Q63384 (NTR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurotensin receptor type 2
Short name=NT-R-2
Short name=NTR2

Alternative name(s):
High-affinity levocabastine-sensitive neurotensin receptor

Gene names

Name:	Ntsr2
Synonyms:	Ntr2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Abundant in cortex and hypothalamus, and lower levels seen in the heart and intestine.
Developmental stage	Expressed maximally in 7-day-old brain and expression decreases progressively until adulthood (35-day-old brain).
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled neurotensin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Neurotensin receptor type 2		PRO_0000069951
Regions
	Topological domain	1 – 32	32	Extracellular Potential
	Transmembrane	33 – 55	23	Helical; Name=1; Potential
	Topological domain	56 – 64	9	Cytoplasmic Potential
	Transmembrane	65 – 87	23	Helical; Name=2; Potential
	Topological domain	88 – 109	22	Extracellular Potential
	Transmembrane	110 – 131	22	Helical; Name=3; Potential
	Topological domain	132 – 154	23	Cytoplasmic Potential
	Transmembrane	155 – 176	22	Helical; Name=4; Potential
	Topological domain	177 – 216	40	Extracellular Potential
	Transmembrane	217 – 237	21	Helical; Name=5; Potential
	Topological domain	238 – 297	60	Cytoplasmic Potential
	Transmembrane	298 – 318	21	Helical; Name=6; Potential
	Topological domain	319 – 337	19	Extracellular Potential
	Transmembrane	338 – 358	21	Helical; Name=7; Potential
	Topological domain	359 – 416	58	Cytoplasmic Potential
Amino acid modifications
	Lipidation	377	1	S-palmitoyl cysteine Potential
	Disulfide bond	108 ↔ 194		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q63384 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 127FC5F5CB6FE208	FASTA	416	46,266
	10 20 30 40 50 60 METSSPWPPR PSPSAGLSLE ARLGVDTRLW AKVLFTALYS LIFAFGTAGN ALSVHVVLKA 70 80 90 100 110 120 RAGRPGRLRY HVLSLALSAL LLLLVSMPME LYNFVWSHYP WVFGDLGCRG YYFVRELCAY 130 140 150 160 170 180 ATVLSVASLS AERCLAVCQP LRARRLLTPR RTRRLLSLVW VASLGLALPM AVIMGQKHEV 190 200 210 220 230 240 ESADGEPEPA SRVCTVLVSR ATLQVFIQVN VLVSFALPLA LTAFLNGITV NHLMALYSQV 250 260 270 280 290 300 PSASAQVSSI PSRLELLSEE GLLGFITWRK TLSLGVQASL VRHKDASQIR SLQHSAQVLR 310 320 330 340 350 360 AIVAVYVICW LPYHARRLMY CYIPDDGWTN ELYDFYHYFY MVTNTLFYVS SAVTPILYNA 370 380 390 400 410 VSSSFRKLFL ESLGSLCGEQ HSLVPLPQEA PESTTSTYSF RLWGSPRNPS LGEIQV

References

[1]	"Molecular cloning of a levocabastine-sensitive neurotensin binding site." Chalon P., Vita N., Kaghad M., Guillemont M., Bonin J., Delpech B., le Fur G., Ferrara P., Caput D. FEBS Lett. 386:91-94(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hypothalamus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97121 mRNA. Translation: CAA65787.1.
IPI	IPI00208095.
PIR	S68822.
RefSeq	NP_073186.1. NM_022695.2.
UniGene	Rn.127792.
3D structure databases
ProteinModelPortal	Q63384.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q63384.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	64636.
KEGG	rno:64636.
Organism-specific databases
CTD	23620.
RGD	70962. Ntsr2.
Phylogenomic databases
HOVERGEN	HBG098285.
KO	K04212.
Gene expression databases
Genevestigator	Q63384.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR003986. NT2_rcpt. IPR003984. NT_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01479. NEUROTENSINR. PR01481. NEUROTENSN2R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q63384.
ChEMBL	CHEMBL5106.
NextBio	613612.

Entry information

Entry name

NTR2_RAT

Accession

Primary (citable) accession number: Q63384

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program