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Protein

Monocarboxylate transporter 2

Gene

Slc16a7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 2
Short name:
MCT 2
Alternative name(s):
Solute carrier family 16 member 7
Gene namesi
Name:Slc16a7
Synonyms:Mct2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3691. Slc16a7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 65ExtracellularSequence analysisAdd BLAST23
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 95CytoplasmicSequence analysis9
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 121ExtracellularSequence analysis5
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 154CytoplasmicSequence analysisAdd BLAST12
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 179ExtracellularSequence analysis4
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 250CytoplasmicSequence analysisAdd BLAST50
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 286ExtracellularSequence analysisAdd BLAST15
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 316CytoplasmicSequence analysis9
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Topological domaini338 – 342ExtracellularSequence analysis5
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 377CytoplasmicSequence analysisAdd BLAST14
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 410ExtracellularSequence analysisAdd BLAST12
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Topological domaini432 – 489CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

  • cytoplasm Source: RGD
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113891 – 489Monocarboxylate transporter 2Add BLAST489

Proteomic databases

PaxDbiQ63344.
PRIDEiQ63344.

PTM databases

iPTMnetiQ63344.
PhosphoSitePlusiQ63344.

Expressioni

Tissue specificityi

Detected in brain and kidney (at protein level).1 Publication

Interactioni

Subunit structurei

Interacts with GRID2IP (By similarity). Interacts with EMB.By similarity2 Publications

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054845.

Structurei

3D structure databases

ProteinModelPortaliQ63344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiQ63344.
PhylomeDBiQ63344.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004743. MCT.
IPR027178. MCT2.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF25. PTHR11360:SF25. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63344-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSESSVKAT AAPPPFPLPP DGGWGWVVVC ASFISIGFSY AFPKAVTVFF
60 70 80 90 100
NDIKDIFKTT SSQIAWISSI MLAVMYAGGP ISSVLVNNYG SRPVLIVGGL
110 120 130 140 150
LCCTGMILAS FSSSVIELYL TVGFIGGLGL AFNLQPALTI IGKYFYRKRP
160 170 180 190 200
LANGFAMAGS PVFLSTLAPF NQFLFNSYGW KGSFLILGAI FLHSCVAGCL
210 220 230 240 250
MRPVGPSPRA AKSKSKVGSR QDSSTKRLSK VSTAEKINRF LDFGLFTHRG
260 270 280 290 300
FLIYLSGNVV LFLGMFAPII FLAPYAKDKG VDDYNSAFLL SVMAFTDMFA
310 320 330 340 350
RPSVGLIANT SLIRPRIQYL FSVAIMFTGI CHLLCPLAHS YTALVVYVIF
360 370 380 390 400
FGIGFGSISS LLFECLMDQV GASRFSSAVG LVTIVECCPV LFGPPLAGKL
410 420 430 440 450
LDITGQYKYL YIASGIVVLS SGIYLLICNA INYRLLEKER KREKARRKKS
460 470 480
ASQASKEMEA LSRSKQDDVT VKVSNTHNPP SDRDKESSI
Length:489
Mass (Da):53,057
Last modified:November 1, 1996 - v1
Checksum:i447E1CE2D707044B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95L → V in AAB04023 (PubMed:9482213).Curated1
Sequence conflicti392F → P in AAB04023 (PubMed:9482213).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97445 mRNA. Translation: CAA66074.1.
U62316 mRNA. Translation: AAB04023.1.
UniGeneiRn.10524.
Rn.217495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97445 mRNA. Translation: CAA66074.1.
U62316 mRNA. Translation: AAB04023.1.
UniGeneiRn.10524.
Rn.217495.

3D structure databases

ProteinModelPortaliQ63344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054845.

PTM databases

iPTMnetiQ63344.
PhosphoSitePlusiQ63344.

Proteomic databases

PaxDbiQ63344.
PRIDEiQ63344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi3691. Slc16a7.

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiQ63344.
PhylomeDBiQ63344.

Miscellaneous databases

PROiQ63344.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004743. MCT.
IPR027178. MCT2.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF25. PTHR11360:SF25. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT2_RAT
AccessioniPrimary (citable) accession number: Q63344
Secondary accession number(s): Q63649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.