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Protein

Inositol 1,4,5-trisphosphate receptor type 3

Gene

Itpr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.

GO - Molecular functioni

  • calcium ion binding Source: RGD
  • calcium ion transmembrane transporter activity Source: RGD
  • calcium-release channel activity Source: UniProtKB
  • inositol 1,3,4,5 tetrakisphosphate binding Source: RGD
  • inositol 1,4,5 trisphosphate binding Source: RGD
  • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: UniProtKB
  • inositol hexakisphosphate binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-RNO-112043. PLC beta mediated events.
R-RNO-1489509. DAG and IP3 signaling.
R-RNO-2029485. Role of phospholipids in phagocytosis.
R-RNO-2871809. FCERI mediated Ca+2 mobilization.
R-RNO-4086398. Ca2+ pathway.
R-RNO-422356. Regulation of insulin secretion.
R-RNO-5218921. VEGFR2 mediated cell proliferation.
R-RNO-5578775. Ion homeostasis.
R-RNO-5607763. CLEC7A (Dectin-1) induces NFAT activation.
R-RNO-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Protein family/group databases

TCDBi1.A.3.2.5. the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor type 3
Alternative name(s):
IP3 receptor isoform 3
Short name:
IP3R 3
Short name:
InsP3R3
Type 3 inositol 1,4,5-trisphosphate receptor
Short name:
Type 3 InsP3 receptor
Gene namesi
Name:Itpr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2934. Itpr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22012201CytoplasmicSequence analysisAdd
BLAST
Transmembranei2202 – 222221HelicalSequence analysisAdd
BLAST
Topological domaini2223 – 223311ExtracellularSequence analysisAdd
BLAST
Transmembranei2234 – 225421HelicalSequence analysisAdd
BLAST
Topological domaini2255 – 22639CytoplasmicSequence analysis
Transmembranei2264 – 228421HelicalSequence analysisAdd
BLAST
Topological domaini2285 – 232440ExtracellularSequence analysisAdd
BLAST
Transmembranei2325 – 234521HelicalSequence analysisAdd
BLAST
Topological domaini2346 – 236722CytoplasmicSequence analysisAdd
BLAST
Transmembranei2368 – 238821HelicalSequence analysisAdd
BLAST
Topological domaini2389 – 2495107ExtracellularSequence analysisAdd
BLAST
Transmembranei2496 – 251621HelicalSequence analysisAdd
BLAST
Topological domaini2517 – 2670154CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical part of cell Source: BHF-UCL
  • brush border Source: BHF-UCL
  • cytoplasm Source: RGD
  • dendrite Source: RGD
  • endoplasmic reticulum Source: BHF-UCL
  • endoplasmic reticulum membrane Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • myelin sheath Source: RGD
  • neuronal cell body Source: RGD
  • nuclear envelope Source: RGD
  • nuclear outer membrane Source: RGD
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2846.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 26702670Inositol 1,4,5-trisphosphate receptor type 3PRO_0000153930Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei916 – 9161PhosphoserineBy similarity
Modified residuei934 – 9341PhosphoserineCombined sources
Modified residuei1152 – 11521PhosphoserineBy similarity
Modified residuei1813 – 18131PhosphoserineBy similarity
Modified residuei1832 – 18321PhosphoserineBy similarity
Modified residuei1834 – 18341PhosphoserineBy similarity
Modified residuei2608 – 26081PhosphoserineBy similarity
Modified residuei2669 – 26691PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63269.
PRIDEiQ63269.

PTM databases

iPTMnetiQ63269.
PhosphoSiteiQ63269.

Interactioni

Subunit structurei

Homotetramer. Interacts with TRPC1, TRPC3, TRPC4. Interacts with TRPV4 (By similarity). Interacts with SIGMAR1 (PubMed:11149946). Interacts with AKT1 and PML. Interacts with LRMP (via coiled-coil domain) (By similarity). Interacts with CABP1 (PubMed:12032348). Interacts with TMBIM4/LFG4 (By similarity). Interacts with CEMIP (By similarity). Interacts with TESPA1 (By similarity). Interacts with TMEM203 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi247708. 1 interaction.
IntActiQ63269. 1 interaction.
STRINGi10116.ENSRNOP00000011516.

Structurei

3D structure databases

ProteinModelPortaliQ63269.
SMRiQ63269. Positions 6-226, 237-602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 17361MIR 1PROSITE-ProRule annotationAdd
BLAST
Domaini174 – 22451MIR 2PROSITE-ProRule annotationAdd
BLAST
Domaini232 – 28857MIR 3PROSITE-ProRule annotationAdd
BLAST
Domaini295 – 37278MIR 4PROSITE-ProRule annotationAdd
BLAST
Domaini378 – 43457MIR 5PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni266 – 2705Inositol 1,4,5-trisphosphate bindingBy similarity
Regioni507 – 5104Inositol 1,4,5-trisphosphate bindingBy similarity
Regioni567 – 5693Inositol 1,4,5-trisphosphate bindingBy similarity

Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

Sequence similaritiesi

Belongs to the InsP3 receptor family.Curated
Contains 5 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3533. Eukaryota.
ENOG410XR97. LUCA.
HOGENOMiHOG000007660.
HOVERGENiHBG052158.
InParanoidiQ63269.
KOiK04960.
PhylomeDBiQ63269.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 2 hits.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK
60 70 80 90 100
KFRDCLFKVC PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME
110 120 130 140 150
QKQNDTENKK VHGDVVKYGS VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV
160 170 180 190 200
TLDATGNEGS WLFIQPFWKL RSNGDNVVVG DKVILNPVNA GQPLHASNYE
210 220 230 240 250
LSDNVGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV VRLFHAEQEK
260 270 280 290 300
FLTCDEYRGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
310 320 330 340 350
NGLYRFKHLA TGNYLAAEEN PSYKGDVSDP KAAGPGAQSR TGRRNAGEKI
360 370 380 390 400
KYRLVAVPHG NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS
410 420 430 440 450
TNAPIDVEEE RPIRLMLGTC PTKEDKEAFA IVSVPVSEIR DLDFANDASS
460 470 480 490 500
MLASAVEKLN EGFISQNDRR FVIQLLEDLV FFVSDVPNNG QNVLDIMVTK
510 520 530 540 550
PNRERQKLMR DENILKQIFG ILKAPFRDKG GEGPLVRLEE LSDQKNAPYQ
560 570 580 590 600
YMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH
610 620 630 640 650
NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NRIAIPVTQE
660 670 680 690 700
LICKCVLDPK NSDILIQTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDRN
710 720 730 740 750
NEHHEKSVRQ LAQEARAGNA HDENVLSYYR YQLKLFARMC LDRQYLAIDE
760 770 780 790 800
ISKQLGVELL FLCMADEMLP FDLRASFCHL MLHVHVDRDP QELVTPVKFA
810 820 830 840 850
RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY LNNVVGEAVP
860 870 880 890 900
FANDEKNILT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCIQAPAA
910 920 930 940 950
VLQAYEEPGG KNVRRSIQGV GHMMSTMVLS RKQSVFGASS LPTGVGVPEQ
960 970 980 990 1000
LDRSKFEDNE HTVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE
1010 1020 1030 1040 1050
VFPMQDSGAD GTAPAFDSST ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE
1060 1070 1080 1090 1100
GGRMFLRVLL HLTMHDYPPL VSGALQLLFK HFSQRQEAMH TFKQVQLLIS
1110 1120 1130 1140 1150
AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSVKGEEGE AGASKDKKER
1160 1170 1180 1190 1200
PSDEEGFLQP HGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM
1210 1220 1230 1240 1250
DAHKVMLDLL QIPYDKNDNK MMEILRYTHQ FLQKFCAGNP GNQALLHKHL
1260 1270 1280 1290 1300
QLFLTPGLLE AETMQHIFLN NYQLCSEISE PVLQHFVHCW PTHGRHVQYL
1310 1320 1330 1340 1350
DFLHTVIKAE GKYVKKCQDM IMTELTNAGD DVVVFYNDKA SLAHLLDMMK
1360 1370 1380 1390 1400
AARDGVEDHS PLMYHISLVD LLAACAEGKN VYTEIKCTSL LPLEDVVSVV
1410 1420 1430 1440 1450
THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL FENFTLDMAL
1460 1470 1480 1490 1500
VCNKREKRLS DPTLEKYVLT VVLDTISAFF SSPFSENSTS LQTHQTIVVQ
1510 1520 1530 1540 1550
LLQSTTRLLE CPWLQQQHKG SVEACVRTLA MVAKSRAILL PMDLDAHMSA
1560 1570 1580 1590 1600
LLSSGGSCSA AAQRSAANYK TATRTFPRVI PTANQWDYKN IIEKLQDIIT
1610 1620 1630 1640 1650
ALEERLKPLV QAELSVLVDM LHWPELLFLE GSEAYQRCES GGFLSKLIRH
1660 1670 1680 1690 1700
TKGLMESEEK LCVKVLRTLQ QMLQKKSKYG DRGNQLRKML LQNYLQNRKS
1710 1720 1730 1740 1750
GPRGELTDPT GSGVDQDWSA IAATQCRLDK EGATKLVCDL ITSTKNEKIF
1760 1770 1780 1790 1800
QESIGLAIRL LDGGNTEIQK SFYNLMTSDK KSERFFKVLH DRMKRAQQET
1810 1820 1830 1840 1850
KSTVAVNMSD LGSQPREDRE PADPTTKGRV SSFSMPSSSR YSLGPGLHRG
1860 1870 1880 1890 1900
HDVSERAQNN EMGTSVLIMR PILRFLQLLC ENHNRDLQNF LRCQNNKTNY
1910 1920 1930 1940 1950
NLVCETLQFL DIMCGSTTGG LGLLGLYINE DNVGLVIQTL ETLTEYCQGP
1960 1970 1980 1990 2000
CHENQTCIVT HESNGIDIIT ALILNDISPL CKYRMDLVLQ LKDNASKLLL
2010 2020 2030 2040 2050
ALMESRHDSE NAERILISLR PQELVDVIKK AYLQEEEREN SEVSPREVGH
2060 2070 2080 2090 2100
NIYILALQLS RHNKQLQHLL KPVKRIQEEE AEGISSMLSL NNKQLSQMLK
2110 2120 2130 2140 2150
SSAPAQEEEE DPLAYYENHT SQIEIVRQDR SMEQIVFPVP AICQFLTEET
2160 2170 2180 2190 2200
KHRLFTTTEQ DEQGSKVSDF FDQSSFLHNE MEWQRRLRSM PLIYWFSRRM
2210 2220 2230 2240 2250
TLWGSISFNL AVFINIIIAF FYPYVEGAST GVLGSPLISL LFWILICFSI
2260 2270 2280 2290 2300
AALFTKHYSV RPLIVALVLR SIYYLGIGPT LNILGALNLT NKIVFVVSFV
2310 2320 2330 2340 2350
GNRGTFIRGY KAMVMDMEFL YHVGYILTSV LGLFAHELFY SILLFDLIYR
2360 2370 2380 2390 2400
EETLFNVIKS VTRNGRSILL TALLALILVY LFSIVGFLFL KDDFILEVDR
2410 2420 2430 2440 2450
LPGNHSRAST LGMPHGAATF MGTCSGDKMD CVSEVSVPEI LEEDEELDST
2460 2470 2480 2490 2500
ERACDTLLMC IVTVMNHGLR NGGGVGDILR KPSKDESLFP ARVVYDLLFF
2510 2520 2530 2540 2550
FIVIIIVLNL IFGVIIDTFA DLRSEKQKKE EILKTTCFIC GLERDKFDNK
2560 2570 2580 2590 2600
TVSFEEHIKL EHNMWNYLYF IVLVRVKNKT DYTGPESYVA QMIKNKNLDW
2610 2620 2630 2640 2650
FPRMRAMSLV SGEGEGEQNE IRILQEKLGS TMKLVSHLTA QLNELKEQMT
2660 2670
EQRKRRQRLG FVDVQNCMSR
Length:2,670
Mass (Da):304,286
Last modified:November 1, 1996 - v1
Checksum:i13C787E4C2886E45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06096 mRNA. Translation: AAA41446.1.
PIRiA46719.
RefSeqiNP_037270.1. NM_013138.1.
UniGeneiRn.11242.

