ID PO3F3_RAT Reviewed; 497 AA. AC Q63262; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1999, sequence version 2. DT 24-JAN-2024, entry version 148. DE RecName: Full=POU domain, class 3, transcription factor 3; DE AltName: Full=Brain-specific homeobox/POU domain protein 1; DE Short=Brain-1; DE Short=Brn-1; GN Name=Pou3f3; Synonyms=Brn-1, Brn1, Rhs2; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=9405434; DOI=10.1074/jbc.272.51.32286; RA Schreiber J., Enderich J., Sock E., Schmidt C., Richter-Landsberg C., RA Wegner M.; RT "Redundancy of class III POU proteins in the oligodendrocyte lineage."; RL J. Biol. Chem. 272:32286-32293(1997). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 325-449. RC TISSUE=Hypothalamus; RX PubMed=1348858; DOI=10.1073/pnas.89.8.3285; RA le Moine C., Young W.S.; RT "RHS2, a POU domain-containing gene, and its expression in developing and RT adult rat."; RL Proc. Natl. Acad. Sci. U.S.A. 89:3285-3289(1992). RN [3] RP FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF 450-TRP-PHE-451. RX PubMed=9632656; DOI=10.1074/jbc.273.26.16050; RA Kuhlbrodt K., Herbarth B., Sock E., Enderich J., Hermans-Borgmeyer I., RA Wegner M.; RT "Cooperative function of POU proteins and SOX proteins in glial cells."; RL J. Biol. Chem. 273:16050-16057(1998). CC -!- FUNCTION: Transcription factor that acts synergistically with SOX11 and CC SOX4. Plays a role in neuronal development. Is implicated in an CC enhancer activity at the embryonic met-mesencephalic junction; the CC enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By CC similarity). {ECO:0000250|UniProtKB:P31361, CC ECO:0000269|PubMed:9632656}. CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P20264}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, CC ECO:0000255|PROSITE-ProRule:PRU00530, ECO:0000269|PubMed:9632656}. CC -!- TISSUE SPECIFICITY: Brain. CC -!- DEVELOPMENTAL STAGE: Expressed from embryonic day 11.5 into adulthood. CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3 CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ001641; CAA04893.1; -; mRNA. DR EMBL; M84644; AAA42041.1; -; mRNA. DR RefSeq; NP_620192.1; NM_138837.1. DR AlphaFoldDB; Q63262; -. DR SMR; Q63262; -. DR STRING; 10116.ENSRNOP00000073663; -. DR iPTMnet; Q63262; -. DR PhosphoSitePlus; Q63262; -. DR PaxDb; 10116-ENSRNOP00000040234; -. DR GeneID; 192109; -. DR KEGG; rno:192109; -. DR UCSC; RGD:619768; rat. DR AGR; RGD:619768; -. DR CTD; 5455; -. DR RGD; 619768; Pou3f3. DR eggNOG; KOG3802; Eukaryota. DR InParanoid; Q63262; -. DR OrthoDB; 4250502at2759; -. DR PhylomeDB; Q63262; -. DR PRO; PR:Q63262; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0003677; F:DNA binding; ISO:RGD. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:RGD. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:MGI. DR GO; GO:0071837; F:HMG box domain binding; ISO:RGD. DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB. DR GO; GO:0021799; P:cerebral cortex radially oriented cell migration; ISO:RGD. DR GO; GO:0048878; P:chemical homeostasis; ISO:RGD. DR GO; GO:0021869; P:forebrain ventricular zone progenitor cell division; ISO:RGD. DR GO; GO:0001822; P:kidney development; ISO:RGD. DR GO; GO:0072218; P:metanephric ascending thin limb development; ISS:UniProtKB. DR GO; GO:0072240; P:metanephric DCT cell differentiation; ISS:UniProtKB. DR GO; GO:0072236; P:metanephric loop of Henle development; ISS:UniProtKB. DR GO; GO:0072227; P:metanephric macula densa development; ISS:UniProtKB. DR GO; GO:0072233; P:metanephric thick ascending limb development; ISS:UniProtKB. DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISS:UniProtKB. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:MGI. DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IMP:UniProtKB. DR GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:RGD. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0071918; P:urea transmembrane transport; ISO:RGD. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf. DR InterPro; IPR013847; POU. DR InterPro; IPR000327; POU_dom. DR InterPro; IPR016362; TF_POU_3. DR PANTHER; PTHR11636; POU DOMAIN; 1. DR PANTHER; PTHR11636:SF125; POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 3; 1. DR Pfam; PF00046; Homeodomain; 1. DR Pfam; PF00157; Pou; 1. DR PIRSF; PIRSF002629; Transcription_factor_POU; 1. DR PRINTS; PR00028; POUDOMAIN. DR SMART; SM00389; HOX; 1. DR SMART; SM00352; POU; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS00035; POU_1; 1. DR PROSITE; PS00465; POU_2; 1. DR PROSITE; PS51179; POU_3; 1. PE 1: Evidence at protein level; KW Developmental protein; DNA-binding; Homeobox; Neurogenesis; Nucleus; KW Reference proteome; Transcription; Transcription regulation. FT CHAIN 1..497 FT /note="POU domain, class 3, transcription factor 3" FT /id="PRO_0000100730" FT DOMAIN 311..385 FT /note="POU-specific" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530" FT DNA_BIND 403..462 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT REGION 31..62 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 121..189 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 230..316 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 458..497 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 132..147 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 168..182 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 270..287 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 462..497 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MUTAGEN 450..451 FT /note="WF->CS: Abolishes synergistic action with SOX11." FT /evidence="ECO:0000269|PubMed:9632656" SQ SEQUENCE 497 AA; 50226 MW; 00640505E343ABC2 CRC64; MATAASNPYL PGNSLLAAGS IVHSDAAGAG GGGGGGGGGG GGAGGGGGGM QPGSAAVTSG AYRGDPSSVK MVQSDFMQGA MAASNGGHML SHAHQWVTAL PHAAAAAAAA AAAAVEASSP WSGSAVGMAG SPQQPPRPPP PPPQGPDVKG GVGREDLHAG TALHHRGPPH LGPPPPPPHQ GHPGGWGAAA AAAAAAAAAA AAAHLPSMAG GQQPPPQSLL YSQPGGFTVN GMLSAPPGPG GGGGGAGGGA QSLVHPGLVR GDTPELAEHH HHHHHHAHPH PPHPHHAQGP PHHGGGGAGP GLNSHDPHSD EDTPTSDDLE QFAKQFKQRR IKLGFTQADV GLALGTLYGN VFSQTTICRF EALQLSFKNM CKLKPLLNKW LEEADSSTGS PTSIDKIAAQ GRKRKKRTSI EVSVKGALES HFLKCPKPSA QEITNLADSL QLEKEVVRVW FCNRRQKEKR MTPPGIQQQT PDDVYSQVGT VSADTPPPHH GLQTSVQ //