Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q63176

- Q63176_RAT

UniProt

Q63176 - Q63176_RAT

Protein
Submitted name:

DNA topoisomerase IIA

Gene

Top2a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. DNA binding, bending Source: InterPro
    3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: InterPro
    4. magnesium ion binding Source: InterPro

    GO - Biological processi

    1. DNA topological change Source: InterPro

    Keywords - Molecular functioni

    IsomeraseImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    DNA topoisomerase IIAImported
    Gene namesi
    Name:Top2aImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi62048. Top2a.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: InterPro

    Expressioni

    Gene expression databases

    GenevestigatoriQ63176.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000216693.
    InParanoidiQ63176.

    Family and domain databases

    Gene3Di3.30.1360.40. 1 hit.
    3.90.199.10. 1 hit.
    InterProiIPR024946. Arg_repress_C-like.
    IPR028466. Top2a.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    [Graphical view]
    PANTHERiPTHR10169:SF33. PTHR10169:SF33. 1 hit.
    PfamiPF00521. DNA_topoisoIV. 1 hit.
    [Graphical view]
    SMARTiSM00434. TOP4c. 1 hit.
    [Graphical view]
    SUPFAMiSSF56719. SSF56719. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q63176-1 [UniParc]FASTAAdd to Basket

    « Hide

    AQLAGSVAEM SSYHHGEMSL MMTIINLAQN FVGSNNLNLL QPIGQFGTRL    50
    HGGKDSASPR YIFTMLSPLA RLLFPSKDDH TLRFLYDDNQ RVEPEWYILI 100
    IPMVLINGAE GIGTGWSCKI PNFDVREVVN NIRRLLDGEE PLPMLPSYKN 150
    YKGTIEELAS NQYVINGEVA ILNSTTIEIT ELPIRTWTQT YKEQVLEPML 200
    NGTEKTPPLI TDYR 214
    Length:214
    Mass (Da):24,173
    Last modified:November 1, 1996 - v1
    Checksum:i46A28A1DEA188A5A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei214 – 2141Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14045 mRNA. Translation: BAA03132.1.
    UniGeneiRn.90996.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14045 mRNA. Translation: BAA03132.1 .
    UniGenei Rn.90996.

    3D structure databases

    ProteinModelPortali Q63176.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 62048. Top2a.

    Phylogenomic databases

    HOGENOMi HOG000216693.
    InParanoidi Q63176.

    Gene expression databases

    Genevestigatori Q63176.

    Family and domain databases

    Gene3Di 3.30.1360.40. 1 hit.
    3.90.199.10. 1 hit.
    InterProi IPR024946. Arg_repress_C-like.
    IPR028466. Top2a.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    [Graphical view ]
    PANTHERi PTHR10169:SF33. PTHR10169:SF33. 1 hit.
    Pfami PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view ]
    SMARTi SM00434. TOP4c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56719. SSF56719. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of partial cDNAs for rat DNA topoisomerase II isoforms and their differential expression in brain development."
      Tsutsui K., Tsutsui K., Okada S., Watanabe M., Shohmori T., Seki S., Inoue Y.
      J. Biol. Chem. 268:19076-19083(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiQ63176_RAT
    AccessioniPrimary (citable) accession number: Q63176
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)