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Q63398

- COE1_RAT

UniProt

Q63398 - COE1_RAT

Protein

Transcription factor COE1

Gene

Ebf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei163 – 1631Interaction with DNABy similarity
    Sitei172 – 1721Interaction with DNABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri151 – 17020C5-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. C2H2 zinc finger domain binding Source: RGD
    2. DNA binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor COE1
    Short name:
    O/E-1
    Short name:
    OE-1
    Alternative name(s):
    Early B-cell factor
    Olf-1
    Olfactory neuronal transcription factor
    Gene namesi
    Name:Ebf1
    Synonyms:Coe1, Ebf, Olf1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620953. Ebf1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 584584Transcription factor COE1PRO_0000107827Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ63398.
    PRIDEiQ63398.

    Expressioni

    Tissue specificityi

    Expressed exclusively in olfactory receptor neurons and their precursors.

    Gene expression databases

    GenevestigatoriQ63398.

    Interactioni

    Subunit structurei

    Forms either a homodimer or a heterodimer with a related family member. Interacts with ZNF423 and ZNF521, leading to prevent EBF1 to bind DNA and activate target genes.1 Publication

    Protein-protein interaction databases

    BioGridi250478. 1 interaction.
    STRINGi10116.ENSRNOP00000050344.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63398.
    SMRiQ63398. Positions 36-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini255 – 33884IPT/TIGAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni63 – 664Interaction with DNABy similarity
    Regioni197 – 2048Interaction with DNABy similarity
    Regioni236 – 2394Interaction with DNABy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi455 – 54389Pro/Ser/Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the COE family.Curated
    Contains 1 IPT/TIG domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri151 – 17020C5-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG259050.
    HOGENOMiHOG000092311.
    HOVERGENiHBG005108.
    InParanoidiQ63398.
    KOiK09103.
    OrthoDBiEOG7J446V.
    PhylomeDBiQ63398.
    TreeFamiTF313391.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR003523. Transcription_factor_COE.
    IPR018350. Transcription_factor_COE_CS.
    [Graphical view]
    PANTHERiPTHR10747. PTHR10747. 1 hit.
    PfamiPF01833. TIG. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    SM00429. IPT. 1 hit.
    [Graphical view]
    SUPFAMiSSF81296. SSF81296. 1 hit.
    PROSITEiPS01345. COE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63398-1 [UniParc]FASTAAdd to Basket

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    MFGIQESIQR SGSSMKEEPL GSGMNAVRTW MQGAGVLDAN TAAQSGVGLA    50
    RAHFEKQPPS NLRKSNFFHF VLALYDRQGQ PVEIERTAFV GFVEKEKEAN 100
    SEKTNNGIHY RLQLLYSNGI RTEQDFYVRL IDSMTKQAIV YEGQDKNPEM 150
    CRVLLTHEIM CSRCCDKKSC GNRNETPSDP VIIDRFFLKF FLKCNQNCLK 200
    NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH GRRARRLDPS 250
    EAATPCIKAI SPSEGWTTGG ATVIIIGDNF FDGLQVIFGT MLVWSELITP 300
    HAIRVQTPPR HIPGVVEVTL SYKSKQFCKG TPGRFIYTAL NEPTIDYGFQ 350
    RLQKVIPRHP GDPERLPKEV ILKRAADLVE ALYGMPHNNQ EIILKRAADI 400
    AEALYSVPRN HNQLPALANT SVHAGMMGVN SFSGQLAVNV SEASQATNQG 450
    FTRNSSSVSP HGYVPSTTPQ QTNYNSVTTS MNGYGSAAMS NLGGSPTFLN 500
    GSAANSPYAI VPSSPTMASS TSLPSNCSSS SGIFSFSPAN MVSAVKQKSA 550
    FAPVVRPQTS PPPTCTSTNG NSLQAISGMI VPPM 584
    Length:584
    Mass (Da):63,650
    Last modified:May 30, 2000 - v2
    Checksum:i1E903A9801BBCFEA
    GO

    Sequence cautioni

    The sequence AAA41759.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L24051 mRNA. Translation: AAA41759.1. Different initiation.
    PIRiS35069.
    RefSeqiNP_446272.2. NM_053820.2.
    UniGeneiRn.11257.

    Genome annotation databases

    GeneIDi116543.
    KEGGirno:116543.
    UCSCiRGD:620953. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L24051 mRNA. Translation: AAA41759.1 . Different initiation.
    PIRi S35069.
    RefSeqi NP_446272.2. NM_053820.2.
    UniGenei Rn.11257.

    3D structure databases

    ProteinModelPortali Q63398.
    SMRi Q63398. Positions 36-406.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 250478. 1 interaction.
    STRINGi 10116.ENSRNOP00000050344.

    Proteomic databases

    PaxDbi Q63398.
    PRIDEi Q63398.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 116543.
    KEGGi rno:116543.
    UCSCi RGD:620953. rat.

    Organism-specific databases

    CTDi 1879.
    RGDi 620953. Ebf1.

    Phylogenomic databases

    eggNOGi NOG259050.
    HOGENOMi HOG000092311.
    HOVERGENi HBG005108.
    InParanoidi Q63398.
    KOi K09103.
    OrthoDBi EOG7J446V.
    PhylomeDBi Q63398.
    TreeFami TF313391.

    Miscellaneous databases

    NextBioi 619137.
    PROi Q63398.

    Gene expression databases

    Genevestigatori Q63398.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR003523. Transcription_factor_COE.
    IPR018350. Transcription_factor_COE_CS.
    [Graphical view ]
    PANTHERi PTHR10747. PTHR10747. 1 hit.
    Pfami PF01833. TIG. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    SM00429. IPT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81296. SSF81296. 1 hit.
    PROSITEi PS01345. COE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast."
      Wang M.M., Reed R.R.
      Nature 364:121-126(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    2. "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development."
      Tsai R.Y.L., Reed R.R.
      J. Neurosci. 17:4159-4169(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZNF423.

    Entry informationi

    Entry nameiCOE1_RAT
    AccessioniPrimary (citable) accession number: Q63398
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3