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Protein

Contactin-1

Gene

Cntn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Notch signaling pathway

Enzyme and pathway databases

ReactomeiR-RNO-2979096. NOTCH2 Activation and Transmission of Signal to the Nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-1
Alternative name(s):
Neural cell surface protein F3
Gene namesi
Name:Cntn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621300. Cntn1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001468921 – 1001Contactin-1Add BLAST981
PropeptideiPRO_00000146901002 – 1021Removed in mature formSequence analysisAdd BLAST20

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 114PROSITE-ProRule annotation
Disulfide bondi158 ↔ 211PROSITE-ProRule annotation
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi263 ↔ 310PROSITE-ProRule annotation
Glycosylationi338N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi352 ↔ 391PROSITE-ProRule annotation
Disulfide bondi436 ↔ 484PROSITE-ProRule annotation
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1
Glycosylationi473N-linked (GlcNAc...)Sequence analysis1
Glycosylationi494N-linked (GlcNAc...)Sequence analysis1
Glycosylationi521N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi526 ↔ 585PROSITE-ProRule annotation
Glycosylationi593N-linked (GlcNAc...)Sequence analysis1
Glycosylationi935N-linked (GlcNAc...)Sequence analysis1
Lipidationi1001GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ63198.
PRIDEiQ63198.

PTM databases

iPTMnetiQ63198.
PhosphoSitePlusiQ63198.
SwissPalmiQ63198.
UniCarbKBiQ63198.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004438.
GenevisibleiQ63198. RN.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with NOTCH1 (By similarity). Interacts with CNTNAP1 in cis form and TNR (PubMed:9118959, PubMed:9081628). Binds to the carbonic-anhydrase like domain of PTPRZ1 (PubMed:7628014). Detected in a complex with NRCAM and PTPRB (By similarity).By similarity3 Publications

Protein-protein interaction databases

DIPiDIP-53082N.
STRINGi10116.ENSRNOP00000006219.

Structurei

3D structure databases

ProteinModelPortaliQ63198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 131Ig-like C2-type 1Add BLAST91
Domaini137 – 223Ig-like C2-type 2Add BLAST87
Domaini241 – 326Ig-like C2-type 3Add BLAST86
Domaini331 – 407Ig-like C2-type 4Add BLAST77
Domaini413 – 500Ig-like C2-type 5Add BLAST88
Domaini504 – 603Ig-like C2-type 6Add BLAST100
Domaini608 – 706Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini711 – 808Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini813 – 908Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini909 – 1002Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi604 – 611Gly/Pro-rich8

