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Protein

Neurexin-2

Gene

Nrxn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi335 – 3351CalciumBy similarity
Metal bindingi352 – 3521Calcium; via carbonyl oxygenBy similarity
Metal bindingi420 – 4201Calcium; via carbonyl oxygenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-2
Alternative name(s):
Neurexin II-alpha
Neurexin-2-alpha
Gene namesi
Name:Nrxn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620211. Nrxn2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 16391610ExtracellularSequence analysisAdd
BLAST
Transmembranei1640 – 166021HelicalSequence analysisAdd
BLAST
Topological domaini1661 – 171555CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929By similarityAdd
BLAST
Chaini30 – 17151686Neurexin-2PRO_0000019496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence analysis
Disulfide bondi206 ↔ 219By similarity
Disulfide bondi213 ↔ 229By similarity
Disulfide bondi231 ↔ 241By similarity
Glycosylationi338 – 3381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi450 ↔ 486By similarity
Disulfide bondi657 ↔ 686By similarity
Disulfide bondi694 ↔ 705By similarity
Disulfide bondi699 ↔ 714By similarity
Disulfide bondi716 ↔ 726By similarity
Glycosylationi844 – 8441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1068 ↔ 1096By similarity
Disulfide bondi1103 ↔ 1114By similarity
Disulfide bondi1108 ↔ 1123By similarity
Disulfide bondi1125 ↔ 1135By similarity
Glycosylationi1239 – 12391N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63374.
PRIDEiQ63374.

PTM databases

iPTMnetiQ63374.
PhosphoSiteiQ63374.

Expressioni

Tissue specificityi

Brain (neuronal synapse).

Interactioni

Subunit structurei

The laminin G-like domain 1 binds to NXPH1. Isoforms alpha 2C bind to alpha-dystroglycan. Interacts with INADL. Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250509. 3 interactions.
IntActiQ63374. 6 interactions.
MINTiMINT-1538394.
STRINGi10116.ENSRNOP00000063600.

Structurei

3D structure databases

ProteinModelPortaliQ63374.
SMRiQ63374. Positions 285-480, 730-915, 1140-1343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 206177Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini202 – 24241EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini289 – 486198Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini493 – 686194Laminin G-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini690 – 72738EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini732 – 907176Laminin G-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini921 – 1096176Laminin G-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini1099 – 113638EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini1140 – 1348209Laminin G-like 6PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1371 – 13744Poly-Thr
Compositional biasi1377 – 13804Poly-Thr
Compositional biasi1447 – 14504Poly-Pro
Compositional biasi1647 – 16504Poly-Ala

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 6 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
HOGENOMiHOG000230481.
HOVERGENiHBG052670.
InParanoidiQ63374.
KOiK07377.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027160. NRXN2.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF593. PTHR10127:SF593. 3 hits.
PfamiPF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 5 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

Sequences (18)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 18 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Note: Two isoform types, alpha-type and beta-type are produced by alternative promoter usage. In addition there are at least five major alternatively spliced sites, each of which may be spliced in up to three different ways. Additional isoforms may derive from a minor cytoplasmic splice site 6. Combinatorial splicing at each of these six sites may lead to the generation of at least 216 isoforms but for simplicity only individual splice events are explicitly described below. Beta-type isoforms share the possibility of alternative splicing at sites 4, 5 and 6. Experimental confirmation may be lacking for some isoforms.2 Publications

