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Q63398 (COE1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor COE1

Short name=O/E-1
Short name=OE-1
Alternative name(s):
Early B-cell factor
Olf-1
Olfactory neuronal transcription factor
Gene names
Name:Ebf1
Synonyms:Coe1, Ebf, Olf1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length584 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.

Subunit structure

Forms either a homodimer or a heterodimer with a related family member. Interacts with ZNF423 and ZNF521, leading to prevent EBF1 to bind DNA and activate target genes. Ref.2

Subcellular location

Nucleus.

Tissue specificity

Expressed exclusively in olfactory receptor neurons and their precursors.

Sequence similarities

Belongs to the COE family.

Contains 1 IPT/TIG domain.

Sequence caution

The sequence AAA41759.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 584584Transcription factor COE1
PRO_0000107827

Regions

Domain255 – 33884IPT/TIG
Zinc finger151 – 17020C5-type Potential
Region63 – 664Interaction with DNA By similarity
Region197 – 2048Interaction with DNA By similarity
Region236 – 2394Interaction with DNA By similarity
Compositional bias455 – 54389Pro/Ser/Thr-rich

Sites

Site1631Interaction with DNA By similarity
Site1721Interaction with DNA By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63398 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 1E903A9801BBCFEA

FASTA58463,650
        10         20         30         40         50         60 
MFGIQESIQR SGSSMKEEPL GSGMNAVRTW MQGAGVLDAN TAAQSGVGLA RAHFEKQPPS 

        70         80         90        100        110        120 
NLRKSNFFHF VLALYDRQGQ PVEIERTAFV GFVEKEKEAN SEKTNNGIHY RLQLLYSNGI 

       130        140        150        160        170        180 
RTEQDFYVRL IDSMTKQAIV YEGQDKNPEM CRVLLTHEIM CSRCCDKKSC GNRNETPSDP 

       190        200        210        220        230        240 
VIIDRFFLKF FLKCNQNCLK NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH 

       250        260        270        280        290        300 
GRRARRLDPS EAATPCIKAI SPSEGWTTGG ATVIIIGDNF FDGLQVIFGT MLVWSELITP 

       310        320        330        340        350        360 
HAIRVQTPPR HIPGVVEVTL SYKSKQFCKG TPGRFIYTAL NEPTIDYGFQ RLQKVIPRHP 

       370        380        390        400        410        420 
GDPERLPKEV ILKRAADLVE ALYGMPHNNQ EIILKRAADI AEALYSVPRN HNQLPALANT 

       430        440        450        460        470        480 
SVHAGMMGVN SFSGQLAVNV SEASQATNQG FTRNSSSVSP HGYVPSTTPQ QTNYNSVTTS 

       490        500        510        520        530        540 
MNGYGSAAMS NLGGSPTFLN GSAANSPYAI VPSSPTMASS TSLPSNCSSS SGIFSFSPAN 

       550        560        570        580 
MVSAVKQKSA FAPVVRPQTS PPPTCTSTNG NSLQAISGMI VPPM 

« Hide

References

[1]"Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast."
Wang M.M., Reed R.R.
Nature 364:121-126(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[2]"Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development."
Tsai R.Y.L., Reed R.R.
J. Neurosci. 17:4159-4169(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ZNF423.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L24051 mRNA. Translation: AAA41759.1. Different initiation.
PIRS35069.
RefSeqNP_446272.2. NM_053820.2.
UniGeneRn.11257.

3D structure databases

ProteinModelPortalQ63398.
SMRQ63398. Positions 36-406.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid250478. 1 interaction.
STRING10116.ENSRNOP00000050344.

Proteomic databases

PaxDbQ63398.
PRIDEQ63398.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID116543.
KEGGrno:116543.
UCSCRGD:620953. rat.

Organism-specific databases

CTD1879.
RGD620953. Ebf1.

Phylogenomic databases

eggNOGNOG259050.
HOGENOMHOG000092311.
HOVERGENHBG005108.
InParanoidQ63398.
KOK09103.
OrthoDBEOG7J446V.
PhylomeDBQ63398.
TreeFamTF313391.

Gene expression databases

GenevestigatorQ63398.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR011598. bHLH_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR003523. Transcription_factor_COE.
IPR018350. Transcription_factor_COE_CS.
[Graphical view]
PANTHERPTHR10747. PTHR10747. 1 hit.
PfamPF01833. TIG. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
SM00429. IPT. 1 hit.
[Graphical view]
SUPFAMSSF81296. SSF81296. 1 hit.
PROSITEPS01345. COE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio619137.
PROQ63398.

Entry information

Entry nameCOE1_RAT
AccessionPrimary (citable) accession number: Q63398
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families