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Q63262

- PO3F3_RAT

UniProt

Q63262 - PO3F3_RAT

Protein

POU domain, class 3, transcription factor 3

Gene

Pou3f3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi403 – 46260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
    2. sequence-specific DNA binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: RGD

    GO - Biological processi

    1. metanephric ascending thin limb development Source: UniProtKB
    2. metanephric DCT cell differentiation Source: UniProtKB
    3. metanephric loop of Henle development Source: UniProtKB
    4. metanephric macula densa development Source: UniProtKB
    5. metanephric thick ascending limb development Source: UniProtKB
    6. negative regulation of apoptotic process Source: UniProtKB
    7. negative regulation of transcription, DNA-templated Source: UniProtKB
    8. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    9. nervous system development Source: UniProtKB-KW
    10. positive regulation of cell proliferation Source: UniProtKB
    11. positive regulation of gene expression Source: UniProtKB
    12. positive regulation of transcription, DNA-templated Source: UniProtKB
    13. positive regulation of transcription from RNA polymerase II promoter Source: RGD
    14. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 3, transcription factor 3
    Alternative name(s):
    Brain-specific homeobox/POU domain protein 1
    Short name:
    Brain-1
    Short name:
    Brn-1
    Gene namesi
    Name:Pou3f3
    Synonyms:Brn-1, Brn1, Rhs2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi619768. Pou3f3.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi450 – 4512WF → CS: Abolishes synergistic action with SOX11. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497POU domain, class 3, transcription factor 3PRO_0000100730Add
    BLAST

    Expressioni

    Tissue specificityi

    Brain.

    Developmental stagei

    Expressed from embryonic day 11.5 into adulthood.

    Gene expression databases

    GenevestigatoriQ63262.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000040234.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63262.
    SMRiQ63262. Positions 317-463.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini311 – 38575POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi28 – 301274Gly-richAdd
    BLAST
    Compositional biasi80 – 203124Ala-richAdd
    BLAST
    Compositional biasi132 – 18352Pro-richAdd
    BLAST
    Compositional biasi269 – 30840His-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    HOGENOMiHOG000116303.
    HOVERGENiHBG053120.
    InParanoidiQ63262.
    KOiK09365.
    PhylomeDBiQ63262.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63262-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATAASNPYL PGNSLLAAGS IVHSDAAGAG GGGGGGGGGG GGAGGGGGGM    50
    QPGSAAVTSG AYRGDPSSVK MVQSDFMQGA MAASNGGHML SHAHQWVTAL 100
    PHAAAAAAAA AAAAVEASSP WSGSAVGMAG SPQQPPRPPP PPPQGPDVKG 150
    GVGREDLHAG TALHHRGPPH LGPPPPPPHQ GHPGGWGAAA AAAAAAAAAA 200
    AAAHLPSMAG GQQPPPQSLL YSQPGGFTVN GMLSAPPGPG GGGGGAGGGA 250
    QSLVHPGLVR GDTPELAEHH HHHHHHAHPH PPHPHHAQGP PHHGGGGAGP 300
    GLNSHDPHSD EDTPTSDDLE QFAKQFKQRR IKLGFTQADV GLALGTLYGN 350
    VFSQTTICRF EALQLSFKNM CKLKPLLNKW LEEADSSTGS PTSIDKIAAQ 400
    GRKRKKRTSI EVSVKGALES HFLKCPKPSA QEITNLADSL QLEKEVVRVW 450
    FCNRRQKEKR MTPPGIQQQT PDDVYSQVGT VSADTPPPHH GLQTSVQ 497
    Length:497
    Mass (Da):50,226
    Last modified:July 15, 1999 - v2
    Checksum:i00640505E343ABC2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001641 mRNA. Translation: CAA04893.1.
    M84644 mRNA. Translation: AAA42041.1.
    RefSeqiNP_620192.1. NM_138837.1.
    UniGeneiRn.11354.

    Genome annotation databases

    GeneIDi192109.
    KEGGirno:192109.
    UCSCiRGD:619768. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001641 mRNA. Translation: CAA04893.1 .
    M84644 mRNA. Translation: AAA42041.1 .
    RefSeqi NP_620192.1. NM_138837.1.
    UniGenei Rn.11354.

    3D structure databases

    ProteinModelPortali Q63262.
    SMRi Q63262. Positions 317-463.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000040234.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 192109.
    KEGGi rno:192109.
    UCSCi RGD:619768. rat.

    Organism-specific databases

    CTDi 5455.
    RGDi 619768. Pou3f3.

    Phylogenomic databases

    HOGENOMi HOG000116303.
    HOVERGENi HBG053120.
    InParanoidi Q63262.
    KOi K09365.
    PhylomeDBi Q63262.

    Miscellaneous databases

    NextBioi 622677.

    Gene expression databases

    Genevestigatori Q63262.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Redundancy of class III POU proteins in the oligodendrocyte lineage."
      Schreiber J., Enderich J., Sock E., Schmidt C., Richter-Landsberg C., Wegner M.
      J. Biol. Chem. 272:32286-32293(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "RHS2, a POU domain-containing gene, and its expression in developing and adult rat."
      le Moine C., Young W.S.
      Proc. Natl. Acad. Sci. U.S.A. 89:3285-3289(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 325-449.
      Tissue: Hypothalamus.
    3. "Cooperative function of POU proteins and SOX proteins in glial cells."
      Kuhlbrodt K., Herbarth B., Sock E., Enderich J., Hermans-Borgmeyer I., Wegner M.
      J. Biol. Chem. 273:16050-16057(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF 450-TRP-PHE-451.

    Entry informationi

    Entry nameiPO3F3_RAT
    AccessioniPrimary (citable) accession number: Q63262
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3