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Protein

Unconventional myosin-Ic

Gene

Myo1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69ATPBy similarity1
Binding sitei77ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi120 – 129ATPBy similarity10
Nucleotide bindingi173 – 177ATPBy similarity5

GO - Molecular functioni

  • actin-dependent ATPase activity Source: RGD
  • actin filament binding Source: RGD
  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: RGD
  • microfilament motor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-5250924. B-WICH complex positively regulates rRNA expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ic
Alternative name(s):
Myosin I beta
Short name:
MMI-beta
Short name:
MMIb
Myosin heavy chain myr 2
Gene namesi
Name:Myo1c
Synonyms:Myr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620443. Myo1c.

Subcellular locationi

GO - Cellular componenti

  • basal plasma membrane Source: Ensembl
  • brush border Source: Ensembl
  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB-SubCell
  • cytoplasmic vesicle Source: RGD
  • extracellular exosome Source: Ensembl
  • filamentous actin Source: Ensembl
  • lateral plasma membrane Source: Ensembl
  • membrane raft Source: UniProtKB
  • microvillus Source: Ensembl
  • myosin I complex Source: Ensembl
  • nucleoplasm Source: Ensembl
  • nucleus Source: RGD
  • ruffle membrane Source: RGD
  • stereocilium bundle Source: RGD
  • stereocilium membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003694141 – 1044Unconventional myosin-IcAdd BLAST1044

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei364N6-methyllysineBy similarity1
Modified residuei389PhosphoserineCombined sources1
Modified residuei467N6-acetyllysineBy similarity1
Modified residuei517PhosphoserineCombined sources1
Modified residuei845PhosphoserineCombined sources1
Modified residuei1022PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ63355.
PRIDEiQ63355.

PTM databases

iPTMnetiQ63355.
PhosphoSitePlusiQ63355.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004072.
GenevisibleiQ63355. RN.

Interactioni

Subunit structurei

Interacts (via its IQ motifs) with CALM; this precludes interaction with YWHAB. Interacts with YWHAB; this precludes interaction with CALM. Interacts with RPS6 and actin. Interacts (via its IQ motifs) with CABP1 and CIB1; the interaction with CABP1 and CIB1 is calcium-dependent. Interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of calcium and CALM. Interacts with BAZ1B, SMARCA5, POLR1A and POLR2A. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (By similarity). Interacts with GLUT4. Interacts with LLPH (By similarity).By similarity1 Publication

GO - Molecular functioni

  • actin filament binding Source: RGD
  • calmodulin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028929.

Structurei

3D structure databases

ProteinModelPortaliQ63355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 712Myosin motorAdd BLAST685
Domaini715 – 744IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini738 – 767IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini866 – 1040TH1PROSITE-ProRule annotationAdd BLAST175

Domaini

Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to a putative PH domain present in its tail domain (By similarity).By similarity

Sequence similaritiesi

Contains 2 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
InParanoidiQ63355.
KOiK10356.
OMAiELCIKNM.
OrthoDBiEOG091G0136.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 2 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYRASALGS DGVRVTMESA LTARDRVGVQ DFVLLENFTS EAAFIENLRR
60 70 80 90 100
RFRENLIYTY IGPVLVSVNP YRDLQIYTRQ HMERYRGVSF YEVPPHLFAV
110 120 130 140 150
ADTVYRALRT ERRDQAVMIS GESGAGKTEA TKRLLQFYAE TCPAPERGGA
160 170 180 190 200
VRDRLLQSNP VLEAFGNAKT LRNDNSSRFG KYMDVQFDFK GAPVGGHILS
210 220 230 240 250
YLLEKSRVVH QNHGERNFHV FYQLLEGGEE EALRRLGLER NPQSYLYLVK
260 270 280 290 300
GQCAKVSSIN DKSDWKVVRK ALSVIDFTED EVEDLLSIVA SVLHLGNIHF
310 320 330 340 350
AADEDSNAQV TTENQLKYLT RLLGVEGTTL REALTHRKII AKGEELLSPL
360 370 380 390 400
NLEQAAYARD ALAKAVYSRT FTWLVRKINR SLASKDAESP SWRSTTVLGL
410 420 430 440 450
LDIYGFEVFQ HNSFEQFCIN YCNEKLQQLF IELTLKSEQE EYEAEGIAWE
460 470 480 490 500
PVQYFNNKII CDLVEEKFKG IISILDEECL RPGEATDLTF LEKLEDTIKH
510 520 530 540 550
HPHFLTHKLA DQKTRKSLDR GEFRLLHYAG EVTYSVTGFL DKNNDLLFRN
560 570 580 590 600
LKETMCSSTN PIMAQCFDKS ELSDKKRPET VATQFKMSLL QLVEILRSKE
610 620 630 640 650
PAYIRCIKPN DAKQPGRFDE VLIRHQVKYL GLMENLRVRR AGFAYRRKYE
660 670 680 690 700
AFLQRYKSLC PETWPVWTGR PQDGVAVLVR HLGYKPEEYK MGRTKIFIRF
710 720 730 740 750
PKTLFATEDS LEVRRQSLAT KIQAAWRGFH WRQKFLRVKR SAICIQSWWR
760 770 780 790 800
GTLGRRKAAK RKWAAQTIRR LIRGFILRHA PRCPENAFFL DHVRTSFLLN
810 820 830 840 850
LRRQLPRNVL DTSWPTPPPA LREASELLRE LCMKNMVWKY CRSISPEWKQ
860 870 880 890 900
QLQQKAVASE IFKGKKDNYP QSVPRLFIST RLGTEEISPR VLQALGSEPI
910 920 930 940 950
QYAVPVVKYD RKGYKPRSRQ LLLTPSAVVI VEDAKVKQRI DYANLTGISV
960 970 980 990 1000
SSLSDSLFVL HVQREDSKQK GDVVLQSDHV IETLTKTALS ADRVNNININ
1010 1020 1030 1040
QGSITFAGGP GRDGIIDFTS GSELLITKAK NGHLAVVAPR LNSR
Length:1,044
Mass (Da):119,811
Last modified:April 14, 2009 - v2
Checksum:iF1BDEDE4CD2159A3
GO

Sequence cautioni

The sequence CAA52807 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74800 mRNA. Translation: CAA52807.1. Different initiation.
PIRiS37146.
RefSeqiNP_075580.2. NM_023092.1.
UniGeneiRn.55135.

Genome annotation databases

EnsembliENSRNOT00000036666; ENSRNOP00000028929; ENSRNOG00000004072.
GeneIDi65261.
KEGGirno:65261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74800 mRNA. Translation: CAA52807.1. Different initiation.
PIRiS37146.
RefSeqiNP_075580.2. NM_023092.1.
UniGeneiRn.55135.

3D structure databases

ProteinModelPortaliQ63355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028929.

PTM databases

iPTMnetiQ63355.
PhosphoSitePlusiQ63355.

Proteomic databases

PaxDbiQ63355.
PRIDEiQ63355.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036666; ENSRNOP00000028929; ENSRNOG00000004072.
GeneIDi65261.
KEGGirno:65261.

Organism-specific databases

CTDi4641.
RGDi620443. Myo1c.

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
InParanoidiQ63355.
KOiK10356.
OMAiELCIKNM.
OrthoDBiEOG091G0136.

Enzyme and pathway databases

ReactomeiR-RNO-5250924. B-WICH complex positively regulates rRNA expression.

Miscellaneous databases

PROiQ63355.

Gene expression databases

BgeeiENSRNOG00000004072.
GenevisibleiQ63355. RN.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 2 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO1C_RAT
AccessioniPrimary (citable) accession number: Q63355
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.