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Protein

Neurexin-1

Gene

Nrxn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca2+-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca2+-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels (By similarity). Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.By similarity2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi345 – 3451CalciumBy similarity
Metal bindingi345 – 3451Calcium 1By similarity
Metal bindingi362 – 3621Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi362 – 3621Calcium; via carbonyl oxygenBy similarity
Metal bindingi430 – 4301Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi430 – 4301Calcium; via carbonyl oxygenBy similarity
Metal bindingi788 – 7881Calcium 2By similarity
Metal bindingi805 – 8051Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi864 – 8641Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi1199 – 11991Calcium 3By similarity
Metal bindingi1216 – 12161Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi1298 – 12981Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi1300 – 13001Calcium 3By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-3000171. Non-integrin membrane-ECM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-1
Alternative name(s):
Neurexin I-alpha
Neurexin-1-alpha
Gene namesi
Name:Nrxn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628659. Nrxn1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 14541424ExtracellularSequence analysisAdd
BLAST
Transmembranei1455 – 147521HelicalSequence analysisAdd
BLAST
Topological domaini1476 – 153055CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 30301 PublicationAdd
BLAST
Chaini31 – 15301500Neurexin-1PRO_0000019491Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Disulfide bondi228 ↔ 243By similarity
Disulfide bondi245 ↔ 255By similarity
Disulfide bondi460 ↔ 496By similarity
Disulfide bondi666 ↔ 695By similarity
Disulfide bondi703 ↔ 714By similarity
Disulfide bondi708 ↔ 723By similarity
Disulfide bondi725 ↔ 735By similarity
Glycosylationi813 – 8131N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1075 ↔ 1103By similarity
Disulfide bondi1110 ↔ 1121By similarity
Disulfide bondi1115 ↔ 1130By similarity
Disulfide bondi1132 ↔ 1142By similarity
Glycosylationi1246 – 12461N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity
O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ63372.

PTM databases

iPTMnetiQ63372.
PhosphoSiteiQ63372.

Expressioni

Tissue specificityi

Brain (neuronal synapse).2 Publications

Interactioni

Subunit structurei

Interacts with SYT13 and SYTL1 (By similarity). Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1 forming a heterotetramer, where one NLGN1 dimer interacts with one NRXN1 dimer. Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1, NLGN2 and NLGN3; these interactions are calcium-dependent. Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity). Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN4. Interacts (via laminin G-like domain 2) with NXPH1 and NXPH3. Alpha-type isoforms (neurexin-1-alpha) interact (via laminin G-like domain 2 and/or laminin G-like domain 6) with DAG1 (via alpha-dystroglycan chain). Alpha-type isoforms interact with alpha-latrotoxin from spider venom. The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. Isoform 9a and isoform 13a bind to DAG1 (via alpha-dystroglycan chain). Isoform 13a binds to alpha-latrotoxin. Interacts with LRRTM1, LRRTM2, LRRTM3 and LRRTM4.By similarity9 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248813. 4 interactions.
MINTiMINT-1506888.

Structurei

Secondary structure

1
1530
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1146 – 116116Combined sources
Helixi1164 – 11663Combined sources
Beta strandi1170 – 118011Combined sources
Beta strandi1184 – 119411Combined sources
Beta strandi1200 – 12067Combined sources
Beta strandi1209 – 121911Combined sources
Beta strandi1221 – 12244Combined sources
Beta strandi1232 – 12343Combined sources
Beta strandi1236 – 12438Combined sources
Beta strandi1246 – 12516Combined sources
Beta strandi1257 – 12593Combined sources
Beta strandi1301 – 13099Combined sources
Turni1310 – 13134Combined sources
Beta strandi1318 – 13258Combined sources
Helixi1330 – 13356Combined sources
Beta strandi1341 – 135010Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BIWX-ray3.50E/F/G/H1146-1361[»]
ProteinModelPortaliQ63372.
SMRiQ63372. Positions 295-491, 739-922, 1146-1356.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63372.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 217187Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini213 – 25543EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini299 – 496198Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini503 – 695193Laminin G-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini699 – 73638EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini741 – 914174Laminin G-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini928 – 1103176Laminin G-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini1106 – 114338EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini1149 – 1347199Laminin G-like 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 6 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052670.
InParanoidiQ63372.
KOiK07377.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 4 hits.
PfamiPF00008. EGF. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 5 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

