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Protein

Low affinity immunoglobulin gamma Fc region receptor II

Gene

Fcgr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens.

GO - Molecular functioni

  • IgG binding Source: RGD
  • immunoglobulin binding Source: RGD

GO - Biological processi

  • cellular response to lipopolysaccharide Source: RGD
  • endocytic recycling Source: RGD
  • immune complex clearance Source: RGD
  • negative regulation of neutrophil apoptotic process Source: RGD
  • receptor-mediated endocytosis Source: RGD
  • response to estradiol Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgG-binding protein

Enzyme and pathway databases

ReactomeiR-RNO-2029481. FCGR activation.
R-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-2029485. Role of phospholipids in phagocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor II
Alternative name(s):
Fc-gamma RII
Short name:
FcRII
IgG Fc receptor II beta
CD_antigen: CD32
Gene namesi
Name:Fcgr2
Synonyms:Fcgr2b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi631331. Fcgr2b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 212181ExtracellularSequence analysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence analysisAdd
BLAST
Topological domaini234 – 28552CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
  • recycling endosome Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 285254Low affinity immunoglobulin gamma Fc region receptor IIPRO_0000015144Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 101PROSITE-ProRule annotation
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence analysis
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence analysis
Disulfide bondi140 ↔ 184PROSITE-ProRule annotation
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence analysis
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence analysis
Modified residuei264 – 2641Phosphotyrosine; by SRC-type Tyr-kinasesBy similarity
Modified residuei277 – 2771PhosphoserineCombined sources
Modified residuei281 – 2811PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ63203.

PTM databases

iPTMnetiQ63203.

Expressioni

Gene expression databases

ExpressionAtlasiQ63203. baseline and differential.
GenevisibleiQ63203. RN.

Interactioni

Subunit structurei

Interacts with FGR and LYN.By similarity

GO - Molecular functioni

  • IgG binding Source: RGD
  • immunoglobulin binding Source: RGD

Protein-protein interaction databases

BioGridi252829. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ63203.
SMRiQ63203. Positions 36-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 11883Ig-like C2-type 1Add
BLAST
Domaini119 – 20183Ig-like C2-type 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi262 – 2676ITIM motif

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119130.
HOVERGENiHBG051602.
InParanoidiQ63203.
KOiK12560.
OrthoDBiEOG708W0N.
PhylomeDBiQ63203.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSNRTVVHV LSRTLYHMLL WTAVLNLVAE SHAGLPKAVV KLEPPWIQVL
60 70 80 90 100
KEDTVTLMCE GTHNTKNCST QWFHNGSSIW HQAQANYTFK ATVNDSGEYR
110 120 130 140 150
CRMEETGISE PIHLGVISDW LLLQTSQLVF EEGETITLRC HSWKNKQLTK
160 170 180 190 200
VLLFQNGKPV RYYHQSSNFS IPKANHSHSG NYYCKAYLGR TMHVSKPVTI
210 220 230 240 250
TVQEPKSSSS LPVLTIVAAV AGIAVAAIVI ILVSLVYLKK KQVPDTPSGL
260 270 280
EEAEKNEVEN TITYSLLKHP EAPDEESDHD YQNHI
Length:285
Mass (Da):32,048
Last modified:November 1, 1997 - v1
Checksum:i255540A584CFFA0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73371 mRNA. Translation: CAA51788.1.
PIRiS36903.
RefSeqiNP_786932.1. NM_175756.1.
UniGeneiRn.33323.

Genome annotation databases

EnsembliENSRNOT00000035400; ENSRNOP00000034321; ENSRNOG00000046452.
GeneIDi289211.
KEGGirno:289211.
UCSCiRGD:631331. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73371 mRNA. Translation: CAA51788.1.
PIRiS36903.
RefSeqiNP_786932.1. NM_175756.1.
UniGeneiRn.33323.

3D structure databases

ProteinModelPortaliQ63203.
SMRiQ63203. Positions 36-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi252829. 1 interaction.

PTM databases

iPTMnetiQ63203.

Proteomic databases

PRIDEiQ63203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035400; ENSRNOP00000034321; ENSRNOG00000046452.
GeneIDi289211.
KEGGirno:289211.
UCSCiRGD:631331. rat.

Organism-specific databases

CTDi2213.
RGDi631331. Fcgr2b.

Phylogenomic databases

GeneTreeiENSGT00760000119130.
HOVERGENiHBG051602.
InParanoidiQ63203.
KOiK12560.
OrthoDBiEOG708W0N.
PhylomeDBiQ63203.

Enzyme and pathway databases

ReactomeiR-RNO-2029481. FCGR activation.
R-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-2029485. Role of phospholipids in phagocytosis.

Miscellaneous databases

PROiQ63203.

Gene expression databases

ExpressionAtlasiQ63203. baseline and differential.
GenevisibleiQ63203. RN.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence of the cDNA coding for rat type II Fc gamma receptor of mast cells."
    Bocek P., Pecht I.
    FEBS Lett. 331:86-90(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFCGR2_RAT
AccessioniPrimary (citable) accession number: Q63203
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.