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Protein

Pleckstrin homology-like domain family B member 1

Gene

Phldb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology-like domain family B member 1
Alternative name(s):
Protein LL5-alpha
Gene namesi
Name:Phldb1
Synonyms:Ll5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620878. Phldb1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 831›831Pleckstrin homology-like domain family B member 1PRO_0000053893Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121PhosphoserineCombined sources
Modified residuei14 – 141PhosphoserineCombined sources
Modified residuei16 – 161PhosphothreonineBy similarity
Modified residuei27 – 271PhosphoserineCombined sources
Modified residuei33 – 331PhosphoserineCombined sources
Modified residuei45 – 451PhosphoserineCombined sources
Modified residuei49 – 491PhosphoserineBy similarity
Modified residuei72 – 721PhosphoserineCombined sources
Modified residuei77 – 771PhosphoserineCombined sources
Modified residuei467 – 4671PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ63312.

PTM databases

PhosphoSiteiQ63312.

Interactioni

Protein-protein interaction databases

IntActiQ63312. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ63312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini721 – 824104PHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili180 – 306127Sequence analysisAdd
BLAST
Coiled coili610 – 67667Sequence analysisAdd
BLAST

Domaini

The PH domain mediates the binding to phosphoinositides.By similarity

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000286004.
HOVERGENiHBG060305.
InParanoidiQ63312.
PhylomeDBiQ63312.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q63312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LTLGARGRRT RSPSPTLGES LAPRKGSFSG RLSPAYSLGS LTGASPRQSP
60 70 80 90 100
HAQRKLSSGD LRVPIPRERK NSITEISDNE DDLLEYHRRQ RQERLREQEM
110 120 130 140 150
ERLERQRLET ILNLCAEYSR ADGGPETGEL PSIGEATAAL ALAGRRPSRG
160 170 180 190 200
LAGAIVVSGR SGEESGGASQ RLWESMERSD EENLKEECSS TESTQQEHED
210 220 230 240 250
APSTKLQGEV LAVEEERAQV LGRVEQLKVR VKELEQQLQE AAREAEMERA
260 270 280 290 300
LLQGEREAER ALLQKEQRAM DQLQEKLVAL ETGIQKERDK EADALETETK
310 320 330 340 350
LFEDLEFQQL ERESRVEEER ELAGQGLLRS KAELLRSVSK RKERLAVLDS
360 370 380 390 400
QAGQIRAQAV QESERLAREK NAVLQLLQKE KEKLTVLERR YHSLTGGRPF
410 420 430 440 450
PKTTSTLKEV YRSKMNGDMA SPLPRTRSGP LPSSSGSSSS SSQLSVATLG
460 470 480 490 500
RSPSPKSALL AQNGTSSLPR NLAATLQDIE TKRQLALQQK VELPPAEPLS
510 520 530 540 550
PEDPAGHQVI EEQRRRLAEL KQKAAAEAQC QWDALHGAAA FPAGPSGFPT
560 570 580 590 600
LMHHSILHHL PAGRERGEEG EHAYDTLSLE SSDSMETSIS TGGNSACSPD
610 620 630 640 650
NMSSASGLDM GKIEEMEKML KEAHAEKSRL MESREREMEL RRQALEEERR
660 670 680 690 700
RREQVERRLQ SESARRQQLV EKEVKLREKQ FSQARPLTRY LPNRKEDFDL
710 720 730 740 750
KTHIESSGHG VDTCLHVVLS SKVCRGYLIK MGGKIKSWKK RWFVFDRLKR
760 770 780 790 800
TLSYYVDKHE TKLKGVIYFQ AIEEVYYDHL RSAAKSPNPA LTFCVKTHDR
810 820 830
LYYMVAPSAE AMRIWMDVIV TGAEGYTQFM N
Length:831
Mass (Da):93,541
Last modified:December 20, 2005 - v2
Checksum:i16AFCA423765E596
GO

Sequence cautioni

The sequence CAA52297.1 differs from that shown. Reason: Frameshift at position 101. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74226 mRNA. Translation: CAA52297.1. Sequence problems.
PIRiS37032.
UniGeneiRn.11128.

Genome annotation databases

UCSCiRGD:620878. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74226 mRNA. Translation: CAA52297.1. Sequence problems.
PIRiS37032.
UniGeneiRn.11128.

3D structure databases

ProteinModelPortaliQ63312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ63312. 1 interaction.

PTM databases

PhosphoSiteiQ63312.

Proteomic databases

PRIDEiQ63312.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620878. rat.

Organism-specific databases

RGDi620878. Phldb1.

Phylogenomic databases

HOGENOMiHOG000286004.
HOVERGENiHBG060305.
InParanoidiQ63312.
PhylomeDBiQ63312.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of LL5, a novel protein-encoding cDNA from a rat pituitary library."
    Levi L., Hanukoglu I., Raikhinstein M., Kohen F., Koch Y.
    Biochim. Biophys. Acta 1216:342-344(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Pituitary.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-14; SER-27; SER-33; SER-45; SER-72 AND SER-77, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPHLB1_RAT
AccessioniPrimary (citable) accession number: Q63312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: January 20, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.