Sequences (17)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 17 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Note: Two isoform types, alpha-type and beta-type are produced by alternative promoter usage. In addition there are at least five alternatively spliced sites, each of which may be spliced in up to seven different ways. Combinatorial splicing at each of these five sites may lead to the generation of at least 96 isoforms but for simplicity only individual splice events or observed combinations are explicitly described below. Beta-type isoforms share the possibility of alternative splicing at sites 4 and 5. Experimental confirmation may be lacking for some isoforms.2 Publications
Isoform 1a (identifier: Q63372-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-1A2A3A4A5A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTALVQHGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC
60 70 80 90 100
ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP
110 120 130 140 150
ATLLADTPVN DGAWHSVRIR RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF
160 170 180 190 200
SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSQALPVDGS
210 220 230 240 250
EVKLDEEPPN SGGGSPCEAG DEGDGGVCLN GGVCSVVDDQ AVCDCSRTGF
260 270 280 290 300
RGKDCSQEDN NVEGLAHLMM GDQGKSKEDN NVEGLAHLMM GDQGKEEYIA
310 320 330 340 350
TFKGSEYFCY DLSQNPIQSS SDEITLSFKT LQRNGLMLHT GKSADYVNLA
360 370 380 390 400
LKNGAVSLVI NLGSGAFEAL VEPVNGKFND NAWHDVKVTR NLRQHSGIGH
410 420 430 440 450
AMVNKLHCSV TISVDGILTT TGYTQEDYTM LGSDDFFYVG GSPSTADLPG
460 470 480 490 500
SPVSNNFMGC LKEVVYKNND VRLELSRLAK QGDPKMKIHG VVAFKCENVA
510 520 530 540 550
TLDPITFETP ESFISLPKWN AKKTGSISFD FRTTEPNGLI LFSHGKPRHQ
560 570 580 590 600
KDAKHPQMIK VDFFAIEMLD GHLYLLLDMG SGTIKIKALQ KKVNDGEWYH
610 620 630 640 650
VDFQRDGRSG TISVNTLRTP YTAPGESEIL DLDDELYLGG LPENKAGLVF
660 670 680 690 700
PTEVWTALLN YGYVGCIRDL FIDGQSKDIR QMAEIQSTAG VKPSCSRETA
710 720 730 740 750
KPCLSNPCKN NGMCRDGWNR YVCDCSGTGY LGRSCEREAT VLSYDGSMFM
760 770 780 790 800
KIQLPVVMHT EAEDVSLRFR SQRAYGILMA TTSRDSADTL RLELDAGRVK
810 820 830 840 850
LTVNLDCIRI NCNSSKGPET LFAGYNLNDN EWHTVRVVRR GKSLKLTVDD
860 870 880 890 900
QQAMTGQMAG DHTRLEFHNI ETGIITERRY LSSVPSNFIG HLQSLTFNGM
910 920 930 940 950
AYIDLCKNGD IDYCELNARF GFRNIIADPV TFKTKSSYVA LATLQAYTSM
960 970 980 990 1000
HLFFQFKTTS LDGLILYNSG DGNDFIVVEL VKGYLHYVFD LGNGANLIKG
1010 1020 1030 1040 1050
SSNKPLNDNQ WHNVMISRDT SNLHTVKIDT KITTQITAGA RNLDLKSDLY
1060 1070 1080 1090 1100
IGGVAKETYK SLPKLVHAKE GFQGCLASVD LNGRLPDLIS DALFCNGQIE
1110 1120 1130 1140 1150
RGCEGPSTTC QEDSCSNQGV CLQQWDGFSC DCSMTSFSGP LCNDPGTTYI
1160 1170 1180 1190 1200
FSKGGGQITH KWPPNDRPST RADRLAIGFS TVQKEAVLVR VDSSSGLGDY
1210 1220 1230 1240 1250
LELHIHQGKI GVKFNVGTDD IAIEESNAII NDGKYHVVRF TRSGGNATLQ
1260 1270 1280 1290 1300
VDSWPVIERY PAGNNDNERL AIARQRIPYR LGRVVDEWLL DKGRQLTIFN
1310 1320 1330 1340 1350
SQATIIIGGK EQGQPFQGQL SGLYYNGLKV LNMAAENDAN IAIVGNVRLV
1360 1370 1380 1390 1400
GEVPSSMTTE STATAMQSEM STSIMETTTT LATSTARRGK PPTKEPISQT
1410 1420 1430 1440 1450
TDDILVASAE CPSDDEDIDP CEPSSGGLAN PTRVGGREPY PGSAEVIRES
1460 1470 1480 1490 1500
SSTTGMVVGI VAAAALCILI LLYAMYKYRN RDEGSYHVDE SRNYISNSAQ
1510 1520 1530
SNGAVVKEKQ PSSAKSANKN KKNKDKEYYV
Length:1,530
Mass (Da):167,923
Last modified:January 23, 2007 - v3
Checksum:i548109BAF05119FC
GO
Isoform 2a (identifier: Q63372-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-1B

