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Q63245

- FOXD3_RAT

UniProt

Q63245 - FOXD3_RAT

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Protein
Forkhead box protein D3
Gene
Foxd3, Hfh2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi3 – 9795Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: RGD
  2. DNA binding, bending Source: RefGenome
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  4. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  5. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  6. double-stranded DNA binding Source: RGD
  7. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. transcription factor binding Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. axon extension involved in axon guidance Source: RefGenome
  2. branching involved in ureteric bud morphogenesis Source: RefGenome
  3. cartilage development Source: RefGenome
  4. embryonic placenta development Source: RefGenome
  5. enteric nervous system development Source: RefGenome
  6. in utero embryonic development Source: UniProtKB
  7. iridophore differentiation Source: RefGenome
  8. kidney development Source: RefGenome
  9. lateral line nerve glial cell development Source: RefGenome
  10. melanocyte differentiation Source: RefGenome
  11. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  12. neural crest cell migration Source: RefGenome
  13. pattern specification process Source: RefGenome
  14. peripheral nervous system development Source: RefGenome
  15. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  16. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  17. regulation of transcription, DNA-templated Source: RGD
  18. sympathetic nervous system development Source: RefGenome
  19. transcription from RNA polymerase II promoter Source: GOC
  20. trophectodermal cell differentiation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_212185. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D3
Alternative name(s):
HNF3/FH transcription factor genesis
Hepatocyte nuclear factor 3 forkhead homolog 2
Short name:
HFH-2
Gene namesi
Name:Foxd3
Synonyms:Hfh2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621715. Foxd3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›101›101Forkhead box protein D3
PRO_0000091819Add
BLAST

Proteomic databases

PaxDbiQ63245.

PTM databases

PhosphoSiteiQ63245.

Expressioni

Gene expression databases

GenevestigatoriQ63245.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054694.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 1710
Turni20 – 223
Helixi26 – 3611
Helixi38 – 436
Helixi47 – 5913
Beta strandi62 – 643
Beta strandi71 – 733
Beta strandi76 – 783
Helixi83 – 897
Beta strandi94 – 963

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HDCNMR-A2-98[»]
2HFHNMR-A2-101[»]
ProteinModelPortaliQ63245.
SMRiQ63245. Positions 2-98.

Miscellaneous databases

EvolutionaryTraceiQ63245.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000231285.
HOVERGENiHBG083674.
InParanoidiQ63245.
PhylomeDBiQ63245.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q63245-1 [UniParc]FASTAAdd to Basket

« Hide

LVKPPYSYIA LITMAILQSP QKKLTLSGIC EFISNRFPYY REKFPAWQNS    50
IRHNLSLNDC FVKIPREPGN PGKGNYWTLD PQSEDMFDNG SFLRRRKRFK 100
R 101
Length:101
Mass (Da):11,943
Last modified:November 1, 1996 - v1
Checksum:iDC0ADEC15A1DD143
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei101 – 1011

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13202 mRNA. Translation: AAA41319.1.
PIRiI60917.
UniGeneiRn.92964.

Genome annotation databases

UCSCiRGD:621715. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13202 mRNA. Translation: AAA41319.1 .
PIRi I60917.
UniGenei Rn.92964.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HDC NMR - A 2-98 [» ]
2HFH NMR - A 2-101 [» ]
ProteinModelPortali Q63245.
SMRi Q63245. Positions 2-98.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000054694.

PTM databases

PhosphoSitei Q63245.

Proteomic databases

PaxDbi Q63245.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:621715. rat.

Organism-specific databases

RGDi 621715. Foxd3.

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000231285.
HOVERGENi HBG083674.
InParanoidi Q63245.
PhylomeDBi Q63245.

Enzyme and pathway databases

Reactomei REACT_212185. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Miscellaneous databases

EvolutionaryTracei Q63245.

Gene expression databases

Genevestigatori Q63245.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family."
    Clevidence D.E., Overdier D.G., Tao W., Qian X., Pani L., Lai E., Costa R.H.
    Proc. Natl. Acad. Sci. U.S.A. 90:3948-3952(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Structural changes in the region directly adjacent to the DNA-binding helix highlight a possible mechanism to explain the observed changes in the sequence-specific binding of winged helix proteins."
    Marsden I., Jin C., Liao X.
    J. Mol. Biol. 278:293-299(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 3-97.

Entry informationi

Entry nameiFOXD3_RAT
AccessioniPrimary (citable) accession number: Q63245
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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