Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q63384

- NTR2_RAT

UniProt

Q63384 - NTR2_RAT

Protein

Neurotensin receptor type 2

Gene

Ntsr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. G-protein coupled neurotensin receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotensin receptor type 2
    Short name:
    NT-R-2
    Short name:
    NTR2
    Alternative name(s):
    High-affinity levocabastine-sensitive neurotensin receptor
    Gene namesi
    Name:Ntsr2
    Synonyms:Ntr2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi70962. Ntsr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Neurotensin receptor type 2PRO_0000069951Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi108 ↔ 194PROSITE-ProRule annotation
    Lipidationi377 – 3771S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Lipoprotein, Palmitate

    PTM databases

    PhosphoSiteiQ63384.

    Expressioni

    Tissue specificityi

    Abundant in cortex and hypothalamus, and lower levels seen in the heart and intestine.

    Developmental stagei

    Expressed maximally in 7-day-old brain and expression decreases progressively until adulthood (35-day-old brain).

    Gene expression databases

    GenevestigatoriQ63384.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ63384.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini56 – 649CytoplasmicSequence Analysis
    Topological domaini88 – 10922ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini132 – 15423CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini177 – 21640ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini238 – 29760CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini319 – 33719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini359 – 41658CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5523Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 8723Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei110 – 13122Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17622Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG098285.
    KOiK04212.
    PhylomeDBiQ63384.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003986. NT2_rcpt.
    IPR003984. NT_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01479. NEUROTENSINR.
    PR01481. NEUROTENSN2R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63384-1 [UniParc]FASTAAdd to Basket

    « Hide

    METSSPWPPR PSPSAGLSLE ARLGVDTRLW AKVLFTALYS LIFAFGTAGN    50
    ALSVHVVLKA RAGRPGRLRY HVLSLALSAL LLLLVSMPME LYNFVWSHYP 100
    WVFGDLGCRG YYFVRELCAY ATVLSVASLS AERCLAVCQP LRARRLLTPR 150
    RTRRLLSLVW VASLGLALPM AVIMGQKHEV ESADGEPEPA SRVCTVLVSR 200
    ATLQVFIQVN VLVSFALPLA LTAFLNGITV NHLMALYSQV PSASAQVSSI 250
    PSRLELLSEE GLLGFITWRK TLSLGVQASL VRHKDASQIR SLQHSAQVLR 300
    AIVAVYVICW LPYHARRLMY CYIPDDGWTN ELYDFYHYFY MVTNTLFYVS 350
    SAVTPILYNA VSSSFRKLFL ESLGSLCGEQ HSLVPLPQEA PESTTSTYSF 400
    RLWGSPRNPS LGEIQV 416
    Length:416
    Mass (Da):46,266
    Last modified:November 1, 1996 - v1
    Checksum:i127FC5F5CB6FE208
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97121 mRNA. Translation: CAA65787.1.
    PIRiS68822.
    RefSeqiNP_073186.1. NM_022695.2.
    UniGeneiRn.127792.

    Genome annotation databases

    GeneIDi64636.
    KEGGirno:64636.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97121 mRNA. Translation: CAA65787.1 .
    PIRi S68822.
    RefSeqi NP_073186.1. NM_022695.2.
    UniGenei Rn.127792.

    3D structure databases

    ProteinModelPortali Q63384.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q63384.
    ChEMBLi CHEMBL5106.
    GuidetoPHARMACOLOGYi 310.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q63384.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 64636.
    KEGGi rno:64636.

    Organism-specific databases

    CTDi 23620.
    RGDi 70962. Ntsr2.

    Phylogenomic databases

    HOVERGENi HBG098285.
    KOi K04212.
    PhylomeDBi Q63384.

    Miscellaneous databases

    NextBioi 613612.
    PROi Q63384.

    Gene expression databases

    Genevestigatori Q63384.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003986. NT2_rcpt.
    IPR003984. NT_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01479. NEUROTENSINR.
    PR01481. NEUROTENSN2R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a levocabastine-sensitive neurotensin binding site."
      Chalon P., Vita N., Kaghad M., Guillemont M., Bonin J., Delpech B., le Fur G., Ferrara P., Caput D.
      FEBS Lett. 386:91-94(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiNTR2_RAT
    AccessioniPrimary (citable) accession number: Q63384
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3