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Protein

Claudin-3

Gene

Cldn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-3
Alternative name(s):
Rat ventral prostate.1 protein
Short name:
RVP1
Gene namesi
Name:Cldn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi68425. Cldn3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence analysis
Transmembranei9 – 2921HelicalSequence analysisAdd
BLAST
Topological domaini30 – 8051ExtracellularSequence analysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Topological domaini102 – 11514CytoplasmicSequence analysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence analysisAdd
BLAST
Topological domaini137 – 16125ExtracellularSequence analysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST
Topological domaini183 – 21937CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Claudin-3PRO_0000144740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei197 – 1971PhosphotyrosineCombined sources
Modified residuei198 – 1981PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63400.
PRIDEiQ63400.

PTM databases

iPTMnetiQ63400.
PhosphoSiteiQ63400.

Expressioni

Gene expression databases

GenevisibleiQ63400. RN.

Interactioni

Subunit structurei

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064411.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni218 – 2192Interactions with TJP1, TJP2 and TJP3By similarity

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOVERGENiHBG000643.
InParanoidiQ63400.
KOiK06087.
OMAiVPDAQKR.
OrthoDBiEOG79KPGQ.
PhylomeDBiQ63400.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01378. CLAUDIN3.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63400-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMGLEITGT SLAVLGWLCT IVCCALPMWR VSAFIGSSII TAQITWEGLW
60 70 80 90 100
MNCVVQSTGQ MQCKMYDSLL ALPQDLQAAR ALIVVSILLA AFGLLVALVG
110 120 130 140 150
AQCTNCVQDE TAKAKITIVA GVLFLLAAVL TLVPVSWSAN TIIRDFYNPL
160 170 180 190 200
VPEAQKREMG TGLYVGWAAA ALQLLGGALL CCSCPPREKY APTKILYSAP
210
RSTGPGTGTG TAYDRKDYV
Length:219
Mass (Da):23,315
Last modified:May 30, 2000 - v2
Checksum:i820CC6BFC20D122D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41G → S in AAA41760 (PubMed:1723140).Curated
Sequence conflicti55 – 551Missing in AAA41760 (PubMed:1723140).Curated
Sequence conflicti217 – 2193DYV → TTSERPGARTPHHHHYQPSM YPTRPACSLASETTPPSRRL QTPRSLLARLEEDRQPGVPF SPVAT (PubMed:1723140).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74067 mRNA. Translation: AAA41760.1.
AJ011656 Genomic DNA. Translation: CAA09727.1.
BC062411 mRNA. Translation: AAH62411.1.
PIRiA39484.
RefSeqiNP_113888.2. NM_031700.2.
UniGeneiRn.4513.

Genome annotation databases

EnsembliENSRNOT00000075280; ENSRNOP00000064411; ENSRNOG00000046007.
GeneIDi65130.
KEGGirno:65130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74067 mRNA. Translation: AAA41760.1.
AJ011656 Genomic DNA. Translation: CAA09727.1.
BC062411 mRNA. Translation: AAH62411.1.
PIRiA39484.
RefSeqiNP_113888.2. NM_031700.2.
UniGeneiRn.4513.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064411.

PTM databases

iPTMnetiQ63400.
PhosphoSiteiQ63400.

Proteomic databases

PaxDbiQ63400.
PRIDEiQ63400.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000075280; ENSRNOP00000064411; ENSRNOG00000046007.
GeneIDi65130.
KEGGirno:65130.

Organism-specific databases

CTDi1365.
RGDi68425. Cldn3.

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOVERGENiHBG000643.
InParanoidiQ63400.
KOiK06087.
OMAiVPDAQKR.
OrthoDBiEOG79KPGQ.
PhylomeDBiQ63400.

Miscellaneous databases

PROiQ63400.

Gene expression databases

GenevisibleiQ63400. RN.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01378. CLAUDIN3.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of transcripts induced by androgen withdrawal and apoptotic cell death in the rat ventral prostate."
    Briehl M.M., Miesfeld R.L.
    Mol. Endocrinol. 5:1381-1388(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Keen T.J., Inglehearn C.F.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-197 AND SER-198, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCLD3_RAT
AccessioniPrimary (citable) accession number: Q63400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: June 8, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.