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Protein

Cadherin-22

Gene

Cdh22

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-22
Alternative name(s):
Pituitary and brain cadherin
Short name:
PB-cadherin
Gene namesi
Name:Cdh22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2321. Cdh22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 621ExtracellularSequence analysisAdd BLAST588
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 813CytoplasmicSequence analysisAdd BLAST171

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000000382334 – 813Cadherin-22Add BLAST780

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1
Glycosylationi463N-linked (GlcNAc...)Sequence analysis1
Glycosylationi609N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ63315.

Expressioni

Tissue specificityi

Strongly expressed in the pituitary gland and the brain (in the inner granular and glomerular layers of the olfactory bulb, anterior olfactory nucleus, primary olfactory cortex, Purkinje cell layer of cerebellum, and pineal gland). Low expression in lung and heart. No expression in submandibular gland, thymus, liver, spleen, adrenal, and kidney.

Developmental stagei

Expressed strongly in fetal brain.

Gene expression databases

BgeeiENSRNOG00000018557.
ExpressionAtlasiQ63315. baseline and differential.
GenevisibleiQ63315. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025150.

Structurei

3D structure databases

ProteinModelPortaliQ63315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 165Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini166 – 274Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini275 – 391Cadherin 3PROSITE-ProRule annotationAdd BLAST117
Domaini392 – 495Cadherin 4PROSITE-ProRule annotationAdd BLAST104
Domaini496 – 613Cadherin 5PROSITE-ProRule annotationAdd BLAST118

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOVERGENiHBG005217.
InParanoidiQ63315.
KOiK06812.
OMAiHHKSHLS.
OrthoDBiEOG091G02GU.
PhylomeDBiQ63315.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q63315-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPRPAGALR AGAALSPVLL LLLLLQLLGH LWAASTPAPS SLSPGTQQDN
60 70 80 90 100
QLGAGRVKRG WVWNQFFVVE EYTGTEPLYV GKIHSDSDEG DGTIKYTISG
110 120 130 140 150
EGAGTIFLID ELTGDIHATE RLDREQKTFY TLRAQARDRA TNRLLEPESE
160 170 180 190 200
FIIKVQDIND SEPRFLHGPY IGSVAELSPT GTSVMQVMAS DADDPTYGSS
210 220 230 240 250
ARLVYSVLDG EHHFTVDPKT GVIRTAVPDL DRESQERYEV VIQATDMAGQ
260 270 280 290 300
LGGLSGSTTV TIVVTDVNDN PPRFPQKMYQ FSIQESAPIG TAVGRVKAED
310 320 330 340 350
SDVGENTDMT YHLREESGSG GDAFKVTTDS DTQEAIIVVQ KHLDFESQQV
360 370 380 390 400
HTVVLEALNK FVDPRFADLG TFRDQAIVRV AVTDVDEPPE FRPPSGLLEV
410 420 430 440 450
QEDAQVGSLV GVVTARDPDA ANRPVRYAID RDSDLEQIFD IDADTGAIVT
460 470 480 490 500
GKGLDRETAG WHNITVLAME ADNHAQLSRA SLRIRILDVN DNPPELATPY
510 520 530 540 550
EAAVCEDAKP GQLIQTISVV DRDEPQGGHR FYFRLVPEEP SNPHFSLLDI
560 570 580 590 600
EDNTAAVHTQ HVGFNRQEQD VFLLPILVVD SGPPTLSSTG TLTIRICGCD
610 620 630 640 650
SSGTIQSCNT TAFVMAASLS PGALIALLVC VLILVVLALL ILTLRRHHKS
660 670 680 690 700
HLSSDVDEDM RDNVIKYNDE GGGEQDTEAY DMSALRSLYD FGELKGGDPG
710 720 730 740 750
GGAASPPQAA SSSERHSLPR GPSSPEPDFS VFRDFISRKV ALADADLSVP
760 770 780 790 800
PYDAFQTYAF EGAGSPAASL SSLHSGSTGS EQDFAFLRAW GPRFRPLAAL
810
YAGHRGDDEA PAS
Length:813
Mass (Da):87,979
Last modified:November 1, 1996 - v1
Checksum:i30BEA60B5D2D467B
GO
Isoform 2 (identifier: Q63315-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     668-694: NDEGGGEQDTEAYDMSALRSLYDFGEL → TLGSGHRGTSNKEDHQCPASLSLGFKP
     695-813: Missing.

Note: No experimental confirmation available.
Show »
Length:694
Mass (Da):75,545
Checksum:i8EDAF75552AEA9D3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000643668 – 694NDEGG…DFGEL → TLGSGHRGTSNKEDHQCPAS LSLGFKP in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_000644695 – 813Missing in isoform 2. 1 PublicationAdd BLAST119

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83348 mRNA. Translation: BAA11894.1.
D83349 mRNA. Translation: BAA11895.1.
RefSeqiNP_062034.2. NM_019161.2. [Q63315-1]
UniGeneiRn.108785.

Genome annotation databases

EnsembliENSRNOT00000025150; ENSRNOP00000025150; ENSRNOG00000018557. [Q63315-1]
GeneIDi29182.
KEGGirno:29182.
UCSCiRGD:2321. rat. [Q63315-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83348 mRNA. Translation: BAA11894.1.
D83349 mRNA. Translation: BAA11895.1.
RefSeqiNP_062034.2. NM_019161.2. [Q63315-1]
UniGeneiRn.108785.

3D structure databases

ProteinModelPortaliQ63315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025150.

Proteomic databases

PaxDbiQ63315.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025150; ENSRNOP00000025150; ENSRNOG00000018557. [Q63315-1]
GeneIDi29182.
KEGGirno:29182.
UCSCiRGD:2321. rat. [Q63315-1]

Organism-specific databases

CTDi64405.
RGDi2321. Cdh22.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOVERGENiHBG005217.
InParanoidiQ63315.
KOiK06812.
OMAiHHKSHLS.
OrthoDBiEOG091G02GU.
PhylomeDBiQ63315.

Miscellaneous databases

PROiQ63315.

Gene expression databases

BgeeiENSRNOG00000018557.
ExpressionAtlasiQ63315. baseline and differential.
GenevisibleiQ63315. RN.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD22_RAT
AccessioniPrimary (citable) accession number: Q63315
Secondary accession number(s): Q63561
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.