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Protein

Neurexophilin-1

Gene

Nxph1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexophilin-1
Short name:
Neurophilin
Gene namesi
Name:Nxph1
Synonyms:Nph1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3218. Nxph1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 271250Neurexophilin-1PRO_0000020061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence analysis
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence analysis
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence analysis
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ63366.

PTM databases

iPTMnetiQ63366.
PhosphoSiteiQ63366.

Expressioni

Tissue specificityi

Highest level in brain.

Gene expression databases

BgeeiENSRNOG00000008939.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011833.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 9776IIAdd
BLAST
Regioni98 – 17679IIIAdd
BLAST
Regioni177 – 1859IV (linker domain)
Regioni186 – 27186V (Cys-rich)Add
BLAST

Sequence similaritiesi

Belongs to the neurexophilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410YYWH. LUCA.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiQ63366.
KOiK16656.
PhylomeDBiQ63366.

Family and domain databases

InterProiIPR010450. Nxph.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiPF06312. Neurexophilin. 1 hit.
[Graphical view]
PIRSFiPIRSF038019. Neurexophilin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAACWYVLL LLQPTVYLVT CANLTNGGKS ELLKSGNSKS TLKHIWTESS
60 70 80 90 100
KDLSISRLLS QTFRGKENGT DLDLRYDTPE PYSEQDLWDW LRNSTDLQEP
110 120 130 140 150
RPRAKRRPIV KTGKFKKMFG WGDFHSNIKT VKLNLLITGK IVDHGNGTFS
160 170 180 190 200
VYFRHNSTGQ GNVSVSLVPP TKIVEFDLAQ QTVIDAKDSK SFNCRIEYEK
210 220 230 240 250
VDKATKNTLC NYDPSKTCYQ EQTQSHVSWL CSKPFKVICI YISFYSTDYK
260 270
LVQKVCPDYN YHSDTPYFPS G
Length:271
Mass (Da):31,017
Last modified:November 1, 1997 - v1
Checksum:i472D12D0B071E97A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27867 mRNA. Translation: AAB18420.1.
BC105770 mRNA. Translation: AAI05771.1.
RefSeqiNP_037126.1. NM_012994.2.
UniGeneiRn.10610.

Genome annotation databases

GeneIDi25501.
KEGGirno:25501.
UCSCiRGD:3218. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27867 mRNA. Translation: AAB18420.1.
BC105770 mRNA. Translation: AAI05771.1.
RefSeqiNP_037126.1. NM_012994.2.
UniGeneiRn.10610.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011833.

PTM databases

iPTMnetiQ63366.
PhosphoSiteiQ63366.

Proteomic databases

PaxDbiQ63366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25501.
KEGGirno:25501.
UCSCiRGD:3218. rat.

Organism-specific databases

CTDi30010.
RGDi3218. Nxph1.

Phylogenomic databases

eggNOGiENOG410YYWH. LUCA.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiQ63366.
KOiK16656.
PhylomeDBiQ63366.

Miscellaneous databases

PROiQ63366.

Gene expression databases

BgeeiENSRNOG00000008939.

Family and domain databases

InterProiIPR010450. Nxph.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiPF06312. Neurexophilin. 1 hit.
[Graphical view]
PIRSFiPIRSF038019. Neurexophilin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNXPH1_RAT
AccessioniPrimary (citable) accession number: Q63366
Secondary accession number(s): Q3KRD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.