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Q63250 (FOXE3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein E3
Alternative name(s):
Forkhead-related protein FKHL12
Forkhead-related transcription factor 8
Short name=FREAC-8
Hepatocyte nuclear factor 3 forkhead homolog 7
Short name=HFH-7
Gene names
Name:Foxe3
Synonyms:Fkhl12, Freac8, Hfh7
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length101 AA.
Sequence statusFragment.
Protein existencePredicted

General annotation (Comments)

Subcellular location

Nucleus.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell development

Inferred from electronic annotation. Source: Ensembl

embryonic organ morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

hair follicle morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

hard palate development

Inferred from Biological aspect of Ancestor. Source: RefGenome

lens morphogenesis in camera-type eye

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

pattern specification process

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

regulation of sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

soft palate development

Inferred from Biological aspect of Ancestor. Source: RefGenome

thyroid gland development

Inferred from Biological aspect of Ancestor. Source: RefGenome

thyroid hormone generation

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Non-traceable author statement Ref.1. Source: RGD

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›101›101Forkhead box protein E3
PRO_0000091831

Regions

DNA binding2 – 9392Fork-head

Experimental info

Non-terminal residue11
Non-terminal residue1011

Sequences

Sequence LengthMass (Da)Tools
Q63250 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: B887C9151B4E8DC0

FASTA10111,802
        10         20         30         40         50         60 
RGKPPYSYIA LIAMALAHAP GRRLTLAAIY RFITERFAFY RDSPRKWQNS IRHNLTLNDC 

        70         80         90        100 
FVKVPREPGN PGKGNYWTLD PAAADMFDNG SFLRRRKRFK R 

« Hide

References

[1]"Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family."
Clevidence D.E., Overdier D.G., Tao W., Qian X., Pani L., Lai E., Costa R.H.
Proc. Natl. Acad. Sci. U.S.A. 90:3948-3952(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L13207 mRNA. Translation: AAA41323.1.
PIRI60921.
UniGeneRn.92407.

3D structure databases

ProteinModelPortalQ63250.
SMRQ63250. Positions 3-98.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000010208.

PTM databases

PhosphoSiteQ63250.

Proteomic databases

PaxDbQ63250.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:621727. rat.

Organism-specific databases

RGD621727. Foxe3.

Phylogenomic databases

eggNOGCOG5025.
HOGENOMHOG000231286.
InParanoidQ63250.
PhylomeDBQ63250.

Gene expression databases

ArrayExpressQ63250.
GenevestigatorQ63250.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOXE3_RAT
AccessionPrimary (citable) accession number: Q63250
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families