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Q63199 (TNR6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor receptor superfamily member 6
Alternative name(s):
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD_antigen=CD95
Gene names
Name:Fas
Synonyms:Apt1, Tnfrsf6
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both By similarity.

Subunit structure

Binds DAXX and RIPK1. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Interacts with BRE and FEM1B By similarity. Interacts with FADD By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Domain

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Sequence similarities

Contains 1 death domain.

Contains 3 TNFR-Cys repeats.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentMembrane
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaging

Inferred from expression pattern PubMed 16936193. Source: RGD

apoptotic process

Traceable author statement PubMed 12121892. Source: RGD

apoptotic signaling pathway

Inferred from mutant phenotype PubMed 16953119. Source: RGD

cellular response to organic cyclic compound

Inferred from expression pattern PubMed 16987298. Source: RGD

dendrite regeneration

Inferred from mutant phenotype PubMed 18692025. Source: RGD

extrinsic apoptotic signaling pathway via death domain receptors

Inferred from expression pattern PubMed 17195944. Source: RGD

immune response

Inferred from electronic annotation. Source: InterPro

ovulation cycle

Inferred from expression pattern PubMed 16461545. Source: RGD

regulation of cell proliferation

Inferred from mutant phenotype PubMed 17991709. Source: RGD

response to cytokine

Inferred from expression pattern PubMed 17105443. Source: RGD

response to drug

Inferred from expression pattern PubMed 16687611. Source: RGD

response to estrogen

Inferred from expression pattern PubMed 16099864. Source: RGD

response to growth factor

Inferred from expression pattern PubMed 18692025. Source: RGD

response to hypoxia

Inferred from expression pattern PubMed 16870148. Source: RGD

response to inorganic substance

Inferred from expression pattern PubMed 17953211. Source: RGD

response to lipopolysaccharide

Inferred from expression pattern PubMed 17899301. Source: RGD

response to peptide hormone

Inferred from expression pattern PubMed 16392621. Source: RGD

response to toxic substance

Inferred from expression pattern PubMed 17900647. Source: RGD

spermatogenesis

Inferred from expression pattern PubMed 17195944. Source: RGD

tumor necrosis factor-mediated signaling pathway

Inferred from mutant phenotype PubMed 16154149. Source: GOC

   Cellular_componentCD95 death-inducing signaling complex

Inferred from direct assay PubMed 16493077. Source: RGD

cell surface

Inferred from direct assay PubMed 18045865. Source: RGD

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane raft

Inferred from direct assay PubMed 17518537. Source: RGD

perinuclear region of cytoplasm

Inferred from direct assay PubMed 17518537. Source: RGD

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 15557468. Source: RGD

receptor activity

Traceable author statement PubMed 12121892. Source: RGD

transmembrane signaling receptor activity

Non-traceable author statement Ref.1. Source: RGD

tumor necrosis factor-activated receptor activity

Inferred from mutant phenotype PubMed 16154149. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 324303Tumor necrosis factor receptor superfamily member 6
PRO_0000034569

Regions

Topological domain22 – 171150Extracellular Potential
Transmembrane172 – 18817Helical; Potential
Topological domain189 – 324136Cytoplasmic Potential
Repeat43 – 7937TNFR-Cys 1
Repeat80 – 12344TNFR-Cys 2
Repeat124 – 16340TNFR-Cys 3
Domain219 – 30385Death
Region201 – 306106Interaction with HIPK3 By similarity

Amino acid modifications

Glycosylation431N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1321N-linked (GlcNAc...) Potential
Disulfide bond44 ↔ 55 By similarity
Disulfide bond56 ↔ 69 By similarity
Disulfide bond59 ↔ 78 By similarity
Disulfide bond81 ↔ 97 By similarity
Disulfide bond100 ↔ 115 By similarity
Disulfide bond103 ↔ 123 By similarity
Disulfide bond125 ↔ 139 By similarity
Disulfide bond142 ↔ 154 By similarity
Disulfide bond145 ↔ 162 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63199 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D25D583C909D9D09

FASTA32436,835
        10         20         30         40         50         60 
MLWIMAVLPL VLAGPELNVR MQGTDSIFEG LELKRSVRET DNNCSEGLYQ VGPFCCQPCQ 

        70         80         90        100        110        120 
PGERKVKDCT TSGGAPTCHP CTEGEEYTDR KHYSDKCRRC AFCDEGHGLE VETNCTRTQN 

       130        140        150        160        170        180 
TKCRCKENFY CNASLCDHCY HCTSCGLEDI LEPCTRTSNT KCKKQSSNYK LLWLLILPGL 

       190        200        210        220        230        240 
AILFVFIYKR YRKRQPGDPE SGIPSPESVP MNVSDVNLNK YIWRTAEKMK ICDAKKFARQ 

       250        260        270        280        290        300 
HKIPESKIDE IEHNSPQDAA EQKIQLLQCW YQSHGKTGAC QALIQGLRKA NRCDIAEEIQ 

       310        320 
AMVWEDHENS ISNSRNENEG QSLE 

« Hide

References

[1]"A variant mRNA species encoding a truncated form of Fas antigen in the rat liver."
Kimura K., Yamamoto M., Wakatsuki T.
Biochem. Biophys. Res. Commun. 198:666-674(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D26112 mRNA. Translation: BAA05108.1.
PIRJC2395.
RefSeqNP_631933.2. NM_139194.2.
UniGeneRn.162521.

3D structure databases

ProteinModelPortalQ63199.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ63199. 1 interaction.
STRING10116.ENSRNOP00000040348.

Chemistry

ChEMBLCHEMBL2417350.

Proteomic databases

PRIDEQ63199.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID246097.
KEGGrno:246097.
UCSCRGD:619831. rat.

Organism-specific databases

CTD355.
RGD619831. Fas.

Phylogenomic databases

eggNOGNOG45364.
HOGENOMHOG000139681.
HOVERGENHBG004091.
KOK04390.
PhylomeDBQ63199.

Gene expression databases

GenevestigatorQ63199.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
InterProIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamPF00531. Death. 1 hit.
PF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSPR01680. TNFACTORR6.
SMARTSM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
[Graphical view]
SUPFAMSSF47986. SSF47986. 1 hit.
PROSITEPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio623366.
PROQ63199.

Entry information

Entry nameTNR6_RAT
AccessionPrimary (citable) accession number: Q63199
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families