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Protein

Sodium/potassium-transporting ATPase subunit beta-3

Gene

Atp1b3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-RNO-210991 Basigin interactions
R-RNO-5578775 Ion homeostasis
R-RNO-936837 Ion transport by P-type ATPases
SABIO-RKQ63377

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-3
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3
Short name:
ATPB-3
CD_antigen: CD298
Gene namesi
Name:Atp1b3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi2172 Atp1b3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini57 – 279ExtracellularSequence analysisAdd BLAST223

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191101 – 279Sodium/potassium-transporting ATPase subunit beta-3Add BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 144By similarity
Disulfide bondi154 ↔ 170By similarity
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi191 ↔ 250By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63377
PRIDEiQ63377

PTM databases

SwissPalmiQ63377

Expressioni

Gene expression databases

BgeeiENSRNOG00000011501
GenevisibleiQ63377 RN

Interactioni

Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.Curated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247428, 1 interactor
IntActiQ63377, 1 interactor
STRINGi10116.ENSRNOP00000015475

Structurei

3D structure databases

ProteinModelPortaliQ63377
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 279immunoglobulin-likeBy similarityAdd BLAST94

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927 Eukaryota
ENOG411150A LUCA
GeneTreeiENSGT00550000074530
HOGENOMiHOG000039248
HOVERGENiHBG050603
InParanoidiQ63377
KOiK01540
OMAiLMISPKP
OrthoDBiEOG091G0DJ4
PhylomeDBiQ63377
TreeFamiTF314618

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402 Na/K_ATPase_sub_beta
IPR038702 Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523 PTHR11523, 1 hit
PfamiView protein in Pfam
PF00287 Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107 Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390 ATPASE_NA_K_BETA_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q63377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTEKKSFH QSLAEWKLFI YNPTSGEFLG RTSKSWGLIL LFYLVFYGFL
60 70 80 90 100
AALFTFTMWV MLQTLNDEVP KYRDQIPSPG LMVFPKPPTA LDYTYSMSDP
110 120 130 140 150
HTYKKFVEDL KNFLKPYSVE EQKNLTDCPG GALFHQEGPD YSACQFPVSL
160 170 180 190 200
LQECSGVNDS NFGYSKGQPC VLVKMNRIIE LVPDGAPYIT CITKEENIAN
210 220 230 240 250
IVTYPDDGLI DLKYFPYYGK KRHVGYRQPL VAVQVIFGAD ATKKEVTIEC
260 270
QIDGTRNLKN KNERDKFLGR VSFKVIAHA
Length:279
Mass (Da):31,830
Last modified:November 1, 1996 - v1
Checksum:i45DD461CFE2A6E1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84450 mRNA Translation: BAA12668.1
BC061719 mRNA Translation: AAH61719.1
RefSeqiNP_037045.1, NM_012913.1
UniGeneiRn.5041

Genome annotation databases

EnsembliENSRNOT00000015476; ENSRNOP00000015475; ENSRNOG00000011501
GeneIDi25390
KEGGirno:25390
UCSCiRGD:2172 rat

Similar proteinsi

Entry informationi

Entry nameiAT1B3_RAT
AccessioniPrimary (citable) accession number: Q63377
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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