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Protein

Interleukin-1 beta

Gene

Il1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.By similarity

Miscellaneous

IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.By similarity

GO - Molecular functioni

  • cytokine activity Source: RGD
  • interleukin-1 receptor binding Source: GO_Central

GO - Biological processi

  • acute inflammatory response Source: RGD
  • cellular response to antibiotic Source: RGD
  • cellular response to fatty acid Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • cellular response to lipid Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • chronic inflammatory response to antigenic stimulus Source: RGD
  • cytokine-mediated signaling pathway Source: GO_Central
  • fever generation Source: RGD
  • learning or memory Source: RGD
  • memory Source: RGD
  • negative regulation of branching morphogenesis of a nerve Source: RGD
  • negative regulation of gene expression Source: RGD
  • negative regulation of glutamate secretion Source: RGD
  • negative regulation of neural precursor cell proliferation Source: RGD
  • negative regulation of neurogenesis Source: RGD
  • negative regulation of neuron differentiation Source: RGD
  • negative regulation of transcription from RNA polymerase II promoter Source: RGD
  • ovulation Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of astrocyte differentiation Source: RGD
  • positive regulation of cell death Source: RGD
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of glial cell differentiation Source: RGD
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
  • positive regulation of immature T cell proliferation in thymus Source: RGD
  • positive regulation of interleukin-6 production Source: RGD
  • positive regulation of JNK cascade Source: RGD
  • positive regulation of JUN kinase activity Source: RGD
  • positive regulation of neuron apoptotic process Source: RGD
  • positive regulation of neutrophil chemotaxis Source: RGD
  • positive regulation of stress-activated MAPK cascade Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • response to dexamethasone Source: RGD
  • response to drug Source: RGD
  • response to estradiol Source: RGD
  • response to ethanol Source: RGD
  • response to gamma radiation Source: RGD
  • response to glucocorticoid Source: RGD
  • response to heat Source: RGD
  • response to hypoxia Source: RGD
  • response to immobilization stress Source: RGD
  • response to L-ascorbic acid Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to morphine Source: RGD
  • response to nutrient Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organonitrogen compound Source: RGD
  • response to ozone Source: RGD
  • response to peptide hormone Source: RGD
  • response to stilbenoid Source: RGD
  • response to vitamin D Source: RGD
  • social behavior Source: RGD
  • wound healing Source: RGD

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 beta
Short name:
IL-1 beta
Gene namesi
Name:Il1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2891. Il1b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000153171 – 116By similarityAdd BLAST116
ChainiPRO_0000015318117 – 268Interleukin-1 betaAdd BLAST152

Proteomic databases

PaxDbiQ63264.
PRIDEiQ63264.

PTM databases

PhosphoSitePlusiQ63264.

Expressioni

Inductioni

In pancreatic islets, release is increased by high glucose treatment and, to a lesser extent, by endocannabinoid anandamide/AEA. The induction is more prononced in Zucker diabetic fatty (ZDF) rats compared to lean animals.1 Publication

Interactioni

Subunit structurei

Monomer. Interacts with MEFV (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: RGD
  • interleukin-1 receptor binding Source: GO_Central

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006308.

Structurei

3D structure databases

ProteinModelPortaliQ63264.
SMRiQ63264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410IGSZ. Eukaryota.
ENOG410XU2E. LUCA.
HOGENOMiHOG000246399.
HOVERGENiHBG007328.
InParanoidiQ63264.
PhylomeDBiQ63264.

Family and domain databases

InterProiView protein in InterPro
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
IPR008996. IL1/FGF.
PANTHERiPTHR10078:SF42. PTHR10078:SF42. 1 hit.
PfamiView protein in Pfam
PF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
PRINTSiPR00264. INTERLEUKIN1.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00253. INTERLEUKIN_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63264-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVPELNCE IAAFDSEEND LFFEADRPQK IKDCFQALDL GCPDESIQLQ
60 70 80 90 100
ISQQHLDKSF RKAVSLIVAV EKLWQLPMSC PWSFQDEDPS TFFSFIFEEE
110 120 130 140 150
PVLCDSWDDD DLLVCDVPIR QLHCRLRDEQ QKCLVLSDPC ELKALHLNGQ
160 170 180 190 200
NISQQVVFSM SFVQGETSND KIPVALGLKG LNLYLSCVMK DGTPTLQLES
210 220 230 240 250
VDPKQYPKKK MEKRFVFNKI EVKTKVEFES AQFPNWYIST SQAEHRPVFL
260
GNSNGRDIVD FTMEPVSS
Length:268
Mass (Da):30,644
Last modified:November 1, 1997 - v1
Checksum:i109C19EBF69C242D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98820 mRNA. Translation: AAA41426.1.
UniGeneiRn.9869.

Genome annotation databases

UCSCiRGD:2891. rat.

Similar proteinsi

Entry informationi

Entry nameiIL1B_RAT
AccessioniPrimary (citable) accession number: Q63264
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: August 30, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families