Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neurexophilin-1

Gene

Nxph1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexophilin-1
Short name:
Neurophilin
Gene namesi
Name:Nxph1
Synonyms:Nph1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3218. Nxph1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002006122 – 271Neurexophilin-1Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ63366.

PTM databases

iPTMnetiQ63366.
PhosphoSitePlusiQ63366.

Expressioni

Tissue specificityi

Highest level in brain.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011833.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 97IIAdd BLAST76
Regioni98 – 176IIIAdd BLAST79
Regioni177 – 185IV (linker domain)9
Regioni186 – 271V (Cys-rich)Add BLAST86

Sequence similaritiesi

Belongs to the neurexophilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410YYWH. LUCA.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiQ63366.
KOiK16656.
PhylomeDBiQ63366.

Family and domain databases

InterProiView protein in InterPro
IPR010450. Nxph.
IPR026845. NXPH/NXPE.
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiView protein in Pfam
PF06312. Neurexophilin. 1 hit.
PIRSFiPIRSF038019. Neurexophilin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAACWYVLL LLQPTVYLVT CANLTNGGKS ELLKSGNSKS TLKHIWTESS
60 70 80 90 100
KDLSISRLLS QTFRGKENGT DLDLRYDTPE PYSEQDLWDW LRNSTDLQEP
110 120 130 140 150
RPRAKRRPIV KTGKFKKMFG WGDFHSNIKT VKLNLLITGK IVDHGNGTFS
160 170 180 190 200
VYFRHNSTGQ GNVSVSLVPP TKIVEFDLAQ QTVIDAKDSK SFNCRIEYEK
210 220 230 240 250
VDKATKNTLC NYDPSKTCYQ EQTQSHVSWL CSKPFKVICI YISFYSTDYK
260 270
LVQKVCPDYN YHSDTPYFPS G
Length:271
Mass (Da):31,017
Last modified:November 1, 1997 - v1
Checksum:i472D12D0B071E97A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27867 mRNA. Translation: AAB18420.1.
BC105770 mRNA. Translation: AAI05771.1.
RefSeqiNP_037126.1. NM_012994.2.
UniGeneiRn.10610.

Genome annotation databases

GeneIDi25501.
KEGGirno:25501.
UCSCiRGD:3218. rat.

Similar proteinsi

Entry informationi

Entry nameiNXPH1_RAT
AccessioniPrimary (citable) accession number: Q63366
Secondary accession number(s): Q3KRD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 22, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families