The sequence of this isoform differs from the canonical sequence as follows:
     278-293: Missing.

Show »
Length:1,514
Mass (Da):166,168
Checksum:iD99492302968DE14
GO
Isoform 3a (identifier: Q63372-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-1C

The sequence of this isoform differs from the canonical sequence as follows:
     258-258: Missing.

Show »
Length:1,529
Mass (Da):167,793
Checksum:iE2A8F0E2F36DC63B
GO
Isoform 4a (identifier: Q63372-4) [UniParc]FASTAAdd to basket
Also known as: Alpha-1D

The sequence of this isoform differs from the canonical sequence as follows:
     274-277: Missing.

Show »
Length:1,526
Mass (Da):167,522
Checksum:i0F6B90B5C75BA53A
GO
Isoform 5a (identifier: Q63372-5) [UniParc]FASTAAdd to basket
Also known as: Alpha-1E

The sequence of this isoform differs from the canonical sequence as follows:
     258-258: Missing.
     274-277: Missing.

Show »
Length:1,525
Mass (Da):167,393
Checksum:i7C574F7204E238EF
GO
Isoform 6a (identifier: Q63372-6) [UniParc]FASTAAdd to basket
Also known as: Alpha-1F

The sequence of this isoform differs from the canonical sequence as follows:
     264-273: Missing.

Show »
Length:1,520
Mass (Da):166,868
Checksum:i19E1AC1A1390A591
GO
Isoform 7a (identifier: Q63372-7) [UniParc]FASTAAdd to basket
Also known as: Alpha-1G

The sequence of this isoform differs from the canonical sequence as follows:
     258-277: Missing.

Show »
Length:1,510
Mass (Da):165,767
Checksum:iF5ACC7697545A4F8
GO
Isoform 8a (identifier: Q63372-8) [UniParc]FASTAAdd to basket
Also known as: Alpha-2B

The sequence of this isoform differs from the canonical sequence as follows:
     403-409: Missing.

Show »
Length:1,523
Mass (Da):167,141
Checksum:i1F5C53D9C38F561B
GO
Isoform 9a (identifier: Q63372-9) [UniParc]FASTAAdd to basket
Also known as: Alpha-2C

The sequence of this isoform differs from the canonical sequence as follows:
     395-409: Missing.

Show »
Length:1,515
Mass (Da):166,350
Checksum:iF93A3CDBA856BD02
GO
Isoform 10a (identifier: Q63372-10) [UniParc]FASTAAdd to basket
Also known as: Alpha-3B

The sequence of this isoform differs from the canonical sequence as follows:
     806-815: DCIRINCNSS → G

Show »
Length:1,521
Mass (Da):166,873
Checksum:i0DA2BBDA3172D950
GO
Isoform 11a (identifier: Q63372-11) [UniParc]FASTAAdd to basket
Also known as: Alpha-4B

The sequence of this isoform differs from the canonical sequence as follows:
     1263-1292: Missing.

