Q63340 (DUS7_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity protein phosphatase 7
EC=3.1.3.16
EC=3.1.3.48

Alternative name(s):
Dual specificity protein phosphatase MKP-X

Gene names

Name:	Dusp7
Synonyms:	Mkpx

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	280 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Regulates the activity of the MAP kinase family in response to changes in the cellular environment By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytosol Inferred from direct assay Ref.1. Source: RGD
Molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity Inferred from Biological aspect of Ancestor. Source: RefGenome protein tyrosine phosphatase activity Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 280	›280	Dual specificity protein phosphatase 7		PRO_0000094809
Regions
	Domain	169 – 237	69	Tyrosine-protein phosphatase
Sites
	Active site	192	1	Phosphocysteine intermediate By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q63340 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 45D6F4A92F2BBDDF	FASTA	280	30,668
	10 20 30 40 50 60 TAEWQPEPGA PASVLGLLLQ KLRDDGCQAY YLQGGFNKFQ TEYSEHCETN VDSSSSPSGS 70 80 90 100 110 120 PPTSVLGLGG LRISSDCSDG ESDRELPSSA TESDGSPVPS SQPAFPVQIL PYLYLGCAKD 130 140 150 160 170 180 STNLDVLGKY GIKYILNVTP NLPNAFEHGG EFTYKQIPIS DHWSQNLSQF FPEAISFIDE 190 200 210 220 230 240 ARSKKCGVLV HCLAGISRSV TVTVAYLMQK MNLSLNDAYD FVKRKKSNIS PNFNFMGQLL 250 260 270 280 DFERTLGLSS PCDNHTPSEQ LYFSTPTNHN LFPINTLEST

References

[1]

"MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase." Muda M., Boschert U., Dickinson R., Martinou J.-C., Martinou I., Camps M., Schlegel W., Arkinstall S. J. Biol. Chem. 271:4319-4326(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Neuron.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X94186 mRNA. Translation: CAA63896.1.
IPI	IPI00372474.
UniGene	Rn.104502.
3D structure databases
ProteinModelPortal	Q63340.
SMR	Q63340. Positions 24-54, 104-246.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000014770.
Proteomic databases
PaxDb	Q63340.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:735026. rat.
Organism-specific databases
RGD	735026. Dusp7.
Phylogenomic databases
eggNOG	COG2453.
HOGENOM	HOG000294079.
HOVERGEN	HBG007347.
InParanoid	Q63340.
OrthoDB	EOG4GB76F.
Gene expression databases
ArrayExpress	Q63340.
Genevestigator	Q63340.
GermOnline	ENSRNOG00000010789. Rattus norvegicus.
Family and domain databases
Gene3D	3.40.250.10. 1 hit.
InterPro	IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR008343. MKP. IPR001763. Rhodanese-like_dom. IPR000387. Tyr/Dual-sp_Pase. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PIRSF	PIRSF000939. MAPK_Ptase. 1 hit.
PRINTS	PR01764. MAPKPHPHTASE.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUS7_RAT

Accession

Primary (citable) accession number: Q63340

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program