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Protein

Pleckstrin homology-like domain family B member 1

Gene

Phldb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology-like domain family B member 1
Alternative name(s):
Protein LL5-alpha
Gene namesi
Name:Phldb1
Synonyms:Ll5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620878. Phldb1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000053893‹1 – 831Pleckstrin homology-like domain family B member 1Add BLAST›831

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6Omega-N-methylarginineBy similarity1
Modified residuei12PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei16PhosphothreonineBy similarity1
Modified residuei27PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei49PhosphoserineBy similarity1
Modified residuei57PhosphoserineBy similarity1
Modified residuei72PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei175PhosphoserineBy similarity1
Modified residuei421PhosphoserineBy similarity1
Modified residuei467PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PRIDEiQ63312.

PTM databases

iPTMnetiQ63312.

Interactioni

Protein-protein interaction databases

IntActiQ63312. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ63312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini721 – 824PHPROSITE-ProRule annotationAdd BLAST104

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili180 – 306Sequence analysisAdd BLAST127
Coiled coili610 – 676Sequence analysisAdd BLAST67

Domaini

The PH domain mediates the binding to phosphoinositides.By similarity

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000286004.
HOVERGENiHBG060305.
InParanoidiQ63312.
PhylomeDBiQ63312.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q63312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LTLGARGRRT RSPSPTLGES LAPRKGSFSG RLSPAYSLGS LTGASPRQSP
60 70 80 90 100
HAQRKLSSGD LRVPIPRERK NSITEISDNE DDLLEYHRRQ RQERLREQEM
110 120 130 140 150
ERLERQRLET ILNLCAEYSR ADGGPETGEL PSIGEATAAL ALAGRRPSRG
160 170 180 190 200
LAGAIVVSGR SGEESGGASQ RLWESMERSD EENLKEECSS TESTQQEHED
210 220 230 240 250
APSTKLQGEV LAVEEERAQV LGRVEQLKVR VKELEQQLQE AAREAEMERA
260 270 280 290 300
LLQGEREAER ALLQKEQRAM DQLQEKLVAL ETGIQKERDK EADALETETK
310 320 330 340 350
LFEDLEFQQL ERESRVEEER ELAGQGLLRS KAELLRSVSK RKERLAVLDS
360 370 380 390 400
QAGQIRAQAV QESERLAREK NAVLQLLQKE KEKLTVLERR YHSLTGGRPF
410 420 430 440 450
PKTTSTLKEV YRSKMNGDMA SPLPRTRSGP LPSSSGSSSS SSQLSVATLG
460 470 480 490 500
RSPSPKSALL AQNGTSSLPR NLAATLQDIE TKRQLALQQK VELPPAEPLS
510 520 530 540 550
PEDPAGHQVI EEQRRRLAEL KQKAAAEAQC QWDALHGAAA FPAGPSGFPT
560 570 580 590 600
LMHHSILHHL PAGRERGEEG EHAYDTLSLE SSDSMETSIS TGGNSACSPD
610 620 630 640 650
NMSSASGLDM GKIEEMEKML KEAHAEKSRL MESREREMEL RRQALEEERR
660 670 680 690 700
RREQVERRLQ SESARRQQLV EKEVKLREKQ FSQARPLTRY LPNRKEDFDL
710 720 730 740 750
KTHIESSGHG VDTCLHVVLS SKVCRGYLIK MGGKIKSWKK RWFVFDRLKR
760 770 780 790 800
TLSYYVDKHE TKLKGVIYFQ AIEEVYYDHL RSAAKSPNPA LTFCVKTHDR
810 820 830
LYYMVAPSAE AMRIWMDVIV TGAEGYTQFM N
Length:831
Mass (Da):93,541
Last modified:December 20, 2005 - v2
Checksum:i16AFCA423765E596
GO

Sequence cautioni

The sequence CAA52297 differs from that shown. Reason: Frameshift at position 101.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74226 mRNA. Translation: CAA52297.1. Sequence problems.
PIRiS37032.
UniGeneiRn.11128.

Genome annotation databases

UCSCiRGD:620878. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74226 mRNA. Translation: CAA52297.1. Sequence problems.
PIRiS37032.
UniGeneiRn.11128.

3D structure databases

ProteinModelPortaliQ63312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ63312. 1 interactor.

PTM databases

iPTMnetiQ63312.

Proteomic databases

PRIDEiQ63312.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620878. rat.

Organism-specific databases

RGDi620878. Phldb1.

Phylogenomic databases

HOGENOMiHOG000286004.
HOVERGENiHBG060305.
InParanoidiQ63312.
PhylomeDBiQ63312.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHLB1_RAT
AccessioniPrimary (citable) accession number: Q63312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.