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Protein

Low affinity immunoglobulin gamma Fc region receptor II

Gene

Fcgr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens.

GO - Molecular functioni

  • IgG binding Source: RGD
  • immunoglobulin binding Source: RGD

GO - Biological processi

  • cellular response to amyloid-beta Source: ARUK-UCL
  • cellular response to lipopolysaccharide Source: RGD
  • endocytic recycling Source: RGD
  • immune complex clearance Source: RGD
  • negative regulation of neutrophil apoptotic process Source: RGD
  • positive regulation of neuron death Source: ARUK-UCL
  • positive regulation of response to endoplasmic reticulum stress Source: ARUK-UCL
  • receptor-mediated endocytosis Source: RGD
  • response to estradiol Source: RGD

Keywordsi

Molecular functionIgG-binding protein, Receptor

Enzyme and pathway databases

ReactomeiR-RNO-2029481 FCGR activation
R-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation
R-RNO-2029485 Role of phospholipids in phagocytosis
R-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor II
Alternative name(s):
Fc-gamma RII
Short name:
FcRII
IgG Fc receptor II beta
CD_antigen: CD32
Gene namesi
Name:Fcgr2
Synonyms:Fcgr2b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi631331 Fcgr2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 212ExtracellularSequence analysisAdd BLAST181
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 285CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001514432 – 285Low affinity immunoglobulin gamma Fc region receptor IIAdd BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 101PROSITE-ProRule annotation
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140 ↔ 184PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei264Phosphotyrosine; by SRC-type Tyr-kinasesBy similarity1
Modified residuei277PhosphoserineCombined sources1
Modified residuei281PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ63203

PTM databases

iPTMnetiQ63203
PhosphoSitePlusiQ63203

Expressioni

Gene expression databases

BgeeiENSRNOG00000046452
ExpressionAtlasiQ63203 baseline and differential
GenevisibleiQ63203 RN

Interactioni

Subunit structurei

Interacts with FGR and LYN.By similarity

Protein-protein interaction databases

BioGridi252829, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ63203
SMRiQ63203
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 118Ig-like C2-type 1Add BLAST83
Domaini119 – 201Ig-like C2-type 2Add BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi262 – 267ITIM motif6

Domaini

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119130
HOVERGENiHBG051602
InParanoidiQ63203
KOiK12560
PhylomeDBiQ63203

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSNRTVVHV LSRTLYHMLL WTAVLNLVAE SHAGLPKAVV KLEPPWIQVL
60 70 80 90 100
KEDTVTLMCE GTHNTKNCST QWFHNGSSIW HQAQANYTFK ATVNDSGEYR
110 120 130 140 150
CRMEETGISE PIHLGVISDW LLLQTSQLVF EEGETITLRC HSWKNKQLTK
160 170 180 190 200
VLLFQNGKPV RYYHQSSNFS IPKANHSHSG NYYCKAYLGR TMHVSKPVTI
210 220 230 240 250
TVQEPKSSSS LPVLTIVAAV AGIAVAAIVI ILVSLVYLKK KQVPDTPSGL
260 270 280
EEAEKNEVEN TITYSLLKHP EAPDEESDHD YQNHI
Length:285
Mass (Da):32,048
Last modified:November 1, 1997 - v1
Checksum:i255540A584CFFA0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73371 mRNA Translation: CAA51788.1
PIRiS36903
RefSeqiNP_786932.1, NM_175756.1
UniGeneiRn.33323

Genome annotation databases

EnsembliENSRNOT00000035400; ENSRNOP00000034321; ENSRNOG00000046452
GeneIDi289211
KEGGirno:289211
UCSCiRGD:631331 rat

Similar proteinsi

Entry informationi

Entry nameiFCGR2_RAT
AccessioniPrimary (citable) accession number: Q63203
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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