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Protein

Glutamate receptor ionotropic, kainate 5

Gene

Grik5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > glutamate >> AMPA.

GO - Molecular functioni

  • extracellular-glutamate-gated ion channel activity Source: InterPro
  • glutamate receptor activity Source: UniProtKB
  • identical protein binding Source: UniProtKB
  • kainate selective glutamate receptor activity Source: RGD
  • PDZ domain binding Source: UniProtKB
  • SH3 domain binding Source: UniProtKB

GO - Biological processi

  • cellular response to glucose stimulus Source: RGD
  • chemical synaptic transmission Source: RGD
  • establishment of localization in cell Source: UniProtKB
  • excitatory postsynaptic potential Source: Ensembl
  • positive regulation of neuron apoptotic process Source: RGD
  • protein retention in ER lumen Source: UniProtKB
  • receptor clustering Source: UniProtKB
  • regulation of synaptic vesicle fusion to presynaptic membrane Source: Ensembl
  • synaptic transmission, glutamatergic Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-451308. Activation of Ca-permeable Kainate Receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 5
Short name:
GluK5
Alternative name(s):
Glutamate receptor KA-2
Short name:
KA2
Gene namesi
Name:Grik5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2735. Grik5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini15 – 544ExtracellularSequence analysisAdd BLAST530
Transmembranei545 – 565HelicalSequence analysisAdd BLAST21
Topological domaini566 – 622CytoplasmicSequence analysisAdd BLAST57
Transmembranei623 – 643HelicalSequence analysisAdd BLAST21
Topological domaini644 – 803ExtracellularSequence analysisAdd BLAST160
Transmembranei804 – 824HelicalSequence analysisAdd BLAST21
Topological domaini825 – 979CytoplasmicSequence analysisAdd BLAST155

GO - Cellular componenti

  • axon Source: RGD
  • cell junction Source: UniProtKB-KW
  • dendrite Source: UniProtKB
  • endoplasmic reticulum Source: Ensembl
  • ionotropic glutamate receptor complex Source: UniProtKB
  • kainate selective glutamate receptor complex Source: Ensembl
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • perikaryon Source: RGD
  • postsynaptic density Source: RGD
  • postsynaptic membrane Source: UniProtKB-SubCell
  • presynaptic membrane Source: Ensembl
  • terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4041.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000001155415 – 979Glutamate receptor ionotropic, kainate 5Add BLAST965

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 292
Disulfide bondi83 ↔ 334
Disulfide bondi165 ↔ 170
Glycosylationi219N-linked (GlcNAc...)1 Publication1
Glycosylationi271N-linked (GlcNAc...)1 Publication1
Glycosylationi285N-linked (GlcNAc...)1 Publication1
Glycosylationi322N-linked (GlcNAc...)1 Publication1
Glycosylationi372N-linked (GlcNAc...)1 Publication1
Glycosylationi394N-linked (GlcNAc...)Sequence analysis1
Glycosylationi400N-linked (GlcNAc...)Sequence analysis1
Glycosylationi407N-linked (GlcNAc...)Sequence analysis1
Glycosylationi414N-linked (GlcNAc...)Sequence analysis1
Glycosylationi478N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63273.
PRIDEiQ63273.

PTM databases

iPTMnetiQ63273.
PhosphoSitePlusiQ63273.

Expressioni

Tissue specificityi

High expression in the cerebral cortex, pyriform cortex, caudate-putamen, hippocampal complex, medial habenulata and granule cell layer of the cerebellum. Weak expression in globus pallidus, thalamus, colliculi and the reticular thalamic nucleus.

Developmental stagei

From embryonic day 14 through postnatal day 1, high expression in spinal cord, brain and some areas of the PNS. At E17 and E19, high expression in spinal cord, mesencephalon and telencephalic structures as in olfactory neurons and in nasal epithelium. Strong expression also in the pituitary.

Gene expression databases

BgeeiENSRNOG00000020310.
GenevisibleiQ63273. RN.

Interactioni

Subunit structurei

Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity.1 Publication

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • PDZ domain binding Source: UniProtKB
  • SH3 domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi246572. 1 interactor.
STRINGi10116.ENSRNOP00000027578.

Chemistry databases

BindingDBiQ63273.

Structurei

Secondary structure

1979
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 30Combined sources8
Beta strandi34 – 37Combined sources4
Helixi40 – 53Combined sources14
Beta strandi62 – 69Combined sources8
Beta strandi71 – 73Combined sources3
Helixi75 – 85Combined sources11
Helixi86 – 88Combined sources3
Helixi100 – 113Combined sources14
Beta strandi117 – 119Combined sources3
Helixi129 – 134Combined sources6
Beta strandi136 – 139Combined sources4
Helixi142 – 155Combined sources14
Beta strandi161 – 167Combined sources7
Helixi170 – 173Combined sources4
Helixi175 – 183Combined sources9
Beta strandi184 – 186Combined sources3
Beta strandi188 – 192Combined sources5
Helixi200 – 209Combined sources10
Beta strandi212 – 218Combined sources7
Helixi220 – 232Combined sources13
Turni233 – 236Combined sources4
Beta strandi237 – 239Combined sources3
Beta strandi241 – 244Combined sources4
Helixi249 – 251Combined sources3
Turni255 – 257Combined sources3
Beta strandi263 – 268Combined sources6
Helixi277 – 288Combined sources12
Turni289 – 291Combined sources3
Helixi294 – 296Combined sources3
Helixi302 – 321Combined sources20
Turni322 – 324Combined sources3
Helixi343 – 350Combined sources8
Beta strandi355 – 357Combined sources3
Beta strandi360 – 362Combined sources3
Beta strandi374 – 381Combined sources8
Beta strandi384 – 392Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OM0X-ray1.40A20-406[»]
3OM1X-ray1.68A/B20-406[»]
3QLUX-ray2.91A/B20-406[»]
3QLVX-ray3.94A/B/E/G/I20-406[»]
ProteinModelPortaliQ63273.
SMRiQ63273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi860 – 866Poly-Arg7

