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Protein
Submitted name:

Alpha-2u globulin

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-2u globulinImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Protein family/group databases

Allergomei611. Rat n 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 181162Sequence analysisPRO_5007707229Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 176Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZQ3X-ray2.80A/B/C/D20-179[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 174140Lipocln_cytosolic_FA-bd_domInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOGENOMiHOG000231458.
HOVERGENiHBG000215.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLLLLLCL GLTLVCGHAE EASFERGNLD VDKLNGDWFS IVVASDKREK
60 70 80 90 100
IEENGSMRVF VQHIDVLENS LGFTFRIKEN GVCTEFSLVA DKTAKDGEYF
110 120 130 140 150
VEYDGENTFT ILKTDYDNYV MFHLVNVNNG ETFQLMELYG RTKDLSSDIK
160 170 180
EKFAKLCVAH GITRDNIIDL TKTDRCLQAR G
Length:181
Mass (Da):20,562
Last modified:November 1, 1996 - v1
Checksum:i9F560E6ACB21EB5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00738 mRNA. Translation: AAA88508.1.
AB039825 mRNA. Translation: BAA96482.1.
PIRiS05440.
UniGeneiRn.86413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00738 mRNA. Translation: AAA88508.1.
AB039825 mRNA. Translation: BAA96482.1.
PIRiS05440.
UniGeneiRn.86413.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZQ3X-ray2.80A/B/C/D20-179[»]
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei611. Rat n 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000231458.
HOVERGENiHBG000215.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Tissue-specific control of alpha 2u globulin gene expression: constitutive synthesis in the submaxillary gland."
    Laperche Y., Lynch K.R., Dolan K.P., Feigelson P.
    Cell 32:453-460(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: Submaxillary glandImported.
  2. "Molecular evidence of complex tissue- and sex-specific mRNA expression of the rat alpha(2u)-globulin multigene family."
    Saito K., Nishikawa J., Imagawa M., Nishihara T., Matsuo M.
    Biochem. Biophys. Res. Commun. 272:337-344(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: Preputial glandImported.
  3. "Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3."
    Portman K.L., Long J., Carr S., Briand L., Winzor D.J., Searle M.S., Scott D.J.
    Biochemistry 53:2371-2379(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 20-179, DISULFIDE BONDS.

Entry informationi

Entry nameiQ63213_RAT
AccessioniPrimary (citable) accession number: Q63213
Secondary accession number(s): Q63022
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.