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Q63199

- TNR6_RAT

UniProt

Q63199 - TNR6_RAT

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Protein

Tumor necrosis factor receptor superfamily member 6

Gene

Fas

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).By similarity

GO - Molecular functioni

  1. protease binding Source: RGD
  2. protein complex binding Source: RGD
  3. receptor activity Source: RGD
  4. transmembrane signaling receptor activity Source: RGD
  5. tumor necrosis factor-activated receptor activity Source: RGD

GO - Biological processi

  1. aging Source: RGD
  2. apoptotic process Source: RGD
  3. apoptotic signaling pathway Source: RGD
  4. cellular response to cobalt ion Source: RGD
  5. cellular response to cytokine stimulus Source: RGD
  6. cellular response to estrogen stimulus Source: RGD
  7. cellular response to glucose stimulus Source: RGD
  8. cellular response to hydrogen peroxide Source: RGD
  9. cellular response to hydrostatic pressure Source: RGD
  10. cellular response to hypoxia Source: RGD
  11. cellular response to interleukin-1 Source: RGD
  12. cellular response to organic cyclic compound Source: RGD
  13. cellular response to phenylalanine Source: RGD
  14. cellular response to tumor necrosis factor Source: RGD
  15. chordate embryonic development Source: RGD
  16. dendrite regeneration Source: RGD
  17. extrinsic apoptotic signaling pathway via death domain receptors Source: RGD
  18. immune response Source: InterPro
  19. liver regeneration Source: RGD
  20. maternal process involved in female pregnancy Source: RGD
  21. ovarian follicle atresia Source: RGD
  22. ovulation cycle Source: RGD
  23. positive regulation of apoptotic process Source: RGD
  24. positive regulation of cell death Source: RGD
  25. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  26. regulation of apoptotic process Source: RGD
  27. regulation of cell proliferation Source: RGD
  28. regulation of gene expression Source: RGD
  29. response to cycloheximide Source: RGD
  30. response to cytokine Source: RGD
  31. response to drug Source: RGD
  32. response to estrogen Source: RGD
  33. response to fluoride Source: RGD
  34. response to growth factor Source: RGD
  35. response to hypoxia Source: RGD
  36. response to inorganic substance Source: RGD
  37. response to lipopolysaccharide Source: RGD
  38. response to peptide hormone Source: RGD
  39. response to toxic substance Source: RGD
  40. spermatogenesis Source: RGD
  41. telencephalon development Source: RGD
  42. tumor necrosis factor-mediated signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 6
Alternative name(s):
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD_antigen: CD95
Gene namesi
Name:Fas
Synonyms:Apt1, Tnfrsf6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619831. Fas.

Subcellular locationi

GO - Cellular componenti

  1. apical dendrite Source: RGD
  2. apical plasma membrane Source: RGD
  3. CD95 death-inducing signaling complex Source: RGD
  4. cell surface Source: RGD
  5. cytoplasm Source: RGD
  6. death-inducing signaling complex Source: RGD
  7. extracellular space Source: RGD
  8. integral component of membrane Source: UniProtKB-KW
  9. membrane raft Source: RGD
  10. neuronal cell body Source: RGD
  11. neuron projection Source: RGD
  12. perinuclear region of cytoplasm Source: RGD
  13. sarcolemma Source: RGD
  14. secretory granule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 324303Tumor necrosis factor receptor superfamily member 6PRO_0000034569Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi44 ↔ 55PROSITE-ProRule annotation
Disulfide bondi56 ↔ 69PROSITE-ProRule annotation
Disulfide bondi59 ↔ 78PROSITE-ProRule annotation
Disulfide bondi81 ↔ 97PROSITE-ProRule annotation
Disulfide bondi100 ↔ 115PROSITE-ProRule annotation
Disulfide bondi103 ↔ 123PROSITE-ProRule annotation
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi125 ↔ 139PROSITE-ProRule annotation
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi142 ↔ 154PROSITE-ProRule annotation
Disulfide bondi145 ↔ 162PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ63199.

Expressioni

Gene expression databases

GenevestigatoriQ63199.

Interactioni

Subunit structurei

Binds DAXX and RIPK1. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Interacts with BRE and FEM1B (By similarity). Interacts with FADD (By similarity).By similarity

Protein-protein interaction databases

IntActiQ63199. 1 interaction.
STRINGi10116.ENSRNOP00000040348.

Structurei

3D structure databases

ProteinModelPortaliQ63199.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 171150ExtracellularSequence AnalysisAdd
BLAST
Topological domaini189 – 324136CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei172 – 18817HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 7937TNFR-Cys 1Add
BLAST
Repeati80 – 12344TNFR-Cys 2Add
BLAST
Repeati124 – 16340TNFR-Cys 3Add
BLAST
Domaini219 – 30385DeathPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni201 – 306106Interaction with HIPK3By similarityAdd
BLAST

Domaini

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45364.
HOGENOMiHOG000139681.
HOVERGENiHBG004091.
InParanoidiQ63199.
KOiK04390.
PhylomeDBiQ63199.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01680. TNFACTORR6.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63199-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLWIMAVLPL VLAGPELNVR MQGTDSIFEG LELKRSVRET DNNCSEGLYQ
60 70 80 90 100
VGPFCCQPCQ PGERKVKDCT TSGGAPTCHP CTEGEEYTDR KHYSDKCRRC
110 120 130 140 150
AFCDEGHGLE VETNCTRTQN TKCRCKENFY CNASLCDHCY HCTSCGLEDI
160 170 180 190 200
LEPCTRTSNT KCKKQSSNYK LLWLLILPGL AILFVFIYKR YRKRQPGDPE
210 220 230 240 250
SGIPSPESVP MNVSDVNLNK YIWRTAEKMK ICDAKKFARQ HKIPESKIDE
260 270 280 290 300
IEHNSPQDAA EQKIQLLQCW YQSHGKTGAC QALIQGLRKA NRCDIAEEIQ
310 320
AMVWEDHENS ISNSRNENEG QSLE
Length:324
Mass (Da):36,835
Last modified:November 1, 1996 - v1
Checksum:iD25D583C909D9D09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26112 mRNA. Translation: BAA05108.1.
PIRiJC2395.
RefSeqiNP_631933.2. NM_139194.2.
UniGeneiRn.162521.

Genome annotation databases

GeneIDi246097.
KEGGirno:246097.
UCSCiRGD:619831. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26112 mRNA. Translation: BAA05108.1 .
PIRi JC2395.
RefSeqi NP_631933.2. NM_139194.2.
UniGenei Rn.162521.

3D structure databases

ProteinModelPortali Q63199.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q63199. 1 interaction.
STRINGi 10116.ENSRNOP00000040348.

Chemistry

ChEMBLi CHEMBL2417350.

Proteomic databases

PRIDEi Q63199.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 246097.
KEGGi rno:246097.
UCSCi RGD:619831. rat.

Organism-specific databases

CTDi 355.
RGDi 619831. Fas.

Phylogenomic databases

eggNOGi NOG45364.
HOGENOMi HOG000139681.
HOVERGENi HBG004091.
InParanoidi Q63199.
KOi K04390.
PhylomeDBi Q63199.

Miscellaneous databases

NextBioi 623366.
PROi Q63199.

Gene expression databases

Genevestigatori Q63199.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
InterProi IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view ]
Pfami PF00531. Death. 1 hit.
PF00020. TNFR_c6. 1 hit.
[Graphical view ]
PRINTSi PR01680. TNFACTORR6.
SMARTi SM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A variant mRNA species encoding a truncated form of Fas antigen in the rat liver."
    Kimura K., Yamamoto M., Wakatsuki T.
    Biochem. Biophys. Res. Commun. 198:666-674(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiTNR6_RAT
AccessioniPrimary (citable) accession number: Q63199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3