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Protein

P2Y purinoceptor 6

Gene

P2ry6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for extracellular UTP > ADP = 2-methylthio-ATP > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Functionally coupled to phospholipase C.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.
R-RNO-417957. P2Y receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 6
Short name:
P2Y6
Gene namesi
Name:P2ry6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620269. P2ry6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 62CytoplasmicSequence analysisAdd BLAST14
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini84 – 101ExtracellularSequence analysisAdd BLAST18
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 144CytoplasmicSequence analysisAdd BLAST22
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 194ExtracellularSequence analysisAdd BLAST29
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 236CytoplasmicSequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 280ExtracellularSequence analysisAdd BLAST23
Transmembranei281 – 303Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini304 – 328CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • basolateral plasma membrane Source: RGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3543.
GuidetoPHARMACOLOGYi326.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700301 – 328P2Y purinoceptor 6Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi99 ↔ 177PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63371.

PTM databases

PhosphoSitePlusiQ63371.

Expressioni

Tissue specificityi

Abundantly expressed in various tissues including lung, stomach, intestine, spleen, mesentery, heart, and, most prominently, aorta.

Gene expression databases

BgeeiENSRNOG00000019270.
GenevisibleiQ63371. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049439.

Chemistry databases

BindingDBiQ63371.

Structurei

3D structure databases

ProteinModelPortaliQ63371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJR4. Eukaryota.
ENOG410YAZW. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiQ63371.
KOiK04272.
OMAiRPFASAN.
OrthoDBiEOG091G0DD3.
PhylomeDBiQ63371.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001973. P2Y6_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF16. PTHR24231:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01068. P2Y6PRNOCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERDNGTIQA PGLPPTTCVY REDFKRLLLP PVYSVVLVVG LPLNVCVIAQ
60 70 80 90 100
ICASRRTLTR SAVYTLNLAL ADLLYACSLP LLIYNYARGD HWPFGDLACR
110 120 130 140 150
LVRFLFYANL HGSILFLTCI SFQRYLGICH PLAPWHKRGG RRAAWVVCGV
160 170 180 190 200
VWLVVTAQCL PTAVFAATGI QRNRTVCYDL SPPILSTRYL PYGMALTVIG
210 220 230 240 250
FLLPFTALLA CYCRMARRLC RQDGPAGPVA QERRSKAARM AVVVAAVFVI
260 270 280 290 300
SFLPFHITKT AYLAVRSTPG VSCPVLETFA AAYKGTRPFA SANSVLDPIL
310 320
FYFTQQKFRR QPHDLLQKLT AKWQRQRV
Length:328
Mass (Da):36,677
Last modified:November 1, 1996 - v1
Checksum:i58EBE1997038BA5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63665 mRNA. Translation: BAA09816.1.
BC072520 mRNA. Translation: AAH72520.1.
PIRiI55450.
RefSeqiNP_476465.1. NM_057124.2.
XP_006229773.1. XM_006229711.2.
XP_006229774.1. XM_006229712.2.
XP_006229775.1. XM_006229713.3.
XP_006229776.1. XM_006229714.3.
XP_006229777.1. XM_006229715.2.
XP_006229778.1. XM_006229716.2.
XP_006229779.1. XM_006229717.3.
UniGeneiRn.10671.

Genome annotation databases

EnsembliENSRNOT00000050227; ENSRNOP00000049439; ENSRNOG00000019270.
GeneIDi117264.
KEGGirno:117264.
UCSCiRGD:620269. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63665 mRNA. Translation: BAA09816.1.
BC072520 mRNA. Translation: AAH72520.1.
PIRiI55450.
RefSeqiNP_476465.1. NM_057124.2.
XP_006229773.1. XM_006229711.2.
XP_006229774.1. XM_006229712.2.
XP_006229775.1. XM_006229713.3.
XP_006229776.1. XM_006229714.3.
XP_006229777.1. XM_006229715.2.
XP_006229778.1. XM_006229716.2.
XP_006229779.1. XM_006229717.3.
UniGeneiRn.10671.

3D structure databases

ProteinModelPortaliQ63371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049439.

Chemistry databases

BindingDBiQ63371.
ChEMBLiCHEMBL3543.
GuidetoPHARMACOLOGYi326.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ63371.

Proteomic databases

PaxDbiQ63371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000050227; ENSRNOP00000049439; ENSRNOG00000019270.
GeneIDi117264.
KEGGirno:117264.
UCSCiRGD:620269. rat.

Organism-specific databases

CTDi5031.
RGDi620269. P2ry6.

Phylogenomic databases

eggNOGiENOG410IJR4. Eukaryota.
ENOG410YAZW. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiQ63371.
KOiK04272.
OMAiRPFASAN.
OrthoDBiEOG091G0DD3.
PhylomeDBiQ63371.
TreeFamiTF330775.

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.
R-RNO-417957. P2Y receptors.

Miscellaneous databases

PROiQ63371.

Gene expression databases

BgeeiENSRNOG00000019270.
GenevisibleiQ63371. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001973. P2Y6_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF16. PTHR24231:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01068. P2Y6PRNOCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2RY6_RAT
AccessioniPrimary (citable) accession number: Q63371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.