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Protein

Forkhead box protein E3

Gene

Foxe3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (By similarity). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi64 – 158Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA binding transcription factor activity Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central
  • sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • anatomical structure morphogenesis Source: GO_Central
  • camera-type eye development Source: RGD
  • cell development Source: RGD
  • cell differentiation Source: GO_Central
  • ciliary body morphogenesis Source: UniProtKB
  • cornea development in camera-type eye Source: UniProtKB
  • eye development Source: UniProtKB
  • iris morphogenesis Source: UniProtKB
  • lens development in camera-type eye Source: UniProtKB
  • mRNA transcription by RNA polymerase II Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cell cycle arrest Source: UniProtKB
  • negative regulation of lens fiber cell differentiation Source: UniProtKB
  • positive regulation of epithelial cell proliferation Source: RGD
  • positive regulation of lens epithelial cell proliferation Source: UniProtKB
  • trabecular meshwork development Source: UniProtKB
  • transcription by RNA polymerase II Source: RGD

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein E3
Alternative name(s):
Forkhead-related protein FKHL12
Forkhead-related transcription factor 8
Short name:
FREAC-8
Hepatocyte nuclear factor 3 forkhead homolog 7
Short name:
HFH-7
Gene namesi
Name:Foxe3
Synonyms:Fkhl12, Freac8, Hfh7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621727 Foxe3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004332361 – 286Forkhead box protein E3Add BLAST286

Proteomic databases

PaxDbiQ63250

PTM databases

PhosphoSitePlusiQ63250

Expressioni

Gene expression databases

BgeeiENSRNOG00000007770

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010208

Structurei

3D structure databases

SMRiQ63250
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi166 – 252Pro-richPROSITE-ProRule annotationAdd BLAST87

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00900000140781
HOGENOMiHOG000231286
InParanoidiQ63250
KOiK09398
OMAiPEPPCCA
OrthoDBiEOG091G0TOA
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.101 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q63250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAHVAFSGF PTLPSVSPSG PQPPSLAGDE PGREPEEVVG GGDSEPPAAP
60 70 80 90 100
GPGRRRRRPL QRGKPPYSYI ALIAMALAHA PGRRLTLAAI YRFITERFAF
110 120 130 140 150
YRDSPRKWQN SIRHNLTLND CFVKVPREPG NPGKGNYWTL DPAAADMFDN
160 170 180 190 200
GSFLRRRKRF KRTELPAPPP PPFPYAPFPP APAPAPAPPA RLFRLDSLLG
210 220 230 240 250
LQTEPPGPLA PEPPCCAAPD ASFPPCAAAA SPPLYSPAPE RLGLPAPLPA
260 270 280
EPLLALAGSA GALGPLGAGE AYLRQPGFPP GLERYL
Length:286
Mass (Da):30,469
Last modified:June 24, 2015 - v2
Checksum:i4238A421281D4141
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13207 mRNA Translation: AAA41323.1
AABR06039461 Genomic DNA No translation available.
CH474008 Genomic DNA Translation: EDL90326.1
PIRiI60921
RefSeqiNP_599166.1, NM_134339.1
UniGeneiRn.92407

Genome annotation databases

EnsembliENSRNOT00000010208; ENSRNOP00000010208; ENSRNOG00000007770
GeneIDi171302
KEGGirno:171302
UCSCiRGD:621727 rat

Similar proteinsi

Entry informationi

Entry nameiFOXE3_RAT
AccessioniPrimary (citable) accession number: Q63250
Secondary accession number(s): G3V6Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 24, 2015
Last modified: March 28, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome