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Protein
Submitted name:

DNA topoisomerase IIA

Gene

Top2a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Names & Taxonomyi

Protein namesi
Submitted name:
DNA topoisomerase IIAImported
Gene namesi
Name:Top2aImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi62048. Top2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040257.

Structurei

3D structure databases

ProteinModelPortaliQ63176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000216693.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
InterProiIPR024946. Arg_repress_C-like.
IPR028466. Top2a.
IPR013760. Topo_IIA-like_dom.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
[Graphical view]
PANTHERiPTHR10169:SF33. PTHR10169:SF33. 1 hit.
PfamiPF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q63176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AQLAGSVAEM SSYHHGEMSL MMTIINLAQN FVGSNNLNLL QPIGQFGTRL
60 70 80 90 100
HGGKDSASPR YIFTMLSPLA RLLFPSKDDH TLRFLYDDNQ RVEPEWYILI
110 120 130 140 150
IPMVLINGAE GIGTGWSCKI PNFDVREVVN NIRRLLDGEE PLPMLPSYKN
160 170 180 190 200
YKGTIEELAS NQYVINGEVA ILNSTTIEIT ELPIRTWTQT YKEQVLEPML
210
NGTEKTPPLI TDYR
Length:214
Mass (Da):24,173
Last modified:November 1, 1996 - v1
Checksum:i46A28A1DEA188A5A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei214 – 2141Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14045 mRNA. Translation: BAA03132.1.
UniGeneiRn.90996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14045 mRNA. Translation: BAA03132.1.
UniGeneiRn.90996.

3D structure databases

ProteinModelPortaliQ63176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi62048. Top2a.

Phylogenomic databases

HOGENOMiHOG000216693.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
InterProiIPR024946. Arg_repress_C-like.
IPR028466. Top2a.
IPR013760. Topo_IIA-like_dom.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
[Graphical view]
PANTHERiPTHR10169:SF33. PTHR10169:SF33. 1 hit.
PfamiPF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of partial cDNAs for rat DNA topoisomerase II isoforms and their differential expression in brain development."
    Tsutsui K., Tsutsui K., Okada S., Watanabe M., Shohmori T., Seki S., Inoue Y.
    J. Biol. Chem. 268:19076-19083(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ63176_RAT
AccessioniPrimary (citable) accession number: Q63176
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.