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Protein

Forkhead box protein E3

Gene

Foxe3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (By similarity). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi64 – 158Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central
  • sequence-specific DNA binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • anatomical structure morphogenesis Source: GO_Central
  • cell development Source: Ensembl
  • cell differentiation Source: GO_Central
  • ciliary body morphogenesis Source: UniProtKB
  • cornea development in camera-type eye Source: UniProtKB
  • eye development Source: UniProtKB
  • iris morphogenesis Source: UniProtKB
  • lens development in camera-type eye Source: UniProtKB
  • mRNA transcription from RNA polymerase II promoter Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cell cycle arrest Source: UniProtKB
  • negative regulation of lens fiber cell differentiation Source: UniProtKB
  • positive regulation of lens epithelial cell proliferation Source: UniProtKB
  • trabecular meshwork development Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein E3
Alternative name(s):
Forkhead-related protein FKHL12
Forkhead-related transcription factor 8
Short name:
FREAC-8
Hepatocyte nuclear factor 3 forkhead homolog 7
Short name:
HFH-7
Gene namesi
Name:Foxe3
Synonyms:Fkhl12, Freac8, Hfh7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621727. Foxe3.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • transcription factor complex Source: Ensembl

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004332361 – 286Forkhead box protein E3Add BLAST286

Proteomic databases

PaxDbiQ63250.

PTM databases

PhosphoSitePlusiQ63250.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007770.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010208.

Structurei

3D structure databases

SMRiQ63250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi166 – 252Pro-richPROSITE-ProRule annotationAdd BLAST87

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231286.
InParanoidiQ63250.
KOiK09398.
OMAiPEPPCCA.
OrthoDBiEOG091G0TOA.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAHVAFSGF PTLPSVSPSG PQPPSLAGDE PGREPEEVVG GGDSEPPAAP
60 70 80 90 100
GPGRRRRRPL QRGKPPYSYI ALIAMALAHA PGRRLTLAAI YRFITERFAF
110 120 130 140 150
YRDSPRKWQN SIRHNLTLND CFVKVPREPG NPGKGNYWTL DPAAADMFDN
160 170 180 190 200
GSFLRRRKRF KRTELPAPPP PPFPYAPFPP APAPAPAPPA RLFRLDSLLG
210 220 230 240 250
LQTEPPGPLA PEPPCCAAPD ASFPPCAAAA SPPLYSPAPE RLGLPAPLPA
260 270 280
EPLLALAGSA GALGPLGAGE AYLRQPGFPP GLERYL
Length:286
Mass (Da):30,469
Last modified:June 24, 2015 - v2
Checksum:i4238A421281D4141
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13207 mRNA. Translation: AAA41323.1.
AABR06039461 Genomic DNA. No translation available.
CH474008 Genomic DNA. Translation: EDL90326.1.
PIRiI60921.
RefSeqiNP_599166.1. NM_134339.1.
UniGeneiRn.92407.

Genome annotation databases

EnsembliENSRNOT00000010208; ENSRNOP00000010208; ENSRNOG00000007770.
GeneIDi171302.
KEGGirno:171302.
UCSCiRGD:621727. rat.

Similar proteinsi

Entry informationi

Entry nameiFOXE3_RAT
AccessioniPrimary (citable) accession number: Q63250
Secondary accession number(s): G3V6Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 24, 2015
Last modified: August 30, 2017
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome