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Protein

Forkhead box protein J1

Gene

Foxj1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required for motile ciliogenesis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi120 – 21091Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cellular response to insulin-like growth factor stimulus Source: RGD
  • cilium assembly Source: UniProtKB
  • cilium morphogenesis Source: UniProtKB
  • response to estradiol Source: RGD
  • response to organic cyclic compound Source: RGD
  • spermatogenesis Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cilium biogenesis/degradation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein J1
Alternative name(s):
Hepatocyte nuclear factor 3 forkhead homolog 4
Short name:
HFH-4
Gene namesi
Name:Foxj1
Synonyms:Hfh4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621764. Foxj1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Forkhead box protein J1PRO_0000091852Add
BLAST

Expressioni

Tissue specificityi

Pulmonary epithelium, testis and oviduct.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ63247.
SMRiQ63247. Positions 120-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG056832.
InParanoidiQ63247.
KOiK09402.
PhylomeDBiQ63247.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESWLRLCG AGPGEEAGPE GGMEEPDALD DSLTSLQWLQ EFSILNAKAP
60 70 80 90 100
TLPPGGTDPL GYHQVPGLVA PGSPLAADPA CLGQPHTPGK PTSSCTSRSA
110 120 130 140 150
PPGLQAPPPD DVDYATNPHV KPPYSYATLI CMAMQASKAT KITLSAIYKW
160 170 180 190 200
ITDNFCYFRH ADPTWQNSIR HNLSLNKCFI KVPREKDEPG KGGFWRIDPQ
210 220 230 240 250
YAERLLSGAF KKRRLPPVHI HPAFARQAAQ EPSTAPWGGP LTVNREAQQL
260 270 280 290 300
LQEFEEATGE GGWGTGEGRL GHKRKQPLPK RVAKVLRPPS TLLLTQEEQG
310 320 330 340 350
ELEPLKGNFD WEAIFEAGAL GEELSSLEGL ELSPPLSPSS HGEVDLTVHG
360 370 380 390 400
RHINCPATWG PPVEQATDSL DFDETFLATS FLQHPWDESS SGCLPPEPLF
410 420
EAGDATLAAD LQDWASVGAF L
Length:421
Mass (Da):45,566
Last modified:November 1, 1997 - v1
Checksum:iF5365D33B20926AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36388 mRNA. Translation: AAC37671.1.
RefSeqiNP_446284.1. NM_053832.1.
UniGeneiRn.202954.

Genome annotation databases

GeneIDi116557.
KEGGirno:116557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36388 mRNA. Translation: AAC37671.1.
RefSeqiNP_446284.1. NM_053832.1.
UniGeneiRn.202954.

3D structure databases

ProteinModelPortaliQ63247.
SMRiQ63247. Positions 120-215.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116557.
KEGGirno:116557.

Organism-specific databases

CTDi2302.
RGDi621764. Foxj1.

Phylogenomic databases

HOVERGENiHBG056832.
InParanoidiQ63247.
KOiK09402.
PhylomeDBiQ63247.

Miscellaneous databases

PROiQ63247.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOXJ1_RAT
AccessioniPrimary (citable) accession number: Q63247
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.