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Protein

Claudin-3

Gene

Cldn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-3
Alternative name(s):
Rat ventral prostate.1 protein
Short name:
RVP1
Gene namesi
Name:Cldn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi68425. Cldn3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 80ExtracellularSequence analysisAdd BLAST51
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 115CytoplasmicSequence analysisAdd BLAST14
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 161ExtracellularSequence analysisAdd BLAST25
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 219CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

  • apicolateral plasma membrane Source: Ensembl
  • bicellular tight junction Source: UniProtKB
  • cytoplasm Source: RGD
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • lateral plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447401 – 219Claudin-3Add BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei197PhosphotyrosineCombined sources1
Modified residuei198PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63400.
PRIDEiQ63400.

PTM databases

iPTMnetiQ63400.
PhosphoSitePlusiQ63400.

Expressioni

Gene expression databases

BgeeiENSRNOG00000046007.
GenevisibleiQ63400. RN.

Interactioni

Subunit structurei

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064411.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni218 – 219Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOVERGENiHBG000643.
InParanoidiQ63400.
KOiK06087.
OMAiVPDAQKR.
OrthoDBiEOG091G0MMR.
PhylomeDBiQ63400.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01378. CLAUDIN3.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63400-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMGLEITGT SLAVLGWLCT IVCCALPMWR VSAFIGSSII TAQITWEGLW
60 70 80 90 100
MNCVVQSTGQ MQCKMYDSLL ALPQDLQAAR ALIVVSILLA AFGLLVALVG
110 120 130 140 150
AQCTNCVQDE TAKAKITIVA GVLFLLAAVL TLVPVSWSAN TIIRDFYNPL
160 170 180 190 200
VPEAQKREMG TGLYVGWAAA ALQLLGGALL CCSCPPREKY APTKILYSAP
210
RSTGPGTGTG TAYDRKDYV
Length:219
Mass (Da):23,315
Last modified:May 30, 2000 - v2
Checksum:i820CC6BFC20D122D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4G → S in AAA41760 (PubMed:1723140).Curated1
Sequence conflicti55Missing in AAA41760 (PubMed:1723140).Curated1
Sequence conflicti217 – 219DYV → TTSERPGARTPHHHHYQPSM YPTRPACSLASETTPPSRRL QTPRSLLARLEEDRQPGVPF SPVAT (PubMed:1723140).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74067 mRNA. Translation: AAA41760.1.
AJ011656 Genomic DNA. Translation: CAA09727.1.
BC062411 mRNA. Translation: AAH62411.1.
PIRiA39484.
RefSeqiNP_113888.2. NM_031700.2.
UniGeneiRn.4513.

Genome annotation databases

EnsembliENSRNOT00000075280; ENSRNOP00000064411; ENSRNOG00000046007.
GeneIDi65130.
KEGGirno:65130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74067 mRNA. Translation: AAA41760.1.
AJ011656 Genomic DNA. Translation: CAA09727.1.
BC062411 mRNA. Translation: AAH62411.1.
PIRiA39484.
RefSeqiNP_113888.2. NM_031700.2.
UniGeneiRn.4513.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064411.

PTM databases

iPTMnetiQ63400.
PhosphoSitePlusiQ63400.

Proteomic databases

PaxDbiQ63400.
PRIDEiQ63400.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000075280; ENSRNOP00000064411; ENSRNOG00000046007.
GeneIDi65130.
KEGGirno:65130.

Organism-specific databases

CTDi1365.
RGDi68425. Cldn3.

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOVERGENiHBG000643.
InParanoidiQ63400.
KOiK06087.
OMAiVPDAQKR.
OrthoDBiEOG091G0MMR.
PhylomeDBiQ63400.

Miscellaneous databases

PROiQ63400.

Gene expression databases

BgeeiENSRNOG00000046007.
GenevisibleiQ63400. RN.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01378. CLAUDIN3.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD3_RAT
AccessioniPrimary (citable) accession number: Q63400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.