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Protein

Keratin, type I cytoskeletal 19

Gene

Krt19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity).By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei270Stutter1
Sitei330Stutter1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-6805567 Keratinization
R-RNO-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 19
Alternative name(s):
Cytokeratin-19
Short name:
CK-19
Keratin-19
Short name:
K19
Type I keratin Ka19
Gene namesi
Name:Krt19
Synonyms:Ka19, Krt1-19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi619936 Krt19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636741 – 403Keratin, type I cytoskeletal 19Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7Omega-N-methylarginineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei24Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei24Omega-N-methylarginine; alternateBy similarity1
Modified residuei27PhosphoserineCombined sources1
Modified residuei32Omega-N-methylarginineBy similarity1
Modified residuei35PhosphoserineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei43Omega-N-methylarginineBy similarity1
Modified residuei51Omega-N-methylarginineBy similarity1
Modified residuei57PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei326PhosphothreonineBy similarity1
Modified residuei394PhosphotyrosineBy similarity1
Modified residuei398PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ63279
PRIDEiQ63279

PTM databases

iPTMnetiQ63279
PhosphoSitePlusiQ63279

Expressioni

Tissue specificityi

Expressed in brain, heart, skin and in costameres of myoplasm at the sarcolemmal membrane in skeletal and cardiac muscle fibers. Undifferentiated gonads and somatic cells of ovarian cords throughout the fetal ovary development.2 Publications

Developmental stagei

Found in somatic cells of ovarian cords throughout the fetal ovary development.1 Publication

Gene expression databases

BgeeiENSRNOG00000014233
GenevisibleiQ63279 RN

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with PNN (By similarity). Interacts with the actin-binding domain of DMD.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DmdP115303EBI-876985,EBI-706166

Protein-protein interaction databases

IntActiQ63279, 1 interactor
STRINGi10116.ENSRNOP00000019133

Structurei

3D structure databases

ProteinModelPortaliQ63279
SMRiQ63279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 394IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 82HeadAdd BLAST82
Regioni83 – 118Coil 1AAdd BLAST36
Regioni119 – 136Linker 1Add BLAST18
Regioni137 – 228Coil 1BAdd BLAST92
Regioni229 – 251Linker 12Add BLAST23
Regioni247 – 393Necessary for interaction with PNNBy similarityAdd BLAST147
Regioni252 – 390Coil 2Add BLAST139
Regioni391 – 403Rod-like helical tailAdd BLAST13

Domaini

This keratin differs from all other IF proteins in lacking the C-terminal tail domain.

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00900000140820
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ63279
KOiK07604
OMAiAHYNNLP
OrthoDBiEOG091G087I
PhylomeDBiQ63279
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 Intermediate_filament_CS
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q63279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSYSYRQSS AMSSYGGMGG GPVRFGSGGV FRAPSIHGGS GGRGVSVSST
60 70 80 90 100
RIVSSSSGGY VGGRGGSFSG ALTVTDGLLG GNEKITMQNL NDRLASYLDK
110 120 130 140 150
VRALEQANGE LEVKIRDWYQ KQGPGPFRDY SQYFKTIEDL RDKILGATIE
160 170 180 190 200
NSKIVLQIDN ARLAADDFRT KFETEQALRM SVEADINGLR RVLDELTLAR
210 220 230 240 250
TDLEMQIENL KEELAYLKKN HEEEISALRS QVGGQVSVEV DSTPGIDLAK
260 270 280 290 300
ILSEMRSQYE AMAEKNRKDA EAWYLTQIDE LNTQVAVHTT QIQINKTEVT
310 320 330 340 350
ELRRKVQDLE IELQSQLSMK AALEGTVAEI EARYGAQLSH IQGVISSIEV
360 370 380 390 400
QLSNVRADTE RQNQEYQQLM DIKSRLEQEI ATYRSLLEGQ EAHYNSLSIA

KAL
Length:403
Mass (Da):44,636
Last modified:August 30, 2005 - v2
Checksum:i8D8E4ED8109EE158
GO

Sequence cautioni

The sequence AAH88424 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143K → N in CAA57205 (PubMed:8541209).Curated1
Sequence conflicti168F → L in CAA57205 (PubMed:8541209).Curated1
Sequence conflicti177A → G in CAA57205 (PubMed:8541209).Curated1
Sequence conflicti248L → H in CAA57205 (PubMed:8541209).Curated1
Sequence conflicti265 – 266KN → MD in CAA57205 (PubMed:8541209).Curated2
Sequence conflicti274 – 280YLTQIDE → LLKIDET in CAA57205 (PubMed:8541209).Curated7
Sequence conflicti303R → E in CAA57205 (PubMed:8541209).Curated1
Sequence conflicti364 – 365QE → HQ in CAA57205 (PubMed:8541209).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY464140 mRNA Translation: AAR36876.1
AABR03073341 Genomic DNA No translation available.
BC088424 mRNA Translation: AAH88424.1 Different initiation.
BC126075 mRNA Translation: AAI26076.1
AH006934 Genomic DNA Translation: AAC64402.1
X81449 mRNA Translation: CAA57205.1
BK004046 mRNA Translation: DAA04480.1
RefSeqiNP_955792.1, NM_199498.2
UniGeneiRn.9359

Genome annotation databases

EnsembliENSRNOT00000019133; ENSRNOP00000019133; ENSRNOG00000014233
GeneIDi360626
KEGGirno:360626
UCSCiRGD:619936 rat

Similar proteinsi

Entry informationi

Entry nameiK1C19_RAT
AccessioniPrimary (citable) accession number: Q63279
Secondary accession number(s): A0JN08
, Q5M7V2, Q6S6J4, Q9Z253
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: August 30, 2005
Last modified: April 25, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health