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Protein

Sodium/potassium-transporting ATPase subunit beta-3

Gene

Atp1b3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

Potassium, Sodium

Enzyme and pathway databases

ReactomeiR-RNO-210991. Basigin interactions.
R-RNO-5578775. Ion homeostasis.
R-RNO-936837. Ion transport by P-type ATPases.
SABIO-RKQ63377.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-3
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3
Short name:
ATPB-3
CD_antigen: CD298
Gene namesi
Name:Atp1b3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi2172. Atp1b3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535CytoplasmicSequence analysisAdd
BLAST
Transmembranei36 – 5621Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini57 – 279223ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • caveola Source: RGD
  • extracellular exosome Source: Ensembl
  • melanosome Source: UniProtKB-SubCell
  • plasma membrane Source: RGD
  • sodium:potassium-exchanging ATPase complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Sodium/potassium-transporting ATPase subunit beta-3PRO_0000219110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence analysis
Disulfide bondi128 ↔ 144By similarity
Disulfide bondi154 ↔ 170By similarity
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence analysis
Disulfide bondi191 ↔ 250By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63377.
PRIDEiQ63377.

PTM databases

SwissPalmiQ63377.

Expressioni

Gene expression databases

GenevisibleiQ63377. RN.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Protein-protein interaction databases

BioGridi247428. 1 interaction.
IntActiQ63377. 1 interaction.
STRINGi10116.ENSRNOP00000015475.

Structurei

3D structure databases

ProteinModelPortaliQ63377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni186 – 27994immunoglobulin-likeBy similarityAdd
BLAST

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiQ63377.
KOiK01540.
OMAiHQSLAEW.
OrthoDBiEOG7M6D85.
PhylomeDBiQ63377.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTEKKSFH QSLAEWKLFI YNPTSGEFLG RTSKSWGLIL LFYLVFYGFL
60 70 80 90 100
AALFTFTMWV MLQTLNDEVP KYRDQIPSPG LMVFPKPPTA LDYTYSMSDP
110 120 130 140 150
HTYKKFVEDL KNFLKPYSVE EQKNLTDCPG GALFHQEGPD YSACQFPVSL
160 170 180 190 200
LQECSGVNDS NFGYSKGQPC VLVKMNRIIE LVPDGAPYIT CITKEENIAN
210 220 230 240 250
IVTYPDDGLI DLKYFPYYGK KRHVGYRQPL VAVQVIFGAD ATKKEVTIEC
260 270
QIDGTRNLKN KNERDKFLGR VSFKVIAHA
Length:279
Mass (Da):31,830
Last modified:November 1, 1996 - v1
Checksum:i45DD461CFE2A6E1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84450 mRNA. Translation: BAA12668.1.
BC061719 mRNA. Translation: AAH61719.1.
RefSeqiNP_037045.1. NM_012913.1.
UniGeneiRn.5041.

Genome annotation databases

EnsembliENSRNOT00000015476; ENSRNOP00000015475; ENSRNOG00000011501.
GeneIDi25390.
KEGGirno:25390.
UCSCiRGD:2172. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84450 mRNA. Translation: BAA12668.1.
BC061719 mRNA. Translation: AAH61719.1.
RefSeqiNP_037045.1. NM_012913.1.
UniGeneiRn.5041.

3D structure databases

ProteinModelPortaliQ63377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247428. 1 interaction.
IntActiQ63377. 1 interaction.
STRINGi10116.ENSRNOP00000015475.

PTM databases

SwissPalmiQ63377.

Proteomic databases

PaxDbiQ63377.
PRIDEiQ63377.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015476; ENSRNOP00000015475; ENSRNOG00000011501.
GeneIDi25390.
KEGGirno:25390.
UCSCiRGD:2172. rat.

Organism-specific databases

CTDi483.
RGDi2172. Atp1b3.

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiQ63377.
KOiK01540.
OMAiHQSLAEW.
OrthoDBiEOG7M6D85.
PhylomeDBiQ63377.
TreeFamiTF314618.

Enzyme and pathway databases

ReactomeiR-RNO-210991. Basigin interactions.
R-RNO-5578775. Ion homeostasis.
R-RNO-936837. Ion transport by P-type ATPases.
SABIO-RKQ63377.

Miscellaneous databases

NextBioi606457.
PROiQ63377.

Gene expression databases

GenevisibleiQ63377. RN.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Watanabe T., Sato M., Yoshida T., Suzuki Y.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiAT1B3_RAT
AccessioniPrimary (citable) accession number: Q63377
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.