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Q63340 (DUS7_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase 7

EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
Dual specificity protein phosphatase MKP-X
Gene names
Name:Dusp7
Synonyms:Mkpx
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length280 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulates the activity of the MAP kinase family in response to changes in the cellular environment By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 280›280Dual specificity protein phosphatase 7
PRO_0000094809

Regions

Domain169 – 23769Tyrosine-protein phosphatase

Sites

Active site1921Phosphocysteine intermediate By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q63340 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 45D6F4A92F2BBDDF

FASTA28030,668
        10         20         30         40         50         60 
TAEWQPEPGA PASVLGLLLQ KLRDDGCQAY YLQGGFNKFQ TEYSEHCETN VDSSSSPSGS 

        70         80         90        100        110        120 
PPTSVLGLGG LRISSDCSDG ESDRELPSSA TESDGSPVPS SQPAFPVQIL PYLYLGCAKD 

       130        140        150        160        170        180 
STNLDVLGKY GIKYILNVTP NLPNAFEHGG EFTYKQIPIS DHWSQNLSQF FPEAISFIDE 

       190        200        210        220        230        240 
ARSKKCGVLV HCLAGISRSV TVTVAYLMQK MNLSLNDAYD FVKRKKSNIS PNFNFMGQLL 

       250        260        270        280 
DFERTLGLSS PCDNHTPSEQ LYFSTPTNHN LFPINTLEST 

« Hide

References

[1]"MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase."
Muda M., Boschert U., Dickinson R., Martinou J.-C., Martinou I., Camps M., Schlegel W., Arkinstall S.
J. Biol. Chem. 271:4319-4326(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Neuron.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X94186 mRNA. Translation: CAA63896.1.
UniGeneRn.104502.

3D structure databases

ProteinModelPortalQ63340.
SMRQ63340. Positions 24-54, 104-246.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000014770.

Proteomic databases

PaxDbQ63340.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:735026. rat.

Organism-specific databases

RGD735026. Dusp7.

Phylogenomic databases

eggNOGCOG2453.
HOGENOMHOG000294079.
HOVERGENHBG007347.
InParanoidQ63340.
PhylomeDBQ63340.

Gene expression databases

GenevestigatorQ63340.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PIRSFPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSPR01764. MAPKPHPHTASE.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ63340.

Entry information

Entry nameDUS7_RAT
AccessionPrimary (citable) accession number: Q63340
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families