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Q63199

- TNR6_RAT

UniProt

Q63199 - TNR6_RAT

Protein

Tumor necrosis factor receptor superfamily member 6

Gene

Fas

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both By similarity.By similarity

    GO - Molecular functioni

    1. protease binding Source: RGD
    2. protein binding Source: RGD
    3. protein complex binding Source: RGD
    4. receptor activity Source: RGD
    5. transmembrane signaling receptor activity Source: RGD
    6. tumor necrosis factor-activated receptor activity Source: RGD

    GO - Biological processi

    1. aging Source: RGD
    2. apoptotic process Source: RGD
    3. apoptotic signaling pathway Source: RGD
    4. cellular response to cobalt ion Source: RGD
    5. cellular response to cytokine stimulus Source: RGD
    6. cellular response to estrogen stimulus Source: RGD
    7. cellular response to glucose stimulus Source: RGD
    8. cellular response to hydrogen peroxide Source: RGD
    9. cellular response to hypoxia Source: RGD
    10. cellular response to interleukin-1 Source: RGD
    11. cellular response to organic cyclic compound Source: RGD
    12. cellular response to phenylalanine Source: RGD
    13. cellular response to tumor necrosis factor Source: RGD
    14. dendrite regeneration Source: RGD
    15. extrinsic apoptotic signaling pathway via death domain receptors Source: RGD
    16. immune response Source: InterPro
    17. liver regeneration Source: RGD
    18. maternal process involved in female pregnancy Source: RGD
    19. ovarian follicle atresia Source: RGD
    20. ovulation cycle Source: RGD
    21. positive regulation of apoptotic process Source: RGD
    22. positive regulation of cell death Source: RGD
    23. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
    24. regulation of apoptotic process Source: RGD
    25. regulation of cell proliferation Source: RGD
    26. regulation of gene expression Source: RGD
    27. response to cycloheximide Source: RGD
    28. response to cytokine Source: RGD
    29. response to drug Source: RGD
    30. response to estrogen Source: RGD
    31. response to fluoride Source: RGD
    32. response to growth factor Source: RGD
    33. response to hypoxia Source: RGD
    34. response to inorganic substance Source: RGD
    35. response to lipopolysaccharide Source: RGD
    36. response to peptide hormone Source: RGD
    37. response to toxic substance Source: RGD
    38. spermatogenesis Source: RGD
    39. telencephalon development Source: RGD
    40. tumor necrosis factor-mediated signaling pathway Source: GOC

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 6
    Alternative name(s):
    Apo-1 antigen
    Apoptosis-mediating surface antigen FAS
    FASLG receptor
    CD_antigen: CD95
    Gene namesi
    Name:Fas
    Synonyms:Apt1, Tnfrsf6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi619831. Fas.

    Subcellular locationi

    GO - Cellular componenti

    1. apical dendrite Source: RGD
    2. apical plasma membrane Source: RGD
    3. CD95 death-inducing signaling complex Source: RGD
    4. cell surface Source: RGD
    5. cytoplasm Source: RGD
    6. death-inducing signaling complex Source: RGD
    7. extracellular space Source: RGD
    8. integral component of membrane Source: UniProtKB-KW
    9. membrane raft Source: RGD
    10. neuronal cell body Source: RGD
    11. neuron projection Source: RGD
    12. perinuclear region of cytoplasm Source: RGD
    13. sarcolemma Source: RGD
    14. secretory granule Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 324303Tumor necrosis factor receptor superfamily member 6PRO_0000034569Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi44 ↔ 55PROSITE-ProRule annotation
    Disulfide bondi56 ↔ 69PROSITE-ProRule annotation
    Disulfide bondi59 ↔ 78PROSITE-ProRule annotation
    Disulfide bondi81 ↔ 97PROSITE-ProRule annotation
    Disulfide bondi100 ↔ 115PROSITE-ProRule annotation
    Disulfide bondi103 ↔ 123PROSITE-ProRule annotation
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi125 ↔ 139PROSITE-ProRule annotation
    Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi142 ↔ 154PROSITE-ProRule annotation
    Disulfide bondi145 ↔ 162PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ63199.

    Expressioni

    Gene expression databases

    GenevestigatoriQ63199.