Genome annotation databases

GeneIDi25679.
KEGGirno:25679.
UCSCiRGD:2934. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06096 mRNA. Translation: AAA41446.1.
PIRiA46719.
RefSeqiNP_037270.1. NM_013138.1.
UniGeneiRn.11242.

3D structure databases

ProteinModelPortaliQ63269.
SMRiQ63269. Positions 6-226, 237-602.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247708. 1 interaction.
IntActiQ63269. 1 interaction.
STRINGi10116.ENSRNOP00000011516.

Chemistry

ChEMBLiCHEMBL2846.

Protein family/group databases

TCDBi1.A.3.2.5. the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family.

PTM databases

iPTMnetiQ63269.
PhosphoSiteiQ63269.

Proteomic databases

PaxDbiQ63269.
PRIDEiQ63269.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25679.
KEGGirno:25679.
UCSCiRGD:2934. rat.

Organism-specific databases

CTDi3710.
RGDi2934. Itpr3.

Phylogenomic databases

eggNOGiKOG3533. Eukaryota.
ENOG410XR97. LUCA.
HOGENOMiHOG000007660.
HOVERGENiHBG052158.
InParanoidiQ63269.
KOiK04960.
PhylomeDBiQ63269.

Enzyme and pathway databases

ReactomeiR-RNO-112043. PLC beta mediated events.
R-RNO-1489509. DAG and IP3 signaling.
R-RNO-2029485. Role of phospholipids in phagocytosis.
R-RNO-2871809. FCERI mediated Ca+2 mobilization.
R-RNO-4086398. Ca2+ pathway.
R-RNO-422356. Regulation of insulin secretion.
R-RNO-5218921. VEGFR2 mediated cell proliferation.
R-RNO-5578775. Ion homeostasis.
R-RNO-5607763. CLEC7A (Dectin-1) induces NFAT activation.
R-RNO-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Miscellaneous databases

PROiQ63269.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 2 hits.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITPR3_RAT
AccessioniPrimary (citable) accession number: Q63269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.