Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myelin-oligodendrocyte glycoprotein

Gene

Mog

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.By similarity

GO - Biological processi

  • aging Source: RGD
  • cell adhesion Source: UniProtKB-KW
  • response to folic acid Source: RGD
  • response to lipid Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin-oligodendrocyte glycoprotein
Gene namesi
Name:Mog
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3102. Mog.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 155128ExtracellularSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Topological domaini177 – 20832CytoplasmicSequence analysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST
Topological domaini230 – 24516ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: RGD
  • myelin sheath Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 PublicationAdd
BLAST
Chaini28 – 245218Myelin-oligodendrocyte glycoproteinPRO_0000014890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 125PROSITE-ProRule annotation
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63345.
PRIDEiQ63345.

PTM databases

iPTMnetiQ63345.
SwissPalmiQ63345.
UniCarbKBiQ63345.

Expressioni

Tissue specificityi

Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.

Developmental stagei

A peak of expression has been observed between postnatal days 15 and 25, coinciding with the period of active myelination.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001008.

Structurei

Secondary structure

1
245
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi31 – 333Combined sources
Beta strandi39 – 424Combined sources
Beta strandi47 – 559Combined sources
Beta strandi62 – 687Combined sources
Turni69 – 724Combined sources
Beta strandi74 – 796Combined sources
Helixi85 – 873Combined sources
Turni91 – 944Combined sources
Beta strandi95 – 995Combined sources
Helixi103 – 1053Combined sources
Beta strandi107 – 1148Combined sources
Helixi117 – 1193Combined sources
Beta strandi121 – 1299Combined sources
Beta strandi132 – 14312Combined sources
Turni145 – 1484Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PKOX-ray1.45A28-152[»]
1PKQX-ray3.00E/J28-152[»]
3CSPX-ray1.70A27-152[»]
ProteinModelPortaliQ63345.
SMRiQ63345. Positions 28-145.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63345.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 139110Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKKW. Eukaryota.
ENOG41119UE. LUCA.
HOGENOMiHOG000139597.
HOVERGENiHBG004565.
InParanoidiQ63345.
PhylomeDBiQ63345.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR016663. Myelin-oligodendrocyte_glycop.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PIRSFiPIRSF016522. MOG. 1 hit.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63345-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVWSLSLP SCLLSLLLLL QLSRSYAGQF RVIGPGHPIR ALVGDEAELP
60 70 80 90 100
CRISPGKNAT GMEVGWYRSP FSRVVHLYRN GKDQDAEQAP EYRGRTELLK
110 120 130 140 150
ESIGEGKVAL RIQNVRFSDE GGYTCFFRDH SYQEEAAVEL KVEDPFYWIN
160 170 180 190 200
PGVLALIALV PMLLLQVSVG LVFLFLQHRL RGKLRAEVEN LHRTFDPHFL
210 220 230 240
RVPCWKITLF VIVPVLGPLV ALIICYNWLH RRLAGQFLEE LRNPF
Length:245
Mass (Da):27,882
Last modified:November 1, 1997 - v1
Checksum:iC97F8AD60D6A32B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99485 mRNA. Translation: AAA41628.1.
L21995 mRNA. Translation: AAF74786.1.
PIRiB47712.
UniGeneiRn.9687.

Genome annotation databases

UCSCiRGD:3102. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99485 mRNA. Translation: AAA41628.1.
L21995 mRNA. Translation: AAF74786.1.
PIRiB47712.
UniGeneiRn.9687.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PKOX-ray1.45A28-152[»]
1PKQX-ray3.00E/J28-152[»]
3CSPX-ray1.70A27-152[»]
ProteinModelPortaliQ63345.
SMRiQ63345. Positions 28-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001008.

PTM databases

iPTMnetiQ63345.
SwissPalmiQ63345.
UniCarbKBiQ63345.

Proteomic databases

PaxDbiQ63345.
PRIDEiQ63345.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3102. rat.

Organism-specific databases

RGDi3102. Mog.

Phylogenomic databases

eggNOGiENOG410IKKW. Eukaryota.
ENOG41119UE. LUCA.
HOGENOMiHOG000139597.
HOVERGENiHBG004565.
InParanoidiQ63345.
PhylomeDBiQ63345.

Miscellaneous databases

EvolutionaryTraceiQ63345.
PROiQ63345.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR016663. Myelin-oligodendrocyte_glycop.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PIRSFiPIRSF016522. MOG. 1 hit.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Myelin/oligodendrocyte glycoprotein is a unique member of the immunoglobulin superfamily."
    Gardinier M.V., Amiguet P., Linington C., Matthieu J.-M.
    J. Neurosci. Res. 33:177-187(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
  2. "Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex."
    Pham-Dinh D., Mattei M.-G., Nussbaum J.-L., Roussel G., Pontarotti P., Roeckel N., Mather I.H., Artzt K., Lindahl K.F., Dautigny A.
    Proc. Natl. Acad. Sci. U.S.A. 90:7990-7994(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-245.
    Tissue: Brain.
  3. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 32-68; 83-93; 129-141; 186-193 AND 233-242, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  4. "A conformational study of the human and rat encephalitogenic myelin oligodendrocyte glycoprotein peptides 35-55."
    Albouz-Abo S., Wilson J.C., Bernard C.C.A., von Itzstein M.
    Eur. J. Biochem. 246:59-70(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 62-82.

Entry informationi

Entry nameiMOG_RAT
AccessioniPrimary (citable) accession number: Q63345
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 11, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.