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISR4. Eukaryota.
ENOG410XRUE. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiQ63273.
KOiK05205.
OMAiCTSSNIW.
OrthoDBiEOG091G02LN.
PhylomeDBiQ63273.
TreeFamiTF334668.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAELLLLLI VAFANPSCQV LSSLRMAAIL DDQTVCGRGE RLALALAREQ
60 70 80 90 100
INGIIEVPAK ARVEVDIFEL QRDSQYETTD TMCQILPKGV VSVLGPSSSP
110 120 130 140 150
ASASTVSHIC GEKEIPHIKV GPEETPRLQY LRFASVSLYP SNEDVSLAVS
160 170 180 190 200
RILKSFNYPS ASLICAKAEC LLRLEELVRG FLISKETLSV RMLDDSRDPT
210 220 230 240 250
PLLKEIRDDK VSTIIIDANA SISHLVLRKA SELGMTSAFY KYILTTMDFP
260 270 280 290 300
ILHLDGIVED SSNILGFSMF NTSHPFYPEF VRSLNMSWRE NCEASTYPGP
310 320 330 340 350
ALSAALMFDA VHVVVSAVRE LNRSQEIGVK PLACTSANIW PHGTSLMNYL
360 370 380 390 400
RMVEYDGLTG RVEFNSKGQR TNYTLRILEK SRQGHREIGV WYSNRTLAMN
410 420 430 440 450
ATTLDINLSQ TLANKTLVVT TILENPYVMR RPNFQALSGN ERFEGFCVDM
460 470 480 490 500
LRELAELLRF RYRLRLVEDG LYGAPEPNGS WTGMVGELIN RKADLAVAAF
510 520 530 540 550
TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD PFSPAVWLFM
560 570 580 590 600
LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ARPHILENQY TLGNSLWFPV
610 620 630 640 650
GGFMQQGSEI MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV
660 670 680 690 700
PVESADDLAD QTNIEYGTIH AGSTMTFFQN SRYQTYQRMW NYMQSKQPSV
710 720 730 740 750
FVKSTEEGIA RVLNSRYAFL LESTMNEYHR RLNCNLTQIG GLLDTKGYGI
760 770 780 790 800
GMPLGSPFRD EITLAILQLQ ENNRLEILKR KWWEGGRCPK EEDHRAKGLG
810 820 830 840 850
MENIGGIFVV LICGLIIAVF VAVMEFIWST RRSAESEEVS VCQEMLQELR
860 870 880 890 900
HAVSCRKTSR SRRRRRPGGP SRALLSLRAV REMRLSNGKL YSAGAGGDAG
910 920 930 940 950
AHGGPQRLLD DPGPPGGPRP QAPTPCTHVR VCQECRRIQA LRASGAGAPP
960 970
RGLGTPAEAT SPPRPRPGPT GPRELTEHE
Length:979
Mass (Da):109,276
Last modified:November 1, 1996 - v1
Checksum:i313E2862746474B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti887N → G (Ref. 2) Curated1
Sequence conflicti889K → R (Ref. 2) Curated1
Sequence conflicti910D → N in AAA17831 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11581 mRNA. Translation: CAA77667.1.
U08258 mRNA. Translation: AAA17831.1.
PIRiJH0592.
RefSeqiNP_113696.1. NM_031508.2.
UniGeneiRn.74042.

Genome annotation databases

EnsembliENSRNOT00000027578; ENSRNOP00000027578; ENSRNOG00000020310.
GeneIDi24407.
KEGGirno:24407.
UCSCiRGD:2735. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11581 mRNA. Translation: CAA77667.1.
U08258 mRNA. Translation: AAA17831.1.
PIRiJH0592.
RefSeqiNP_113696.1. NM_031508.2.
UniGeneiRn.74042.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OM0X-ray1.40A20-406[»]
3OM1X-ray1.68A/B20-406[»]
3QLUX-ray2.91A/B20-406[»]
3QLVX-ray3.94A/B/E/G/I20-406[»]
ProteinModelPortaliQ63273.
SMRiQ63273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246572. 1 interactor.
STRINGi10116.ENSRNOP00000027578.

Chemistry databases

BindingDBiQ63273.
ChEMBLiCHEMBL4041.

PTM databases

iPTMnetiQ63273.
PhosphoSitePlusiQ63273.

Proteomic databases

PaxDbiQ63273.
PRIDEiQ63273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027578; ENSRNOP00000027578; ENSRNOG00000020310.
GeneIDi24407.
KEGGirno:24407.
UCSCiRGD:2735. rat.

Organism-specific databases

CTDi2901.
RGDi2735. Grik5.

Phylogenomic databases

eggNOGiENOG410ISR4. Eukaryota.
ENOG410XRUE. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiQ63273.
KOiK05205.
OMAiCTSSNIW.
OrthoDBiEOG091G02LN.
PhylomeDBiQ63273.
TreeFamiTF334668.

Enzyme and pathway databases

ReactomeiR-RNO-451308. Activation of Ca-permeable Kainate Receptor.

Miscellaneous databases

PROiQ63273.

Gene expression databases

BgeeiENSRNOG00000020310.
GenevisibleiQ63273. RN.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGRIK5_RAT
AccessioniPrimary (citable) accession number: Q63273
Secondary accession number(s): Q62643
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.