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Protein

Transcription factor COE1

Gene

Ebf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei163 – 1631Interaction with DNABy similarity
Sitei172 – 1721Interaction with DNABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri151 – 17020C5-typeSequence AnalysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor COE1
Short name:
O/E-1
Short name:
OE-1
Alternative name(s):
Early B-cell factor
Olf-1
Olfactory neuronal transcription factor
Gene namesi
Name:Ebf1
Synonyms:Coe1, Ebf, Olf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620953. Ebf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Transcription factor COE1PRO_0000107827Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ63398.
PRIDEiQ63398.

Expressioni

Tissue specificityi

Expressed exclusively in olfactory receptor neurons and their precursors.

Gene expression databases

GenevisibleiQ63398. RN.

Interactioni

Subunit structurei

Forms either a homodimer or a heterodimer with a related family member. Interacts with ZNF423 and ZNF521, leading to prevent EBF1 to bind DNA and activate target genes.1 Publication

Protein-protein interaction databases

BioGridi250478. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ63398.
SMRiQ63398. Positions 36-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini255 – 33884IPT/TIGAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 664Interaction with DNABy similarity
Regioni197 – 2048Interaction with DNABy similarity
Regioni236 – 2394Interaction with DNABy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi455 – 54389Pro/Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the COE family.Curated
Contains 1 IPT/TIG domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri151 – 17020C5-typeSequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG259050.
GeneTreeiENSGT00390000014051.
HOGENOMiHOG000092311.
HOVERGENiHBG005108.
InParanoidiQ63398.
KOiK09103.
OrthoDBiEOG7J446V.
PhylomeDBiQ63398.
TreeFamiTF313391.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR003523. Transcription_factor_COE.
IPR018350. Transcription_factor_COE_CS.
[Graphical view]
PANTHERiPTHR10747. PTHR10747. 1 hit.
PfamiPF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS01345. COE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGIQESIQR SGSSMKEEPL GSGMNAVRTW MQGAGVLDAN TAAQSGVGLA
60 70 80 90 100
RAHFEKQPPS NLRKSNFFHF VLALYDRQGQ PVEIERTAFV GFVEKEKEAN
110 120 130 140 150
SEKTNNGIHY RLQLLYSNGI RTEQDFYVRL IDSMTKQAIV YEGQDKNPEM
160 170 180 190 200
CRVLLTHEIM CSRCCDKKSC GNRNETPSDP VIIDRFFLKF FLKCNQNCLK
210 220 230 240 250
NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH GRRARRLDPS
260 270 280 290 300
EAATPCIKAI SPSEGWTTGG ATVIIIGDNF FDGLQVIFGT MLVWSELITP
310 320 330 340 350
HAIRVQTPPR HIPGVVEVTL SYKSKQFCKG TPGRFIYTAL NEPTIDYGFQ
360 370 380 390 400
RLQKVIPRHP GDPERLPKEV ILKRAADLVE ALYGMPHNNQ EIILKRAADI
410 420 430 440 450
AEALYSVPRN HNQLPALANT SVHAGMMGVN SFSGQLAVNV SEASQATNQG
460 470 480 490 500
FTRNSSSVSP HGYVPSTTPQ QTNYNSVTTS MNGYGSAAMS NLGGSPTFLN
510 520 530 540 550
GSAANSPYAI VPSSPTMASS TSLPSNCSSS SGIFSFSPAN MVSAVKQKSA
560 570 580
FAPVVRPQTS PPPTCTSTNG NSLQAISGMI VPPM
Length:584
Mass (Da):63,650
Last modified:May 30, 2000 - v2
Checksum:i1E903A9801BBCFEA
GO

Sequence cautioni

The sequence AAA41759.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24051 mRNA. Translation: AAA41759.1. Different initiation.
PIRiS35069.
RefSeqiNP_446272.2. NM_053820.2.
UniGeneiRn.11257.

Genome annotation databases

EnsembliENSRNOT00000076664; ENSRNOP00000068319; ENSRNOG00000028845.
GeneIDi116543.
KEGGirno:116543.
UCSCiRGD:620953. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24051 mRNA. Translation: AAA41759.1. Different initiation.
PIRiS35069.
RefSeqiNP_446272.2. NM_053820.2.
UniGeneiRn.11257.

3D structure databases

ProteinModelPortaliQ63398.
SMRiQ63398. Positions 36-406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250478. 1 interaction.

Proteomic databases

PaxDbiQ63398.
PRIDEiQ63398.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000076664; ENSRNOP00000068319; ENSRNOG00000028845.
GeneIDi116543.
KEGGirno:116543.
UCSCiRGD:620953. rat.

Organism-specific databases

CTDi1879.
RGDi620953. Ebf1.

Phylogenomic databases

eggNOGiNOG259050.
GeneTreeiENSGT00390000014051.
HOGENOMiHOG000092311.
HOVERGENiHBG005108.
InParanoidiQ63398.
KOiK09103.
OrthoDBiEOG7J446V.
PhylomeDBiQ63398.
TreeFamiTF313391.

Miscellaneous databases

NextBioi619137.
PROiQ63398.

Gene expression databases

GenevisibleiQ63398. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR003523. Transcription_factor_COE.
IPR018350. Transcription_factor_COE_CS.
[Graphical view]
PANTHERiPTHR10747. PTHR10747. 1 hit.
PfamiPF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS01345. COE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast."
    Wang M.M., Reed R.R.
    Nature 364:121-126(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  2. "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development."
    Tsai R.Y.L., Reed R.R.
    J. Neurosci. 17:4159-4169(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZNF423.

Entry informationi

Entry nameiCOE1_RAT
AccessioniPrimary (citable) accession number: Q63398
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 22, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.