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Protein

Unconventional myosin-Id

Gene

Myo1d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi102 – 109ATPSequence analysis8

GO - Molecular functioni

  • actin-dependent ATPase activity Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • calcium-dependent protein binding Source: RGD
  • calmodulin binding Source: UniProtKB
  • microfilament motor activity Source: RGD
  • microtubule binding Source: InterPro
  • microtubule motor activity Source: InterPro
  • protein domain specific binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Id
Alternative name(s):
Myosin heavy chain myr 4
Gene namesi
Name:Myo1d
Synonyms:Myr4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi621321 Myo1d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001234492 – 1006Unconventional myosin-IdAdd BLAST1005

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei200PhosphoserineBy similarity1
Modified residuei536PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ63357
PRIDEiQ63357

PTM databases

iPTMnetiQ63357
PhosphoSitePlusiQ63357

Expressioni

Tissue specificityi

Widely expressed. Highest levels in adult brain, and spinal chord. Moderate levels in lung, kidney, liver and spleen. Low levels in testis and heart.1 Publication

Developmental stagei

Expression is developmentally regulated during brain ontogeny, rising 2-3 week postnatally, and is maximal in adult brain.1 Publication

Gene expression databases

BgeeiENSRNOG00000003276
GenevisibleiQ63357 RN

Interactioni

Subunit structurei

Binds calmodulin through its IQ motifs.1 Publication

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • calcium-dependent protein binding Source: RGD
  • calmodulin binding Source: UniProtKB
  • microtubule binding Source: InterPro
  • protein domain specific binding Source: Ensembl

Protein-protein interaction databases

BioGridi247518, 1 interactor
STRINGi10116.ENSRNOP00000004609

Structurei

3D structure databases

ProteinModelPortaliQ63357
SMRiQ63357
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 695Myosin motorPROSITE-ProRule annotationAdd BLAST687
Domaini698 – 727IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini728 – 741IQ 2PROSITE-ProRule annotationAdd BLAST14
Domaini812 – 1005TH1PROSITE-ProRule annotationAdd BLAST194

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni572 – 594Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140778
HOGENOMiHOG000260264
HOVERGENiHBG062373
InParanoidiQ63357
KOiK10356
OMAiFNRWRAS
OrthoDBiEOG091G0136
PhylomeDBiQ63357
TreeFamiTF312960

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQESLEFG KADFVLMDTV SMPEFMANLR LRFEKGRIYT FIGEVVVSVN
60 70 80 90 100
PYKVLNIYGR DTIEQYKGRE LYERPPHLFA IADAAYKAMK RRSKDTCIMI
110 120 130 140 150
SGESGAGKTE ASKYIMQYIA AITNPSQRAE IERVKNMLLK SNCVLEAFGN
160 170 180 190 200
AKTNRNDNSS RFGKYMDINF DFKGDPIGGH INNYLLEKSR VIVQQPGERS
210 220 230 240 250
FHSFYQLLQG GSEQMLHSLH LQKSLSSYNY IRVGAQLKSS INDAAEFKVV
260 270 280 290 300
ADAMKVIGFK PEEIQTVYKI LAAILHLGNL KFIVDGDTPL IENGKVVSVI
310 320 330 340 350
AELLSTKADM VEKALLYRTV ATGRDIIDKQ HTEQEASYGR DAFAKAIYER
360 370 380 390 400
LFCWIVTRIN DIIEVKNYDT TVHGKNTVIG VLDIYGFEIF DNNSFEQFCI
410 420 430 440 450
NYCNEKLQQL FIQLVLKQEQ EEYQREGIPW KHIDYFNNQI IVDLVEQQHK
460 470 480 490 500
GIIAILDDAC MNVGKVTDGM FLEALNSKLG KHGHFSSRKT CASDKILEFD
510 520 530 540 550
RDFRIRHYAG DVVYSVIGFI DKNKDTLFQD FKRLMYNSSN PVLKNMWPEG
560 570 580 590 600
KLSITEVTKR PLTAATLFKN SMIALVDNLA SKEPYYVRCI KPNDKKSPQI
610 620 630 640 650
FDDERCRHQV EYLGLLENVR VRRAGFAFRQ TYEKFLHRYK MISEFTWPNH
660 670 680 690 700
DLPSDKEAVK KLIERCGFQD DVAYGKTKIF IRTPRTLFTL EELRAQMLVR
710 720 730 740 750
VVLFLQKVWR GTLARMRYKR TKAALTIIRY YRRYKVKSYI HEVARRFHGV
760 770 780 790 800
KNMRDYGKHV KWPTPPKVLR RFEEALQSIF NRWRASQLIK TIPASDLPQV
810 820 830 840 850
RAKVAAMEML KGQRADLGLQ RAWEGNYLAS KPDTPQTSGT FVPVANELKR
860 870 880 890 900
KDKYMNVLFS CHVRKVNRFS KVEDRAIFVT DRHLYKMDPT KQYKVMKTIP
910 920 930 940 950
LYNLTGLSVS NGKDQLVVFH TKDNKDLIVC LFSKQPTHES RIGELVGVLV
960 970 980 990 1000
NHFKSEKRHL QVNVTNPVQC SLHGKKCTVS VETRLNQPQP DFTKNRSGFI

LSVPGN
Length:1,006
Mass (Da):116,095
Last modified:January 10, 2006 - v3
Checksum:iECD245C8ACACEA53
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82A → L in CAA50871 (PubMed:8034741).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71997 mRNA Translation: CAA50871.1
BC087027 mRNA Translation: AAH87027.1
PIRiA53933
RefSeqiNP_037115.2, NM_012983.2
UniGeneiRn.10376

Genome annotation databases

EnsembliENSRNOT00000004609; ENSRNOP00000004609; ENSRNOG00000003276
GeneIDi25485
KEGGirno:25485

Similar proteinsi

Entry informationi

Entry nameiMYO1D_RAT
AccessioniPrimary (citable) accession number: Q63357
Secondary accession number(s): Q5PQU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 10, 2006
Last modified: May 23, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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