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Protein

Unconventional myosin-Id

Gene

Myo1d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 1098ATPSequence analysis

GO - Molecular functioni

  • actin-dependent ATPase activity Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • calcium-dependent protein binding Source: RGD
  • calmodulin binding Source: UniProtKB
  • microfilament motor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Id
Alternative name(s):
Myosin heavy chain myr 4
Gene namesi
Name:Myo1d
Synonyms:Myr4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621321. Myo1d.

Subcellular locationi

GO - Cellular componenti

  • apical dendrite Source: UniProtKB
  • axolemma Source: RGD
  • basolateral plasma membrane Source: UniProtKB
  • brush border Source: UniProtKB
  • cytoplasmic vesicle Source: UniProtKB
  • extracellular exosome Source: Ensembl
  • myelin sheath Source: UniProtKB
  • myosin complex Source: RGD
  • neuronal cell body Source: UniProtKB
  • plasma membrane raft Source: UniProtKB
  • smooth endoplasmic reticulum Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 10061005Unconventional myosin-IdPRO_0000123449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei200 – 2001PhosphoserineBy similarity
Modified residuei536 – 5361PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ63357.
PRIDEiQ63357.

PTM databases

iPTMnetiQ63357.
PhosphoSiteiQ63357.

Expressioni

Tissue specificityi

Widely expressed. Highest levels in adult brain, and spinal chord. Moderate levels in lung, kidney, liver and spleen. Low levels in testis and heart.1 Publication

Developmental stagei

Expression is developmentally regulated during brain ontogeny, rising 2-3 week postnatally, and is maximal in adult brain.1 Publication

Gene expression databases

GenevisibleiQ63357. RN.

Interactioni

Subunit structurei

Binds calmodulin through its IQ motifs.1 Publication

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • calcium-dependent protein binding Source: RGD
  • calmodulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi247518. 1 interaction.
MINTiMINT-4568060.
STRINGi10116.ENSRNOP00000004609.

Structurei

3D structure databases

ProteinModelPortaliQ63357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 695687Myosin motorAdd
BLAST
Domaini698 – 72730IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini728 – 74114IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini812 – 1005194TH1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiQ63357.
KOiK10356.
OMAiNRWRASQ.
OrthoDBiEOG7V49XQ.
PhylomeDBiQ63357.
TreeFamiTF312960.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQESLEFG KADFVLMDTV SMPEFMANLR LRFEKGRIYT FIGEVVVSVN
60 70 80 90 100
PYKVLNIYGR DTIEQYKGRE LYERPPHLFA IADAAYKAMK RRSKDTCIMI
110 120 130 140 150
SGESGAGKTE ASKYIMQYIA AITNPSQRAE IERVKNMLLK SNCVLEAFGN
160 170 180 190 200
AKTNRNDNSS RFGKYMDINF DFKGDPIGGH INNYLLEKSR VIVQQPGERS
210 220 230 240 250
FHSFYQLLQG GSEQMLHSLH LQKSLSSYNY IRVGAQLKSS INDAAEFKVV
260 270 280 290 300
ADAMKVIGFK PEEIQTVYKI LAAILHLGNL KFIVDGDTPL IENGKVVSVI
310 320 330 340 350
AELLSTKADM VEKALLYRTV ATGRDIIDKQ HTEQEASYGR DAFAKAIYER
360 370 380 390 400
LFCWIVTRIN DIIEVKNYDT TVHGKNTVIG VLDIYGFEIF DNNSFEQFCI
410 420 430 440 450
NYCNEKLQQL FIQLVLKQEQ EEYQREGIPW KHIDYFNNQI IVDLVEQQHK
460 470 480 490 500
GIIAILDDAC MNVGKVTDGM FLEALNSKLG KHGHFSSRKT CASDKILEFD
510 520 530 540 550
RDFRIRHYAG DVVYSVIGFI DKNKDTLFQD FKRLMYNSSN PVLKNMWPEG
560 570 580 590 600
KLSITEVTKR PLTAATLFKN SMIALVDNLA SKEPYYVRCI KPNDKKSPQI
610 620 630 640 650
FDDERCRHQV EYLGLLENVR VRRAGFAFRQ TYEKFLHRYK MISEFTWPNH
660 670 680 690 700
DLPSDKEAVK KLIERCGFQD DVAYGKTKIF IRTPRTLFTL EELRAQMLVR
710 720 730 740 750
VVLFLQKVWR GTLARMRYKR TKAALTIIRY YRRYKVKSYI HEVARRFHGV
760 770 780 790 800
KNMRDYGKHV KWPTPPKVLR RFEEALQSIF NRWRASQLIK TIPASDLPQV
810 820 830 840 850
RAKVAAMEML KGQRADLGLQ RAWEGNYLAS KPDTPQTSGT FVPVANELKR
860 870 880 890 900
KDKYMNVLFS CHVRKVNRFS KVEDRAIFVT DRHLYKMDPT KQYKVMKTIP
910 920 930 940 950
LYNLTGLSVS NGKDQLVVFH TKDNKDLIVC LFSKQPTHES RIGELVGVLV
960 970 980 990 1000
NHFKSEKRHL QVNVTNPVQC SLHGKKCTVS VETRLNQPQP DFTKNRSGFI

LSVPGN
Length:1,006
Mass (Da):116,095
Last modified:January 10, 2006 - v3
Checksum:iECD245C8ACACEA53
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821A → L in CAA50871 (PubMed:8034741).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71997 mRNA. Translation: CAA50871.1.
BC087027 mRNA. Translation: AAH87027.1.
PIRiA53933.
RefSeqiNP_037115.2. NM_012983.2.
UniGeneiRn.10376.

Genome annotation databases

EnsembliENSRNOT00000004609; ENSRNOP00000004609; ENSRNOG00000003276.
GeneIDi25485.
KEGGirno:25485.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71997 mRNA. Translation: CAA50871.1.
BC087027 mRNA. Translation: AAH87027.1.
PIRiA53933.
RefSeqiNP_037115.2. NM_012983.2.
UniGeneiRn.10376.

3D structure databases

ProteinModelPortaliQ63357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247518. 1 interaction.
MINTiMINT-4568060.
STRINGi10116.ENSRNOP00000004609.

PTM databases

iPTMnetiQ63357.
PhosphoSiteiQ63357.

Proteomic databases

PaxDbiQ63357.
PRIDEiQ63357.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004609; ENSRNOP00000004609; ENSRNOG00000003276.
GeneIDi25485.
KEGGirno:25485.

Organism-specific databases

CTDi4642.
RGDi621321. Myo1d.

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiQ63357.
KOiK10356.
OMAiNRWRASQ.
OrthoDBiEOG7V49XQ.
PhylomeDBiQ63357.
TreeFamiTF312960.

Miscellaneous databases

NextBioi606837.
PROiQ63357.

Gene expression databases

GenevisibleiQ63357. RN.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rat myr4 defines a novel subclass of myosin I: identification, distribution, localization, and mapping of calmodulin-binding sites with differential calcium sensitivity."
    Baehler M., Kroschewski R., Stoeffler H.E., Behrmann T.
    J. Cell Biol. 126:375-389(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiMYO1D_RAT
AccessioniPrimary (citable) accession number: Q63357
Secondary accession number(s): Q5PQU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 10, 2006
Last modified: May 11, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.