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ63198.
KOiK06759.
OMAiFTWYRRY.
PhylomeDBiQ63198.
TreeFamiTF351103.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032991. Contactin-1.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PANTHERiPTHR10489:SF531. PTHR10489:SF531. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63198-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTPLLVSHL LLISLTSCLG EFTWHRRYGH GVSEEDKGFG PIFEEQPINT
60 70 80 90 100
IYPEESLEGK VSLNCRARAS PFPVYKWRMN NGDVDLTNDR YSMVGGNLVI
110 120 130 140 150
NNPDKQKDAG IYYCLASNNY GMVRSTEATL SFGYLDPFPP EDRPEVKVKE
160 170 180 190 200
GKGMVLLCDP PYHFPDDLSY RWLLNEFPVF ITMDKRRFVS QTNGNLYIAN
210 220 230 240 250
VESSDRGNYS CFVSSPSITK SVFSKFIPLI PIPERTTKPY PADIVVQFKD
260 270 280 290 300
IYTMMGQNVT LECFALGNPV PDIRWRKVLE PMPTTAEIST SGAVLKIFNI
310 320 330 340 350
QLEDEGLYEC EAENIRGKDK HQARIYVQAF PEWVEHINDT EVDIGSDLYW
360 370 380 390 400
PCVATGKPIP TIRWLKNGYA YHKGELRLYD VTFENAGMYQ CIAENAYGTI
410 420 430 440 450
YANAELKILA LAPTFEMNPM KKKILAAKGG RVIIECKPKA APKPKFSWSK
460 470 480 490 500
GTEWLVNSSR ILIWEDGSLE INNITRNDGG IYTCFAENNR GKANSTGTLV
510 520 530 540 550
ITNPTRIILA PINADITVGE NATMQCAASF DPSLDLTFVW SFNGYVIDFN
560 570 580 590 600
KEITNIHYQR NFMLDANGEL LIRNAQLKHA GRYTCTAQTI VDNSSASADL
610 620 630 640 650
VVRGPPGPPG GLRIEDIRAT SVALTWSRGS DNHSPISKYT IQTKTILSDD
660 670 680 690 700
WKDAKTDPPI IEGNMESAKA VDLIPWMEYE FRVVATNTLG TGEPSIPSNR
710 720 730 740 750
IKTDGAAPNV APSDVGGGGG TNRELTITWA PLSREYHYGN NFGYIVAFKP
760 770 780 790 800
FDGEEWKKVT VTNPDTGRYV HKDETMTPST AFQVKVKAFN NKGDGPYSLI
810 820 830 840 850
AVINSAQDAP SEAPTEVGVK VLSSSEISVH WKHVLEKIVE SYQIRYWAGH
860 870 880 890 900
DKEAAAHRVQ VTSQEYSARL ENLLPDTQYF IEVGACNSAG CGPSSDVIET
910 920 930 940 950
FTRKAPPSQP PRIISSVRSG SRYIITWDHV VALSNESTVT GYKILYRPDG
960 970 980 990 1000
QHDGKLFSTH KHSIEVPIPR DGEYVVEVRA HSDGGDGVVS QVKISGVSTL
1010 1020
SSGLLSLLLP SLGFLVFYSE F
Length:1,021
Mass (Da):113,495
Last modified:August 1, 1998 - v2
Checksum:iFC8DC13055EE5C68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38492 mRNA. Translation: BAA07504.1.
PIRiA57112.
RefSeqiNP_476459.1. NM_057118.2.
XP_006242239.1. XM_006242177.3.
XP_017450105.1. XM_017594616.1.
UniGeneiRn.143291.
Rn.21397.

Genome annotation databases

EnsembliENSRNOT00000006219; ENSRNOP00000006219; ENSRNOG00000004438.
ENSRNOT00000080621; ENSRNOP00000071355; ENSRNOG00000004438.
GeneIDi117258.
KEGGirno:117258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38492 mRNA. Translation: BAA07504.1.
PIRiA57112.
RefSeqiNP_476459.1. NM_057118.2.
XP_006242239.1. XM_006242177.3.
XP_017450105.1. XM_017594616.1.
UniGeneiRn.143291.
Rn.21397.

3D structure databases

ProteinModelPortaliQ63198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-53082N.
STRINGi10116.ENSRNOP00000006219.

PTM databases

iPTMnetiQ63198.
PhosphoSitePlusiQ63198.
SwissPalmiQ63198.
UniCarbKBiQ63198.

Proteomic databases

PaxDbiQ63198.
PRIDEiQ63198.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006219; ENSRNOP00000006219; ENSRNOG00000004438.
ENSRNOT00000080621; ENSRNOP00000071355; ENSRNOG00000004438.
GeneIDi117258.
KEGGirno:117258.

Organism-specific databases

CTDi1272.
RGDi621300. Cntn1.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ63198.
KOiK06759.
OMAiFTWYRRY.
PhylomeDBiQ63198.
TreeFamiTF351103.

Enzyme and pathway databases

ReactomeiR-RNO-2979096. NOTCH2 Activation and Transmission of Signal to the Nucleus.

Miscellaneous databases

PROiQ63198.

Gene expression databases

BgeeiENSRNOG00000004438.
GenevisibleiQ63198. RN.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032991. Contactin-1.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PANTHERiPTHR10489:SF531. PTHR10489:SF531. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTN1_RAT
AccessioniPrimary (citable) accession number: Q63198
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.