Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q63384 (NTR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotensin receptor type 2

Short name=NT-R-2
Short name=NTR2
Alternative name(s):
High-affinity levocabastine-sensitive neurotensin receptor
Gene names
Name:Ntsr2
Synonyms:Ntr2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Abundant in cortex and hypothalamus, and lower levels seen in the heart and intestine.

Developmental stage

Expressed maximally in 7-day-old brain and expression decreases progressively until adulthood (35-day-old brain).

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Neurotensin receptor type 2
PRO_0000069951

Regions

Topological domain1 – 3232Extracellular Potential
Transmembrane33 – 5523Helical; Name=1; Potential
Topological domain56 – 649Cytoplasmic Potential
Transmembrane65 – 8723Helical; Name=2; Potential
Topological domain88 – 10922Extracellular Potential
Transmembrane110 – 13122Helical; Name=3; Potential
Topological domain132 – 15423Cytoplasmic Potential
Transmembrane155 – 17622Helical; Name=4; Potential
Topological domain177 – 21640Extracellular Potential
Transmembrane217 – 23721Helical; Name=5; Potential
Topological domain238 – 29760Cytoplasmic Potential
Transmembrane298 – 31821Helical; Name=6; Potential
Topological domain319 – 33719Extracellular Potential
Transmembrane338 – 35821Helical; Name=7; Potential
Topological domain359 – 41658Cytoplasmic Potential

Amino acid modifications

Lipidation3771S-palmitoyl cysteine Potential
Disulfide bond108 ↔ 194 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63384 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 127FC5F5CB6FE208

FASTA41646,266
        10         20         30         40         50         60 
METSSPWPPR PSPSAGLSLE ARLGVDTRLW AKVLFTALYS LIFAFGTAGN ALSVHVVLKA 

        70         80         90        100        110        120 
RAGRPGRLRY HVLSLALSAL LLLLVSMPME LYNFVWSHYP WVFGDLGCRG YYFVRELCAY 

       130        140        150        160        170        180 
ATVLSVASLS AERCLAVCQP LRARRLLTPR RTRRLLSLVW VASLGLALPM AVIMGQKHEV 

       190        200        210        220        230        240 
ESADGEPEPA SRVCTVLVSR ATLQVFIQVN VLVSFALPLA LTAFLNGITV NHLMALYSQV 

       250        260        270        280        290        300 
PSASAQVSSI PSRLELLSEE GLLGFITWRK TLSLGVQASL VRHKDASQIR SLQHSAQVLR 

       310        320        330        340        350        360 
AIVAVYVICW LPYHARRLMY CYIPDDGWTN ELYDFYHYFY MVTNTLFYVS SAVTPILYNA 

       370        380        390        400        410 
VSSSFRKLFL ESLGSLCGEQ HSLVPLPQEA PESTTSTYSF RLWGSPRNPS LGEIQV 

« Hide

References

[1]"Molecular cloning of a levocabastine-sensitive neurotensin binding site."
Chalon P., Vita N., Kaghad M., Guillemont M., Bonin J., Delpech B., le Fur G., Ferrara P., Caput D.
FEBS Lett. 386:91-94(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hypothalamus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X97121 mRNA. Translation: CAA65787.1.
PIRS68822.
RefSeqNP_073186.1. NM_022695.2.
UniGeneRn.127792.

3D structure databases

ProteinModelPortalQ63384.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ63384.
ChEMBLCHEMBL5106.
GuidetoPHARMACOLOGY310.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ63384.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID64636.
KEGGrno:64636.

Organism-specific databases

CTD23620.
RGD70962. Ntsr2.

Phylogenomic databases

HOVERGENHBG098285.
KOK04212.

Gene expression databases

GenevestigatorQ63384.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio613612.
PROQ63384.

Entry information

Entry nameNTR2_RAT
AccessionPrimary (citable) accession number: Q63384
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries