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Protein

Emerin

Gene

Emd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C (By similarity).By similarity

GO - Biological processi

  • nuclear envelope reassembly Source: RGD
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Emerin
Gene namesi
Name:Emd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2551. Emd.

Subcellular locationi

  • Nucleus inner membrane By similarity; Single-pass membrane protein By similarity; Nucleoplasmic side By similarity
  • Nucleus outer membrane By similarity

  • Note: Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: RGD
  • microtubule Source: UniProtKB-KW
  • nuclear envelope Source: RGD
  • nuclear inner membrane Source: UniProtKB-SubCell
  • nuclear outer membrane Source: UniProtKB-SubCell
  • spindle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260EmerinPRO_0000206142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei8 – 81PhosphoserineBy similarity
Modified residuei29 – 291PhosphoserineBy similarity
Modified residuei49 – 491Phosphoserine; by PKABy similarity
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei69 – 691PhosphoserineCombined sources
Modified residuei72 – 721PhosphoserineCombined sources
Modified residuei88 – 881PhosphoserineBy similarity
Modified residuei99 – 991PhosphoserineBy similarity
Modified residuei142 – 1421PhosphoserineCombined sources
Modified residuei143 – 1431PhosphoserineCombined sources
Modified residuei144 – 1441PhosphoserineCombined sources
Modified residuei162 – 1621PhosphotyrosineBy similarity
Modified residuei172 – 1721PhosphoserineBy similarity
Modified residuei175 – 1751PhosphoserineBy similarity
Modified residuei177 – 1771PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ63190.
PRIDEiQ63190.

PTM databases

iPTMnetiQ63190.
PhosphoSiteiQ63190.

Interactioni

Subunit structurei

Interacts with lamins A and C, BANF1, GMCL, BCLAF1 and YTHDC1/YT521. Interacts with TMEM43; the interaction retains emerin in the inner nuclear membrane. Interacts with ACTB, SPTAN1, F-actin, CTNNB1 and beta-tubulin. Interacts with SUN1 and SUN2 (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-4997343.
STRINGi10116.ENSRNOP00000053121.

Structurei

3D structure databases

ProteinModelPortaliQ63190.
SMRiQ63190. Positions 2-54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4545LEMPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 224179Interaction with F-actinBy similarityAdd
BLAST
Regioni169 – 18820Interaction with CTNNB1By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi52 – 598Poly-Ser
Compositional biasi187 – 20115Poly-SerAdd
BLAST

Sequence similaritiesi

Contains 1 LEM domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ10. Eukaryota.
ENOG410ZEWX. LUCA.
HOGENOMiHOG000081509.
HOVERGENiHBG001099.
InParanoidiQ63190.
KOiK12569.
PhylomeDBiQ63190.

Family and domain databases

Gene3Di1.10.720.40. 1 hit.
InterProiIPR011015. LEM/LEM-like_dom.
IPR003887. LEM_dom.
[Graphical view]
PfamiPF03020. LEM. 1 hit.
[Graphical view]
SMARTiSM00540. LEM. 1 hit.
[Graphical view]
SUPFAMiSSF63451. SSF63451. 1 hit.
PROSITEiPS50954. LEM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDYAVLSDT ELAAVLRQYN IPHGPILGST RKLYEKKIFE YETQRRRLSP
60 70 80 90 100
PSSSSSSFSY RFSDLDSASV DSDMYDLPKK EDALLYQSKD YNDDYYEESY
110 120 130 140 150
LTTRTYGEPE SVGMSKSFRR PGTSLVDADD TFHHQVRDDI FSSSEEEGKD
160 170 180 190 200
RERPIYGRDS AYQSIAEYRP ISNVSRSSLG LSYYPRSSTS SVSSSSSSPS
210 220 230 240 250
SWLTRRAIRP EKQAPTAALG QDRQVPLWGQ LLLFLAFATF LLFVYYSIQA
260
QEGNPFWMDP
Length:260
Mass (Da):29,676
Last modified:November 1, 1996 - v1
Checksum:iF7ACD132BF281FF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98377 mRNA. Translation: CAA67023.1.
RefSeqiNP_037080.1. NM_012948.1.
UniGeneiRn.10968.

Genome annotation databases

GeneIDi25437.
KEGGirno:25437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98377 mRNA. Translation: CAA67023.1.
RefSeqiNP_037080.1. NM_012948.1.
UniGeneiRn.10968.

3D structure databases

ProteinModelPortaliQ63190.
SMRiQ63190. Positions 2-54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997343.
STRINGi10116.ENSRNOP00000053121.

PTM databases

iPTMnetiQ63190.
PhosphoSiteiQ63190.

Proteomic databases

PaxDbiQ63190.
PRIDEiQ63190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25437.
KEGGirno:25437.

Organism-specific databases

CTDi2010.
RGDi2551. Emd.

Phylogenomic databases

eggNOGiENOG410IJ10. Eukaryota.
ENOG410ZEWX. LUCA.
HOGENOMiHOG000081509.
HOVERGENiHBG001099.
InParanoidiQ63190.
KOiK12569.
PhylomeDBiQ63190.

Miscellaneous databases

PROiQ63190.

Family and domain databases

Gene3Di1.10.720.40. 1 hit.
InterProiIPR011015. LEM/LEM-like_dom.
IPR003887. LEM_dom.
[Graphical view]
PfamiPF03020. LEM. 1 hit.
[Graphical view]
SMARTiSM00540. LEM. 1 hit.
[Graphical view]
SUPFAMiSSF63451. SSF63451. 1 hit.
PROSITEiPS50954. LEM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEMD_RAT
AccessioniPrimary (citable) accession number: Q63190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.