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Protein

Disintegrin and metalloproteinase domain-containing protein 7

Gene

Adam7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM12.956.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 7
Short name:
ADAM 7
Alternative name(s):
Epididymal apical protein I
Short name:
EAP I
Gene namesi
Name:Adam7
Synonyms:Eapi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi62032. Adam7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini177 – 668492ExtracellularSequence analysisAdd
BLAST
Transmembranei669 – 68921HelicalSequence analysisAdd
BLAST
Topological domaini690 – 789100CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical part of cell Source: RGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Propeptidei26 – 176151Sequence analysisPRO_0000029058Add
BLAST
Chaini177 – 789613Disintegrin and metalloproteinase domain-containing protein 7PRO_0000029059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence analysis
Disulfide bondi310 ↔ 388By similarity
Disulfide bondi350 ↔ 372By similarity
Disulfide bondi352 ↔ 357By similarity
Disulfide bondi459 ↔ 479By similarity
Glycosylationi583 – 5831N-linked (GlcNAc...)Sequence analysis
Glycosylationi628 – 6281N-linked (GlcNAc...)Sequence analysis
Glycosylationi664 – 6641N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63180.
PRIDEiQ63180.

Expressioni

Tissue specificityi

Expressed specifically in the caput region of the epididymis.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019209.

Structurei

3D structure databases

ProteinModelPortaliQ63180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini199 – 393195Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini401 – 48787DisintegrinPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi488 – 668181Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
HOGENOMiHOG000230883.
HOVERGENiHBG006978.
InParanoidiQ63180.
KOiK16071.
PhylomeDBiQ63180.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPTGIFLMS VLISQMQGRG IVGVEGQELV HPKKLSLLQK RDLERIHDSD
60 70 80 90 100
TPEEYEEELL YEIKLGRKTL TLHLLKAREF LALNYSETYY NIKREMVTRH
110 120 130 140 150
PQILDHCFYQ GSIIHEFDSA ASISTCNGLR GFFRVNDQRY LIEPVKYSDE
160 170 180 190 200
GDHLVFKYNV KAPYATNYSC EGLNFTKKST LIDAKIIEEH KVEDYHKEKF
210 220 230 240 250
IELFVVADEF VYRRNSKPQN KLRKRIWGMV NFVNMIYKAL NIRVTLTGME
260 270 280 290 300
IWSAGDEIEI VSNLESTLLH FSTWQETVLK KRKDFDHVIL LSGKWLYTSM
310 320 330 340 350
QGIAYPGGIC QTLRSCSVVK DLLPDVNIIG NRMAHQLGHS LGMRHDDFPC
360 370 380 390 400
TCPLGKCVMG AGSIPAIKFS KCSQTQYQQF LKNQKPACIL NNPLPEEFND
410 420 430 440 450
YPFCGNKKVD EGEECDCGPV QECTNPCCDA HKCVLKPGFT CVEGECCESC
460 470 480 490 500
QMKKEGVICR PAKNECDISE VCTGYSPECP KDESQANGFP CKNGEGYCFM
510 520 530 540 550
GLCPTRDDQC AELFSGGAEE SHSLCYRMNQ KGNRFGYCKN KDNTFVPCEE
560 570 580 590 600
KDLKCGKIYC TGGRRSAHLG EDKTYNLKNV KQNISIKCKT MFLYHNSRDM
610 620 630 640 650
GLVNSGTKCG EGMVCSNGEC IEMEKAYNST ICSSLCDEND VDDNEPDCQC
660 670 680 690 700
EEGPIITEWG EALNLTSVSI MVVVLVMVII GVGLVILLIR YQKCIKMKQV
710 720 730 740 750
QSSSREIRGI ENKVYFPDEH QTRSEPIFTD IYPLHNTAES LERVPSTFSS
760 770 780
PHYITLKSVS KDPRGIADPK QNDNMNLNLD SQSDCTRLG
Length:789
Mass (Da):89,362
Last modified:November 1, 1996 - v1
Checksum:iEF11E7F1C5EF0779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66140 mRNA. Translation: CAA46930.1.
PIRiS28259.
RefSeqiNP_064697.1. NM_020301.1.
UniGeneiRn.10357.

Genome annotation databases

GeneIDi29641.
KEGGirno:29641.
UCSCiRGD:62032. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66140 mRNA. Translation: CAA46930.1.
PIRiS28259.
RefSeqiNP_064697.1. NM_020301.1.
UniGeneiRn.10357.

3D structure databases

ProteinModelPortaliQ63180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019209.

Protein family/group databases

MEROPSiM12.956.

Proteomic databases

PaxDbiQ63180.
PRIDEiQ63180.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29641.
KEGGirno:29641.
UCSCiRGD:62032. rat.

Organism-specific databases

CTDi8756.
RGDi62032. Adam7.

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
HOGENOMiHOG000230883.
HOVERGENiHBG006978.
InParanoidiQ63180.
KOiK16071.
PhylomeDBiQ63180.

Miscellaneous databases

NextBioi609898.
PROiQ63180.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A mammalian epididymal protein with remarkable sequence similarity to snake venom haemorrhagic peptides."
    Perry A.C.F., Jones R., Barker P.J., Hall L.
    Biochem. J. 286:671-675(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 26-38.
    Tissue: Epididymis.

Entry informationi

Entry nameiADAM7_RAT
AccessioniPrimary (citable) accession number: Q63180
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.