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Protein

Tumor necrosis factor receptor superfamily member 6

Gene

Fas

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).By similarity

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB
  • identical protein binding Source: RGD
  • kinase binding Source: RGD
  • protease binding Source: RGD
  • protein complex binding Source: RGD
  • receptor activity Source: RGD
  • transmembrane signaling receptor activity Source: RGD
  • tumor necrosis factor-activated receptor activity Source: RGD
  • tumor necrosis factor binding Source: GO_Central

GO - Biological processi

  • activation-induced cell death of T cells Source: RGD
  • aging Source: RGD
  • apoptotic process Source: RGD
  • apoptotic signaling pathway Source: RGD
  • B cell mediated immunity Source: RGD
  • cellular response to amino acid starvation Source: RGD
  • cellular response to cobalt ion Source: RGD
  • cellular response to cytokine stimulus Source: RGD
  • cellular response to estrogen stimulus Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • cellular response to hydrogen peroxide Source: RGD
  • cellular response to hydrostatic pressure Source: RGD
  • cellular response to hyperoxia Source: RGD
  • cellular response to hypoxia Source: RGD
  • cellular response to interleukin-1 Source: RGD
  • cellular response to lithium ion Source: RGD
  • cellular response to mechanical stimulus Source: RGD
  • cellular response to organic cyclic compound Source: RGD
  • cellular response to phenylalanine Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • chordate embryonic development Source: RGD
  • circadian rhythm Source: RGD
  • dendrite regeneration Source: RGD
  • extrinsic apoptotic signaling pathway Source: RGD
  • extrinsic apoptotic signaling pathway in absence of ligand Source: RGD
  • extrinsic apoptotic signaling pathway via death domain receptors Source: RGD
  • Fas signaling pathway Source: RGD
  • gene expression Source: RGD
  • hepatocyte apoptotic process Source: RGD
  • immune response Source: GO_Central
  • immunoglobulin production Source: RGD
  • inflammatory cell apoptotic process Source: RGD
  • inflammatory response Source: GO_Central
  • liver regeneration Source: RGD
  • maternal process involved in female pregnancy Source: RGD
  • motor neuron apoptotic process Source: RGD
  • necroptotic signaling pathway Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of B cell activation Source: RGD
  • negative thymic T cell selection Source: RGD
  • neuron apoptotic process Source: RGD
  • ovarian follicle atresia Source: RGD
  • ovulation cycle Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of apoptotic signaling pathway Source: RGD
  • positive regulation of cell death Source: RGD
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: RGD
  • positive regulation of extrinsic apoptotic signaling pathway Source: RGD
  • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: RGD
  • positive regulation of lymphocyte apoptotic process Source: RGD
  • positive regulation of neuron apoptotic process Source: RGD
  • positive regulation of protein homooligomerization Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • protein homooligomerization Source: RGD
  • regulation of apoptotic process Source: RGD
  • regulation of cell proliferation Source: RGD
  • regulation of gene expression Source: RGD
  • regulation of lymphocyte differentiation Source: RGD
  • regulation of myeloid cell differentiation Source: RGD
  • regulation of stress-activated MAPK cascade Source: RGD
  • renal system process Source: RGD
  • response to cycloheximide Source: RGD
  • response to cytokine Source: RGD
  • response to drug Source: RGD
  • response to estrogen Source: RGD
  • response to fluoride Source: RGD
  • response to glucocorticoid Source: RGD
  • response to growth factor Source: RGD
  • response to hypoxia Source: RGD
  • response to inorganic substance Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to nutrient levels Source: RGD
  • response to peptide hormone Source: RGD
  • response to toxic substance Source: RGD
  • spermatogenesis Source: RGD
  • spleen development Source: RGD
  • T cell homeostasis Source: RGD
  • telencephalon development Source: RGD

