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Protein

Myelin-associated oligodendrocyte basic protein

Gene

Mobp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.1 Publication

GO - Molecular functioni

  • structural constituent of myelin sheath Source: RGD

GO - Biological processi

  • nervous system development Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin-associated oligodendrocyte basic protein
Gene namesi
Name:Mobp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi3101. Mobp.

Subcellular locationi

  • Cytoplasmperinuclear region 2 Publications

  • Note: Present in the major dense line of CNS myelin. Isoform 5 may be differentially localized in the oligodendrocytes or perinuclear region. Isoform 2, 4, 5 and 6 are highly enriched in myelin. Isoform 1 and 3 are not enriched in mylein.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Myelin-associated oligodendrocyte basic proteinPRO_0000281027Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei85 – 851PhosphoserineCombined sources
Modified residuei98 – 981PhosphoserineCombined sources
Modified residuei107 – 1071PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63327.
PRIDEiQ63327.

PTM databases

iPTMnetiQ63327.
PhosphoSiteiQ63327.
SwissPalmiQ63327.

Expressioni

Tissue specificityi

Expressed predominanty in oligodendrocytes, in CNS myelin of the cerebrum and spinal cord. No expression seen in sciatic nerve.2 Publications

Developmental stagei

Expression in different brain regions during development is correlated with the progression of myelin formation. Isoform 5 seems to be the most abundant spliced form expressed during development. Expressed at P7 in optic nerve, at this time point, the first compact myelin is formed. At P9 abundantly expressed in the optic nerve.1 Publication

Gene expression databases

BgeeiENSRNOG00000018700.
ExpressionAtlasiQ63327. baseline and differential.
GenevisibleiQ63327. RN.

Interactioni

Protein-protein interaction databases

BioGridi247116. 1 interaction.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati93 – 10191
Repeati105 – 11062; half-length
Repeati111 – 11993

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 119273 X 9 AA approximate tandem repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi75 – 15581Pro-richAdd
BLAST

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JBJP. Eukaryota.
ENOG41115IU. LUCA.
GeneTreeiENSGT00750000117828.
HOGENOMiHOG000054197.
HOVERGENiHBG081977.
InParanoidiQ63327.
OMAiCACQKTS.
OrthoDBiEOG091G14LC.
PhylomeDBiQ63327.

Family and domain databases

InterProiIPR026666. Mobp.
IPR011011. Znf_FYVE_PHD.
[Graphical view]
PANTHERiPTHR14555:SF5. PTHR14555:SF5. 1 hit.
PfamiPF02318. FYVE_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q63327-1) [UniParc]FASTAAdd to basket
Also known as: rOPRP1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQKVAKEGP RLSKNQKFSE HFSIHCCPPF TFLNSKREIV DRKYSICKSG
60 70 80 90 100
CFYQKKEEDW ICCACQKTSR RATSPQKPKH QPAASPVVVR APPAKPKSPP
110 120 130 140 150
RPAKPRSPPI PAKPRSPSRT ERQPRPRPEV RPPPAKQKPP QKSKQPARSS
160 170
PLRGPGTSRG GSPTRAPRFW
Length:170
Mass (Da):19,103
Last modified:November 1, 1996 - v1
Checksum:i9B2119B1CACDBEF5
GO
Isoform 2 (identifier: Q63327-2) [UniParc]FASTAAdd to basket
Also known as: MOBP169

The sequence of this isoform differs from the canonical sequence as follows:
     170-170: Missing.

Show »
Length:169
Mass (Da):18,917
Checksum:iF119B1CACDBEF5A4
GO
Isoform 3 (identifier: Q63327-3) [UniParc]FASTAAdd to basket
Also known as: MOBP69

The sequence of this isoform differs from the canonical sequence as follows:
     69-69: S → R
     70-170: Missing.

Show »
Length:69
Mass (Da):8,153
Checksum:iB7AD5C115CA0D11C
GO
Isoform 4 (identifier: Q63327-4) [UniParc]FASTAAdd to basket
Also known as: MOBP99

The sequence of this isoform differs from the canonical sequence as follows:
     69-99: SRRATSPQKPKHQPAASPVVVRAPPAKPKSP → RIRAYAYILTAHNPVLVIAYIRRSHRSHSFF
     100-170: Missing.

Show »
Length:99
Mass (Da):11,709
Checksum:iE42E7799C8894F4C
GO
Isoform 5 (identifier: Q63327-5) [UniParc]FASTAAdd to basket
Also known as: MOBP81-A, MOBP81-B

The sequence of this isoform differs from the canonical sequence as follows:
     69-81: SRRATSPQKPKHQ → RLRRRSRSTPRKK
     82-170: Missing.

Show »
Length:81
Mass (Da):9,676
Checksum:i34483F1D9041284F
GO
Isoform 6 (identifier: Q63327-6) [UniParc]FASTAAdd to basket
Also known as: rOP1, MOBP71

The sequence of this isoform differs from the canonical sequence as follows:
     69-71: SRR → RTV
     72-170: Missing.

