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Q63340

- DUS7_RAT

UniProt

Q63340 - DUS7_RAT

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Protein

Dual specificity protein phosphatase 7

Gene

Dusp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regulates the activity of the MAP kinase family in response to changes in the cellular environment.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei192 – 1921Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: Ensembl
  2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  3. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_253470. ERKs are inactivated.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 7 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity protein phosphatase MKP-X
Gene namesi
Name:Dusp7
Synonyms:Mkpx
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi735026. Dusp7.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 280›280Dual specificity protein phosphatase 7PRO_0000094809Add
BLAST

Proteomic databases

PaxDbiQ63340.

Expressioni

Gene expression databases

ExpressionAtlasiQ63340. baseline.
GenevestigatoriQ63340.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014770.

Structurei

3D structure databases

ProteinModelPortaliQ63340.
SMRiQ63340. Positions 24-54, 104-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini169 – 23769Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
HOGENOMiHOG000294079.
HOVERGENiHBG007347.
InParanoidiQ63340.
PhylomeDBiQ63340.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q63340-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
TAEWQPEPGA PASVLGLLLQ KLRDDGCQAY YLQGGFNKFQ TEYSEHCETN
60 70 80 90 100
VDSSSSPSGS PPTSVLGLGG LRISSDCSDG ESDRELPSSA TESDGSPVPS
110 120 130 140 150
SQPAFPVQIL PYLYLGCAKD STNLDVLGKY GIKYILNVTP NLPNAFEHGG
160 170 180 190 200
EFTYKQIPIS DHWSQNLSQF FPEAISFIDE ARSKKCGVLV HCLAGISRSV
210 220 230 240 250
TVTVAYLMQK MNLSLNDAYD FVKRKKSNIS PNFNFMGQLL DFERTLGLSS
260 270 280
PCDNHTPSEQ LYFSTPTNHN LFPINTLEST
Length:280
Mass (Da):30,668
Last modified:November 1, 1996 - v1
Checksum:i45D6F4A92F2BBDDF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94186 mRNA. Translation: CAA63896.1.
UniGeneiRn.104502.

Genome annotation databases

UCSCiRGD:735026. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94186 mRNA. Translation: CAA63896.1 .
UniGenei Rn.104502.

3D structure databases

ProteinModelPortali Q63340.
SMRi Q63340. Positions 24-54, 104-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000014770.

Proteomic databases

PaxDbi Q63340.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:735026. rat.

Organism-specific databases

RGDi 735026. Dusp7.

Phylogenomic databases

eggNOGi COG2453.
HOGENOMi HOG000294079.
HOVERGENi HBG007347.
InParanoidi Q63340.
PhylomeDBi Q63340.

Enzyme and pathway databases

Reactomei REACT_253470. ERKs are inactivated.

Miscellaneous databases

PROi Q63340.

Gene expression databases

ExpressionAtlasi Q63340. baseline.
Genevestigatori Q63340.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PIRSFi PIRSF000939. MAPK_Ptase. 1 hit.
PRINTSi PR01764. MAPKPHPHTASE.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase."
    Muda M., Boschert U., Dickinson R., Martinou J.-C., Martinou I., Camps M., Schlegel W., Arkinstall S.
    J. Biol. Chem. 271:4319-4326(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Neuron.

Entry informationi

Entry nameiDUS7_RAT
AccessioniPrimary (citable) accession number: Q63340
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3