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Q63250

- FOXE3_RAT

UniProt

Q63250 - FOXE3_RAT

Protein

Forkhead box protein E3

Gene

Foxe3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi2 – 9392Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: RGD

    GO - Biological processi

    1. camera-type eye development Source: Ensembl
    2. cell development Source: Ensembl
    3. positive regulation of epithelial cell proliferation Source: Ensembl
    4. transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein E3
    Alternative name(s):
    Forkhead-related protein FKHL12
    Forkhead-related transcription factor 8
    Short name:
    FREAC-8
    Hepatocyte nuclear factor 3 forkhead homolog 7
    Short name:
    HFH-7
    Gene namesi
    Name:Foxe3
    Synonyms:Fkhl12, Freac8, Hfh7
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621727. Foxe3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›101›101Forkhead box protein E3PRO_0000091831Add
    BLAST

    Proteomic databases

    PaxDbiQ63250.

    PTM databases

    PhosphoSiteiQ63250.

    Expressioni

    Gene expression databases

    ArrayExpressiQ63250.
    GenevestigatoriQ63250.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000010208.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63250.
    SMRiQ63250. Positions 3-98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000231286.
    InParanoidiQ63250.
    PhylomeDBiQ63250.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q63250-1 [UniParc]FASTAAdd to Basket

    « Hide

    RGKPPYSYIA LIAMALAHAP GRRLTLAAIY RFITERFAFY RDSPRKWQNS    50
    IRHNLTLNDC FVKVPREPGN PGKGNYWTLD PAAADMFDNG SFLRRRKRFK 100
    R 101
    Length:101
    Mass (Da):11,802
    Last modified:November 1, 1997 - v1
    Checksum:iB887C9151B4E8DC0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei101 – 1011

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13207 mRNA. Translation: AAA41323.1.
    PIRiI60921.
    UniGeneiRn.92407.

    Genome annotation databases

    UCSCiRGD:621727. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13207 mRNA. Translation: AAA41323.1 .
    PIRi I60921.
    UniGenei Rn.92407.

    3D structure databases

    ProteinModelPortali Q63250.
    SMRi Q63250. Positions 3-98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000010208.

    PTM databases

    PhosphoSitei Q63250.

    Proteomic databases

    PaxDbi Q63250.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:621727. rat.

    Organism-specific databases

    RGDi 621727. Foxe3.

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000231286.
    InParanoidi Q63250.
    PhylomeDBi Q63250.

    Gene expression databases

    ArrayExpressi Q63250.
    Genevestigatori Q63250.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family."
      Clevidence D.E., Overdier D.G., Tao W., Qian X., Pani L., Lai E., Costa R.H.
      Proc. Natl. Acad. Sci. U.S.A. 90:3948-3952(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiFOXE3_RAT
    AccessioniPrimary (citable) accession number: Q63250
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3