15:7879-7891(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 176-323.

Entry informationi

Entry nameiOTX1_RAT
AccessioniPrimary (citable) accession number: Q63410
Secondary accession number(s): Q64203
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.