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Q63199

- TNR6_RAT

UniProt

Q63199 - TNR6_RAT

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Protein
Tumor necrosis factor receptor superfamily member 6
Gene
Fas, Apt1, Tnfrsf6
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both By similarity.

GO - Molecular functioni

  1. protein binding Source: RGD
  2. receptor activity Source: RGD
  3. transmembrane signaling receptor activity Source: RGD
  4. tumor necrosis factor-activated receptor activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. aging Source: RGD
  2. apoptotic process Source: RGD
  3. apoptotic signaling pathway Source: RGD
  4. cellular response to organic cyclic compound Source: RGD
  5. dendrite regeneration Source: RGD
  6. extrinsic apoptotic signaling pathway via death domain receptors Source: RGD
  7. immune response Source: InterPro
  8. ovulation cycle Source: RGD
  9. regulation of cell proliferation Source: RGD
  10. response to cytokine Source: RGD
  11. response to drug Source: RGD
  12. response to estrogen Source: RGD
  13. response to growth factor Source: RGD
  14. response to hypoxia Source: RGD
  15. response to inorganic substance Source: RGD
  16. response to lipopolysaccharide Source: RGD
  17. response to peptide hormone Source: RGD
  18. response to toxic substance Source: RGD
  19. spermatogenesis Source: RGD
  20. tumor necrosis factor-mediated signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 6
Alternative name(s):
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD_antigen: CD95
Gene namesi
Name:Fas
Synonyms:Apt1, Tnfrsf6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619831. Fas.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 171150Extracellular Reviewed prediction
Add
BLAST
Transmembranei172 – 18817Helical; Reviewed prediction
Add
BLAST
Topological domaini189 – 324136Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. CD95 death-inducing signaling complex Source: RGD
  2. cell surface Source: RGD
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane raft Source: RGD
  5. perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 324303Tumor necrosis factor receptor superfamily member 6
PRO_0000034569Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi44 ↔ 55 By similarity
Disulfide bondi56 ↔ 69 By similarity
Disulfide bondi59 ↔ 78 By similarity
Disulfide bondi81 ↔ 97 By similarity
Disulfide bondi100 ↔ 115 By similarity
Disulfide bondi103 ↔ 123 By similarity
Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi125 ↔ 139 By similarity
Glycosylationi132 – 1321N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi142 ↔ 154 By similarity
Disulfide bondi145 ↔ 162 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ63199.

Expressioni

Gene expression databases

GenevestigatoriQ63199.

Interactioni

Subunit structurei

Binds DAXX and RIPK1. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Interacts with BRE and FEM1B By similarity. Interacts with FADD By similarity.

Protein-protein interaction databases

IntActiQ63199. 1 interaction.
STRINGi10116.ENSRNOP00000040348.

Structurei

3D structure databases

ProteinModelPortaliQ63199.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 7937TNFR-Cys 1
Add
BLAST
Repeati80 – 12344TNFR-Cys 2
Add
BLAST
Repeati124 – 16340TNFR-Cys 3
Add
BLAST
Domaini219 – 30385Death
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni201 – 306106Interaction with HIPK3 By similarity
Add
BLAST

Domaini

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Sequence similaritiesi

Contains 1 death domain.
Contains 3 TNFR-Cys repeats.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45364.
HOGENOMiHOG000139681.
HOVERGENiHBG004091.
KOiK04390.
PhylomeDBiQ63199.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01680. TNFACTORR6.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63199-1 [UniParc]FASTAAdd to Basket

« Hide

MLWIMAVLPL VLAGPELNVR MQGTDSIFEG LELKRSVRET DNNCSEGLYQ    50
VGPFCCQPCQ PGERKVKDCT TSGGAPTCHP CTEGEEYTDR KHYSDKCRRC 100
AFCDEGHGLE VETNCTRTQN TKCRCKENFY CNASLCDHCY HCTSCGLEDI 150
LEPCTRTSNT KCKKQSSNYK LLWLLILPGL AILFVFIYKR YRKRQPGDPE 200
SGIPSPESVP MNVSDVNLNK YIWRTAEKMK ICDAKKFARQ HKIPESKIDE 250
IEHNSPQDAA EQKIQLLQCW YQSHGKTGAC QALIQGLRKA NRCDIAEEIQ 300
AMVWEDHENS ISNSRNENEG QSLE 324
Length:324
Mass (Da):36,835
Last modified:November 1, 1996 - v1
Checksum:iD25D583C909D9D09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26112 mRNA. Translation: BAA05108.1.
PIRiJC2395.
RefSeqiNP_631933.2. NM_139194.2.
UniGeneiRn.162521.

Genome annotation databases

GeneIDi246097.
KEGGirno:246097.
UCSCiRGD:619831. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26112 mRNA. Translation: BAA05108.1 .
PIRi JC2395.
RefSeqi NP_631933.2. NM_139194.2.
UniGenei Rn.162521.

3D structure databases

ProteinModelPortali Q63199.
ModBasei Search...

Protein-protein interaction databases

IntActi Q63199. 1 interaction.
STRINGi 10116.ENSRNOP00000040348.

Chemistry

ChEMBLi CHEMBL2417350.

Proteomic databases

PRIDEi Q63199.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 246097.
KEGGi rno:246097.
UCSCi RGD:619831. rat.

Organism-specific databases

CTDi 355.
RGDi 619831. Fas.

Phylogenomic databases

eggNOGi NOG45364.
HOGENOMi HOG000139681.
HOVERGENi HBG004091.
KOi K04390.
PhylomeDBi Q63199.

Miscellaneous databases

NextBioi 623366.
PROi Q63199.

Gene expression databases

Genevestigatori Q63199.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
InterProi IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view ]
Pfami PF00531. Death. 1 hit.
PF00020. TNFR_c6. 1 hit.
[Graphical view ]
PRINTSi PR01680. TNFACTORR6.
SMARTi SM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A variant mRNA species encoding a truncated form of Fas antigen in the rat liver."
    Kimura K., Yamamoto M., Wakatsuki T.
    Biochem. Biophys. Res. Commun. 198:666-674(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiTNR6_RAT
AccessioniPrimary (citable) accession number: Q63199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi