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Protein

Neurotensin receptor type 2

Gene

Ntsr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. G-protein coupled neurotensin receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin receptor type 2
Short name:
NT-R-2
Short name:
NTR2
Alternative name(s):
High-affinity levocabastine-sensitive neurotensin receptor
Gene namesi
Name:Ntsr2
Synonyms:Ntr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi70962. Ntsr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei33 – 5523Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini56 – 649CytoplasmicSequence Analysis
Transmembranei65 – 8723Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini88 – 10922ExtracellularSequence AnalysisAdd
BLAST
Transmembranei110 – 13122Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini132 – 15423CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei155 – 17622Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini177 – 21640ExtracellularSequence AnalysisAdd
BLAST
Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini238 – 29760CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei298 – 31821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini319 – 33719ExtracellularSequence AnalysisAdd
BLAST
Transmembranei338 – 35821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini359 – 41658CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Neurotensin receptor type 2PRO_0000069951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi108 ↔ 194PROSITE-ProRule annotation
Lipidationi377 – 3771S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

PTM databases

PhosphoSiteiQ63384.

Expressioni

Tissue specificityi

Abundant in cortex and hypothalamus, and lower levels seen in the heart and intestine.

Developmental stagei

Expressed maximally in 7-day-old brain and expression decreases progressively until adulthood (35-day-old brain).

Gene expression databases

GenevestigatoriQ63384.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ63384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG098285.
InParanoidiQ63384.
KOiK04212.
PhylomeDBiQ63384.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63384-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METSSPWPPR PSPSAGLSLE ARLGVDTRLW AKVLFTALYS LIFAFGTAGN
60 70 80 90 100
ALSVHVVLKA RAGRPGRLRY HVLSLALSAL LLLLVSMPME LYNFVWSHYP
110 120 130 140 150
WVFGDLGCRG YYFVRELCAY ATVLSVASLS AERCLAVCQP LRARRLLTPR
160 170 180 190 200
RTRRLLSLVW VASLGLALPM AVIMGQKHEV ESADGEPEPA SRVCTVLVSR
210 220 230 240 250
ATLQVFIQVN VLVSFALPLA LTAFLNGITV NHLMALYSQV PSASAQVSSI
260 270 280 290 300
PSRLELLSEE GLLGFITWRK TLSLGVQASL VRHKDASQIR SLQHSAQVLR
310 320 330 340 350
AIVAVYVICW LPYHARRLMY CYIPDDGWTN ELYDFYHYFY MVTNTLFYVS
360 370 380 390 400
SAVTPILYNA VSSSFRKLFL ESLGSLCGEQ HSLVPLPQEA PESTTSTYSF
410
RLWGSPRNPS LGEIQV
Length:416
Mass (Da):46,266
Last modified:November 1, 1996 - v1
Checksum:i127FC5F5CB6FE208
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97121 mRNA. Translation: CAA65787.1.
PIRiS68822.
RefSeqiNP_073186.1. NM_022695.2.
UniGeneiRn.127792.

Genome annotation databases

GeneIDi64636.
KEGGirno:64636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97121 mRNA. Translation: CAA65787.1.
PIRiS68822.
RefSeqiNP_073186.1. NM_022695.2.
UniGeneiRn.127792.

3D structure databases

ProteinModelPortaliQ63384.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ63384.
ChEMBLiCHEMBL5106.
GuidetoPHARMACOLOGYi310.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ63384.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64636.
KEGGirno:64636.

Organism-specific databases

CTDi23620.
RGDi70962. Ntsr2.

Phylogenomic databases

HOVERGENiHBG098285.
InParanoidiQ63384.
KOiK04212.
PhylomeDBiQ63384.

Miscellaneous databases

NextBioi613612.
PROiQ63384.

Gene expression databases

GenevestigatoriQ63384.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a levocabastine-sensitive neurotensin binding site."
    Chalon P., Vita N., Kaghad M., Guillemont M., Bonin J., Delpech B., le Fur G., Ferrara P., Caput D.
    FEBS Lett. 386:91-94(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.

Entry informationi

Entry nameiNTR2_RAT
AccessioniPrimary (citable) accession number: Q63384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.