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Protein

Forkhead box protein C2

Gene

Foxc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. Might be involved in the formation of special mesenchymal tissues (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi71 – 165Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein C2
Alternative name(s):
Brain factor 3
Short name:
BF-3
HFH-BF-3
Gene namesi
Name:Foxc2
Synonyms:Hfhbf3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621703. Foxc2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918101 – 494Forkhead box protein C2Add BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki213Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei214PhosphoserineBy similarity1
Modified residuei218PhosphoserineBy similarity1
Modified residuei231PhosphoserineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei246PhosphothreonineBy similarity1
Modified residuei250PhosphoserineBy similarity1
Modified residuei278Omega-N-methylarginineBy similarity1
Modified residuei280PhosphoserineBy similarity1
Modified residuei287PhosphoserineBy similarity1
Modified residuei292Omega-N-methylarginineBy similarity1
Modified residuei366PhosphoserineBy similarity1
Modified residuei452Asymmetric dimethylarginineBy similarity1

Post-translational modificationi

Phosphorylation regulates FOXC2 transcriptional activity by promoting its recruitment to chromatin.By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ63246.
PRIDEiQ63246.

PTM databases

iPTMnetiQ63246.
PhosphoSitePlusiQ63246.

Expressioni

Gene expression databases

BgeeiENSRNOG00000047446.
GenevisibleiQ63246. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065254.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi162 – 166Poly-Arg5
Compositional biasi386 – 395His-rich10
Compositional biasi396 – 411Pro-richAdd BLAST16

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
InParanoidiQ63246.
KOiK09396.
OMAiLNHLPGH.
OrthoDBiEOG091G0HW9.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYGA
60 70 80 90 100
GMGRSYAPYH HQPAAPKDLV KPPYSYIALI TMAIQNAPEK KITLNGIYQF
110 120 130 140 150
IMDRFPFYRE NKQGWQNSIR HNLSLNECFV KVPRDDKKPG KGSYWTLDPD
160 170 180 190 200
SYNMFENGSF LRRRRRFKKK DVPKDKEERA HLKEPPPASA KGAPTGTPVA
210 220 230 240 250
DGPKEAEKKV VVKSEAASPA LPVITKVETL SPEGALQASP RSSASTPAGS
260 270 280 290 300
PDGSLPEHHA AAPNGLPGFS VETIMTLRTS PPGGDLSPAA ARAGLVVPPL
310 320 330 340 350
ALPYAAAPPA AYAQPCAQGL EAAGSAGYQC SMRAMSLYTG AERPAHVCVP
360 370 380 390 400
PALDEALSDH PSGPGSPLGA LNLAAGQEGA LGASGHHHQH HSHLHPQAPP
410 420 430 440 450
PAPQPPPAPQ PATQATSWYL NHGGDLSHLP GHTFATQQQT FPNVREMFNS
460 470 480 490
HRLGLDNSTL GESQVSNASC QLPYRATPSL YRHAAPYSYD CTKY
Length:494
Mass (Da):52,854
Last modified:October 16, 2013 - v2
Checksum:iECCF03CC41F0B454
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80I → S in AAA41320 (PubMed:7683413).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06099147 Genomic DNA. No translation available.
CH473972 Genomic DNA. Translation: EDL92716.1.
L13193 mRNA. Translation: AAA41320.1.
PIRiI60918.
RefSeqiNP_001095150.1. NM_001101680.1.
UniGeneiRn.216723.

Genome annotation databases

EnsembliENSRNOT00000072369; ENSRNOP00000065254; ENSRNOG00000047446.
GeneIDi171356.
KEGGirno:171356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06099147 Genomic DNA. No translation available.
CH473972 Genomic DNA. Translation: EDL92716.1.
L13193 mRNA. Translation: AAA41320.1.
PIRiI60918.
RefSeqiNP_001095150.1. NM_001101680.1.
UniGeneiRn.216723.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065254.

PTM databases

iPTMnetiQ63246.
PhosphoSitePlusiQ63246.

Proteomic databases

PaxDbiQ63246.
PRIDEiQ63246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000072369; ENSRNOP00000065254; ENSRNOG00000047446.
GeneIDi171356.
KEGGirno:171356.

Organism-specific databases

CTDi2303.
RGDi621703. Foxc2.

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
InParanoidiQ63246.
KOiK09396.
OMAiLNHLPGH.
OrthoDBiEOG091G0HW9.

Miscellaneous databases

PROiQ63246.

Gene expression databases

BgeeiENSRNOG00000047446.
GenevisibleiQ63246. RN.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOXC2_RAT
AccessioniPrimary (citable) accession number: Q63246
Secondary accession number(s): M0R736
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 16, 2013
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.