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Protein

Unconventional myosin-Ie

Gene

Myo1e

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function (By similarity). In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi112 – 1198ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Lipid-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ie
Alternative name(s):
Myosin heavy chain myr 3
Unconventional myosin 1E
Gene namesi
Name:Myo1e
Synonyms:Myr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3144. Myo1e.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cytoplasmcytoskeleton 1 Publication
  • Cytoplasmic vesicle 1 Publication
  • Cytoplasmic vesicleclathrin-coated vesicle By similarity
  • Cell junction 1 Publication

  • Note: In cultured podocytes, it localizes close to and is associated with the cytoplasmic membrane, with enrichment at the lamellipodia tips. Colocalizes with cytoplasmic vesicles, including endocytic clathrin-coated vesicles. Colocalizes with dynamin at cytoplasmic vesicles (By similarity). Detected in cytoplasmic punctae. Colocalizes with F-actin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11071107Unconventional myosin-IePRO_0000123451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1001 – 10011PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63356.
PRIDEiQ63356.

PTM databases

iPTMnetiQ63356.
PhosphoSiteiQ63356.

Expressioni

Tissue specificityi

Detected in brain stem, brain cortex, cerebellum, stomach, colon, heart, lung, liver, spleen and kidney. Detected in utricle, cochlea, outer hair cell bundle cuticular plate and vestibular epithelia (at protein level). Detected in cochlea and vestibular tissues. Detected in kidney, lung, spleen and intestine.2 Publications

Interactioni

Subunit structurei

Interacts with CALM and F-actin (PubMed:7730414). Interacts (via SH3 domain) with SYNJ1, DNM1 and DNM2. Interacts with ARL14EP. Interacts with LRRC16A (By similarity).By similarity1 Publication

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • calmodulin binding Source: UniProtKB
  • protein complex binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016482.

Structurei

3D structure databases

ProteinModelPortaliQ63356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 692674Myosin motorAdd
BLAST
Domaini695 – 72430IQPROSITE-ProRule annotationAdd
BLAST
Domaini730 – 922193TH1PROSITE-ProRule annotationAdd
BLAST
Domaini1050 – 110758SH3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni581 – 59111Actin-bindingSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG0162. Eukaryota.
COG5022. LUCA.
HOGENOMiHOG000260265.
HOVERGENiHBG100702.
InParanoidiQ63356.
KOiK10356.
PhylomeDBiQ63356.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
PR00452. SH3DOMAIN.
SMARTiSM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63356-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKGAYRYH WQSHNVKHSG VDDMVLLSKI TESSIVENLK KRYMDDYIFT
60 70 80 90 100
YIGSVLISVN PFKQMPYFGE KEIEMYQGAA QYENPPHIYA LADSMYRNMI
110 120 130 140 150
IDRENQCVII SGESGAGKTV AAKYIMSYVS RVSGGGPKVQ HVKDIILQSN
160 170 180 190 200
PLLEAFGNAK TVRNNNSSRF GKYFEIQFSP GGEPDGGKIS NFLLEKSRVV
210 220 230 240 250
MRNPGERSFH IFYQLIEGAS PEQKQSLGIT SMDYYYYLSL SGSYKVDDID
260 270 280 290 300
DKRDFQETLH AMNVIGIFSE EQTLVLQIVA GILHLGNINF KEVGNYAAVE
310 320 330 340 350
SEEFLAFPAY LLGINQDRLK EKLTSRQMDS KWGGKSESIH VTLNVEQACY
360 370 380 390 400
TRDALAKALH ARVFDFLVDS INKAMEKDHE EYNIGVLDIY GFEIFQKNGF
410 420 430 440 450
EQFCINFVNE KLQQIFIELT LKAEQEEYVQ EGIRWTPIEY FNNKIVCDLI
460 470 480 490 500
ESKVNPPGIM SILDDVCATM HAVGEGADQT LLQKLQMQIG SHEHFNSWNQ
510 520 530 540 550
GFIIHHYAGK VSYDMDGFCE RNRDVLFMDL IELMQSSELP FIKSLFPENL
560 570 580 590 600
QADKKGRPTT AGSKIKKQAN DLVSTLMKCT PHYIRCIKPN ETKKPKDWEE
610 620 630 640 650
SRVKHQVEYL GLKENIRVRR AGYAYRRVFQ KFLQRYAILT KATWPVWRGD
660 670 680 690 700
EKQGVLHLLQ SVNMDSDQFQ LGRSKVFIKA PESLFLLEEM RERKYDGYAR
710 720 730 740 750
VIQKTWRKFV ARKKYVQMRE DASDLLLNKK ERRRNSINRN FIGDYIGMEE
760 770 780 790 800
HPELQQFVGK REKIDFADIV TKYDRRFKGV KRDLLLTPKC LYLIGREKVK
810 820 830 840 850
QGPDKGLVKE VLKRKIEVER ILSVSLSTMQ DDIFILHEQE YDSLLESVFK
860 870 880 890 900
TEFLSLLTKR YEEKTQKQLP LKFSNTLELK LKKENWGPWS AGGSRQVQFY
910 920 930 940 950
QGFGDLAILK PSNKVLQVSI GPGLPKNARP TRRNTVSSRG YSGGTNNNYP
960 970 980 990 1000
MRAAPAPPGC HRNGLTRNQF VHPPRASGNQ RSNQKSLYTS MARPPLPRQQ
1010 1020 1030 1040 1050
STGSDRLSQT PESLDFLKVP DQGAAGVRRQ TTSRPPPAGG RPKPQPKPKP
1060 1070 1080 1090 1100
QVPQCKALYA YDAQDTDELS FNANDVIDII KEDPSGWWTG RLRGKQGLFP

NNYVTKI
Length:1,107
Mass (Da):126,827
Last modified:November 1, 1996 - v1
Checksum:iB9D8FBB0CE047148
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74815 mRNA. Translation: CAA52815.1.
PIRiS52517.
RefSeqiNP_775124.1. NM_173101.1.
UniGeneiRn.8737.

Genome annotation databases

GeneIDi25484.
KEGGirno:25484.
UCSCiRGD:3144. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74815 mRNA. Translation: CAA52815.1.
PIRiS52517.
RefSeqiNP_775124.1. NM_173101.1.
UniGeneiRn.8737.

3D structure databases

ProteinModelPortaliQ63356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016482.

PTM databases

iPTMnetiQ63356.
PhosphoSiteiQ63356.

Proteomic databases

PaxDbiQ63356.
PRIDEiQ63356.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25484.
KEGGirno:25484.
UCSCiRGD:3144. rat.

Organism-specific databases

CTDi4643.
RGDi3144. Myo1e.

Phylogenomic databases

eggNOGiKOG0162. Eukaryota.
COG5022. LUCA.
HOGENOMiHOG000260265.
HOVERGENiHBG100702.
InParanoidiQ63356.
KOiK10356.
PhylomeDBiQ63356.

Miscellaneous databases

PROiQ63356.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
PR00452. SH3DOMAIN.
SMARTiSM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO1E_RAT
AccessioniPrimary (citable) accession number: Q63356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.