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Q63245

- FOXD3_RAT

UniProt

Q63245 - FOXD3_RAT

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Protein

Forkhead box protein D3

Gene

Foxd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi3 – 9795Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: RGD
  2. double-stranded DNA binding Source: RGD
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  5. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. embryonic placenta development Source: Ensembl
  2. in utero embryonic development Source: UniProtKB
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  5. regulation of transcription, DNA-templated Source: RGD
  6. trophectodermal cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_212185. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D3
Alternative name(s):
HNF3/FH transcription factor genesis
Hepatocyte nuclear factor 3 forkhead homolog 2
Short name:
HFH-2
Gene namesi
Name:Foxd3
Synonyms:Hfh2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621715. Foxd3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›101›101Forkhead box protein D3PRO_0000091819Add
BLAST

Proteomic databases

PaxDbiQ63245.

PTM databases

PhosphoSiteiQ63245.

Expressioni

Gene expression databases

ExpressionAtlasiQ63245. baseline and differential.
GenevestigatoriQ63245.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054694.

Structurei

Secondary structure

1
101
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 1710Combined sources
Turni20 – 223Combined sources
Helixi26 – 3611Combined sources
Helixi38 – 436Combined sources
Helixi47 – 5913Combined sources
Beta strandi62 – 643Combined sources
Beta strandi71 – 733Combined sources
Beta strandi76 – 783Combined sources
Helixi83 – 897Combined sources
Beta strandi94 – 963Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HDCNMR-A2-98[»]
2HFHNMR-A2-101[»]
ProteinModelPortaliQ63245.
SMRiQ63245. Positions 2-98.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63245.

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000231285.
HOVERGENiHBG083674.
InParanoidiQ63245.
PhylomeDBiQ63245.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q63245-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LVKPPYSYIA LITMAILQSP QKKLTLSGIC EFISNRFPYY REKFPAWQNS
60 70 80 90 100
IRHNLSLNDC FVKIPREPGN PGKGNYWTLD PQSEDMFDNG SFLRRRKRFK

R
Length:101
Mass (Da):11,943
Last modified:November 1, 1996 - v1
Checksum:iDC0ADEC15A1DD143
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei101 – 1011

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13202 mRNA. Translation: AAA41319.1.
PIRiI60917.
UniGeneiRn.92964.

Genome annotation databases

UCSCiRGD:621715. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13202 mRNA. Translation: AAA41319.1 .
PIRi I60917.
UniGenei Rn.92964.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HDC NMR - A 2-98 [» ]
2HFH NMR - A 2-101 [» ]
ProteinModelPortali Q63245.
SMRi Q63245. Positions 2-98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000054694.

PTM databases

PhosphoSitei Q63245.

Proteomic databases

PaxDbi Q63245.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:621715. rat.

Organism-specific databases

RGDi 621715. Foxd3.

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000231285.
HOVERGENi HBG083674.
InParanoidi Q63245.
PhylomeDBi Q63245.

Enzyme and pathway databases

Reactomei REACT_212185. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Miscellaneous databases

EvolutionaryTracei Q63245.

Gene expression databases

ExpressionAtlasi Q63245. baseline and differential.
Genevestigatori Q63245.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family."
    Clevidence D.E., Overdier D.G., Tao W., Qian X., Pani L., Lai E., Costa R.H.
    Proc. Natl. Acad. Sci. U.S.A. 90:3948-3952(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Structural changes in the region directly adjacent to the DNA-binding helix highlight a possible mechanism to explain the observed changes in the sequence-specific binding of winged helix proteins."
    Marsden I., Jin C., Liao X.
    J. Mol. Biol. 278:293-299(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 3-97.

Entry informationi

Entry nameiFOXD3_RAT
AccessioniPrimary (citable) accession number: Q63245
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3