Q63312 (PHLB1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pleckstrin homology-like domain family B member 1

Alternative name(s):
Protein LL5-alpha

Gene names

Name:	Phldb1
Synonyms:	Ll5

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	831 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Domain	The PH domain mediates the binding to phosphoinositides By similarity.
Sequence similarities	Contains 1 PH domain.
Sequence caution	The sequence CAA52297.1 differs from that shown. Reason: Frameshift at position 101.

Ontologies

Keywords
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 831	›831	Pleckstrin homology-like domain family B member 1		PRO_0000053893
Regions
	Domain	721 – 824	104	PH
	Coiled coil	180 – 306	127	Potential
	Coiled coil	610 – 676	67	Potential
Amino acid modifications
	Modified residue	10	1	Phosphothreonine By similarity
	Modified residue	12	1	Phosphoserine By similarity
	Modified residue	14	1	Phosphoserine By similarity
	Modified residue	33	1	Phosphoserine By similarity
	Modified residue	45	1	Phosphoserine By similarity
	Modified residue	49	1	Phosphoserine By similarity
	Modified residue	57	1	Phosphoserine By similarity
	Modified residue	77	1	Phosphoserine By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q63312 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: 16AFCA423765E596	FASTA	831	93,541
	10 20 30 40 50 60 LTLGARGRRT RSPSPTLGES LAPRKGSFSG RLSPAYSLGS LTGASPRQSP HAQRKLSSGD 70 80 90 100 110 120 LRVPIPRERK NSITEISDNE DDLLEYHRRQ RQERLREQEM ERLERQRLET ILNLCAEYSR 130 140 150 160 170 180 ADGGPETGEL PSIGEATAAL ALAGRRPSRG LAGAIVVSGR SGEESGGASQ RLWESMERSD 190 200 210 220 230 240 EENLKEECSS TESTQQEHED APSTKLQGEV LAVEEERAQV LGRVEQLKVR VKELEQQLQE 250 260 270 280 290 300 AAREAEMERA LLQGEREAER ALLQKEQRAM DQLQEKLVAL ETGIQKERDK EADALETETK 310 320 330 340 350 360 LFEDLEFQQL ERESRVEEER ELAGQGLLRS KAELLRSVSK RKERLAVLDS QAGQIRAQAV 370 380 390 400 410 420 QESERLAREK NAVLQLLQKE KEKLTVLERR YHSLTGGRPF PKTTSTLKEV YRSKMNGDMA 430 440 450 460 470 480 SPLPRTRSGP LPSSSGSSSS SSQLSVATLG RSPSPKSALL AQNGTSSLPR NLAATLQDIE 490 500 510 520 530 540 TKRQLALQQK VELPPAEPLS PEDPAGHQVI EEQRRRLAEL KQKAAAEAQC QWDALHGAAA 550 560 570 580 590 600 FPAGPSGFPT LMHHSILHHL PAGRERGEEG EHAYDTLSLE SSDSMETSIS TGGNSACSPD 610 620 630 640 650 660 NMSSASGLDM GKIEEMEKML KEAHAEKSRL MESREREMEL RRQALEEERR RREQVERRLQ 670 680 690 700 710 720 SESARRQQLV EKEVKLREKQ FSQARPLTRY LPNRKEDFDL KTHIESSGHG VDTCLHVVLS 730 740 750 760 770 780 SKVCRGYLIK MGGKIKSWKK RWFVFDRLKR TLSYYVDKHE TKLKGVIYFQ AIEEVYYDHL 790 800 810 820 830 RSAAKSPNPA LTFCVKTHDR LYYMVAPSAE AMRIWMDVIV TGAEGYTQFM N

References

[1]	"Cloning of LL5, a novel protein-encoding cDNA from a rat pituitary library." Levi L., Hanukoglu I., Raikhinstein M., Kohen F., Koch Y. Biochim. Biophys. Acta 1216:342-344(1993) [PubMed: 8241284] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Pituitary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X74226 mRNA. Translation: CAA52297.1. Sequence problems.
IPI	IPI00779197.
PIR	S37032.
UniGene	Rn.11128.
3D structure databases
ProteinModelPortal	Q63312.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q63312. 1 interaction.
STRING	Q63312.
PTM databases
PhosphoSite	Q63312.
Proteomic databases
PRIDE	Q63312.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	620878. Phldb1.
Phylogenomic databases
eggNOG	roNOG12055.
GeneTree	ENSGT00530000063148.
HOVERGEN	HBG060305.
Gene expression databases
Genevestigator	Q63312.
GermOnline	ENSRNOG00000026985. Rattus norvegicus.
Family and domain databases
InterPro	IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
Pfam	PF00169. PH. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHLB1_RAT

Accession

Primary (citable) accession number: Q63312

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	September 21, 2011
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program