Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine incorporator 5

Gene

Serinc5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes.By similarity2 Publications

GO - Molecular functioni

  • L-serine transmembrane transporter activity Source: HGNC

GO - Biological processi

  • defense response to virus Source: UniProtKB
  • detection of virus Source: UniProtKB
  • innate immune response Source: UniProtKB
  • L-serine transport Source: HGNC
  • myelination Source: RGD
  • phosphatidylserine metabolic process Source: HGNC
  • phospholipid biosynthetic process Source: UniProtKB-KW
  • positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity Source: BHF-UCL
  • positive regulation of serine C-palmitoyltransferase activity Source: BHF-UCL
  • sphingolipid metabolic process Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 5
Alternative name(s):
Developmentally regulated protein TPO11 Publication
Gene namesi
Name:Serinc5
Synonyms:Tpo11 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621571. Serinc5.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis

  • Note: Localizes to the cell membrane, where it is efficiently incorporated into budding gammaretrovirus virions and impairs subsequent virion penetration of susceptible target cells.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636ExtracellularSequence analysisAdd
BLAST
Transmembranei37 – 5721HelicalSequence analysisAdd
BLAST
Topological domaini58 – 8932CytoplasmicSequence analysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence analysisAdd
BLAST
Topological domaini111 – 12414ExtracellularSequence analysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence analysisAdd
BLAST
Topological domaini146 – 15611CytoplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Topological domaini178 – 19720ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence analysisAdd
BLAST
Topological domaini219 – 22911CytoplasmicSequence analysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence analysisAdd
BLAST
Topological domaini251 – 2588ExtracellularSequence analysis
Transmembranei259 – 27921HelicalSequence analysisAdd
BLAST
Topological domaini280 – 30930CytoplasmicSequence analysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence analysisAdd
BLAST
Topological domaini331 – 39060ExtracellularSequence analysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence analysisAdd
BLAST
Topological domaini412 – 42716CytoplasmicSequence analysisAdd
BLAST
Transmembranei428 – 44821HelicalSequence analysisAdd
BLAST
Topological domaini449 – 46012ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Serine incorporator 5PRO_0000330633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence analysis
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ63175.
PRIDEiQ63175.

Expressioni

Tissue specificityi

Brain. Expressed at high levels in the white matter and the oligodendroglial cells of the brain. Expressed at low levels in the liver.2 Publications

Developmental stagei

First detected in significant amounts at postnatal day 2 (P2) and increases about twofold to a peak value at P17-P20 and declines significantly thereafter.1 Publication

Inductioni

Up-regulated during the differentiation of oligodendrocyte lineage cells and during brain development at the time of myelination. Down-regulated in the hippocampal CA fields and dentate gyrus by seizures.2 Publications

Gene expression databases

BgeeiENSRNOG00000024039.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060697.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 2622Cys-richAdd
BLAST
Compositional biasi131 – 1344Poly-Leu

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ63175.
OrthoDBiEOG091G06BW.
PhylomeDBiQ63175.

Family and domain databases

InterProiIPR029555. Serinc5.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF16. PTHR10383:SF16. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q63175-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSARCCAGQL ACCCGSAGCA LCCGCCPKFR QSRSTRFMYL FYFTLVIIPC
60 70 80 90 100
CVMMSPSVMK QMTEHIPFFE DFCKGIKAGD TCENLVGYSA VYRVCFGMAC
110 120 130 140 150
FFFVFCVLTF KVNNSKSCRA SIHNGFWFFK LLLLGAMCSG AFFIPDQETF
160 170 180 190 200
LNVWRYVGAV GSFFFICIQL LLIVEFAHKW NKNWTAGTVR NKLWYASLSL
210 220 230 240 250
ALIMYSIAVG GLALMAVFYT QWDDCMDNKI LLGVHGGLCV LISLAAISPC
260 270 280 290 300
VQNRQPHSGL LQPGLISCYV TYLTFSALTS KPEKVVKDEH GKNVTICVPD
310 320 330 340 350
FGQDFRRDES MVTWLGTLLL VVCISYSCLT STTRSSSDAL QRRYGAPELE
360 370 380 390 400
VARCCFCFGP DGEDTEEQQN VKEGPRVIYD EKKGTVYSYS YFHFVLLLAS
410 420 430 440 450
LYVMMTLTSW FHYENATIET FFVGSWSIFW VKMASCWMCV LLYLWTLVAP
460
LCCPSRQFSV
Length:460
Mass (Da):51,856
Last modified:November 1, 1996 - v1
Checksum:iCB9DA60F66282FB3
GO
Isoform 2 (identifier: Q63175-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Show »
Length:423
Mass (Da):48,033
Checksum:i04AB5F9A1E209C22
GO

Sequence cautioni

The sequence EDM10024 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3737Missing in isoform 2. 1 PublicationVSP_033056Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20319 mRNA. Translation: AAA41097.1.
DQ103710 mRNA. Translation: AAZ80297.1.
AABR07007649 Genomic DNA. No translation available.
AABR07007650 Genomic DNA. No translation available.
AABR07007651 Genomic DNA. No translation available.
AABR07072694 Genomic DNA. No translation available.
AC130639 Genomic DNA. No translation available.
CH473955 Genomic DNA. Translation: EDM10024.1. Sequence problems.
RefSeqiNP_596886.2. NM_133395.2.
UniGeneiRn.4099.

Genome annotation databases

GeneIDi170907.
KEGGirno:170907.
UCSCiRGD:621571. rat. [Q63175-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20319 mRNA. Translation: AAA41097.1.
DQ103710 mRNA. Translation: AAZ80297.1.
AABR07007649 Genomic DNA. No translation available.
AABR07007650 Genomic DNA. No translation available.
AABR07007651 Genomic DNA. No translation available.
AABR07072694 Genomic DNA. No translation available.
AC130639 Genomic DNA. No translation available.
CH473955 Genomic DNA. Translation: EDM10024.1. Sequence problems.
RefSeqiNP_596886.2. NM_133395.2.
UniGeneiRn.4099.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060697.

Proteomic databases

PaxDbiQ63175.
PRIDEiQ63175.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi170907.
KEGGirno:170907.
UCSCiRGD:621571. rat. [Q63175-1]

Organism-specific databases

CTDi256987.
RGDi621571. Serinc5.

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ63175.
OrthoDBiEOG091G06BW.
PhylomeDBiQ63175.

Miscellaneous databases

PROiQ63175.

Gene expression databases

BgeeiENSRNOG00000024039.

Family and domain databases

InterProiIPR029555. Serinc5.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF16. PTHR10383:SF16. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSERC5_RAT
AccessioniPrimary (citable) accession number: Q63175
Secondary accession number(s): G3V9U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.