Keywordsi

Molecular functionCalmodulin-binding, Receptor
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 6
Alternative name(s):
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD_antigen: CD95
Gene namesi
Name:Fas
Synonyms:Apt1, Tnfrsf6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619831. Fas.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 171ExtracellularSequence analysisAdd BLAST150
Transmembranei172 – 188HelicalSequence analysisAdd BLAST17
Topological domaini189 – 324CytoplasmicSequence analysisAdd BLAST136

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2417350.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003456922 – 324Tumor necrosis factor receptor superfamily member 6Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi44 ↔ 55
Disulfide bondi56 ↔ 69
Disulfide bondi59 ↔ 78
Disulfide bondi81 ↔ 97
Disulfide bondi100 ↔ 115
Disulfide bondi103 ↔ 123
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi125 ↔ 139
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi142 ↔ 154
Disulfide bondi145 ↔ 162
Modified residuei214PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63199.
PRIDEiQ63199.

Interactioni

Subunit structurei

Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BABAM2 and FEM1B. Interacts with FADD (By similarity). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (PubMed:15383280). Interacts with CALM (By similarity).By similarity1 Publication

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB
  • identical protein binding Source: RGD
  • kinase binding Source: RGD
  • protease binding Source: RGD
  • protein complex binding Source: RGD
  • tumor necrosis factor binding Source: GO_Central

Protein-protein interaction databases

IntActiQ63199. 1 interactor.
STRINGi10116.ENSRNOP00000025928.

Chemistry databases

BindingDBiQ63199.

Structurei

3D structure databases

ProteinModelPortaliQ63199.
SMRiQ63199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 79TNFR-Cys 1Add BLAST37
Repeati80 – 123TNFR-Cys 2Add BLAST44
Repeati124 – 163TNFR-Cys 3Add BLAST40
Domaini219 – 303DeathAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 306Interaction with HIPK3By similarityAdd BLAST106
Regioni219 – 243Interaction with CALMBy similarityAdd BLAST25

Domaini

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J23A. Eukaryota.
ENOG4112ADB. LUCA.
HOGENOMiHOG000139681.
HOVERGENiHBG004091.
InParanoidiQ63199.
KOiK04390.
PhylomeDBiQ63199.

Family and domain databases

CDDicd08316. Death_FAS_TNFRSF6. 1 hit.
cd10579. TNFRSF6. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom_sf.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR033998. TNFRSF6_death.
IPR033999. TNFRSF6_N.
PANTHERiPTHR23097:SF114. PTHR23097:SF114. 2 hits.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF00020. TNFR_c6. 1 hit.
PRINTSiPR01680. TNFACTORR6.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWIMAVLPL VLAGPELNVR MQGTDSIFEG LELKRSVRET DNNCSEGLYQ
60 70 80 90 100
VGPFCCQPCQ PGERKVKDCT TSGGAPTCHP CTEGEEYTDR KHYSDKCRRC
110 120 130 140 150
AFCDEGHGLE VETNCTRTQN TKCRCKENFY CNASLCDHCY HCTSCGLEDI
160 170 180 190 200
LEPCTRTSNT KCKKQSSNYK LLWLLILPGL AILFVFIYKR YRKRQPGDPE
210 220 230 240 250
SGIPSPESVP MNVSDVNLNK YIWRTAEKMK ICDAKKFARQ HKIPESKIDE
260 270 280 290 300
IEHNSPQDAA EQKIQLLQCW YQSHGKTGAC QALIQGLRKA NRCDIAEEIQ
310 320
AMVWEDHENS ISNSRNENEG QSLE
Length:324
Mass (Da):36,835
Last modified:November 1, 1996 - v1
Checksum:iD25D583C909D9D09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26112 mRNA. Translation: BAA05108.1.
PIRiJC2395.
RefSeqiNP_631933.2. NM_139194.2.
UniGeneiRn.162521.

Genome annotation databases

GeneIDi246097.
KEGGirno:246097.
UCSCiRGD:619831. rat.

Similar proteinsi

Entry informationi

Entry nameiTNR6_RAT
AccessioniPrimary (citable) accession number: Q63199
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome