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Protein

Neurotensin receptor type 2

Gene

Ntsr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • G-protein coupled neurotensin receptor activity Source: InterPro
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of MAPK cascade Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin receptor type 2
Short name:
NT-R-2
Short name:
NTR2
Alternative name(s):
High-affinity levocabastine-sensitive neurotensin receptor
Gene namesi
Name:Ntsr2
Synonyms:Ntr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70962. Ntsr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 55Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini56 – 64CytoplasmicSequence analysis9
Transmembranei65 – 87Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini88 – 109ExtracellularSequence analysisAdd BLAST22
Transmembranei110 – 131Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini132 – 154CytoplasmicSequence analysisAdd BLAST23
Transmembranei155 – 176Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini177 – 216ExtracellularSequence analysisAdd BLAST40
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 297CytoplasmicSequence analysisAdd BLAST60
Transmembranei298 – 318Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini319 – 337ExtracellularSequence analysisAdd BLAST19
Transmembranei338 – 358Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini359 – 416CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

  • cell surface Source: RGD
  • dendritic shaft Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • perikaryon Source: RGD
  • plasma membrane Source: RGD
  • trans-Golgi network Source: RGD

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5106.
GuidetoPHARMACOLOGYi310.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699511 – 416Neurotensin receptor type 2Add BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi108 ↔ 194PROSITE-ProRule annotation
Lipidationi377S-palmitoyl cysteineSequence analysis1
Modified residuei410PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ63384.

PTM databases

iPTMnetiQ63384.
PhosphoSitePlusiQ63384.

Expressioni

Tissue specificityi

Abundant in cortex and hypothalamus, and lower levels seen in the heart and intestine.

Developmental stagei

Expressed maximally in 7-day-old brain and expression decreases progressively until adulthood (35-day-old brain).

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067549.

Chemistry databases

BindingDBiQ63384.

Structurei

3D structure databases

ProteinModelPortaliQ63384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG098285.
InParanoidiQ63384.
KOiK04212.
PhylomeDBiQ63384.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSSPWPPR PSPSAGLSLE ARLGVDTRLW AKVLFTALYS LIFAFGTAGN
60 70 80 90 100
ALSVHVVLKA RAGRPGRLRY HVLSLALSAL LLLLVSMPME LYNFVWSHYP
110 120 130 140 150
WVFGDLGCRG YYFVRELCAY ATVLSVASLS AERCLAVCQP LRARRLLTPR
160 170 180 190 200
RTRRLLSLVW VASLGLALPM AVIMGQKHEV ESADGEPEPA SRVCTVLVSR
210 220 230 240 250
ATLQVFIQVN VLVSFALPLA LTAFLNGITV NHLMALYSQV PSASAQVSSI
260 270 280 290 300
PSRLELLSEE GLLGFITWRK TLSLGVQASL VRHKDASQIR SLQHSAQVLR
310 320 330 340 350
AIVAVYVICW LPYHARRLMY CYIPDDGWTN ELYDFYHYFY MVTNTLFYVS
360 370 380 390 400
SAVTPILYNA VSSSFRKLFL ESLGSLCGEQ HSLVPLPQEA PESTTSTYSF
410
RLWGSPRNPS LGEIQV
Length:416
Mass (Da):46,266
Last modified:November 1, 1996 - v1
Checksum:i127FC5F5CB6FE208
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97121 mRNA. Translation: CAA65787.1.
PIRiS68822.
RefSeqiNP_073186.1. NM_022695.2.
UniGeneiRn.127792.

Genome annotation databases

GeneIDi64636.
KEGGirno:64636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97121 mRNA. Translation: CAA65787.1.
PIRiS68822.
RefSeqiNP_073186.1. NM_022695.2.
UniGeneiRn.127792.

3D structure databases

ProteinModelPortaliQ63384.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067549.

Chemistry databases

BindingDBiQ63384.
ChEMBLiCHEMBL5106.
GuidetoPHARMACOLOGYi310.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ63384.
PhosphoSitePlusiQ63384.

Proteomic databases

PaxDbiQ63384.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64636.
KEGGirno:64636.

Organism-specific databases

CTDi23620.
RGDi70962. Ntsr2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG098285.
InParanoidiQ63384.
KOiK04212.
PhylomeDBiQ63384.

Miscellaneous databases

PROiPR:Q63384.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNTR2_RAT
AccessioniPrimary (citable) accession number: Q63384
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.