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Q63340

- DUS7_RAT

UniProt

Q63340 - DUS7_RAT

Protein

Dual specificity protein phosphatase 7

Gene

Dusp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Regulates the activity of the MAP kinase family in response to changes in the cellular environment.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei192 – 1921Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: Ensembl
    2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 7 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    Dual specificity protein phosphatase MKP-X
    Gene namesi
    Name:Dusp7
    Synonyms:Mkpx
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi735026. Dusp7.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 280›280Dual specificity protein phosphatase 7PRO_0000094809Add
    BLAST

    Proteomic databases

    PaxDbiQ63340.

    Expressioni

    Gene expression databases

    GenevestigatoriQ63340.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000014770.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63340.
    SMRiQ63340. Positions 24-54, 104-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini169 – 23769Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    HOGENOMiHOG000294079.
    HOVERGENiHBG007347.
    InParanoidiQ63340.
    PhylomeDBiQ63340.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
    PRINTSiPR01764. MAPKPHPHTASE.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q63340-1 [UniParc]FASTAAdd to Basket

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    TAEWQPEPGA PASVLGLLLQ KLRDDGCQAY YLQGGFNKFQ TEYSEHCETN    50
    VDSSSSPSGS PPTSVLGLGG LRISSDCSDG ESDRELPSSA TESDGSPVPS 100
    SQPAFPVQIL PYLYLGCAKD STNLDVLGKY GIKYILNVTP NLPNAFEHGG 150
    EFTYKQIPIS DHWSQNLSQF FPEAISFIDE ARSKKCGVLV HCLAGISRSV 200
    TVTVAYLMQK MNLSLNDAYD FVKRKKSNIS PNFNFMGQLL DFERTLGLSS 250
    PCDNHTPSEQ LYFSTPTNHN LFPINTLEST 280
    Length:280
    Mass (Da):30,668
    Last modified:November 1, 1996 - v1
    Checksum:i45D6F4A92F2BBDDF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94186 mRNA. Translation: CAA63896.1.
    UniGeneiRn.104502.

    Genome annotation databases

    UCSCiRGD:735026. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94186 mRNA. Translation: CAA63896.1 .
    UniGenei Rn.104502.

    3D structure databases

    ProteinModelPortali Q63340.
    SMRi Q63340. Positions 24-54, 104-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000014770.

    Proteomic databases

    PaxDbi Q63340.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:735026. rat.

    Organism-specific databases

    RGDi 735026. Dusp7.

    Phylogenomic databases

    eggNOGi COG2453.
    HOGENOMi HOG000294079.
    HOVERGENi HBG007347.
    InParanoidi Q63340.
    PhylomeDBi Q63340.

    Miscellaneous databases

    PROi Q63340.

    Gene expression databases

    Genevestigatori Q63340.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000939. MAPK_Ptase. 1 hit.
    PRINTSi PR01764. MAPKPHPHTASE.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase."
      Muda M., Boschert U., Dickinson R., Martinou J.-C., Martinou I., Camps M., Schlegel W., Arkinstall S.
      J. Biol. Chem. 271:4319-4326(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Neuron.

    Entry informationi

    Entry nameiDUS7_RAT
    AccessioniPrimary (citable) accession number: Q63340
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3