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Protein

Neurotensin receptor type 2

Gene

Ntsr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of MAPK cascade Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin receptor type 2
Short name:
NT-R-2
Short name:
NTR2
Alternative name(s):
High-affinity levocabastine-sensitive neurotensin receptor
Gene namesi
Name:Ntsr2
Synonyms:Ntr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70962 Ntsr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 55Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini56 – 64CytoplasmicSequence analysis9
Transmembranei65 – 87Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini88 – 109ExtracellularSequence analysisAdd BLAST22
Transmembranei110 – 131Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini132 – 154CytoplasmicSequence analysisAdd BLAST23
Transmembranei155 – 176Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini177 – 216ExtracellularSequence analysisAdd BLAST40
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 297CytoplasmicSequence analysisAdd BLAST60
Transmembranei298 – 318Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini319 – 337ExtracellularSequence analysisAdd BLAST19
Transmembranei338 – 358Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini359 – 416CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5106
GuidetoPHARMACOLOGYi310

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699511 – 416Neurotensin receptor type 2Add BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi108 ↔ 194PROSITE-ProRule annotation
Lipidationi377S-palmitoyl cysteineSequence analysis1
Modified residuei410PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ63384

PTM databases

iPTMnetiQ63384
PhosphoSitePlusiQ63384

Expressioni

Tissue specificityi

Abundant in cortex and hypothalamus, and lower levels seen in the heart and intestine.

Developmental stagei

Expressed maximally in 7-day-old brain and expression decreases progressively until adulthood (35-day-old brain).

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067549

Chemistry databases

BindingDBiQ63384

Structurei

3D structure databases

ProteinModelPortaliQ63384
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOVERGENiHBG098285
InParanoidiQ63384
KOiK04212
PhylomeDBiQ63384

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003986 NT2_rcpt
IPR003984 NT_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01479 NEUROTENSINR
PR01481 NEUROTENSN2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q63384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSSPWPPR PSPSAGLSLE ARLGVDTRLW AKVLFTALYS LIFAFGTAGN
60 70 80 90 100
ALSVHVVLKA RAGRPGRLRY HVLSLALSAL LLLLVSMPME LYNFVWSHYP
110 120 130 140 150
WVFGDLGCRG YYFVRELCAY ATVLSVASLS AERCLAVCQP LRARRLLTPR
160 170 180 190 200
RTRRLLSLVW VASLGLALPM AVIMGQKHEV ESADGEPEPA SRVCTVLVSR
210 220 230 240 250
ATLQVFIQVN VLVSFALPLA LTAFLNGITV NHLMALYSQV PSASAQVSSI
260 270 280 290 300
PSRLELLSEE GLLGFITWRK TLSLGVQASL VRHKDASQIR SLQHSAQVLR
310 320 330 340 350
AIVAVYVICW LPYHARRLMY CYIPDDGWTN ELYDFYHYFY MVTNTLFYVS
360 370 380 390 400
SAVTPILYNA VSSSFRKLFL ESLGSLCGEQ HSLVPLPQEA PESTTSTYSF
410
RLWGSPRNPS LGEIQV
Length:416
Mass (Da):46,266
Last modified:November 1, 1996 - v1
Checksum:i127FC5F5CB6FE208
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97121 mRNA Translation: CAA65787.1
PIRiS68822
RefSeqiNP_073186.1, NM_022695.2
UniGeneiRn.127792

Genome annotation databases

GeneIDi64636
KEGGirno:64636

Similar proteinsi

Entry informationi

Entry nameiNTR2_RAT
AccessioniPrimary (citable) accession number: Q63384
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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