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Protein

Transcription factor COE1

Gene

Ebf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 170C5-typeSequence analysisAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor COE1
Short name:
O/E-1
Short name:
OE-1
Alternative name(s):
Early B-cell factor
Olf-1
Olfactory neuronal transcription factor
Gene namesi
Name:Ebf1
Synonyms:Coe1, Ebf, Olf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620953 Ebf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001078271 – 584Transcription factor COE1Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki16Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki16Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ63398
PRIDEiQ63398

Expressioni

Tissue specificityi

Expressed exclusively in olfactory receptor neurons and their precursors.

Gene expression databases

BgeeiENSRNOG00000028845
ExpressionAtlasiQ63398 baseline and differential
GenevisibleiQ63398 RN

Interactioni

Subunit structurei

Forms either a homodimer or a heterodimer with a related family member. Interacts with ZNF423 and ZNF521, leading to prevent EBF1 to bind DNA and activate target genes.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei163Interaction with DNABy similarity1
Sitei172Interaction with DNABy similarity1

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250478, 1 interactor
STRINGi10116.ENSRNOP00000050344

Structurei

3D structure databases

ProteinModelPortaliQ63398
SMRiQ63398
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 338IPT/TIGAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni63 – 66Interaction with DNABy similarity4
Regioni197 – 204Interaction with DNABy similarity8
Regioni236 – 239Interaction with DNABy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi455 – 543Pro/Ser/Thr-richAdd BLAST89

Sequence similaritiesi

Belongs to the COE family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 170C5-typeSequence analysisAdd BLAST20

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00390000014051
HOGENOMiHOG000092311
HOVERGENiHBG005108
InParanoidiQ63398
KOiK09103
OMAiHAATPCI
OrthoDBiEOG091G0A9D
PhylomeDBiQ63398
TreeFamiTF313391

Family and domain databases

CDDicd01175 IPT_COE, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.3180, 1 hit
4.10.280.10, 2 hits
InterProiView protein in InterPro
IPR032200 COE_DBD
IPR038173 COE_DBD_sf
IPR032201 COE_HLH
IPR038006 COE_IPT
IPR036638 HLH_DNA-bd_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR003523 Transcription_factor_COE
IPR018350 Transcription_factor_COE_CS
PANTHERiPTHR10747 PTHR10747, 1 hit
PfamiView protein in Pfam
PF16422 COE1_DBD, 1 hit
PF16423 COE1_HLH, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS01345 COE, 1 hit

Sequencei

Sequence statusi: Complete.

Q63398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGIQESIQR SGSSMKEEPL GSGMNAVRTW MQGAGVLDAN TAAQSGVGLA
60 70 80 90 100
RAHFEKQPPS NLRKSNFFHF VLALYDRQGQ PVEIERTAFV GFVEKEKEAN
110 120 130 140 150
SEKTNNGIHY RLQLLYSNGI RTEQDFYVRL IDSMTKQAIV YEGQDKNPEM
160 170 180 190 200
CRVLLTHEIM CSRCCDKKSC GNRNETPSDP VIIDRFFLKF FLKCNQNCLK
210 220 230 240 250
NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH GRRARRLDPS
260 270 280 290 300
EAATPCIKAI SPSEGWTTGG ATVIIIGDNF FDGLQVIFGT MLVWSELITP
310 320 330 340 350
HAIRVQTPPR HIPGVVEVTL SYKSKQFCKG TPGRFIYTAL NEPTIDYGFQ
360 370 380 390 400
RLQKVIPRHP GDPERLPKEV ILKRAADLVE ALYGMPHNNQ EIILKRAADI
410 420 430 440 450
AEALYSVPRN HNQLPALANT SVHAGMMGVN SFSGQLAVNV SEASQATNQG
460 470 480 490 500
FTRNSSSVSP HGYVPSTTPQ QTNYNSVTTS MNGYGSAAMS NLGGSPTFLN
510 520 530 540 550
GSAANSPYAI VPSSPTMASS TSLPSNCSSS SGIFSFSPAN MVSAVKQKSA
560 570 580
FAPVVRPQTS PPPTCTSTNG NSLQAISGMI VPPM
Length:584
Mass (Da):63,650
Last modified:May 30, 2000 - v2
Checksum:i1E903A9801BBCFEA
GO

Sequence cautioni

The sequence AAA41759 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24051 mRNA Translation: AAA41759.1 Different initiation.
PIRiS35069
RefSeqiNP_446272.2, NM_053820.2
UniGeneiRn.11257

Genome annotation databases

EnsembliENSRNOT00000076664; ENSRNOP00000068319; ENSRNOG00000028845
GeneIDi116543
KEGGirno:116543
UCSCiRGD:620953 rat

Similar proteinsi

Entry informationi

Entry nameiCOE1_RAT
AccessioniPrimary (citable) accession number: Q63398
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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