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Protein

Neurexin-2-beta

Gene

Nrxn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-RNO-6794361. Neurexins and neuroligins.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-2-beta
Alternative name(s):
Neurexin II-beta
Gene namesi
Name:Nrxn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620211. Nrxn2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini47 – 586ExtracellularSequence analysisAdd BLAST540
Transmembranei587 – 607HelicalSequence analysisAdd BLAST21
Topological domaini608 – 662CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 461 PublicationAdd BLAST46
ChainiPRO_000001949847 – 662Neurexin-2-betaAdd BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ63376.

Expressioni

Tissue specificityi

Brain (neuronal synapse).

Gene expression databases

BgeeiENSRNOG00000021103.
ExpressionAtlasiQ63376. baseline and differential.
GenevisibleiQ63376. RN.

Interactioni

Subunit structurei

The cytoplasmic C-terminal region binds to CASK. Isoforms Beta 4b bind alpha-dystroglycan and neuroligins NLGN1, NLGN2 and NLGN3. Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi250509. 3 interactors.
IntActiQ63376. 1 interactor.
MINTiMINT-1891630.

Structurei

3D structure databases

ProteinModelPortaliQ63376.
SMRiQ63376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 295Laminin G-likePROSITE-ProRule annotationAdd BLAST209

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi318 – 321Poly-Thr4
Compositional biasi324 – 327Poly-Thr4
Compositional biasi394 – 397Poly-Pro4
Compositional biasi594 – 597Poly-Ala4

Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230482.
HOVERGENiHBG052670.

Family and domain databases

InterProiView protein in InterPro
IPR013320. ConA-like_dom_sf.
IPR001791. Laminin_G.
IPR037440. Neurexin.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
PANTHERiPTHR44287. PTHR44287. 1 hit.
PfamiView protein in Pfam
PF02210. Laminin_G_2. 1 hit.
PF01034. Syndecan. 1 hit.
SMARTiView protein in SMART
SM00294. 4.1m. 1 hit.
SM00282. LamG. 1 hit.
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiView protein in PROSITE
PS50025. LAM_G_DOMAIN. 1 hit.

Sequences (18)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 18 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Note: A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. There is a combination of two alternatively spliced extracellular domains at sites 4 and 5 and a cytoplasmic domain at site 6 which are shared with alpha isoforms and which seem to be used independently. Experimental confirmation may be lacking for some isoforms.
Isoform 1b (identifier: Q63376-1) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPGGSGQGG CPRRPPALAG PLPPPPPPPP LPLLLGLLLL LGAAEGARVS
60 70 80 90 100
SSLSTTHHVH HFHSKHGTVP IAINRMPFLT RSGHAGTTYI FGKGGALITY
110 120 130 140 150
TWPPNDRPST RMDRLAVGFS THQRSAVLVR VDSASGLGDY LQLHIDQGTV
160 170 180 190 200
GVIFNVGTDD ITIDEPNAIV SDGKYHVVRF TRSGGNATLQ VDSWPVNERY
210 220 230 240 250
PAGNFDNERL AIARQRIPYR LGRVVDEWLL DKGRQLTIFN SQAAIKIGGR
260 270 280 290 300
DQGRPFQGQV SGLYYNGLKV LALAAESDPN VRTEGHLRLV GEGPSVLLSA
310 320 330 340 350
ETTATTLLAD MATTIMETTT TMATTTTRRG RSPTMRDSTT QNTDDLLVAS
360 370 380 390 400
AECPSDDEDL EECEPSTGGE LILPIITEDS LDPPPVATRS PFVPPPPTFY
410 420 430 440 450
PFLTGVGATQ DTLPPPAARR PSSGGPCQAE RDDSDCEEPV EASGFASGEV
460 470 480 490 500
FDSSLPPTDD EDFYTTFPLV TDRTTLLSPR KPAPRPNLRT DGATGAPGVL
510 520 530 540 550
LAPSAPAPNL PAGKMNHRDP LQPLLENPPL GPGVPTAFEP RRPPPLRPGV
560 570 580 590 600
TSVPGFPRLP TANPTGPGER GPPGAVEVIR ESSSTTGMVV GIVAAAALCI
610 620 630 640 650
LILLYAMYKY RNRDEGSYQV DQSRNYISNS AQSNGAVVKE KAPAAPKTPS
660
KAKKNKDKEY YV
Length:662
Mass (Da):70,547
Last modified:November 1, 1996 - v1
Checksum:iA362EFF185F2B56E
GO
Isoform 2b (identifier: Q63376-2) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5B

The sequence of this isoform differs from the canonical sequence as follows:
     368-385: Missing.

Show »
Length:644
Mass (Da):68,688
Checksum:iCF4D5E7F49DF02DB
GO
Isoform 3b (identifier: Q63376-3) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5A

The sequence of this isoform differs from the canonical sequence as follows:
     203-232: Missing.

Show »
Length:632
Mass (Da):66,950
Checksum:iC9389BE146C69B54
GO
Isoform 4b (identifier: Q63376-4) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5B

The sequence of this isoform differs from the canonical sequence as follows:
     203-232: Missing.
     368-385: Missing.

Show »
Length:614
Mass (Da):65,092
Checksum:i6805D53D9AA544FE
GO
Isoform 5b (identifier: Q63376-5) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5A6

The sequence of this isoform differs from the canonical sequence as follows:
     614-662: DEGSYQVDQS...KKNKDKEYYV → CRKSPREEKL...RQMQIYIKNK

Show »
Length:675
Mass (Da):71,891
Checksum:i0F5F2B998E9878A7
GO
Isoform 6b (identifier: Q63376-6) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5B6

The sequence of this isoform differs from the canonical sequence as follows:
     368-385: Missing.
     614-662: DEGSYQVDQS...KKNKDKEYYV → CRKSPREEKL...RQMQIYIKNK

Show »
Length:657
Mass (Da):70,032
Checksum:i5595F1D8BFE807C3
GO
Isoform 7b (identifier: Q63376-7) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5A6

The sequence of this isoform differs from the canonical sequence as follows:
     203-232: Missing.
     614-662: DEGSYQVDQS...KKNKDKEYYV → CRKSPREEKL...RQMQIYIKNK

Show »
Length:645
Mass (Da):68,294
Checksum:iAFFF1D58AC9EE100
GO
Isoform 8b (identifier: Q63376-8) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5B6

The sequence of this isoform differs from the canonical sequence as follows:
     203-232: Missing.
     368-385: Missing.
     614-662: DEGSYQVDQS...KKNKDKEYYV → CRKSPREEKL...RQMQIYIKNK

Show »
Length:627
Mass (Da):66,436
Checksum:i71BBCB9C4DF37694
GO
Isoform 1a (identifier: Q63374-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-1A2A3A4A5A
The sequence of this isoform can be found in the external entry Q63374.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,715
Mass (Da):185,169
GO
Isoform 2a (identifier: Q63374-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-1B
The sequence of this isoform can be found in the external entry Q63374.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,705
Mass (Da):184,181
GO
Isoform 3a (identifier: Q63374-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-1C
The sequence of this isoform can be found in the external entry Q63374.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,681
Mass (Da):181,902
GO
Isoform 4a (identifier: Q63374-4) [UniParc]FASTAAdd to basket
Also known as: Alpha-2B
The sequence of this isoform can be found in the external entry Q63374.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,708
Mass (Da):184,301
GO
Isoform 5a (identifier: Q63374-5) [UniParc]FASTAAdd to basket
Also known as: Alpha-2C
The sequence of this isoform can be found in the external entry Q63374.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,700
Mass (Da):183,526
GO
Isoform 6a (identifier: Q63374-6) [UniParc]FASTAAdd to basket
Also known as: Alpha-3B
The sequence of this isoform can be found in the external entry Q63374.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,712
Mass (Da):184,970
GO
Isoform 7a (identifier: Q63374-7) [UniParc]FASTAAdd to basket
Also known as: Alpha-3C
The sequence of this isoform can be found in the external entry Q63374.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,706
Mass (Da):184,224
GO
Isoform 8a (identifier: Q63374-8) [UniParc]FASTAAdd to basket
Also known as: Alpha-4B
The sequence of this isoform can be found in the external entry Q63374.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,685
Mass (Da):181,573
GO
Isoform 9a (identifier: Q63374-9) [UniParc]FASTAAdd to basket
Also known as: Alpha-5B
The sequence of this isoform can be found in the external entry Q63374.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,521
Mass (Da):164,826
GO
Isoform 10a (identifier: Q63374-10) [UniParc]FASTAAdd to basket
Also known as: Alpha-6
The sequence of this isoform can be found in the external entry Q63374.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,728
Mass (Da):186,513
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003518203 – 232Missing in isoform 3b, isoform 4b, isoform 7b and isoform 8b. CuratedAdd BLAST30
Alternative sequenceiVSP_003519368 – 385Missing in isoform 2b, isoform 4b, isoform 6b and isoform 8b. CuratedAdd BLAST18
Alternative sequenceiVSP_003520614 – 662DEGSY…KEYYV → CRKSPREEKLLPGSAQGLGL DLAKACCVCRCRATCIAGKP LEERGGGRGEGERQMQIYIK NK in isoform 5b, isoform 6b, isoform 7b and isoform 8b. CuratedAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96377 mRNA. Translation: AAA41708.1.
PIRiD40228.
RefSeqiXP_008758286.1. XM_008760064.2. [Q63376-1]
UniGeneiRn.11282.

Genome annotation databases

EnsembliENSRNOT00000028651; ENSRNOP00000028651; ENSRNOG00000021103. [Q63376-1]
GeneIDi116595.
UCSCiRGD:620211. rat. [Q63376-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNRX2B_RAT
AccessioniPrimary (citable) accession number: Q63376
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1996
Last modified: December 20, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families