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Q63250

- FOXE3_RAT

UniProt

Q63250 - FOXE3_RAT

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Protein

Forkhead box protein E3

Gene
Foxe3, Fkhl12, Freac8, Hfh7
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Protein predictedi

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi2 – 9392Fork-headAdd
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: RefGenome
  2. double-stranded DNA binding Source: RefGenome
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  4. sequence-specific DNA binding Source: InterPro
  5. sequence-specific DNA binding transcription factor activity Source: RGD
  6. transcription factor binding Source: RefGenome

GO - Biological processi

  1. cell development Source: Ensembl
  2. embryonic organ morphogenesis Source: RefGenome
  3. hair follicle morphogenesis Source: RefGenome
  4. hard palate development Source: RefGenome
  5. lens morphogenesis in camera-type eye Source: RefGenome
  6. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  7. pattern specification process Source: RefGenome
  8. positive regulation of epithelial cell proliferation Source: Ensembl
  9. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  10. soft palate development Source: RefGenome
  11. thyroid gland development Source: RefGenome
  12. thyroid hormone generation Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein E3
Alternative name(s):
Forkhead-related protein FKHL12
Forkhead-related transcription factor 8
Short name:
FREAC-8
Hepatocyte nuclear factor 3 forkhead homolog 7
Short name:
HFH-7
Gene namesi
Name:Foxe3
Synonyms:Fkhl12, Freac8, Hfh7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621727. Foxe3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›101›101Forkhead box protein E3PRO_0000091831Add
BLAST

Proteomic databases

PaxDbiQ63250.

PTM databases

PhosphoSiteiQ63250.

Expressioni

Gene expression databases

ArrayExpressiQ63250.
GenevestigatoriQ63250.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010208.

Structurei

3D structure databases

ProteinModelPortaliQ63250.
SMRiQ63250. Positions 3-98.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000231286.
InParanoidiQ63250.
PhylomeDBiQ63250.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q63250-1 [UniParc]FASTAAdd to Basket

« Hide

RGKPPYSYIA LIAMALAHAP GRRLTLAAIY RFITERFAFY RDSPRKWQNS    50
IRHNLTLNDC FVKVPREPGN PGKGNYWTLD PAAADMFDNG SFLRRRKRFK 100
R 101
Length:101
Mass (Da):11,802
Last modified:November 1, 1997 - v1
Checksum:iB887C9151B4E8DC0
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei101 – 1011

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13207 mRNA. Translation: AAA41323.1.
PIRiI60921.
UniGeneiRn.92407.

Genome annotation databases

UCSCiRGD:621727. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13207 mRNA. Translation: AAA41323.1 .
PIRi I60921.
UniGenei Rn.92407.

3D structure databases

ProteinModelPortali Q63250.
SMRi Q63250. Positions 3-98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000010208.

PTM databases

PhosphoSitei Q63250.

Proteomic databases

PaxDbi Q63250.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:621727. rat.

Organism-specific databases

RGDi 621727. Foxe3.

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000231286.
InParanoidi Q63250.
PhylomeDBi Q63250.

Gene expression databases

ArrayExpressi Q63250.
Genevestigatori Q63250.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family."
    Clevidence D.E., Overdier D.G., Tao W., Qian X., Pani L., Lai E., Costa R.H.
    Proc. Natl. Acad. Sci. U.S.A. 90:3948-3952(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiFOXE3_RAT
AccessioniPrimary (citable) accession number: Q63250
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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