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Protein

N-myc proto-oncogene protein

Gene

Mycn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
N-myc proto-oncogene protein
Gene namesi
Name:Mycn
Synonyms:Nmyc, Nmyc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1584995. Mycn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273261 – 462N-myc proto-oncogene proteinAdd BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei259Phosphoserine; by CK2By similarity1
Modified residuei261Phosphoserine; by CK2By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63379.
PRIDEiQ63379.

PTM databases

iPTMnetiQ63379.
PhosphoSitePlusiQ63379.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008643.

Structurei

3D structure databases

ProteinModelPortaliQ63379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini379 – 431bHLHPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni431 – 452Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi260 – 276Asp/Glu-rich (acidic)Add BLAST17

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJ8V. Eukaryota.
ENOG41105VW. LUCA.
HOGENOMiHOG000043075.
HOVERGENiHBG000472.
InParanoidiQ63379.
KOiK09109.
PhylomeDBiQ63379.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF01056. Myc_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001705. Myc_protein. 1 hit.
PRINTSiPR00044. LEUZIPPRMYC.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSCTASTMP GMICKNPDLE FDSLQPCFYP DEDDFYFGGP DSTPPGEDIW
60 70 80 90 100
KKFELLPTPP LSPSRAFPEH SPEPSNWATE MLLPEADLWG NPAEEDAFGL
110 120 130 140 150
GGLGGLTPNP VILQDCMWSG FSAREKLERA VNEKLQHGHG PPGASSSCPA
160 170 180 190 200
PGVGASSSGG RALGGSASAG RTGATLPTDL SHPAAECVDP AVVFPFPVNK
210 220 230 240 250
RESASVPAAP TSAPATSAVV TSVSVPAVAP VAAPARGSGR PANSGEHKAL
260 270 280 290 300
STSGEDTLSD SDDEDDEEED EEEEIDVVTV EKRRSSSNNK AVTTFTITVR
310 320 330 340 350
PKTSALGLGR AQPGELILKR CVPIHQQHNY AAPSPYVESE DAPPQKKIKS
360 370 380 390 400
EASPRPLKSV VPPKAKSLSP RNSDSEDSER RRNHNILERQ RRNDLRSSFL
410 420 430 440 450
TLRDHVPELV KNEKAAKVVI LKKATEYVHA LQANEHQLLL EKEKLQARQQ
460
QLLKKIEHAR TC
Length:462
Mass (Da):49,695
Last modified:November 1, 1996 - v1
Checksum:i493130B3E0CAAB16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63281 Genomic DNA. Translation: CAA44920.1.
PIRiS20073.
RefSeqiNP_001013114.1. NM_001013096.1.
UniGeneiRn.81116.

Genome annotation databases

GeneIDi298894.
KEGGirno:298894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63281 Genomic DNA. Translation: CAA44920.1.
PIRiS20073.
RefSeqiNP_001013114.1. NM_001013096.1.
UniGeneiRn.81116.

3D structure databases

ProteinModelPortaliQ63379.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008643.

PTM databases

iPTMnetiQ63379.
PhosphoSitePlusiQ63379.

Proteomic databases

PaxDbiQ63379.
PRIDEiQ63379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi298894.
KEGGirno:298894.

Organism-specific databases

CTDi4613.
RGDi1584995. Mycn.

Phylogenomic databases

eggNOGiENOG410IJ8V. Eukaryota.
ENOG41105VW. LUCA.
HOGENOMiHOG000043075.
HOVERGENiHBG000472.
InParanoidiQ63379.
KOiK09109.
PhylomeDBiQ63379.

Miscellaneous databases

PROiQ63379.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF01056. Myc_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001705. Myc_protein. 1 hit.
PRINTSiPR00044. LEUZIPPRMYC.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYCN_RAT
AccessioniPrimary (citable) accession number: Q63379
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.