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Protein

Interleukin-1 beta

Gene

Il1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.By similarity

Miscellaneous

IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 beta
Short name:
IL-1 beta
Gene namesi
Name:Il1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2891. Il1b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000153171 – 116By similarityAdd BLAST116
ChainiPRO_0000015318117 – 268Interleukin-1 betaAdd BLAST152

Proteomic databases

PaxDbiQ63264.
PRIDEiQ63264.

PTM databases

PhosphoSitePlusiQ63264.

Expressioni

Inductioni

In pancreatic islets, release is increased by high glucose treatment and, to a lesser extent, by endocannabinoid anandamide/AEA. The induction is more prononced in Zucker diabetic fatty (ZDF) rats compared to lean animals.1 Publication

Interactioni

Subunit structurei

Monomer. Interacts with MEFV (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006308.

Structurei

3D structure databases

ProteinModelPortaliQ63264.
SMRiQ63264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410IGSZ. Eukaryota.
ENOG410XU2E. LUCA.
HOGENOMiHOG000246399.
HOVERGENiHBG007328.
InParanoidiQ63264.
PhylomeDBiQ63264.

Family and domain databases

InterProiView protein in InterPro
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
IPR008996. IL1/FGF.
PANTHERiPTHR44849. PTHR44849. 1 hit.
PfamiView protein in Pfam
PF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
PRINTSiPR00264. INTERLEUKIN1.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00253. INTERLEUKIN_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63264-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVPELNCE IAAFDSEEND LFFEADRPQK IKDCFQALDL GCPDESIQLQ
60 70 80 90 100
ISQQHLDKSF RKAVSLIVAV EKLWQLPMSC PWSFQDEDPS TFFSFIFEEE
110 120 130 140 150
PVLCDSWDDD DLLVCDVPIR QLHCRLRDEQ QKCLVLSDPC ELKALHLNGQ
160 170 180 190 200
NISQQVVFSM SFVQGETSND KIPVALGLKG LNLYLSCVMK DGTPTLQLES
210 220 230 240 250
VDPKQYPKKK MEKRFVFNKI EVKTKVEFES AQFPNWYIST SQAEHRPVFL
260
GNSNGRDIVD FTMEPVSS
Length:268
Mass (Da):30,644
Last modified:November 1, 1997 - v1
Checksum:i109C19EBF69C242D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98820 mRNA. Translation: AAA41426.1.
UniGeneiRn.9869.

Genome annotation databases

UCSCiRGD:2891. rat.

Similar proteinsi

Entry informationi

Entry nameiIL1B_RAT
AccessioniPrimary (citable) accession number: Q63264
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 22, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families