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Q63384

- NTR2_RAT

UniProt

Q63384 - NTR2_RAT

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Protein

Neurotensin receptor type 2

Gene
Ntsr2, Ntr2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. G-protein coupled neurotensin receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin receptor type 2
Short name:
NT-R-2
Short name:
NTR2
Alternative name(s):
High-affinity levocabastine-sensitive neurotensin receptor
Gene namesi
Name:Ntsr2
Synonyms:Ntr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi70962. Ntsr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232Extracellular Reviewed predictionAdd
BLAST
Transmembranei33 – 5523Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini56 – 649Cytoplasmic Reviewed prediction
Transmembranei65 – 8723Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini88 – 10922Extracellular Reviewed predictionAdd
BLAST
Transmembranei110 – 13122Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini132 – 15423Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei155 – 17622Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini177 – 21640Extracellular Reviewed predictionAdd
BLAST
Transmembranei217 – 23721Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini238 – 29760Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei298 – 31821Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini319 – 33719Extracellular Reviewed predictionAdd
BLAST
Transmembranei338 – 35821Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini359 – 41658Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Neurotensin receptor type 2PRO_0000069951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi108 ↔ 194 By similarity
Lipidationi377 – 3771S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

PTM databases

PhosphoSiteiQ63384.

Expressioni

Tissue specificityi

Abundant in cortex and hypothalamus, and lower levels seen in the heart and intestine.

Developmental stagei

Expressed maximally in 7-day-old brain and expression decreases progressively until adulthood (35-day-old brain).

Gene expression databases

GenevestigatoriQ63384.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ63384.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG098285.
KOiK04212.
PhylomeDBiQ63384.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63384-1 [UniParc]FASTAAdd to Basket

« Hide

METSSPWPPR PSPSAGLSLE ARLGVDTRLW AKVLFTALYS LIFAFGTAGN    50
ALSVHVVLKA RAGRPGRLRY HVLSLALSAL LLLLVSMPME LYNFVWSHYP 100
WVFGDLGCRG YYFVRELCAY ATVLSVASLS AERCLAVCQP LRARRLLTPR 150
RTRRLLSLVW VASLGLALPM AVIMGQKHEV ESADGEPEPA SRVCTVLVSR 200
ATLQVFIQVN VLVSFALPLA LTAFLNGITV NHLMALYSQV PSASAQVSSI 250
PSRLELLSEE GLLGFITWRK TLSLGVQASL VRHKDASQIR SLQHSAQVLR 300
AIVAVYVICW LPYHARRLMY CYIPDDGWTN ELYDFYHYFY MVTNTLFYVS 350
SAVTPILYNA VSSSFRKLFL ESLGSLCGEQ HSLVPLPQEA PESTTSTYSF 400
RLWGSPRNPS LGEIQV 416
Length:416
Mass (Da):46,266
Last modified:November 1, 1996 - v1
Checksum:i127FC5F5CB6FE208
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97121 mRNA. Translation: CAA65787.1.
PIRiS68822.
RefSeqiNP_073186.1. NM_022695.2.
UniGeneiRn.127792.

Genome annotation databases

GeneIDi64636.
KEGGirno:64636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97121 mRNA. Translation: CAA65787.1 .
PIRi S68822.
RefSeqi NP_073186.1. NM_022695.2.
UniGenei Rn.127792.

3D structure databases

ProteinModelPortali Q63384.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q63384.
ChEMBLi CHEMBL5106.
GuidetoPHARMACOLOGYi 310.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q63384.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 64636.
KEGGi rno:64636.

Organism-specific databases

CTDi 23620.
RGDi 70962. Ntsr2.

Phylogenomic databases

HOVERGENi HBG098285.
KOi K04212.
PhylomeDBi Q63384.

Miscellaneous databases

NextBioi 613612.
PROi Q63384.

Gene expression databases

Genevestigatori Q63384.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a levocabastine-sensitive neurotensin binding site."
    Chalon P., Vita N., Kaghad M., Guillemont M., Bonin J., Delpech B., le Fur G., Ferrara P., Caput D.
    FEBS Lett. 386:91-94(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.

Entry informationi

Entry nameiNTR2_RAT
AccessioniPrimary (citable) accession number: Q63384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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