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Protein

Glia maturation factor beta

Gene

Gmfb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Glia maturation factor beta
Short name:
GMF-beta
Gene namesi
Name:Gmfb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70910. Gmfb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 142141Glia maturation factor betaPRO_0000214946Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Post-translational modificationi

Phosphorylated; stimulated by phorbol ester.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ63228.
PRIDEiQ63228.

PTM databases

iPTMnetiQ63228.
PhosphoSiteiQ63228.

Interactioni

Protein-protein interaction databases

MINTiMINT-4564289.
STRINGi10116.ENSRNOP00000067695.

Structurei

3D structure databases

ProteinModelPortaliQ63228.
SMRiQ63228. Positions 5-139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 139136ADF-HPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ADF-H domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1736. Eukaryota.
ENOG4111RK6. LUCA.
HOGENOMiHOG000175654.
HOVERGENiHBG003045.
InParanoidiQ63228.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF.
[Graphical view]
PANTHERiPTHR11249. PTHR11249. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PIRSFiPIRSF001788. GMF-beta. 1 hit.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63228-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESLVVCDV AEDLVEKLRK FRFRKETHNA AIIMKIDKDK RLVVLDEELE
60 70 80 90 100
GVSPDELKDE LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPLGCKPEQ
110 120 130 140
QMMYAGSKNK LVQTAELTKV FEIRNTEDLT EEWLREKLGF FH
Length:142
Mass (Da):16,736
Last modified:January 23, 2007 - v2
Checksum:iA36B8D8D82B44F6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11558 mRNA. Translation: CAA77650.1.
BC081778 mRNA. Translation: AAH81778.1.
PIRiS22149.
RefSeqiNP_112294.1. NM_031032.2.
UniGeneiRn.10454.

Genome annotation databases

GeneIDi81661.
KEGGirno:81661.
UCSCiRGD:70910. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11558 mRNA. Translation: CAA77650.1.
BC081778 mRNA. Translation: AAH81778.1.
PIRiS22149.
RefSeqiNP_112294.1. NM_031032.2.
UniGeneiRn.10454.

3D structure databases

ProteinModelPortaliQ63228.
SMRiQ63228. Positions 5-139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4564289.
STRINGi10116.ENSRNOP00000067695.

PTM databases

iPTMnetiQ63228.
PhosphoSiteiQ63228.

Proteomic databases

PaxDbiQ63228.
PRIDEiQ63228.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81661.
KEGGirno:81661.
UCSCiRGD:70910. rat.

Organism-specific databases

CTDi2764.
RGDi70910. Gmfb.

Phylogenomic databases

eggNOGiKOG1736. Eukaryota.
ENOG4111RK6. LUCA.
HOGENOMiHOG000175654.
HOVERGENiHBG003045.
InParanoidiQ63228.

Miscellaneous databases

PROiQ63228.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF.
[Graphical view]
PANTHERiPTHR11249. PTHR11249. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PIRSFiPIRSF001788. GMF-beta. 1 hit.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of glia maturation factor beta mRNA and protein in rat organs and cells."
    Zaheer A., Fink B.D., Lim R.
    J. Neurochem. 60:914-920(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. Lubec G., Diao W.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 42-64, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  4. Lubec G., Chen W.-Q.
    Submitted (FEB-2007) to UniProtKB
    Cited for: ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiGMFB_RAT
AccessioniPrimary (citable) accession number: Q63228
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.