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Protein

Disintegrin and metalloproteinase domain-containing protein 7

Gene

Adam7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).By similarity

GO - Molecular functioni

Protein family/group databases

MEROPSiM12.956

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 7
Short name:
ADAM 7
Alternative name(s):
Epididymal apical protein I
Short name:
EAP I
Gene namesi
Name:Adam7
Synonyms:Eapi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi62032 Adam7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini177 – 668ExtracellularSequence analysisAdd BLAST492
Transmembranei669 – 689HelicalSequence analysisAdd BLAST21
Topological domaini690 – 789CytoplasmicSequence analysisAdd BLAST100

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
PropeptideiPRO_000002905826 – 176Sequence analysisAdd BLAST151
ChainiPRO_0000029059177 – 789Disintegrin and metalloproteinase domain-containing protein 7Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi310 ↔ 388By similarity
Disulfide bondi350 ↔ 372By similarity
Disulfide bondi352 ↔ 357By similarity
Disulfide bondi459 ↔ 479By similarity
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi628N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi664N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63180
PRIDEiQ63180

Expressioni

Tissue specificityi

Expressed specifically in the caput region of the epididymis.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019209

Structurei

3D structure databases

ProteinModelPortaliQ63180
SMRiQ63180
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini199 – 393Peptidase M12BPROSITE-ProRule annotationAdd BLAST195
Domaini401 – 487DisintegrinPROSITE-ProRule annotationAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi488 – 668Cys-richAdd BLAST181

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
HOGENOMiHOG000230883
HOVERGENiHBG006978
InParanoidiQ63180
KOiK16071
PhylomeDBiQ63180

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPTGIFLMS VLISQMQGRG IVGVEGQELV HPKKLSLLQK RDLERIHDSD
60 70 80 90 100
TPEEYEEELL YEIKLGRKTL TLHLLKAREF LALNYSETYY NIKREMVTRH
110 120 130 140 150
PQILDHCFYQ GSIIHEFDSA ASISTCNGLR GFFRVNDQRY LIEPVKYSDE
160 170 180 190 200
GDHLVFKYNV KAPYATNYSC EGLNFTKKST LIDAKIIEEH KVEDYHKEKF
210 220 230 240 250
IELFVVADEF VYRRNSKPQN KLRKRIWGMV NFVNMIYKAL NIRVTLTGME
260 270 280 290 300
IWSAGDEIEI VSNLESTLLH FSTWQETVLK KRKDFDHVIL LSGKWLYTSM
310 320 330 340 350
QGIAYPGGIC QTLRSCSVVK DLLPDVNIIG NRMAHQLGHS LGMRHDDFPC
360 370 380 390 400
TCPLGKCVMG AGSIPAIKFS KCSQTQYQQF LKNQKPACIL NNPLPEEFND
410 420 430 440 450
YPFCGNKKVD EGEECDCGPV QECTNPCCDA HKCVLKPGFT CVEGECCESC
460 470 480 490 500
QMKKEGVICR PAKNECDISE VCTGYSPECP KDESQANGFP CKNGEGYCFM
510 520 530 540 550
GLCPTRDDQC AELFSGGAEE SHSLCYRMNQ KGNRFGYCKN KDNTFVPCEE
560 570 580 590 600
KDLKCGKIYC TGGRRSAHLG EDKTYNLKNV KQNISIKCKT MFLYHNSRDM
610 620 630 640 650
GLVNSGTKCG EGMVCSNGEC IEMEKAYNST ICSSLCDEND VDDNEPDCQC
660 670 680 690 700
EEGPIITEWG EALNLTSVSI MVVVLVMVII GVGLVILLIR YQKCIKMKQV
710 720 730 740 750
QSSSREIRGI ENKVYFPDEH QTRSEPIFTD IYPLHNTAES LERVPSTFSS
760 770 780
PHYITLKSVS KDPRGIADPK QNDNMNLNLD SQSDCTRLG
Length:789
Mass (Da):89,362
Last modified:November 1, 1996 - v1
Checksum:iEF11E7F1C5EF0779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66140 mRNA Translation: CAA46930.1
PIRiS28259
RefSeqiNP_064697.1, NM_020301.1
UniGeneiRn.10357

Genome annotation databases

GeneIDi29641
KEGGirno:29641
UCSCiRGD:62032 rat

Similar proteinsi

Entry informationi

Entry nameiADAM7_RAT
AccessioniPrimary (citable) accession number: Q63180
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health