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Protein

Forkhead box protein E3

Gene

Foxe3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi2 – 9392Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central
  3. sequence-specific DNA binding transcription factor activity Source: RGD

GO - Biological processi

  1. anatomical structure morphogenesis Source: GO_Central
  2. camera-type eye development Source: Ensembl
  3. cell development Source: Ensembl
  4. positive regulation of epithelial cell proliferation Source: Ensembl
  5. regulation of transcription from RNA polymerase II promoter Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein E3
Alternative name(s):
Forkhead-related protein FKHL12
Forkhead-related transcription factor 8
Short name:
FREAC-8
Hepatocyte nuclear factor 3 forkhead homolog 7
Short name:
HFH-7
Gene namesi
Name:Foxe3
Synonyms:Fkhl12, Freac8, Hfh7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621727. Foxe3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: GO_Central
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›101›101Forkhead box protein E3PRO_0000091831Add
BLAST

Proteomic databases

PaxDbiQ63250.

PTM databases

PhosphoSiteiQ63250.

Expressioni

Gene expression databases

ExpressionAtlasiQ63250. baseline.
GenevestigatoriQ63250.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010208.

Structurei

3D structure databases

ProteinModelPortaliQ63250.
SMRiQ63250. Positions 3-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000231286.
InParanoidiQ63250.
PhylomeDBiQ63250.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q63250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RGKPPYSYIA LIAMALAHAP GRRLTLAAIY RFITERFAFY RDSPRKWQNS
60 70 80 90 100
IRHNLTLNDC FVKVPREPGN PGKGNYWTLD PAAADMFDNG SFLRRRKRFK

R
Length:101
Mass (Da):11,802
Last modified:November 1, 1997 - v1
Checksum:iB887C9151B4E8DC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei101 – 1011

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13207 mRNA. Translation: AAA41323.1.
PIRiI60921.
UniGeneiRn.92407.

Genome annotation databases

UCSCiRGD:621727. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13207 mRNA. Translation: AAA41323.1.
PIRiI60921.
UniGeneiRn.92407.

3D structure databases

ProteinModelPortaliQ63250.
SMRiQ63250. Positions 3-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010208.

PTM databases

PhosphoSiteiQ63250.

Proteomic databases

PaxDbiQ63250.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:621727. rat.

Organism-specific databases

RGDi621727. Foxe3.

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000231286.
InParanoidiQ63250.
PhylomeDBiQ63250.

Gene expression databases

ExpressionAtlasiQ63250. baseline.
GenevestigatoriQ63250.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family."
    Clevidence D.E., Overdier D.G., Tao W., Qian X., Pani L., Lai E., Costa R.H.
    Proc. Natl. Acad. Sci. U.S.A. 90:3948-3952(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiFOXE3_RAT
AccessioniPrimary (citable) accession number: Q63250
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 29, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.