Isoform 1a (identifier: Q63374-1) [UniParc]FASTAAdd to basket

Also known as: Alpha-1A2A3A4A5A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALGSRWRPP PQLPPLLLLL ALVAGVRGLE FGGGPGQWAR YARWAGAAST
60 70 80 90 100
GELSFSLRTN ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT
110 120 130 140 150
LQLDTPVADD RWHMVLLTRD ARRTALAVDG EARAAEVRSK RREMQVASDL
160 170 180 190 200
FVGGIPPDVR LSALTLSTVK YEPPFRGLLA NLKLGERPPA LLGSQGLRGA
210 220 230 240 250
AADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF CSEGEHPMEG
260 270 280 290 300
PAHLTLNSPV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY
310 320 330 340 350
DLSHNPIQSS TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI
360 370 380 390 400
NLGSGAFEAL VEPVNGKFND NAWHDVRVTR NLRQHAGIGH AMVNKLHYLV
410 420 430 440 450
TISVDGILTT TGYTQEDYTM LGSDDFFYIG GSPNTADLPG SPVSNNFMGC
460 470 480 490 500
LKDVVYKNND FKLELSRLAK EGDPKMKLQG DLSFRCEDVA ALDPVTFESP
510 520 530 540 550
EAFVALPRWS AKRTGSISLD FRTTEPNGLL LFSQGRRAGA GVGSHSSSQR
560 570 580 590 600
ADYFAMELLD GYLYLLLDMG SGGIKLRASS RKVNDGEWCH VDFQRDGRKG
610 620 630 640 650
SISVNSRSTP FLATGESEVL DLESELYLGG LPEGGRVDLP LPPEVWTAAL
660 670 680 690 700
RAGYVGCVRD LFIDGRSRDL RGLAEAQGAV GVAPFCSRET LKQCASAPCR
710 720 730 740 750
NGGICREGWN RFVCDCIGTG FLGRVCEREA TVLSYDGSMY MKIMLPNAMH
760 770 780 790 800
TEAEDVSLRF MSQRAYGLMM ATTSRESADT LRLELDGGQM KLTVNLDCLR
810 820 830 840 850
VGCAPSAAGK GPETLFAGHK LNDNEWHTVR VVRRGKSLQL SVDNVTVEGQ
860 870 880 890 900
MAGAHTRLEF HNIETGIMTE RRFISVVPSN FIGHLSGLVF NGQPYMDQCK
910 920 930 940 950
DGDITYCELN ARFGLRAIVA DPVTFKSRSS YLALATLQAY ASMHLFFQFK
960 970 980 990 1000
TTAPDGLLLF NSGNGNDFIV IELVKGYIHY VFDLGNGPSL MKGNSDKPVN
1010 1020 1030 1040 1050
DNQWHNVVVS RDPGNVHTLK IDSRTVTQHS NGARNLDLKG ELYIGGLSKN
1060 1070 1080 1090 1100
MFSNLPKLVA SRDGFQGCLA SVDLNGRLPD LIADALHRIG QVERGCDGPS
1110 1120 1130 1140 1150
TTCTEESCAN QGVCLQQWDG FTCDCTMTSY GGPVCNDPGT TYIFGKGGAL
1160 1170 1180 1190 1200
ITYTWPPNDR PSTRMDRLAV GFSTHQRSAV LVRVDSASGL GDYLQLHIDQ
1210 1220 1230 1240 1250
GTVGVIFNVG TDDITIDEPN AIVSDGKYHV VRFTRSGGNA TLQVDSWPVN
1260 1270 1280 1290 1300
ERYPAGNFDN ERLAIARQRI PYRLGRVVDE WLLDKGRQLT IFNSQAAIKI
1310 1320 1330 1340 1350
GGRDQGRPFQ GQVSGLYYNG LKVLALAAES DPNVRTEGHL RLVGEGPSVL
1360 1370 1380 1390 1400
LSAETTATTL LADMATTIME TTTTMATTTT RRGRSPTMRD STTQNTDDLL
1410 1420 1430 1440 1450
VASAECPSDD EDLEECEPST GGELILPIIT EDSLDPPPVA TRSPFVPPPP
1460 1470 1480 1490 1500
TFYPFLTGVG ATQDTLPPPA ARRPSSGGPC QAERDDSDCE EPVEASGFAS
1510 1520 1530 1540 1550
GEVFDSSLPP TDDEDFYTTF PLVTDRTTLL SPRKPAPRPN LRTDGATGAP
1560 1570 1580 1590 1600
GVLLAPSAPA PNLPAGKMNH RDPLQPLLEN PPLGPGVPTA FEPRRPPPLR
1610 1620 1630 1640 1650
PGVTSVPGFP RLPTANPTGP GERGPPGAVE VIRESSSTTG MVVGIVAAAA
1660 1670 1680 1690 1700
LCILILLYAM YKYRNRDEGS YQVDQSRNYI SNSAQSNGAV VKEKAPAAPK
1710
TPSKAKKNKD KEYYV
Length:1,715
Mass (Da):185,169
Last modified:January 23, 2007 - v3
Checksum:iC4A7A4129F25736C
GO
Isoform 2a (identifier: Q63374-2) [UniParc]FASTAAdd to basket

Also known as: Alpha-1B

The sequence of this isoform differs from the canonical sequence as follows:
     250-259: Missing.

Show »
Length:1,705
Mass (Da):184,181
Checksum:i42B136F20A8E312C
GO
Isoform 3a (identifier: Q63374-3) [UniParc]FASTAAdd to basket

Also known as: Alpha-1C

The sequence of this isoform differs from the canonical sequence as follows:
     250-283: Missing.

Show »
Length:1,681
Mass (Da):181,902
Checksum:iB88CFBD700F47847
GO
Isoform 4a (identifier: Q63374-4) [UniParc]FASTAAdd to basket

Also known as: Alpha-2B

The sequence of this isoform differs from the canonical sequence as follows:
     393-399: Missing.

Show »
Length:1,708
Mass (Da):184,301
Checksum:i29AE45D36BC8599E
GO
Isoform 5a (identifier: Q63374-5) [UniParc]FASTAAdd to basket

Also known as: Alpha-2C

The sequence of this isoform differs from the canonical sequence as follows:
     385-399: Missing.

Show »
Length:1,700
Mass (Da):183,526
Checksum:i96BE9160C5D0B080
GO
Isoform 6a (identifier: Q63374-6) [UniParc]FASTAAdd to basket

Also known as: Alpha-3B

The sequence of this isoform differs from the canonical sequence as follows:
     807-809: Missing.

Show »
Length:1,712
Mass (Da):184,970
Checksum:iC68A686D8C3E6DB7
GO
Isoform 7a (identifier: Q63374-7) [UniParc]FASTAAdd to basket

Also known as: Alpha-3C

The sequence of this isoform differs from the canonical sequence as follows:
     797-806: DCLRVGCAPS → G

Show »
Length:1,706
Mass (Da):184,224
Checksum:iA77431B274065E98
GO
Isoform 8a (identifier: Q63374-8) [UniParc]FASTAAdd to basket

Also known as: Alpha-4B

The sequence of this isoform differs from the canonical sequence as follows:
     1256-1285: Missing.

Show »
Length:1,685
Mass (Da):181,573
Checksum:i58831E7E2755CC55
GO
Isoform 9a (identifier: Q63374-9) [UniParc]FASTAAdd to basket

Also known as: Alpha-5B

The sequence of this isoform differs from the canonical sequence as follows:
     1421-1614: Missing.

Show »
Length:1,521
Mass (Da):164,826
Checksum:i358B693C6F80FA7F
GO
Isoform 10a (identifier: Q63374-10) [UniParc]FASTAAdd to basket

Also known as: Alpha-6

The sequence of this isoform differs from the canonical sequence as follows:
     1667-1715: DEGSYQVDQS...KKNKDKEYYV → CRKSPREEKL...RQMQIYIKNK

Show »
Length:1,728
Mass (Da):186,513
Checksum:iA0EC3826D24CDBB4
GO
Isoform 1b (identifier: Q63376-1) [UniParc]FASTAAdd to basket

Also known as: Beta-4A5A

The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:662
Mass (Da):70,547
GO
Isoform 2b (identifier: Q63376-2) [UniParc]FASTAAdd to basket

Also known as: Beta-4A5B

The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:644
Mass (Da):68,688
GO
Isoform 3b (identifier: Q63376-3) [UniParc]FASTAAdd to basket

Also known as: Beta-4B5A

The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:632
Mass (Da):66,950
GO
Isoform 4b (identifier: Q63376-4) [UniParc]FASTAAdd to basket

Also known as: Beta-4B5B

The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:614
Mass (Da):65,092
GO
Isoform 5b (identifier: Q63376-5) [UniParc]FASTAAdd to basket

Also known as: Beta-4A5A6

The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:675
Mass (Da):71,891
GO
Isoform 6b (identifier: Q63376-6) [UniParc]FASTAAdd to basket

Also known as: Beta-4A5B6

The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:657
Mass (Da):70,032
GO
Isoform 7b (identifier: Q63376-7) [UniParc]FASTAAdd to basket

Also known as: Beta-4B5A6

The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:645
Mass (Da):68,294
GO
Isoform 8b (identifier: Q63376-8) [UniParc]FASTAAdd to basket

