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Protein

Translation initiation factor eIF-2B subunit delta

Gene

Eif2b4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: RGD
  • translation initiation factor activity Source: UniProtKB
  • translation initiation factor binding Source: RGD

GO - Biological processi

  • cellular response to stimulus Source: UniProtKB
  • hippocampus development Source: RGD
  • myelination Source: UniProtKB
  • negative regulation of guanyl-nucleotide exchange factor activity Source: RGD
  • oligodendrocyte development Source: UniProtKB
  • ovarian follicle development Source: UniProtKB
  • response to glucose Source: UniProtKB
  • response to heat Source: UniProtKB
  • response to peptide hormone Source: UniProtKB
  • translational initiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit delta
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit delta
Gene namesi
Name:Eif2b4
Synonyms:Eif2bd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620208. Eif2b4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 524523Translation initiation factor eIF-2B subunit deltaPRO_0000156070Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei12 – 121PhosphoserineBy similarity
Modified residuei86 – 861PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ63186.

PTM databases

iPTMnetiQ63186.
PhosphoSiteiQ63186.

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

GO - Molecular functioni

  • translation initiation factor binding Source: RGD

Structurei

3D structure databases

ProteinModelPortaliQ63186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000176924.
HOVERGENiHBG051459.
InParanoidiQ63186.
KOiK03680.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVAVAVRE ESRSEMKTEL SPRPGAAGRE LTQEEKLQLR KEKKQQKKKR
60 70 80 90 100
KEEKGADQEI GSAVSAAQRQ DPVRELQGTG SQLGGTTGEK LPAGRSKAEL
110 120 130 140 150
RAERRAKQEA ERALKQARKG EQGGPSPQAC PSTAGEATSG VKRVPEHTQA
160 170 180 190 200
DDPTLLRRLL RKPDRQQVPT RKDYGSKVSL FSHLPQYSRQ SSLTQYMSIP
210 220 230 240 250
SSVIHPAMVR LGLQYSQGLV SGSNARCIAL LHALQQVIQD YTTPPNEELS
260 270 280 290 300
RDLVNKLKPY ISFLTQCRPM SASMCNAIKF FNKEVTGMSS SKREEEAKSE
310 320 330 340 350
LKEAIDRYVQ EKIVLASQAI SRFASKKISD GDVILVYGCS SLVSRILQEA
360 370 380 390 400
WVEGRRFRVV VVDSRPRLEG RHMLHCLVRA GVPTSYLLIP AASYVLPEVS
410 420 430 440 450
KVLLGAHALL ANGSVMSRVG TAQLALVARA HNVPVLVCCE TYKFCERVQT
460 470 480 490 500
DAFVSNELDD PDDLQCKRGD QVTLANWQNN SSLRLLNLVY DVTPPELVDL
510 520
VITELGMIPC SSVPVVLRVK SSDQ
Length:524
Mass (Da):57,809
Last modified:November 1, 1997 - v1
Checksum:i4B63F2AB10313924
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48225 mRNA. Translation: CAA88256.1.
PIRiS71961.
RefSeqiNP_446402.1. NM_053950.1.
UniGeneiRn.11060.

Genome annotation databases

GeneIDi117019.
KEGGirno:117019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48225 mRNA. Translation: CAA88256.1.
PIRiS71961.
RefSeqiNP_446402.1. NM_053950.1.
UniGeneiRn.11060.

3D structure databases

ProteinModelPortaliQ63186.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ63186.
PhosphoSiteiQ63186.

Proteomic databases

PRIDEiQ63186.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117019.
KEGGirno:117019.

Organism-specific databases

CTDi8890.
RGDi620208. Eif2b4.

Phylogenomic databases

HOGENOMiHOG000176924.
HOVERGENiHBG051459.
InParanoidiQ63186.
KOiK03680.

Miscellaneous databases

PROiQ63186.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast."
    Price N.T., Mellor H., Craddock B.L., Flowers K.M., Kimball S.R., Wilmer T., Jefferson L.S., Proud C.G.
    Biochem. J. 318:637-643(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiEI2BD_RAT
AccessioniPrimary (citable) accession number: Q63186
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.