Q63377 (AT1B3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit beta-3

Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3
Short name=ATPB-3
CD_antigen=CD298

Gene names

Name:

Atp1b3

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
Subunit structure	Composed of three subunits: alpha (catalytic), beta and gamma.
Subcellular location	Membrane; Single-pass type II membrane protein. Melanosome By similarity.
Sequence similarities	Belongs to the X(+)/potassium ATPases subunit beta family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Sodium transport Sodium/potassium transport Transport
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Potassium Sodium
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	caveola Inferred from direct assay. Source: RGD melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell sodium:potassium-exchanging ATPase complex Inferred from direct assay. Source: RGD
Molecular function	sodium:potassium-exchanging ATPase activity Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Sodium/potassium-transporting ATPase subunit beta-3		PRO_0000219110
Regions
	Topological domain	1 – 35	35	Cytoplasmic Potential
	Transmembrane	36 – 56	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	57 – 279	223	Extracellular Potential
Amino acid modifications
	Glycosylation	124	1	N-linked (GlcNAc...) Potential
	Glycosylation	158	1	N-linked (GlcNAc...) Potential
	Disulfide bond	128 ↔ 144		By similarity
	Disulfide bond	154 ↔ 170		By similarity
	Disulfide bond	191 ↔ 250		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q63377 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 45DD461CFE2A6E1E	FASTA	279	31,830
	10 20 30 40 50 60 MTKTEKKSFH QSLAEWKLFI YNPTSGEFLG RTSKSWGLIL LFYLVFYGFL AALFTFTMWV 70 80 90 100 110 120 MLQTLNDEVP KYRDQIPSPG LMVFPKPPTA LDYTYSMSDP HTYKKFVEDL KNFLKPYSVE 130 140 150 160 170 180 EQKNLTDCPG GALFHQEGPD YSACQFPVSL LQECSGVNDS NFGYSKGQPC VLVKMNRIIE 190 200 210 220 230 240 LVPDGAPYIT CITKEENIAN IVTYPDDGLI DLKYFPYYGK KRHVGYRQPL VAVQVIFGAD 250 260 270 ATKKEVTIEC QIDGTRNLKN KNERDKFLGR VSFKVIAHA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Watanabe T., Sato M., Yoshida T., Suzuki Y. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D84450 mRNA. Translation: BAA12668.1. BC061719 mRNA. Translation: AAH61719.1.
IPI	IPI00208061.
RefSeq	NP_037045.1. NM_012913.1.
UniGene	Rn.5041.
3D structure databases
ProteinModelPortal	Q63377.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q63377. 1 interaction.
STRING	Q63377.
Proteomic databases
PRIDE	Q63377.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000015476; ENSRNOP00000015475; ENSRNOG00000011501.
GeneID	25390.
KEGG	rno:25390.
NMPDR	fig|10116.3.peg.29106.
UCSC	NM_012913. rat.
Organism-specific databases
CTD	483.
RGD	2172. Atp1b3.
Phylogenomic databases
eggNOG	roNOG06299.
GeneTree	ENSGT00550000074530.
HOVERGEN	HBG050603.
InParanoid	Q63377.
OMA	LMISPKP.
OrthoDB	EOG447FTQ.
PhylomeDB	Q63377.
Gene expression databases
ArrayExpress	Q63377.
Genevestigator	Q63377.
GermOnline	ENSRNOG00000011501. Rattus norvegicus.
Family and domain databases
InterPro	IPR000402. ATPase_P-typ_cation-exchng_bsu. [Graphical view]
KO	K01540.
PANTHER	PTHR11523. ATPase_H_Na/K_b. 1 hit.
Pfam	PF00287. Na_K-ATPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITE	PS00390. ATPASE_NA_K_BETA_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	606457.

Entry information

Entry name

AT1B3_RAT

Accession

Primary (citable) accession number: Q63377

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program