Show »
Length:71
Mass (Da):8,354
Checksum:iDC7137AD5C115CA0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei69 – 9931SRRAT…KPKSP → RIRAYAYILTAHNPVLVIAY IRRSHRSHSFF in isoform 4. 1 PublicationVSP_023943Add
BLAST
Alternative sequencei69 – 8113SRRAT…KPKHQ → RLRRRSRSTPRKK in isoform 5. 2 PublicationsVSP_023944Add
BLAST
Alternative sequencei69 – 713SRR → RTV in isoform 6. 1 PublicationVSP_023945
Alternative sequencei69 – 691S → R in isoform 3. 1 PublicationVSP_023946
Alternative sequencei70 – 170101Missing in isoform 3. 1 PublicationVSP_023947Add
BLAST
Alternative sequencei72 – 17099Missing in isoform 6. 1 PublicationVSP_023948Add
BLAST
Alternative sequencei82 – 17089Missing in isoform 5. 2 PublicationsVSP_023949Add
BLAST
Alternative sequencei100 – 17071Missing in isoform 4. 1 PublicationVSP_023950Add
BLAST
Alternative sequencei170 – 1701Missing in isoform 2. 1 PublicationVSP_023951

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28110 mRNA. Translation: BAA05657.1.
D28111 mRNA. Translation: BAA05658.1.
AF157498 mRNA. Translation: AAD44968.1.
X87900 mRNA. Translation: CAA61151.1.
X89637 mRNA. Translation: CAA61795.1.
X89638 mRNA. Translation: CAA61796.1.
X90402 mRNA. Translation: CAA62039.1.
BC087694 mRNA. Translation: AAH87694.1.
PIRiB55663.
RefSeqiNP_036852.1. NM_012720.1. [Q63327-5]
XP_006244127.1. XM_006244065.2. [Q63327-1]
XP_006244129.1. XM_006244067.2. [Q63327-1]
XP_006244131.1. XM_006244069.2. [Q63327-2]
XP_008764891.1. XM_008766669.1. [Q63327-1]
UniGeneiRn.91185.

Genome annotation databases

EnsembliENSRNOT00000025279; ENSRNOP00000025279; ENSRNOG00000018700. [Q63327-1]
ENSRNOT00000025343; ENSRNOP00000025344; ENSRNOG00000018700. [Q63327-5]
GeneIDi25037.
KEGGirno:25037.
UCSCiRGD:3101. rat. [Q63327-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28110 mRNA. Translation: BAA05657.1.
D28111 mRNA. Translation: BAA05658.1.
AF157498 mRNA. Translation: AAD44968.1.
X87900 mRNA. Translation: CAA61151.1.
X89637 mRNA. Translation: CAA61795.1.
X89638 mRNA. Translation: CAA61796.1.
X90402 mRNA. Translation: CAA62039.1.
BC087694 mRNA. Translation: AAH87694.1.
PIRiB55663.
RefSeqiNP_036852.1. NM_012720.1. [Q63327-5]
XP_006244127.1. XM_006244065.2. [Q63327-1]
XP_006244129.1. XM_006244067.2. [Q63327-1]
XP_006244131.1. XM_006244069.2. [Q63327-2]
XP_008764891.1. XM_008766669.1. [Q63327-1]
UniGeneiRn.91185.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247116. 1 interaction.

PTM databases

iPTMnetiQ63327.
PhosphoSiteiQ63327.
SwissPalmiQ63327.

Proteomic databases

PaxDbiQ63327.
PRIDEiQ63327.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025279; ENSRNOP00000025279; ENSRNOG00000018700. [Q63327-1]
ENSRNOT00000025343; ENSRNOP00000025344; ENSRNOG00000018700. [Q63327-5]
GeneIDi25037.
KEGGirno:25037.
UCSCiRGD:3101. rat. [Q63327-1]

Organism-specific databases

CTDi4336.
RGDi3101. Mobp.

Phylogenomic databases

eggNOGiENOG410JBJP. Eukaryota.
ENOG41115IU. LUCA.
GeneTreeiENSGT00750000117828.
HOGENOMiHOG000054197.
HOVERGENiHBG081977.
InParanoidiQ63327.
OMAiCACQKTS.
OrthoDBiEOG091G14LC.
PhylomeDBiQ63327.

Miscellaneous databases

PROiQ63327.

Gene expression databases

BgeeiENSRNOG00000018700.
ExpressionAtlasiQ63327. baseline and differential.
GenevisibleiQ63327. RN.

Family and domain databases

InterProiIPR026666. Mobp.
IPR011011. Znf_FYVE_PHD.
[Graphical view]
PANTHERiPTHR14555:SF5. PTHR14555:SF5. 1 hit.
PfamiPF02318. FYVE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOBP_RAT
AccessioniPrimary (citable) accession number: Q63327
Secondary accession number(s): Q63328
, Q63343, Q63519, Q64266, Q9QZV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.