Show »
Length:1,500
Mass (Da):164,360
Checksum:i74546E646BDDD629
GO
Isoform 12a (identifier: Q63372-12) [UniParc]FASTAAdd to basket
Also known as: Alpha-5B

The sequence of this isoform differs from the canonical sequence as follows:
     1426-1427: Missing.

Show »
Length:1,528
Mass (Da):167,809
Checksum:iF243C341B8A14188
GO
Isoform 13a (identifier: Q63372-13) [UniParc]FASTAAdd to basket
Also known as: Alpha-1B2B

The sequence of this isoform differs from the canonical sequence as follows:
     278-293: Missing.
     403-409: Missing.

Show »
Length:1,507
Mass (Da):165,386
Checksum:iE7B72436D2C9A68C
GO
Isoform 1b (identifier: Q63373-1) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5A
The sequence of this isoform can be found in the external entry Q63373.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:468
Mass (Da):50,268
GO
Isoform 2b (identifier: Q63373-2) [UniParc]FASTAAdd to basket
Also known as: Beta-4A5B
The sequence of this isoform can be found in the external entry Q63373.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:362
Mass (Da):38,808
GO
Isoform 3b (identifier: Q63373-3) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5A
The sequence of this isoform can be found in the external entry Q63373.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:438
Mass (Da):46,704
GO
Isoform 4b (identifier: Q63373-4) [UniParc]FASTAAdd to basket
Also known as: Beta-4B5B
The sequence of this isoform can be found in the external entry Q63373.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:332
Mass (Da):35,245
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei258 – 27720Missing in isoform 7a. CuratedVSP_003487Add
BLAST
Alternative sequencei258 – 2581Missing in isoform 3a and isoform 5a. CuratedVSP_003486
Alternative sequencei264 – 27310Missing in isoform 6a. CuratedVSP_022559
Alternative sequencei274 – 2774Missing in isoform 4a and isoform 5a. CuratedVSP_003488
Alternative sequencei278 – 29316Missing in isoform 2a and isoform 13a. 1 PublicationVSP_022560Add
BLAST
Alternative sequencei395 – 40915Missing in isoform 9a. CuratedVSP_003489Add
BLAST
Alternative sequencei403 – 4097Missing in isoform 8a and isoform 13a. 1 PublicationVSP_003490
Alternative sequencei806 – 81510DCIRINCNSS → G in isoform 10a. CuratedVSP_003491
Alternative sequencei1263 – 129230Missing in isoform 11a. CuratedVSP_003492Add
BLAST
Alternative sequencei1426 – 14272Missing in isoform 12a. CuratedVSP_003493

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96374 mRNA. Translation: AAA41704.1.
PIRiA40228.
RefSeqiNP_068535.2. NM_021767.2. [Q63372-13]
UniGeneiRn.54924.

Genome annotation databases

GeneIDi60391.
KEGGirno:60391.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96374 mRNA. Translation: AAA41704.1.
PIRiA40228.
RefSeqiNP_068535.2. NM_021767.2. [Q63372-13]
UniGeneiRn.54924.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BIWX-ray3.50E/F/G/H1146-1361[»]
ProteinModelPortaliQ63372.
SMRiQ63372. Positions 295-491, 739-922, 1146-1356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248813. 4 interactions.
MINTiMINT-1506888.

PTM databases

iPTMnetiQ63372.
PhosphoSiteiQ63372.

Proteomic databases

PRIDEiQ63372.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi60391.
KEGGirno:60391.

Organism-specific databases

CTDi9378.
RGDi628659. Nrxn1.

Phylogenomic databases

HOVERGENiHBG052670.
InParanoidiQ63372.
KOiK07377.

Enzyme and pathway databases

ReactomeiR-RNO-3000171. Non-integrin membrane-ECM interactions.

Miscellaneous databases

EvolutionaryTraceiQ63372.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 4 hits.
PfamiPF00008. EGF. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 5 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRX1A_RAT
AccessioniPrimary (citable) accession number: Q63372
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Alpha-latrotoxin competes with alpha-dystroglycan for binding.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.