SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q63176

- Q63176_RAT

UniProt

Q63176 - Q63176_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

DNA topoisomerase IIA

Gene
Top2a
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA binding, bending Source: InterPro
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: InterPro
  4. magnesium ion binding Source: InterPro

GO - Biological processi

  1. DNA topological change Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Names & Taxonomyi

Protein namesi
Submitted name:
DNA topoisomerase IIAImported
Gene namesi
Name:Top2aImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi62048. Top2a.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ63176.

Structurei

3D structure databases

ProteinModelPortaliQ63176.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000216693.
InParanoidiQ63176.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
InterProiIPR024946. Arg_repress_C-like.
IPR028466. Top2a.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PANTHERiPTHR10169:SF33. PTHR10169:SF33. 1 hit.
PfamiPF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q63176-1 [UniParc]FASTAAdd to Basket

« Hide

AQLAGSVAEM SSYHHGEMSL MMTIINLAQN FVGSNNLNLL QPIGQFGTRL    50
HGGKDSASPR YIFTMLSPLA RLLFPSKDDH TLRFLYDDNQ RVEPEWYILI 100
IPMVLINGAE GIGTGWSCKI PNFDVREVVN NIRRLLDGEE PLPMLPSYKN 150
YKGTIEELAS NQYVINGEVA ILNSTTIEIT ELPIRTWTQT YKEQVLEPML 200
NGTEKTPPLI TDYR 214
Length:214
Mass (Da):24,173
Last modified:November 1, 1996 - v1
Checksum:i46A28A1DEA188A5A
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei214 – 2141Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14045 mRNA. Translation: BAA03132.1.
UniGeneiRn.90996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14045 mRNA. Translation: BAA03132.1 .
UniGenei Rn.90996.

3D structure databases

ProteinModelPortali Q63176.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 62048. Top2a.

Phylogenomic databases

HOGENOMi HOG000216693.
InParanoidi Q63176.

Gene expression databases

Genevestigatori Q63176.

Family and domain databases

Gene3Di 3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
InterProi IPR024946. Arg_repress_C-like.
IPR028466. Top2a.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view ]
PANTHERi PTHR10169:SF33. PTHR10169:SF33. 1 hit.
Pfami PF00521. DNA_topoisoIV. 1 hit.
[Graphical view ]
SMARTi SM00434. TOP4c. 1 hit.
[Graphical view ]
SUPFAMi SSF56719. SSF56719. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of partial cDNAs for rat DNA topoisomerase II isoforms and their differential expression in brain development."
    Tsutsui K., Tsutsui K., Okada S., Watanabe M., Shohmori T., Seki S., Inoue Y.
    J. Biol. Chem. 268:19076-19083(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ63176_RAT
AccessioniPrimary (citable) accession number: Q63176
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi