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Protein

Unconventional myosin-Ic

Gene

Myo1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity).By similarity1 Publication

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69ATPBy similarity1
Binding sitei77ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi120 – 129ATPBy similarity10
Nucleotide bindingi173 – 177ATPBy similarity5

GO - Molecular functioni

  • actin-dependent ATPase activity Source: RGD
  • actin filament binding Source: RGD
  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: RGD
  • microfilament motor activity Source: RGD
  • microtubule binding Source: InterPro
  • microtubule motor activity Source: InterPro
  • protein C-terminus binding Source: Ensembl
  • Ral GTPase binding Source: Ensembl
  • signaling receptor binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processProtein transport, Translocation, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation
R-RNO-5250924 B-WICH complex positively regulates rRNA expression

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ic
Alternative name(s):
Myosin I beta
Short name:
MMI-beta
Short name:
MMIb
Myosin heavy chain myr 2
Gene namesi
Name:Myo1c
Synonyms:Myr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620443 Myo1c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003694141 – 1044Unconventional myosin-IcAdd BLAST1044

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei364N6-methyllysineBy similarity1
Modified residuei389PhosphoserineCombined sources1
Modified residuei467N6-acetyllysineBy similarity1
Modified residuei517PhosphoserineCombined sources1
Modified residuei845PhosphoserineCombined sources1
Modified residuei1022PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ63355
PRIDEiQ63355

PTM databases

iPTMnetiQ63355
PhosphoSitePlusiQ63355

Expressioni

Gene expression databases

BgeeiENSRNOG00000004072
GenevisibleiQ63355 RN

Interactioni

Subunit structurei

Interacts (via its IQ motifs) with CALM; this precludes interaction with YWHAB. Interacts with YWHAB; this precludes interaction with CALM. Interacts with RPS6 and actin. Interacts (via its IQ motifs) with CABP1 and CIB1; the interaction with CABP1 and CIB1 is calcium-dependent. Interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of calcium and CALM. Interacts with BAZ1B, SMARCA5, POLR1A and POLR2A. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (By similarity). Interacts with GLUT4. Interacts with LLPH (By similarity).By similarity1 Publication

GO - Molecular functioni

  • actin filament binding Source: RGD
  • calmodulin binding Source: RGD
  • microtubule binding Source: InterPro
  • protein C-terminus binding Source: Ensembl
  • Ral GTPase binding Source: Ensembl
  • signaling receptor binding Source: Ensembl

Protein-protein interaction databases

IntActiQ63355, 1 interactor
STRINGi10116.ENSRNOP00000028929

Structurei

3D structure databases

ProteinModelPortaliQ63355
SMRiQ63355
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 712Myosin motorPROSITE-ProRule annotationAdd BLAST685
Domaini715 – 744IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini738 – 767IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini866 – 1040TH1PROSITE-ProRule annotationAdd BLAST175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni589 – 611Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Domaini

Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to a putative PH domain present in its tail domain (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140778
HOGENOMiHOG000260264
InParanoidiQ63355
KOiK10356
OMAiDAYQAKK
OrthoDBiEOG091G0136

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 2 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 2 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit

Sequencei

Sequence statusi: Complete.

Q63355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYRASALGS DGVRVTMESA LTARDRVGVQ DFVLLENFTS EAAFIENLRR
60 70 80 90 100
RFRENLIYTY IGPVLVSVNP YRDLQIYTRQ HMERYRGVSF YEVPPHLFAV
110 120 130 140 150
ADTVYRALRT ERRDQAVMIS GESGAGKTEA TKRLLQFYAE TCPAPERGGA
160 170 180 190 200
VRDRLLQSNP VLEAFGNAKT LRNDNSSRFG KYMDVQFDFK GAPVGGHILS
210 220 230 240 250
YLLEKSRVVH QNHGERNFHV FYQLLEGGEE EALRRLGLER NPQSYLYLVK
260 270 280 290 300
GQCAKVSSIN DKSDWKVVRK ALSVIDFTED EVEDLLSIVA SVLHLGNIHF
310 320 330 340 350
AADEDSNAQV TTENQLKYLT RLLGVEGTTL REALTHRKII AKGEELLSPL
360 370 380 390 400
NLEQAAYARD ALAKAVYSRT FTWLVRKINR SLASKDAESP SWRSTTVLGL
410 420 430 440 450
LDIYGFEVFQ HNSFEQFCIN YCNEKLQQLF IELTLKSEQE EYEAEGIAWE
460 470 480 490 500
PVQYFNNKII CDLVEEKFKG IISILDEECL RPGEATDLTF LEKLEDTIKH
510 520 530 540 550
HPHFLTHKLA DQKTRKSLDR GEFRLLHYAG EVTYSVTGFL DKNNDLLFRN
560 570 580 590 600
LKETMCSSTN PIMAQCFDKS ELSDKKRPET VATQFKMSLL QLVEILRSKE
610 620 630 640 650
PAYIRCIKPN DAKQPGRFDE VLIRHQVKYL GLMENLRVRR AGFAYRRKYE
660 670 680 690 700
AFLQRYKSLC PETWPVWTGR PQDGVAVLVR HLGYKPEEYK MGRTKIFIRF
710 720 730 740 750
PKTLFATEDS LEVRRQSLAT KIQAAWRGFH WRQKFLRVKR SAICIQSWWR
760 770 780 790 800
GTLGRRKAAK RKWAAQTIRR LIRGFILRHA PRCPENAFFL DHVRTSFLLN
810 820 830 840 850
LRRQLPRNVL DTSWPTPPPA LREASELLRE LCMKNMVWKY CRSISPEWKQ
860 870 880 890 900
QLQQKAVASE IFKGKKDNYP QSVPRLFIST RLGTEEISPR VLQALGSEPI
910 920 930 940 950
QYAVPVVKYD RKGYKPRSRQ LLLTPSAVVI VEDAKVKQRI DYANLTGISV
960 970 980 990 1000
SSLSDSLFVL HVQREDSKQK GDVVLQSDHV IETLTKTALS ADRVNNININ
1010 1020 1030 1040
QGSITFAGGP GRDGIIDFTS GSELLITKAK NGHLAVVAPR LNSR
Length:1,044
Mass (Da):119,811
Last modified:April 14, 2009 - v2
Checksum:iF1BDEDE4CD2159A3
GO

Sequence cautioni

The sequence CAA52807 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74800 mRNA Translation: CAA52807.1 Different initiation.
PIRiS37146
RefSeqiNP_075580.2, NM_023092.1
UniGeneiRn.55135

Genome annotation databases

EnsembliENSRNOT00000036666; ENSRNOP00000028929; ENSRNOG00000004072
GeneIDi65261
KEGGirno:65261

Similar proteinsi

Entry informationi

Entry nameiMYO1C_RAT
AccessioniPrimary (citable) accession number: Q63355
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: May 23, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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