Also known as: Beta-4B5B6

The sequence of this isoform can be found in the external entry Q63376.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:627
Mass (Da):66,436
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti244 – 2441G → E in AAA41706 (PubMed:1621094).Curated
Sequence conflicti244 – 2441G → E in AAA41707 (PubMed:1621094).Curated
Sequence conflicti259 – 2591P → E in AAA41706 (PubMed:1621094).Curated
Sequence conflicti259 – 2591P → E in AAA41707 (PubMed:1621094).Curated
Sequence conflicti277 – 2771D → N in AAA41706 (PubMed:1621094).Curated
Sequence conflicti277 – 2771D → N in AAA41707 (PubMed:1621094).Curated
Sequence conflicti297 – 2971F → S in AAA41706 (PubMed:1621094).Curated
Sequence conflicti297 – 2971F → S in AAA41707 (PubMed:1621094).Curated
Sequence conflicti335 – 3351D → N in AAA41706 (PubMed:1621094).Curated
Sequence conflicti335 – 3351D → N in AAA41707 (PubMed:1621094).Curated
Sequence conflicti349 – 3491V → I in AAA41706 (PubMed:1621094).Curated
Sequence conflicti349 – 3491V → I in AAA41707 (PubMed:1621094).Curated
Sequence conflicti809 – 8091G → A in AAA41706 (PubMed:1621094).Curated
Sequence conflicti809 – 8091G → A in AAA41707 (PubMed:1621094).Curated
Sequence conflicti829 – 8291V → L in AAA41706 (PubMed:1621094).Curated
Sequence conflicti829 – 8291V → L in AAA41707 (PubMed:1621094).Curated
Sequence conflicti987 – 9871G → S in AAA41706 (PubMed:1621094).Curated
Sequence conflicti987 – 9871G → S in AAA41707 (PubMed:1621094).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti434 – 4341N → L.1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei250 – 28334Missing in isoform 3a. CuratedVSP_003510Add
BLAST
Alternative sequencei250 – 25910Missing in isoform 2a. CuratedVSP_003509
Alternative sequencei385 – 39915Missing in isoform 5a. CuratedVSP_003511Add
BLAST
Alternative sequencei393 – 3997Missing in isoform 4a. CuratedVSP_003512
Alternative sequencei797 – 80610DCLRVGCAPS → G in isoform 7a. CuratedVSP_003513
Alternative sequencei807 – 8093Missing in isoform 6a. CuratedVSP_003514
Alternative sequencei1256 – 128530Missing in isoform 8a. CuratedVSP_003515Add
BLAST
Alternative sequencei1421 – 1614194Missing in isoform 9a. CuratedVSP_003516Add
BLAST
Alternative sequencei1667 – 171549DEGSY…KEYYV → CRKSPREEKLLPGSAQGLGL DLAKACCVCRCRATCIAGKP LEERGGGRGEGERQMQIYIK NK in isoform 10a. 1 PublicationVSP_003517Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96376 mRNA. Translation: AAA41706.1.
M96376 mRNA. Translation: AAA41707.1.
AABR03000676 Genomic DNA. No translation available.
AABR03002856 Genomic DNA. No translation available.
AABR03004066 Genomic DNA. No translation available.
AABR03004601 Genomic DNA. No translation available.
AABR03004809 Genomic DNA. No translation available.
AABR03005995 Genomic DNA. No translation available.
AABR03006603 Genomic DNA. No translation available.
AABR03006786 Genomic DNA. No translation available.
AABR03008290 Genomic DNA. No translation available.
AABR03009435 Genomic DNA. No translation available.
PIRiC40228.
RefSeqiNP_446298.1. NM_053846.1.
UniGeneiRn.11282.

Genome annotation databases

GeneIDi116595.
KEGGirno:116595.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96376 mRNA. Translation: AAA41706.1.
M96376 mRNA. Translation: AAA41707.1.
AABR03000676 Genomic DNA. No translation available.
AABR03002856 Genomic DNA. No translation available.
AABR03004066 Genomic DNA. No translation available.
AABR03004601 Genomic DNA. No translation available.
AABR03004809 Genomic DNA. No translation available.
AABR03005995 Genomic DNA. No translation available.
AABR03006603 Genomic DNA. No translation available.
AABR03006786 Genomic DNA. No translation available.
AABR03008290 Genomic DNA. No translation available.
AABR03009435 Genomic DNA. No translation available.
PIRiC40228.
RefSeqiNP_446298.1. NM_053846.1.
UniGeneiRn.11282.

3D structure databases

ProteinModelPortaliQ63374.
SMRiQ63374. Positions 285-480, 730-915, 1140-1343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250509. 3 interactions.
IntActiQ63374. 6 interactions.
MINTiMINT-1538394.
STRINGi10116.ENSRNOP00000063600.

PTM databases

iPTMnetiQ63374.
PhosphoSiteiQ63374.

Proteomic databases

PaxDbiQ63374.
PRIDEiQ63374.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116595.
KEGGirno:116595.

Organism-specific databases

CTDi9379.
RGDi620211. Nrxn2.

Phylogenomic databases

eggNOGiKOG3514. Eukaryota.
ENOG410XNU6. LUCA.
HOGENOMiHOG000230481.
HOVERGENiHBG052670.
InParanoidiQ63374.
KOiK07377.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027160. NRXN2.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF593. PTHR10127:SF593. 3 hits.
PfamiPF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 5 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin."
    Ushkaryov Y.A., Petrenko A.G., Geppert M., Suedhof T.C.
    Science 257:50-56(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 10A), VARIANT LEU-434, ALTERNATIVE SPLICING.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  3. "Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons."
    Ullrich B., Ushkaryov Y.A., Suedhof T.C.
    Neuron 14:497-507(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  4. "Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit."
    Missler M., Hammer R.E., Suedhof T.C.
    J. Biol. Chem. 273:34716-34723(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NXPH1.
  5. "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins."
    Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.
    Mol. Cell. Neurosci. 11:161-172(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INADL.
  6. "A stoichiometric complex of neurexins and dystroglycan in brain."
    Sugita S., Saito F., Tang J., Satz J., Campbell K., Suedhof T.C.
    J. Cell Biol. 154:435-445(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ALPHA-DYSTROGLYCAN.

Entry informationi

Entry nameiNRX2A_RAT
AccessioniPrimary (citable) accession number: Q63374
Secondary accession number(s): Q63375
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.