    Interactioni

    Subunit structurei

    Binds DAXX and RIPK1. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Interacts with BRE and FEM1B By similarity. Interacts with FADD By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ63199. 1 interaction.
    STRINGi10116.ENSRNOP00000040348.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63199.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 171150ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini189 – 324136CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei172 – 18817HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati43 – 7937TNFR-Cys 1Add
    BLAST
    Repeati80 – 12344TNFR-Cys 2Add
    BLAST
    Repeati124 – 16340TNFR-Cys 3Add
    BLAST
    Domaini219 – 30385DeathPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni201 – 306106Interaction with HIPK3By similarityAdd
    BLAST

    Domaini

    Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

    Sequence similaritiesi

    Contains 1 death domain.PROSITE-ProRule annotation
    Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45364.
    HOGENOMiHOG000139681.
    HOVERGENiHBG004091.
    KOiK04390.
    PhylomeDBiQ63199.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR008063. Fas_rcpt.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    [Graphical view]
    PfamiPF00531. Death. 1 hit.
    PF00020. TNFR_c6. 1 hit.
    [Graphical view]
    PRINTSiPR01680. TNFACTORR6.
    SMARTiSM00005. DEATH. 1 hit.
    SM00208. TNFR. 3 hits.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q63199-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLWIMAVLPL VLAGPELNVR MQGTDSIFEG LELKRSVRET DNNCSEGLYQ    50
    VGPFCCQPCQ PGERKVKDCT TSGGAPTCHP CTEGEEYTDR KHYSDKCRRC 100
    AFCDEGHGLE VETNCTRTQN TKCRCKENFY CNASLCDHCY HCTSCGLEDI 150
    LEPCTRTSNT KCKKQSSNYK LLWLLILPGL AILFVFIYKR YRKRQPGDPE 200
    SGIPSPESVP MNVSDVNLNK YIWRTAEKMK ICDAKKFARQ HKIPESKIDE 250
    IEHNSPQDAA EQKIQLLQCW YQSHGKTGAC QALIQGLRKA NRCDIAEEIQ 300
    AMVWEDHENS ISNSRNENEG QSLE 324
    Length:324
    Mass (Da):36,835
    Last modified:November 1, 1996 - v1
    Checksum:iD25D583C909D9D09
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26112 mRNA. Translation: BAA05108.1.
    PIRiJC2395.
    RefSeqiNP_631933.2. NM_139194.2.
    UniGeneiRn.162521.

    Genome annotation databases

    GeneIDi246097.
    KEGGirno:246097.
    UCSCiRGD:619831. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26112 mRNA. Translation: BAA05108.1 .
    PIRi JC2395.
    RefSeqi NP_631933.2. NM_139194.2.
    UniGenei Rn.162521.

    3D structure databases

    ProteinModelPortali Q63199.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q63199. 1 interaction.
    STRINGi 10116.ENSRNOP00000040348.

    Chemistry

    ChEMBLi CHEMBL2417350.

    Proteomic databases

    PRIDEi Q63199.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 246097.
    KEGGi rno:246097.
    UCSCi RGD:619831. rat.

    Organism-specific databases

    CTDi 355.
    RGDi 619831. Fas.

    Phylogenomic databases

    eggNOGi NOG45364.
    HOGENOMi HOG000139681.
    HOVERGENi HBG004091.
    KOi K04390.
    PhylomeDBi Q63199.

    Miscellaneous databases

    NextBioi 623366.
    PROi Q63199.

    Gene expression databases

    Genevestigatori Q63199.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR008063. Fas_rcpt.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    [Graphical view ]
    Pfami PF00531. Death. 1 hit.
    PF00020. TNFR_c6. 1 hit.
    [Graphical view ]
    PRINTSi PR01680. TNFACTORR6.
    SMARTi SM00005. DEATH. 1 hit.
    SM00208. TNFR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A variant mRNA species encoding a truncated form of Fas antigen in the rat liver."
      Kimura K., Yamamoto M., Wakatsuki T.
      Biochem. Biophys. Res. Commun. 198:666-674(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.

    Entry informationi

    Entry nameiTNR6_RAT
    AccessioniPrimary (citable) accession number: Q63199
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3